Two-Dimensional SEC-SEC-UV-MALS-dRI Workflow for Streamlined Analysis and Characterization of Biopharmaceuticals

Authors: Barrientos, Rodell C., Singh, Andrew N., Ukaegbu, Ophelia, Hemida, Mohamed, Wang, Heather, Ahmad, Imad Haidar, Hu, Hang, Dunn, Zachary D., Appiah-Amponsah, Emmanuel, Regalado, Erik L.

Source: ANALYTICAL CHEMISTRY -WASHINGTON DC-. 96(12):4960-4968

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632791811&indx=1&recIds=ETOCRN632791811

Two-dimensional size exclusion reversed-phase liquid chromatography for quantitative analysis of L1 proteins in complex vaccine matrices

Authors: Arcinas, Arthur J. ^{a, ⁎}, Larson, Eli J. ^b, Buchhalter, Eric P. ^a, Dunn, Zachary D. ^b, Wang, Heather ^b, Singh, Andrew N. ^b, Barrientos, Rodell C. ^b, Ukaegbu, Ophelia ^b, Mukherjee, Malini ^a, Appiah-Amponsah, Emmanuel ^a, Regalado, Erik L. ^b

Source: In Journal of Chromatography A 10 May 2025 1748

Automated multicolumn screening workflow in ultra-high pressure hydrophilic interaction chromatography for streamlined method development of polar analytes

Authors: Hemida, Mohamed, Barrientos, Rodell C., Singh, Andrew N., Losacco, Gioacchino Luca, Wang, Heather, Guillarme, Davy, Larson, Eli, Xu, Wei, Appiah-Amponsah, Emmanuel, Regalado, Erik L.

Source: In Journal of Chromatography A 27 September 2024 1733

Real-time in situ monitoring of CRM-197 and polysaccharide conjugation reaction by fluorescence spectroscopy

Authors: Saha-Shah, Anumita, Smith, Joseph P, Konietzko, Janelle, Costell, Emily, McHugh, Patrick M, Lo-Mont, Justin P, Ralbovsky, Nicole M, Obando, Louis, Wang, Sheng-ching, Appiah-Amponsah, Emmanuel, Mangion, Ian

Source: Bioanalysis. 15(9):493-501

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188394631.0x000001&indx=1&recIds=ETOCvdc_100188394631.0x000001

Implementation of Innovative Process Analytical Technologies to Characterize Critical Quality Attributes of Co‐Formulated Monoclonal Antibody Products.

Authors: Godbole, Apurva, Chen, Lyufei, Desai, Jay, Raghava, Smita, Ruzanski, Richard, Patel, Bhumit, Appiah‐Amponsah, Emmanuel, Feng, Hanzhou

Source: Biotechnology & Bioengineering; Feb2025, Vol. 122 Issue 2, p322-332, 11p

Digitally Enabled Generic Analytical Framework Accelerating the Pace of Liquid Chromatography Method Development for Vaccine Adjuvant Formulations.

Authors: Hemida, Mohamed, Barrientos, Rodell C., Kinsey, Caleb, Kuster, Nathan, Bhavsar, Mayank, Beck, Armen G., Wang, Heather, Singh, Andrew, Aggarwal, Pankaj, Arcinas, Arthur, Mukherjee, Malini, Appiah-Amponsah, Emmanuel, Regalado, Erik L.

Source: ACS Pharmacology & Translational Science; 10/11/2024, Vol. 7 Issue 10, p3108-3118, 11p

Robust platform for inline Raman monitoring and control of perfusion cell culture.

Authors: Wan, Boyong, Patel, Misaal, Zhou, George, Olma, Michael, Bieri, Marco, Mueller, Marvin, Appiah‐Amponsah, Emmanuel, Patel, Bhumit, Jayapal, Karthik

Source: Biotechnology & Bioengineering; May2024, Vol. 121 Issue 5, p1688-1701, 14p

Pioneering Just-in-Time (JIT) Strategy for Accelerating Raman Method Development and Implementation for Biologic Continuous Manufacturing.

Authors: Feng, Hanzhou, Dunn, Zachary D., Kargupta, Roli, Desai, Jay, Phuangthong, Chelsea, Venkata, Tayi, Appiah-Amponsah, Emmanuel, Patel, Bhumit

Source: Analytical Chemistry; 2/20/2024, Vol. 96 Issue 7, p3168-3176, 9p

Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 4Applications of Process Analytical Technology in Heterogeneous Biocatalytic Hydroxylation.

Authors: Qin, Yangzhong, Mattern, Keith A., Zhang, Victoria, Abe, Kotoe, Kim, Jungchul, Zheng, Michelle, Gangam, Rekha, Kalinin, Alexei, Kolev, Joshua N., Axnanda, Stephanus, Dance, Zachary E. X., Ayesa, Umme, Ji, Yining, Grosser, Shane T., Appiah-Amponsah, Emmanuel, McMullen, Jonathan P.

Source: Organic Process Research & Development; 2/16/2024, Vol. 28 Issue 2, p432-440, 9p

Accelerating Pharmaceutical Process Development with an Acoustic Droplet Ejection-Multiple Reaction Monitoring-Mass Spectrometry Workflow.

Authors: Hu, Hang, Singh, Andrew N., Lehnherr, Dan, Mdluli, Velabo, Chun, Stephanie W., Makarewicz, Amanda M., Gouker, Joseph R., Ukaegbu, Ophelia, Li, Shasha, Wen, Xiujuan, McLaren, David G., Velasquez, Juan E., Moore, Jeffrey C., Galanie, Stephanie, Appiah-Amponsah, Emmanuel, Regalado, Erik L.

Source: Analytical Chemistry; 1/23/2024, Vol. 96 Issue 3, p1138-1146, 9p

Automated Online-Sampling Multidimensional Liquid Chromatography with Feedback-Control Capability as a Framework for Real-Time Monitoring of mAb Critical Quality Attributes in Multiple Bioreactors.

Authors: Dunn, Zachary D., Bohman, Patrick, Quinteros, Alexis, Sauerborn, Brian, Milman, Felix, Patel, Misaal, Kargupta, Roli, Wu, Suyang, Hornshaw, Martin, Barrientos, Rodell, Bones, Jonathan, Tayi, Venkata S., Abaroa, Nicholas, Patel, Bhumit, Appiah-Amponsah, Emmanuel, Regalado, Erik L.

Source: Analytical Chemistry; 12/12/2023, Vol. 95 Issue 49, p18130-18138, 9p

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