Reinforcement learning for intensive care medicine: actionable clinical insights from novel approaches to reward shaping and off-policy model evaluation

Authors: Luca F. Roggeveen, Ali el Hassouni, Harm-Jan de Grooth, Armand R. J. Girbes, Mark Hoogendoorn, Paul W. G. Elbers, the Dutch ICU Data Sharing Against COVID-19 Collaborators

Source: Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-13 (2024)

Subject Terms: Reinforcement learning, Explainability, Safety, Mechanical ventilation, Peep, fo2, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/2197-425X

Access URL: https://doaj.org/article/4208842b159948619a3883a836399732

Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study

Authors: Philipp Kloss, Maximilian Lindholz, Annette Milnik, Elie Azoulay, Maurizio Cecconi, Giuseppe Citerio, Thomas De Corte, Frantisek Duska, Laura Galarza, Massimiliano Greco, Armand R. J. Girbes, Jozef Kesecioglu, Johannes Mellinghoff, Marlies Ostermann, Mariangela Pellegrini, Jean-Louis Teboul, Jan De Waele, Adrian Wong, Stefan J. Schaller, for the ESICM UNITE COVID Investigators

Source: Annals of Intensive Care, Vol 13, Iss 1, Pp 1-12 (2023)

Subject Terms: COVID-19, SARS-CoV-2, Early ambulation, Critical care, Intensive care units, Physical therapy specialty, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/2110-5820

Access URL: https://doaj.org/article/0c82a4a455dc4ecb8a1c9b9db319fd1a

Predicting responders to prone positioning in mechanically ventilated patients with COVID-19 using machine learning

Authors: Tariq A. Dam, Luca F. Roggeveen, Fuda van Diggelen, Lucas M. Fleuren, Ameet R. Jagesar, Martijn Otten, Heder J. de Vries, Diederik Gommers, Olaf L. Cremer, Rob J. Bosman, Sander Rigter, Evert-Jan Wils, Tim Frenzel, Dave A. Dongelmans, Remko de Jong, Marco A. A. Peters, Marlijn J. A. Kamps, Dharmanand Ramnarain, Ralph Nowitzky, Fleur G. C. A. Nooteboom, Wouter de Ruijter, Louise C. Urlings-Strop, Ellen G. M. Smit, D. Jannet Mehagnoul-Schipper, Tom Dormans, Cornelis P. C. de Jager, Stefaan H. A. Hendriks, Sefanja Achterberg, Evelien Oostdijk, Auke C. Reidinga, Barbara Festen-Spanjer, Gert B. Brunnekreef, Alexander D. Cornet, Walter van den Tempel, Age D. Boelens, Peter Koetsier, Judith Lens, Harald J. Faber, A. Karakus, Robert Entjes, Paul de Jong, Thijs C. D. Rettig, Sesmu Arbous, Sebastiaan J. J. Vonk, Tomas Machado, Willem E. Herter, Harm-Jan de Grooth, Patrick J. Thoral, Armand R. J. Girbes, Mark Hoogendoorn, Paul W. G. Elbers, The Dutch ICU Data Sharing Against COVID-19 Collaborators

Source: Annals of Intensive Care, Vol 12, Iss 1, Pp 1-9 (2022)

Subject Terms: COVID-19, Mechanical ventilation, Acute respiratory distress syndrome, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/2110-5820

Access URL: https://doaj.org/article/a3584c779f174b4ab55ecd74982c5e66

Right dose, right now: bedside, real-time, data-driven, and personalised antibiotic dosing in critically ill patients with sepsis or septic shock—a two-centre randomised clinical trial

Authors: Luca F. Roggeveen, Tingjie Guo, Lucas M. Fleuren, Ronald Driessen, Patrick Thoral, Reinier M. van Hest, Ron A. A. Mathot, Eleonora L. Swart, Harm-Jan de Grooth, Bas van den Bogaard, Armand R. J. Girbes, Rob J. Bosman, Paul W. G. Elbers

