Association between synovial tissue damage and pain in late-stage knee osteoarthritis: A cross-sectional study

Authors: Philpott, Holly T. ^{#, †}, Birmingham, Trevor B. ^{#, †}, Carter, McKenzie M. ^{†, ‡}, Cecchini, Matthew J. ^§, Giffin, J. Robert ^¶, Vasarhelyi, Edward M. ^{†, ¶}, MacDonald, Steven J. ^¶, Lanting, Brent A. ^{†, ¶}, Appleton, C. Thomas ^{†, ‡, ∥, *}

Source: In Osteoarthritis and Cartilage November 2024 32(11):1503-1512

Quantification of macrophage activity in knee synovial tissue using [18F]FEPPA positron emission tomography

Authors: Koudys, Zachary J., Lanting, Brent A., Blackler, Garth, Klapak, Joseph Daniel, Fox, Matthew, Appleton, C. Thomas, Thiessen, Jonathan D., Teeter, Matthew G.

Source: In Osteoarthritis Imaging September 2024 4(3)

A scoping review of how early-stage knee osteoarthritis has been defined

Authors: Liew, Jean W., King, Lauren K., Mahmoudian, Armaghan, Wang, Qiuke, Atkinson, Hayden F., Flynn, David B., Appleton, C. Thomas, Englund, Martin, Haugen, Ida K., Lohmander, L. Stefan, Runhaar, Jos, Neogi, Tuhina, Hawker, Gillian

Source: Osteoarthritis and cartilage. 31(9):1234-1241

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195572255.0x000001&indx=1&recIds=ETOCvdc_100195572255.0x000001

Changes and Associations Between Gait Biomechanics and Knee Inflammation After Aspiration and Glucocorticoid Injection for Knee Osteoarthritis

Authors: Pinto, Ryan F., Birmingham, Trevor B., Philpott, Holly T., Primeau, Codie A., Leitch, Kristyn M., Arsenault, Dominique A., Appleton, C. Thomas

Source: Arthritis care & research. 75(8):1764-1772

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188257156.0x000001&indx=1&recIds=ETOCvdc_100188257156.0x000001

Responders to Medial Opening Wedge High Tibial Osteotomy for Knee Osteoarthritis

Authors: Primeau, Codie A., Birmingham, Trevor B., Appleton, C. Thomas

Source: Journal of rheumatology. 50(6):809-816

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632561633&indx=1&recIds=ETOCRN632561633

Impaired Efferocytosis by Synovial Macrophages in Patients With Knee Osteoarthritis

Authors: Del Sordo, Luigi, Blackler, Garth B., Philpott, Holly T., Riviere, Jared, Gunaratnam, Lakshman, Heit, Bryan, Appleton, C. Thomas

Source: Arthritis & rheumatology. 75(5):685-696

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181600025.0x000001&indx=1&recIds=ETOCvdc_100181600025.0x000001

Test–Retest Reliability and Sensitivity to Change of Ultrasound‐Based Methods of Measuring Synovial Inflammation in Knee Osteoarthritis

Authors: Philpott, Holly T., Birmingham, Trevor B., Dima, Robert, Pinto, Ryan, Bryant, Dianne, Appleton, C. Thomas

Source: Arthritis care & research. 75(4):902-910

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181413753.0x000001&indx=1&recIds=ETOCvdc_100181413753.0x000001

Cross-sectional reliability and concurrent validity of a quantitative 2-dimensional ultrasound image analysis of effusion and synovial hypertrophy in knee osteoarthritis

Authors: Dima, Robert, Birmingham, Trevor B., Philpott, Holly T., Bryant, Dianne, Fenster, Aaron, Appleton, C. Thomas

Source: In Osteoarthritis and Cartilage Open June 2023 5(2)

Synovial macrophage diversity and activation of M- CSF signaling in post-traumatic osteoarthritis.

Authors: Knights, Alexander J., Farrell, Easton C., Ellis, Olivia M., Song, Michelle J., Appleton, C. Thomas, Maerz, Tristan

Source: eLife; 2/19/2025, p1-25, 25p

Development of methodology to support molecular endotype discovery from synovial fluid of individuals with knee osteoarthritis: The STEpUP OA consortium.

