New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrases

Authors: Doretta Cuffaro, Riccardo Di Leo, Lidia Ciccone, Alessio Nocentini, Claudiu T. Supuran, Elisa Nuti, Armando Rossello

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Subject Terms: Carbonic anhydrase activators, isoxazolines, neurodegenerative diseases, amino alcohols, metalloenzymes, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/7dff52c7a680471b9681ec8b3fcfb28f

New Hybrid Compounds Incorporating Natural Products as Multifunctional Agents against Alzheimer’s Disease

Authors: Lidia Ciccone, Caterina Camodeca, Nicolò Tonali, Lucia Barlettani, Armando Rossello, Carole Fruchart Gaillard, Julia Kaffy, Giovanni Petrarolo, Concettina La Motta, Susanna Nencetti, Elisabetta Orlandini

Source: Pharmaceutics, Vol 15, Iss 10, p 2369 (2023)

Subject Terms: neuroprotection, amyloid β (Aβ), chelating agents, antioxidant, Transthyretin, TTR, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/15/10/2369; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/9600a40359d640529d4c3d967198f601

Pomegranate: A Source of Multifunctional Bioactive Compounds Potentially Beneficial in Alzheimer’s Disease

Authors: Lidia Ciccone, Susanna Nencetti, Armando Rossello, Elisabetta Orlandini

Source: Pharmaceuticals, Vol 16, Iss 7, p 1036 (2023)

Subject Terms: Alzheimer’s disease, AD, pomegranate fruit, nutraceuticals, antioxidants, multifunctional compounds, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/7/1036; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/4d7b863fe6a243e4b28a97d592c1ed0b

Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines

Authors: Susanna Nencetti, Doretta Cuffaro, Elisa Nuti, Lidia Ciccone, Armando Rossello, Marina Fabbi, Flavio Ballante, Gabriella Ortore, Grazia Carbotti, Francesco Campelli, Irene Banti, Rosaria Gangemi, Garland R. Marshall, Elisabetta Orlandini

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 34-47 (2021)

Subject Terms: uveal melanoma, hdac inhibitors, hdac6, saha, (arylidene)aminoxy-based hydroxamates, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/dd29395ad7324c7e95f604e5f4b25f96

Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

Authors: Salvatore Santamaria, Doretta Cuffaro, Elisa Nuti, Lidia Ciccone, Tiziano Tuccinardi, Francesca Liva, Felicia D’Andrea, Rens de Groot, Armando Rossello, Josefin Ahnström

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/56c563a9e37d4463930edc6fb1a77ba9

Development of a fluorogenic ADAMTS-7 substrate

Authors: Salvatore Santamaria, Frederic Buemi, Elisa Nuti, Doretta Cuffaro, Elena De Vita, Tiziano Tuccinardi, Armando Rossello, Steven Howell, Shahid Mehmood, Ambrosius P. Snijders, Rens de Groot

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 2160-2169 (2021)

Subject Terms: adamts-7, adamts7, activity assay, inhibitor, coronary artery disease, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/3421a4ab52224930ae597bd94dec09dc

Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators

Authors: Alessio Nocentini, Doretta Cuffaro, Lidia Ciccone, Elisabetta Orlandini, Susanna Nencetti, Elisa Nuti, Armando Rossello, Claudiu T. Supuran

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 48-57 (2021)

Subject Terms: metalloenzyme, activation, selectivity, cns-disease, cognition, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/5e4b7f680e684ae183c6d9e3314fe9ca

Ionic liquid-promoted green synthesis of biologically relevant diaryl thioethers

Authors: Doretta Cuffaro, Felicia D’Andrea, Andrea Mezzetta, Lorenzo Guazzelli, Cinzia Chiappe, Elisa Nuti, Armando Rossello

Source: Green Chemistry Letters and Reviews, Vol 13, Iss 4, Pp 295-302 (2020)

Subject Terms: ionic liquids, diaryl thioethers, ullmann reaction, suzuki cross-coupling, microwave irradiation, Science, Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/1751-8253; https://doaj.org/toc/1751-7192

Access URL: https://doaj.org/article/19c2c7b13d6e4584b2d683c0f5f68798

Bacterial Zinc Metalloenzyme Inhibitors: Recent Advances and Future Perspectives

Authors: Riccardo Di Leo, Doretta Cuffaro, Armando Rossello, Elisa Nuti

Source: Molecules, Vol 28, Iss 11, p 4378 (2023)

Subject Terms: zinc metalloenzymes, LpxC, pseudolysin, thermolysin, antivirulence agents, Gram-negative bacteria, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/11/4378; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/d0b29400211f4d62894f150044c62438

An overview of carbohydrate-based carbonic anhydrase inhibitors

Authors: Doretta Cuffaro, Elisa Nuti, Armando Rossello

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1906-1922 (2020)

Subject Terms: carbonic anhydrases, glycoconjugates, ca ix, ca inhibitors, hypoxic tumours, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/3e57a9ff072a437892a87ae714948fb2

Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach

Authors: Elisa Nuti, Valeria La Pietra, Simona Daniele, Doretta Cuffaro, Lidia Ciccone, Chiara Giacomelli, Carolina Cason, Alfonso Carotenuto, Vincenzo Maria D’Amore, Eleonora Da Pozzo, Barbara Costa, Riccardo Di Leo, Manola Comar, Luciana Marinelli, Claudia Martini, Armando Rossello