Source: Critical Care, Vol 26, Iss 1, Pp 1-11 (2022)

Subject Terms: Sepsis, Therapeutic drug monitoring, Pharmacokinetics, Clinical decision support, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/6a01424511e0433f9b3a6d071324f5c2

The impact of lung ultrasound on clinical-decision making across departments: a systematic review

Authors: Micah L. A. Heldeweg, Lian Vermue, Max Kant, Michelle Brouwer, Armand R. J. Girbes, Mark E. Haaksma, Leo M. A. Heunks, Amne Mousa, Jasper M. Smit, Thomas W. Smits, Frederique Paulus, Johannes C. F. Ket, Marcus J. Schultz, Pieter Roel Tuinman

Source: The Ultrasound Journal, Vol 14, Iss 1, Pp 1-8 (2022)

Subject Terms: Ultrasonography, Lung, Chest, Management, Clinical-decision making, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/2524-8987

Access URL: https://doaj.org/article/d32da65969ad44cda6dc40cb1f13cda1

Predictors for extubation failure in COVID-19 patients using a machine learning approach

Authors: Lucas M. Fleuren, Tariq A. Dam, Michele Tonutti, Daan P. de Bruin, Robbert C. A. Lalisang, Diederik Gommers, Olaf L. Cremer, Rob J. Bosman, Sander Rigter, Evert-Jan Wils, Tim Frenzel, Dave A. Dongelmans, Remko de Jong, Marco Peters, Marlijn J. A. Kamps, Dharmanand Ramnarain, Ralph Nowitzky, Fleur G. C. A. Nooteboom, Wouter de Ruijter, Louise C. Urlings-Strop, Ellen G. M. Smit, D. Jannet Mehagnoul-Schipper, Tom Dormans, Cornelis P. C. de Jager, Stefaan H. A. Hendriks, Sefanja Achterberg, Evelien Oostdijk, Auke C. Reidinga, Barbara Festen-Spanjer, Gert B. Brunnekreef, Alexander D. Cornet, Walter van den Tempel, Age D. Boelens, Peter Koetsier, Judith Lens, Harald J. Faber, A. Karakus, Robert Entjes, Paul de Jong, Thijs C. D. Rettig, Sesmu Arbous, Sebastiaan J. J. Vonk, Mattia Fornasa, Tomas Machado, Taco Houwert, Hidde Hovenkamp, Roberto Noorduijn Londono, Davide Quintarelli, Martijn G. Scholtemeijer, Aletta A. de Beer, Giovanni Cinà, Adam Kantorik, Tom de Ruijter, Willem E. Herter, Martijn Beudel, Armand R. J. Girbes, Mark Hoogendoorn, Patrick J. Thoral, Paul W. G. Elbers, the Dutch ICU Data Sharing Against Covid-19 Collaborators

Source: Critical Care, Vol 25, Iss 1, Pp 1-10 (2021)

Subject Terms: Extubation, Prediction, Risk factors, Extubation failure, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/c04ef1ea0f0b493fb77ba8e33296e30c

Lung ultrasound in a tertiary intensive care unit population: a diagnostic accuracy study

Authors: Jasper M. Smit, Mark E. Haaksma, Michiel H. Winkler, Micah L. A. Heldeweg, Luca Arts, Erik J. Lust, Paul W. G. Elbers, Lilian J. Meijboom, Armand R. J. Girbes, Leo M. A. Heunks, Pieter R. Tuinman

Source: Critical Care, Vol 25, Iss 1, Pp 1-9 (2021)

Subject Terms: Lung ultrasound, Thoracic computed tomography, Chest CT, Diagnostic accuracy, Acute respiratory failure, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/63bedb6419ed4e47814ff68051d19510

Breathing variability—implications for anaesthesiology and intensive care

Authors: Oscar F. C. van den Bosch, Ricardo Alvarez-Jimenez, Harm-Jan de Grooth, Armand R. J. Girbes, Stephan A. Loer