Authors: Deng, Yun, Perry, Thomas A., Hulley, Philippa, Maciewicz, Rose A., Mitchelmore, Joanna, Perry, Darryl, Larsson, Staffan, Brachat, Sophie, Struglics, André, Appleton, C. Thomas, Kluzek, Stefan, Arden, Nigel K., Felson, David, Marsden, Brian, Tom, Brian D. M., Bondi, Laura, Kapoor, Mohit, Batchelor, Vicky, Mackay-Alderson, Jennifer, Kumar, Vinod

Source: PLoS ONE; 11/18/2024, Vol. 19 Issue 11, p1-24, 24p

Subject Terms: SYNOVIAL fluid, KNEE osteoarthritis, NUCLEAR proteins, BIOLOGICAL networks, JOINT injuries

Changes and associations between synovial fluid and magnetic resonance imaging markers of osteoarthritis after high tibial osteotomy.

Authors: Schulz, Jenna M., Birmingham, Trevor B., Philpott, Holly T., Appleton, C. Thomas, Atkinson, Hayden F., Giffin, J. Robert, Beier, Frank

Source: Arthritis Research & Therapy; 10/10/2024, Vol. 26 Issue 1, p1-11, 11p

Preventing Cardiovascular Events in Patients With Inflammatory Arthritis: Are We Missing the Mark?

Authors: Appleton, C. Thomas, Hegele, Robert A.

Source: Canadian journal of cardiology. 38(8):1138-1140

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173503338.0x000001&indx=1&recIds=ETOCvdc_100173503338.0x000001

100 - Etiology and Pathogenesis of Osteoarthritis

Authors: Philpott, Holly T., Blackler, Garth B., Appleton, C. Thomas

Source: In Firestein & Kelley’s Textbook of Rheumatology, 2-Volume Set Edition: Twelfth Edition. 2025:1762-1784

Degenerative Meniscal Tears and High Tibial Osteotomy: Do Current Treatment Algorithms Need to Be Realigned?

Authors: Primeau, Codie A., Birmingham, Trevor B., Leitch, Kristyn M., Appleton, C. Thomas, Giffin, J. Robert

Source: In Clinics in Sports Medicine July 2019 38(3):471-482

Timing is everything: Towards classification criteria for early-stage symptomatic knee osteoarthritis

Authors: Mahmoudian, Armaghan ^{#, †}, King, Lauren K. ^‡, Liew, Jean W. ^§, Wang, Qiuke ^¶, Appleton, C. Thomas ^{||, ##, ††}, Englund, Martin ^#, Haugen, Ida K. ^‡‡, Lohmander, L. Stefan ^§§, Runhaar, Jos ^¶, Turkiewicz, Aleksandra ^#, Neogi, Tuhina ^§, Hawker, Gillian A. ^†

Source: In Osteoarthritis and Cartilage June 2024 32(6):649-653

Targeting STAT6-mediated synovial macrophage activation improves pain in experimental knee osteoarthritis.

Authors: Blackler, Garth, Lai-Zhao, Yue, Klapak, Joseph, Philpott, Holly T., Pitchers, Kyle K., Maher, Andrew R., Fiset, Benoit, Walsh, Logan A., Gillies, Elizabeth R., Appleton, C. Thomas

Source: Arthritis Research & Therapy; 3/20/2024, Vol. 26 Issue 1, p1-15, 15p

Response to letter to the editor regarding ‘Association between synovial tissue damage and pain in late-stage knee osteoarthritis: A cross-sectional study’

Authors: Philpott, Holly T. ^{#, †, ‡, *}, Birmingham, Trevor B. ^{#, †}, Appleton, C. Thomas ^{†, ‡, §}

