Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle

Authors: Simon T. Bond, Emily J. King, Shannen M. Walker, Christine Yang, Yingying Liu, Kevin H. Liu, Aowen Zhuang, Aaron W. Jurrjens, Haoyun A. Fang, Luke E. Formosa, Artika P. Nath, Sergio Ruiz Carmona, Michael Inouye, Thy Duong, Kevin Huynh, Peter J. Meikle, Simon Crawford, Georg Ramm, Sheik Nadeem Elahee Doomun, David P. de Souza, Danielle L. Rudler, Anna C. Calkin, Aleksandra Filipovska, David W. Greening, Darren C. Henstridge, Brian G. Drew

Source: Nature Communications, Vol 16, Iss 1, Pp 1-21 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/345a906e47c24af198ae8e2c6ca1d92f

Deletion of the muscle enriched lncRNA Oip5os1 induces atrial dysfunction in male mice with diabetes

Authors: Aowen Zhuang, Yanie Tan, Yingying Liu, Christine Yang, Helen Kiriazis, Kyah Grigolon, Shannen Walker, Simon T. Bond, Julie R. McMullen, Anna C. Calkin, Brian G. Drew

Source: Physiological Reports, Vol 11, Iss 23, Pp n/a-n/a (2023)

Subject Terms: atrial dysfunction, cardiomyopathy, diabetes, non‐coding RNA, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2051-817X

Access URL: https://doaj.org/article/1b95d6a3a9ba480f80f77c3578a83ad1

Tissue-specific expression of Cas9 has no impact on whole-body metabolism in four transgenic mouse lines

Authors: Simon T. Bond, Aowen Zhuang, Christine Yang, Eleanor A.M. Gould, Tim Sikora, Yingying Liu, Ying Fu, Kevin I. Watt, Yanie Tan, Helen Kiriazis, Graeme I. Lancaster, Paul Gregorevic, Darren C. Henstridge, Julie R. McMullen, Peter J. Meikle, Anna C. Calkin, Brian G. Drew

Source: Molecular Metabolism, Vol 53, Iss , Pp 101292- (2021)

Subject Terms: CRISPR, Cas9, Transgenic mice, Metabolism, Tissue specific, Phenotype, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221287782100137X; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/9b56d5f453674ef7a4d560824691508a

SOD2 in skeletal muscle: New insights from an inducible deletion model

Authors: Aowen Zhuang, Christine Yang, Yingying Liu, Yanie Tan, Simon T. Bond, Shannen Walker, Tim Sikora, Adrienne Laskowski, Arpeeta Sharma, Judy B. de Haan, Peter J. Meikle, Takahiko Shimizu, Melinda T. Coughlan, Anna C. Calkin, Brian G. Drew

Source: Redox Biology, Vol 47, Iss , Pp 102135- (2021)

Subject Terms: Skeletal muscle, Superoxide, ROS, Lipid metabolism, Mitochondria, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231721002949; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/ae96313ccf2649e18f91a9351306e975

The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)

Authors: Aowen Zhuang, Felicia Y. T. Yap, Danielle J. Borg, Domenica McCarthy, Amelia Fotheringham, Sherman Leung, Sally A. Penfold, Karly C. Sourris, Melinda T. Coughlan, Benjamin L. Schulz, Josephine M. Forbes

Source: Endocrinology, Diabetes & Metabolism, Vol 4, Iss 3, Pp n/a-n/a (2021)

Subject Terms: advanced glycation end‐product receptor 1, advanced glycation end‐products, diabetes, diabetic kidney disease, endoplasmic reticulum stress, oligosaccharyltransferase‐48 diabetic nephropathy, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://doaj.org/toc/2398-9238

Access URL: https://doaj.org/article/512a9a47a4444cfdae8b1dbd9a75a8da

Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner

Authors: Aowen Zhuang, Anna C. Calkin, Shannen Lau, Helen Kiriazis, Daniel G. Donner, Yingying Liu, Simon T. Bond, Sarah C. Moody, Eleanor A.M. Gould, Timothy D. Colgan, Sergio Ruiz Carmona, Michael Inouye, Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling, Gregory A. Quaife-Ryan, James E. Hudson, Enzo R. Porrello, Paul Gregorevic, Xiao-Ming Gao, Xiao-Jun Du, Julie R. McMullen, Brian G. Drew

Source: iScience, Vol 24, Iss 6, Pp 102537- (2021)

Subject Terms: Cardiovascular medicine, Molecular physiology, Transcriptomics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004221005058; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/453eb2947cf84c34a110e74e3feab67a