Source: Critical Care, Vol 25, Iss 1, Pp 1-13 (2021)

Subject Terms: Respiratory variability, Control of breathing, Spontaneous respiration, Coefficient of variation, Detrended fluctuation analysis, Entropy analysis, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/7d7589ce5388417c8e9ae395a4b13ea3

Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial

Authors: Sander Rozemeijer, Harm-Jan de Grooth, Paul W. G. Elbers, Armand R. J. Girbes, Corstiaan A. den Uil, Eric A. Dubois, Evert-Jan Wils, Thijs C. D. Rettig, Arthur R. H. van Zanten, Roel Vink, Bas van den Bogaard, Rob J. Bosman, Heleen M. Oudemans-van Straaten, Angélique M. E. de Man

Source: Trials, Vol 22, Iss 1, Pp 1-10 (2021)

Subject Terms: Out-of-hospital cardiac arrest, Ischemia/reperfusion injury, Post-cardiac arrest syndrome, Cardiac arrest, Free radicals, Reactive oxygen species, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/4251b9b9d5694d92ae89fd0a11a19626

The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients

Authors: Lucas M. Fleuren, Tariq A. Dam, Michele Tonutti, Daan P. de Bruin, Robbert C. A. Lalisang, Diederik Gommers, Olaf L. Cremer, Rob J. Bosman, Sander Rigter, Evert-Jan Wils, Tim Frenzel, Dave A. Dongelmans, Remko de Jong, Marco Peters, Marlijn J. A. Kamps, Dharmanand Ramnarain, Ralph Nowitzky, Fleur G. C. A. Nooteboom, Wouter de Ruijter, Louise C. Urlings-Strop, Ellen G. M. Smit, D. Jannet Mehagnoul-Schipper, Tom Dormans, Cornelis P. C. de Jager, Stefaan H. A. Hendriks, Sefanja Achterberg, Evelien Oostdijk, Auke C. Reidinga, Barbara Festen-Spanjer, Gert B. Brunnekreef, Alexander D. Cornet, Walter van den Tempel, Age D. Boelens, Peter Koetsier, Judith Lens, Harald J. Faber, A. Karakus, Robert Entjes, Paul de Jong, Thijs C. D. Rettig, Sesmu Arbous, Sebastiaan J. J. Vonk, Mattia Fornasa, Tomas Machado, Taco Houwert, Hidde Hovenkamp, Roberto Noorduijn-Londono, Davide Quintarelli, Martijn G. Scholtemeijer, Aletta A. de Beer, Giovanni Cina, Martijn Beudel, Willem E. Herter, Armand R. J. Girbes, Mark Hoogendoorn, Patrick J. Thoral, Paul W. G. Elbers

Source: Critical Care, Vol 25, Iss 1, Pp 1-12 (2021)

Subject Terms: Database, Big data, COVID-19, Data sharing, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/fda39d22c4e340efbc3a04cd3073f6b4

Rapid screening of critically ill patients for low plasma vitamin C concentrations using a point-of-care oxidation–reduction potential measurement

Authors: Sander Rozemeijer, Bob Smit, Paul W. G. Elbers, Armand R. J. Girbes, Heleen M. Oudemans-van Straaten, Angelique M. E. de Man

Source: Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-13 (2021)

Subject Terms: Vitamin C deficiency, Ascorbic acid, Plasma vitamin C concentration, Reactive oxygen species, Oxidative stress, Oxidation–reduction potential, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/2197-425X

Access URL: https://doaj.org/article/575eaa2462b7458fa5782f95593e51be

Risk factors for adverse outcomes during mechanical ventilation of 1152 COVID-19 patients: a multicenter machine learning study with highly granular data from the Dutch Data Warehouse