Source: In Osteoarthritis and Cartilage January 2025 33(1):182-183

Contributors

Authors: Aggarwal, Rohit, Ahn, Christine S., Anderson, Meghan, Andrade, Felipe, Appleton, C. Thomas, Ardoin, Stacy P., Ayaz, Nuray Aktay, Baker, Joshua F., Balboni, Imelda, Barbhaiya, Medha, Barbour, Kamil E., Barton, Anne, Baughman, Robert P., Behrens, Edward M., Bermas, Bonnie L., Bertsias, George, Bewtra, Meenakshi, Bhardwaj, Nina, Bieber, Amir, Bingham, Clifton O., III, Blackler, Garth B., Bober, Michael B., Bockenstedt, Linda K., Boilard, Eric, Boin, Francesco, Boumpas, Dimitrios T., Broderick, Lori, Brown, Matthew, Buckley, Christopher D., Budd, Ralph C., Burstein, Sumner, Butler, Andrew J., Canna, Scott W., Cannella, Amy C., Cappelli, Laura C., Carpintero, Maria F., Carter, John D., Chan, Andrew C., Chang, Christopher, Cheng, Joseph, Chiodo, Christopher P., Chowdhary, Vaidehi R., Chung, Sharon A., Cohen, Stanley Bruce, Cook, Paul P., Costello, Kerry E., Cowley, Sharon, Crispín, José C., Crofford, Leslie J., Cronstein, Bruce, Crow, Mary K., Cunnane, Gaye, Daien, Claire I., Dalbeth, Nicola, Dall’Era, Maria, Darrah, Erika, Davis, John M., III, de Almeida, Pedro H.T.Q., De Bari, Cosimo, Eduardo de Barros Branco, Carlos, De Craemer, Ann-Sophie, Dell’Accio, Francesco, DeMarco, Paul J., De Ponti, Federico F., DeQuattro, Kimberly A., Diamond, Betty, Diekhoff, Torsten, di Matteo, Andrea, Distler, Jörg H.W., Dixit, Rajiv, Donohue, Kenneth W., Elewaut, Dirk, El-Gabalawy, Hani S., England, Bryant R., Erkan, Doruk, Eyre, Stephen, Falasinnu, Titilola, Fanouriakis, Antonis C., Fearon, Ursula, Filer, Andrew, Fiorentino, David F., Firestein, Gary S., Fischer, Saloumeh K., Fishman, Felicity G., Fitzgerald, Gillian, Flaherty, John P., Friedman, Marcia, Galli, Stephen J., Gasque, Philippe, Gensler, Lianne S., George, Michael D., Gershwin, M. Eric, Gerstbacher, Dana, Gilbert, Mileka, Goldring, Mary B., Gonzalez, Yoly, Goodman, Stuart B., Graef, Elizabeth R., Graf, Jonathan, Graham, Gerard, Greenspan, Adam, Grimaldi, Christine, Guilherme, Luiza, Guillot, Xavier, Guma, Monica, Gupta, Sarthak, Haberman, Rebecca H., Hajj-Ali, Rula A., Helget, Lindsay N., Hellmann, David B., Hoffman, Hal M., Holers, V. Michael, Huddleston, James I., III, Hudson, Alan P., Humphrey, Mary Beth, Hunder, Gene G., Ikdahl, Eirik, Inman, Robert D., Isaacs, John D., Itoh, Yoshifumi, Iwasaki, Laura, Jaremko, Jacob L., Jeffries, Matlock A., Johnson, Tate M., Jordan, Martha S., Jorizzo, Joseph L., Kaplan, Mariana J., Kapoor, Mohit, Karp, David R., Katz, Patricia, Kavanaugh, Arthur, Kerola, Anne, Kerr, Darcy A., Kievit, Corlinda R.E., Kim, Alfred H.J., Kim, Susan, Kissin, Eugene Y., Klein, Michael J., Kono, Dwight H., Koretzky, Gary A., Korsten, Peter, Krakow, Deborah, Kriegel, Martin Alexander, Kuhn, Kristine A., Kumar, Deepak, Kurata-Sato, Izumi, Lachmann, Helen J., Lafeber, Floris P.J.G., Lane, Nancy E., Langford, Carol A., Lauvau, Gregoire, Lebron, Dora A., Lee, Tzielan C., Leverenz, David L., Lewis, Cara L., Liew, Jean W., Lillegraven, Siri, Lindquist, Ingrid, Loeser, Richard F., Lozada, Carlos J., Lundberg, Ingrid E., Mader, Reuven, Malfait, Anne-Marie, Markenson, Joseph A., Mastbergen, Simon C., Matteson, Eric L., Mayer, Adam, McCarthy, Geraldine M., McCarthy, Katharine, McInnes, Iain B., Mehta, Puja, Merkel, Peter A., Mikuls, Ted R., Millar, Neal L., Miller, John B., Mobasheri, Ali, Monach, Paul A., Morishita, Kimberly A., Motley, Benjamin, Mulders-Manders, Catharina M., Murrell, George A.C., Nagaraju, Kanneboyina, Naovarat, Benjamin S., Naraghi, Kamran, Nasser, Rani, Nelson, Amanda E., Neogi, Tuhina, Nickel, Jeffrey, Nigrovic, Peter A., Oatis, Carol A., O’Dell, James R., Ogdie, Alexis, O’Neil, Liam J., Østergaard, Mikkel, Ozen, Seza, Pacifici, Maurizio, Paley, Michael, Panush, Richard S., Peng, Stanford L., Peterson, Erik J., Philpott, Holly T., Pillai, Shiv, Pillinger, Michael H., Plotz, Benjamin H., Polston, Gregory R., Porcelli, Steven A., Powell-Hamilton, Nina, Pratt, Arthur G., Price, Mark D., Rector, Amadeia, Reddy, Virginia, Reveille, John D., Rhee, Rennie L., Ritchlin, Christopher T., Robinson, Philip C., Rockel, Jason S., Rosen, Antony, Rosenbaum, James T., Rosenberg, Andrew E., Rosenthal, Ann K., Ruderman, Eric M., Saag, Kenneth G., Salmon, Jane E., Sammaritano, Lisa R., Sandborg, Christy I., Santora, Arthur C., II, Sattui, Sebastian E., Sawalha, Amr H., Saxena, Mansi, Scanzello, Carla R., Schenk, Simon, Scher, Jose U., Scherlinger, Marc, Schulert, Grant S., Scott, Charlotte L., Sellam, Jérémie, Semb, Anne Grete, Shah, Ami A., Shah, Sameer B., Sharpley, Faye A., Simard, Julia Fridman, Solow, E. Blair, Sparks, Jeffrey A., St. Clair, E. William, Stang, Alexandra T., Stone, John H., Strowd, Lindsay C., Sweiss, Nadera J., Swigart, Carrie R., Szekanecz, Zoltán, Tanner, Stacy, Taylor, Peter C., Taylor, William J., Tedeschi, Sara K., Thanarajasingam, Uma, Theofilopoulos, Argyrios N., Thoma, Louise M., Toprover, Michael, Torok, Kathryn S., Townsend, Michael J., Trouw, Leendert A., Tsai, Mindy, Tsokos, George C., Vabret, Nicolas, Vakil-Gilani, Kiana, van de Sande, Marleen G.H., Van der Laken, Conny J., van der Linden, Sjef, van der Meer, Jos W.M., van Laar, Jacob M., van Vollenhoven, Ronald F., van Vulpen, Lize F.D., Varga, John, Vaseer, Samera, Veale, Douglas J., Wakefield, Richard J., Wallace, Mark S., Walsh, David Andrew, Ward, Samuel R., Werth, Victoria P., Wigley, Fredrick M., Winthrop, Kevin L., Wright, Tracey, Wu, Ying, Yokoyama, Wayne, Zayat, Ahmed S., Zou, Yong-Rui, Zurier, Robert B.