Source: Pharmaceuticals, Vol 15, Iss 11, p 1318 (2022)

Subject Terms: p53 modulator, antibacterial activity, glioblastoma multiforme, p53–MDM2 complex, Chlamydia trachomatis, virtual screening, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/15/11/1318; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/6617491cc612473bbc9d99a6af5636a2

Inhibitors of ADAM10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect

Authors: Roberta Pece, Sara Tavella, Delfina Costa, Serena Varesano, Caterina Camodeca, Doretta Cuffaro, Elisa Nuti, Armando Rossello, Massimo Alfano, Cristina D’Arrigo, Denise Galante, Jean-Louis Ravetti, Marco Gobbi, Francesca Tosetti, Alessandro Poggi, Maria Raffaella Zocchi

Source: Haematologica, Vol 107, Iss 4 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10295; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/0c5074d89a3f49278187593917287dfc

Editorial: ADAM10 in Cancer Immunology and Autoimmunity: More Than a Simple Biochemical Scissor

Authors: Armando Rossello, Alexander Steinle, Alessandro Poggi, Maria R. Zocchi

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: metzincin, NKG2D, NKG2DL, CD30, Hodgkin lymphoma, ADAM10 exocyte, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.01483/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/bed5dbe660ac47c69a7209c521ac9e87

Antioxidant Quercetin 3-O-Glycosylated Plant Flavonols Contribute to Transthyretin Stabilization

Authors: Lidia Ciccone, Nicolò Tonali, Carole Fruchart-Gaillard, Lucia Barlettani, Armando Rossello, Alessandra Braca, Elisabetta Orlandini, Susanna Nencetti

Source: Crystals, Vol 12, Iss 5, p 638 (2022)

Subject Terms: transthyretin, TTR, quercetin 3-O-glycosylated derivatives, amyloidosis, antioxidant, plant bioactive metabolites, Crystallography, QD901-999

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4352/12/5/638; https://doaj.org/toc/2073-4352

Access URL: https://doaj.org/article/72f6ee8c1bec4f2fac76590accd8df40

Identification of Broad-Spectrum MMP Inhibitors by Virtual Screening

Authors: Aleix Gimeno, Doretta Cuffaro, Elisa Nuti, María José Ojeda-Montes, Raúl Beltrán-Debón, Miquel Mulero, Armando Rossello, Gerard Pujadas, Santiago Garcia-Vallvé

Source: Molecules, Vol 26, Iss 15, p 4553 (2021)

Subject Terms: photoaging, skin treatment, non-selective matrix metalloproteinases, natural products, bioactivity prediction, in vitro validation, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/15/4553; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/329fb1eec2ae4d9097a4f3ca6842d0f7

Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution

Authors: Matteo Calligaris, Doretta Cuffaro, Simone Bonelli, Donatella Pia Spanò, Armando Rossello, Elisa Nuti, Simone Dario Scilabra

Source: Molecules, Vol 26, Iss 4, p 944 (2021)

Subject Terms: ectodomain shedding, ADAM17, iRhoms, metalloproteinases, TIMPs, TNF, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/4/944; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/5d2e9a94bdde463bb8cdfac8ec4d6bde

Developments in Carbohydrate-Based Metzincin Inhibitors

Authors: Doretta Cuffaro, Elisa Nuti, Felicia D’Andrea, Armando Rossello

Source: Pharmaceuticals, Vol 13, Iss 11, p 376 (2020)

Subject Terms: carbohydrates, glycoconjugates, MMPs, ADAMs, iminosugars, metzincin inhibitors, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/13/11/376; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/31bbc63a39464c9a946f4ed3d2b49c56

Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms

Authors: Elisa Nuti, Armando Rossello, Doretta Cuffaro, Caterina Camodeca, Jens Van Bael, Dries van der Maat, Erik Martens, Pierre Fiten, Rafaela Vaz Sousa Pereira, Estefania Ugarte-Berzal, Mieke Gouwy, Ghislain Opdenakker, Jennifer Vandooren

Source: Cells, Vol 9, Iss 7, p 1634 (2020)

Subject Terms: MMP-9, inflammation, endotoxemia, leukocytosis, chemotaxis, sepsis, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/7/1634; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/598faee1983745e0a58f6bed59c8b4c2

Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells

Authors: Francesca Tosetti, Roberta Venè, Caterina Camodeca, Elisa Nuti, Armando Rossello, Cristina D'Arrigo, Denise Galante, Nicoletta Ferrari, Alessandro Poggi, Maria Raffaella Zocchi

Source: OncoImmunology, Vol 7, Iss 5 (2018)

Subject Terms: immune escape, immune stress, alfa-secretase, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/8b21581894684e339c882ae7f8bd821e

Multicomponent mixtures for cryoprotection and ligand solubilization

Authors: Lidia Ciccone, Laura Vera, Livia Tepshi, Lea Rosalia, Armando Rossello, Enrico A. Stura

Source: Biotechnology Reports, Vol 7, Iss C, Pp 120-127 (2015)

Subject Terms: Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2215017X15000351; https://doaj.org/toc/2215-017X

Access URL: https://doaj.org/article/89ef1af888194602a35159ce0497cba3