Authors: Lucas M. Fleuren, Michele Tonutti, Daan P. de Bruin, Robbert C. A. Lalisang, Tariq A. Dam, Diederik Gommers, Olaf L. Cremer, Rob J. Bosman, Sebastiaan J. J. Vonk, Mattia Fornasa, Tomas Machado, Nardo J. M. van der Meer, Sander Rigter, Evert-Jan Wils, Tim Frenzel, Dave A. Dongelmans, Remko de Jong, Marco Peters, Marlijn J. A. Kamps, Dharmanand Ramnarain, Ralph Nowitzky, Fleur G. C. A. Nooteboom, Wouter de Ruijter, Louise C. Urlings-Strop, Ellen G. M. Smit, D. Jannet Mehagnoul-Schipper, Tom Dormans, Cornelis P. C. de Jager, Stefaan H. A. Hendriks, Evelien Oostdijk, Auke C. Reidinga, Barbara Festen-Spanjer, Gert Brunnekreef, Alexander D. Cornet, Walter van den Tempel, Age D. Boelens, Peter Koetsier, Judith Lens, Sefanja Achterberg, Harald J. Faber, A. Karakus, Menno Beukema, Robert Entjes, Paul de Jong, Taco Houwert, Hidde Hovenkamp, Roberto Noorduijn Londono, Davide Quintarelli, Martijn G. Scholtemeijer, Aletta A. de Beer, Giovanni Cinà, Martijn Beudel, Nicolet F. de Keizer, Mark Hoogendoorn, Armand R. J. Girbes, Willem E. Herter, Paul W. G. Elbers, Patrick J. Thoral, Dutch ICU Data Sharing Against COVID-19 Collaborators

Source: Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-15 (2021)

Subject Terms: COVID-19, Mortality prediction, Risk factors, Machine learning, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/2197-425X

Access URL: https://doaj.org/article/02fac2c9c60242bebdd4de7e0fafb6d2

Alkaline phosphatase in pulmonary inflammation—a translational study in ventilated critically ill patients and rats

Authors: Jenny Juschten, Sarah A. Ingelse, Lieuwe D. J. Bos, Armand R. J. Girbes, Nicole P. Juffermans, Tom van der Poll, Marcus J. Schultz, Pieter Roel Tuinman, for the BASIC study investigators

Source: Intensive Care Medicine Experimental, Vol 8, Iss S1, Pp 1-14 (2020)

Subject Terms: Alkaline phosphatase, Acute lung injury, AP, ARDS, Pulmonary inflammation, Mechanical ventilation, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/2197-425X

Access URL: https://doaj.org/article/3def5745b8fe4896996a156d0e8e6485

Breath-synchronized electrical stimulation of the expiratory muscles in mechanically ventilated patients: a randomized controlled feasibility study and pooled analysis

Authors: Annemijn H. Jonkman, Tim Frenzel, Euan J. McCaughey, Angus J. McLachlan, Claire L. Boswell-Ruys, David W. Collins, Simon C. Gandevia, Armand R. J. Girbes, Oscar Hoiting, Matthijs Kox, Eline Oppersma, Marco Peters, Peter Pickkers, Lisanne H. Roesthuis, Jeroen Schouten, Zhong-Hua Shi, Peter H. Veltink, Heder J. de Vries, Cyndi Shannon Weickert, Carsten Wiedenbach, Yingrui Zhang, Pieter R. Tuinman, Angélique M. E. de Man, Jane E. Butler, Leo M. A. Heunks

Source: Critical Care, Vol 24, Iss 1, Pp 1-11 (2020)

Subject Terms: Functional electrical stimulation, Expiratory muscles, Mechanical ventilation, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13054-020-03352-0; https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/22b4c7d1ae37486b908d588cc18e78fe

Some Patients Are More Equal Than Others: Variation in Ventilator Settings for Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