Source: In Firestein & Kelley’s Textbook of Rheumatology, 2-Volume Set Edition: Twelfth Edition. 2025:vi-xxv

Brentuximab vedotin compared with historical controls for severe skin involvement in cutaneous systemic sclerosis.

Authors: Fernández-Codina, Andreu, Nevskaya, Tatiana, Baron, Murray, Appleton, C Thomas, Cecchini, Matthew J, Philip, Amanda, El-Shimy, Maha, Vanderhoek, Louise, Pinal-Fernández, Iago, Pope, Janet E

Source: Rheumatology; Feb2025, Vol. 64 Issue 2, p888-889, 2p

Subject Terms: THERAPEUTIC use of monoclonal antibodies, VITAL capacity (Respiration), T-test (Statistics), DATA analysis, STATISTICAL significance, FISHER exact test, DESCRIPTIVE statistics, MONOCLONAL antibodies, SYSTEMIC scleroderma, RESEARCH, STATISTICS, HEALTH outcome assessment, COMPARATIVE studies, IMMUNOSUPPRESSION

What's pain (sensitization) got to do with it? Microgliosis may be a treatment target in osteoarthritis-related pain sensitization

Authors: Appleton, C. Thomas

Source: Osteoarthritis and cartilage. 25(5):613-615

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100043594549.0x000001&indx=1&recIds=ETOCvdc_100043594549.0x000001