Authors: Tariq A. Dam, MD, Harm-Jan de Grooth, MD, PhD, Thomas Klausch, PhD, Lucas M. Fleuren, MD, Daan P. de Bruin, MSc, Robert Entjes, MD, Thijs C. D. Rettig, MD, PhD, Dave A. Dongelmans, MD, PhD, Age D. Boelens, MD, Sander Rigter, MD, Stefaan H. A. Hendriks, MD, Remko de Jong, MD, Marlijn J. A Kamps, MD, Marco Peters, MD, A. Karakus, MD, Diederik Gommers, MD, PhD, Dharmanand Ramnarain, MD, Evert-Jan Wils, MD, PhD, Sefanja Achterberg, MD, PhD, Ralph Nowitzky, MD, Walter van den Tempel, MD, Cornelis P. C. de Jager, MD, PhD, Fleur G. C. A. Nooteboom, MD, Evelien Oostdijk, MD, PhD, Peter Koetsier, MD, Alexander D. Cornet, MD, PhD, FRCP, Auke C. Reidinga, MD, Wouter de Ruijter, MD, PhD, Rob J. Bosman, MD, Tim Frenzel, MD, PhD, Louise C. Urlings-Strop, MD, PhD, Paul de Jong, MD, Ellen G. M. Smit, MD, Olaf L. Cremer, MD, PhD, D. Jannet Mehagnoul-Schipper, MD, PhD, Harald J. Faber, MD, Judith Lens, MD, Gert B. Brunnekreef, MD, Barbara Festen-Spanjer, MD, Tom Dormans, MD, PhD, Annemieke Dijkstra, MD, Bram Simons, MD, A. A. Rijkeboer, MD, Sesmu Arbous, MD, PhD, Marcel Aries, MD, PhD, Menno Beukema, MD, Daniël Pretorius, MD, Rutger van Raalte, MD, Martijn van Tellingen, MD, EDIC, Niels C. Gritters van den Oever, MD, Robbert C. A. Lalisang, MD, Michele Tonutti, MRes, Armand R. J. Girbes, MD, PhD, EDIC, Mark Hoogendoorn, PhD, Patrick J. Thoral, MD, EDIC, Paul W. G. Elbers, MD, PhD, EDIC, on behalf of the Dutch ICU Data Sharing Against COVID-19 Collaborators, Remko van den Akker, Tom A. Rijpstra, M. C. Reuland, Klaas Sierk Arnold, Arend Jan Meinders, Nicolas Schroten, Laura van Manen, Leon Montenij, Julia Koeter, J. W. Fijen, Jasper van Bommel, Roy van den Berg, Martha de Bruin, Roger van Rietschote, Ellen van Geest, Koen S. Simons, Anisa Hana, Joost Labout, Michael Kuiper, Albertus Beishuizen, Bart van de Gaauw, Roos Renckens, B. van den Bogaard, Peter Pickkers, Pim van der Heiden, Dennis Geutjes, Claudia (C. W.) van Gemeren, Emma Rademaker, Frits H. M. van Osch, Johan Lutisan, Jacomar J. M. van Koesveld, Bart P. Grady, Martijn de Kruif, Martin E. Haan, Luca Roggeveen, Dagmar M. Ouweneel, Ronald Driessen, Jan Peppink, G. J. Zijlstra, A. J. van Tienhoven, Evelien van der Heiden, Jan Jaap Spijkstra, Hans van der Spoel, Angelique de Man, Heder J. de Vries, Fuda van Diggelen, Ali el Hassouni, David Romero Guzman, Sandjai Bhulai, Sebastiaan J. J. Vonk, Mattia Fornasa, Tomas Machado, Adam Izdebski, Taco Houwert, Hidde Hovenkamp, Roberto Noorduijn Londono, Davide Quintarelli, Martijn G. Scholtemeijer, Aletta A. de Beer, Giovanni Cinà, Willem E. Herter, Michael de Neree tot Babberich, Olivier Thijssens, Lot Wagemakers, Hilde G. A. van der Pol, Tom Hendriks, Julie Berend, Virginia Ceni Silva, Robert F. J. Kullberg, Leo Heunks, Nicole Juffermans, Arjen J. C. Slooter, Martijn Beudel, Nicolet F. de Keizer

Source: Critical Care Explorations, Vol 3, Iss 10, p e0555 (2021)

Subject Terms: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/CCE.0000000000000555; https://doaj.org/toc/2639-8028

Access URL: https://doaj.org/article/32f239460e134af0a3cea6a1b4ef0a1c

Right Dose Right Now: bedside data-driven personalized antibiotic dosing in severe sepsis and septic shock — rationale and design of a multicenter randomized controlled superiority trial

Authors: Luca F. Roggeveen, Lucas M. Fleuren, Tingjie Guo, Patrick Thoral, Harm Jan de Grooth, Eleonora L. Swart, Thomas L. T. Klausch, Peter H. J. van der Voort, Armand R. J. Girbes, Rob J. Bosman, Paul W. G. Elbers

Source: Trials, Vol 20, Iss 1, Pp 1-13 (2019)

Subject Terms: Personalized medicine, Antibiotic dosing, Clinical decision support, Intensive care medicine, Pharmacokinetics, Data science, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/2b27308607ef4e9fa44e0add70ba8348

Clinically relevant pharmacokinetic knowledge on antibiotic dosing among intensive care professionals is insufficient: a cross-sectional study

Authors: Lucas M. Fleuren, Luca F. Roggeveen, Tingjie Guo, Petr Waldauf, Peter H. J. van der Voort, Rob J. Bosman, Eleonora L. Swart, Armand R. J. Girbes, Paul W. G. Elbers

Source: Critical Care, Vol 23, Iss 1, Pp 1-9 (2019)

Subject Terms: Antibiotics, Intensive care, Pharmacokinetics, Drug dosing, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13054-019-2438-1; https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/bc3f6b1b19dc470598477a7381dd8d8b

Explainable Machine Learning on AmsterdamUMCdb for ICU Discharge Decision Support: Uniting Intensivists and Data Scientists

Authors: Patrick J. Thoral, MD, Mattia Fornasa, PhD, Daan P. de Bruin, MSc, Michele Tonutti, MRes, Hidde Hovenkamp, MSc, Ronald H. Driessen, Armand R. J. Girbes, MD, PhD, Mark Hoogendoorn, PhD, Paul W. G. Elbers, MD, PhD

Source: Critical Care Explorations, Vol 3, Iss 9, p e0529 (2021)

Subject Terms: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/CCE.0000000000000529; https://doaj.org/toc/2639-8028

Access URL: https://doaj.org/article/8a0a2ea2cb5e4db094ce4edc87399592

Right Dose, Right Now: Development of AutoKinetics for Real Time Model Informed Precision Antibiotic Dosing Decision Support at the Bedside of Critically Ill Patients

Authors: Luca F. Roggeveen, Tingjie Guo, Ronald H. Driessen, Lucas M. Fleuren, Patrick Thoral, Peter H. J. van der Voort, Armand R. J. Girbes, Rob J. Bosman, Paul Elbers

Source: Frontiers in Pharmacology, Vol 11 (2020)

Subject Terms: clinical decision support, precision medicine, antibiotic dosing, sepsis, TDM (therapeutic drug monitoring), Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2020.00646/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/14b67b93653c458aa8af08df6f0b2300

Effects of hyperoxia on vascular tone in animal models: systematic review and meta-analysis

Authors: Bob Smit, Yvo M. Smulders, Etto C. Eringa, Heleen M. Oudemans - van Straaten, Armand R. J. Girbes, Kimberley E. Wever, Carlijn R. Hooijmans, Angelique M. E. Spoelstra - de Man

Source: Critical Care, Vol 22, Iss 1, Pp 1-16 (2018)

Subject Terms: Hyperoxia, Microcirculation, Vasoconstriction, Meta-analysis, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13054-018-2123-9; https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/013c1ac7ea7940d0b10c9f825448406d