A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease

Authors: Young, Clara ^{1, 2}, Singh, Mandeep ^{1, 2}, Jackson, Katherine J.L. ¹, Field, Matt A. ^{1, 3, 4}, Peters, Timothy J. ^{1, 2}, Angioletti-Uberti, Stefano ⁵, Frenkel, Daan ⁶, Ravishankar, Shyamsundar ¹, Gupta, Money ^{7, 8}, Wang, Jing J. ⁹, Agapiou, David ⁸, Faulks, Megan L. ¹, Al-Eryani, Ghamdan ¹, Luciani, Fabio ^{7, 8}, Gordon, Tom P. ⁹, Reed, Joanne H. ^{1, 11}, Danta, Mark ², Carr, Andrew ¹⁰, Kelleher, Anthony D. ^{8, 10}, Dore, Gregory J. ^{2, 8}, Matthews, Gail ^{2, 8}, Brink, Robert ^{1, 2}, Bull, Rowena A. ^{7, 8}, Suan, Dan ^{1, 2, 12, ∗}, Goodnow, Christopher C. ^{1, 2, 12, 13, ∗∗}

Source: In Immunity 11 February 2025 58(2):412-430

Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 therapy

Authors: Ashley Priddey, Michael Xin Hua Chen-Xu, Daniel James Cooper, Serena MacMillan, Georg Meisl, Catherine K. Xu, Myra Hosmillo, Ian G. Goodfellow, Rafael Kollyfas, Rainer Doffinger, John R. Bradley, Irina I. Mohorianu, Rachel Jones, Tuomas P. J. Knowles, Rona Smith, Vasilis Kosmoliaptsis

Source: Frontiers in Immunology, Vol 14 (2024)

Subject Terms: antibody affinity, rituximab, SARS-CoV-2 vaccination, neutralisation capacity, Omicron (B.1.1.529), antibody concentration, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1296148/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9abd8088be4647aa809eb3c937e8e385

The characters of antibodies against PLA2R in healthy individuals and in the patient with PLA2R associated membranous nephropathy

Authors: Yan-jiao Cheng, Miao Wang, Jia Wang, Zhao Cui, Ming-hui Zhao

Source: European Journal of Medical Research, Vol 28, Iss 1, Pp 1-11 (2023)

Subject Terms: Membranous nephropathy, Phospholipase A2 receptor, Natural antibodies, Antibody titer, IgG subclass, Antibody affinity, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2047-783X

Access URL: https://doaj.org/article/718141be80604d0cbedabe42c4a80eb0

Effect of trifluoroethanol on antibodies binding properties

Authors: S. A. Bobrovnik, M. O. Demchenko, S. V. Komisarenko

Source: The Ukrainian Biochemical Journal, Vol 95, Iss 1, Pp 20-30 (2023)

Subject Terms: 2-trifluoroethanol, antibody affinity, antigen-antibody interaction, monoclonal antibodies, ovalbumin, Biochemistry, QD415-436, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://ukrbiochemjournal.org/wp-content/uploads/2023/04/Bobrovnik_95_1.pdf; https://doaj.org/toc/2409-4943; https://doaj.org/toc/2413-5003

Access URL: https://doaj.org/article/5b3b9666dc0048c8a869b92048efdf24

Balancing the Affinity and Tumor Cell Binding of a Two-in-One Antibody Simultaneously Targeting EGFR and PD-L1

Authors: Julia Harwardt, Felix Klaus Geyer, Katrin Schoenfeld, David Baumstark, Vera Molkenthin, Harald Kolmar

Source: Antibodies, Vol 13, Iss 2, p 36 (2024)

Subject Terms: antibody affinity maturation, bispecific antibody, Two-in-One antibody, yeast display, EGFR binding, PD-L1 binding, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4468/13/2/36; https://doaj.org/toc/2073-4468

Access URL: https://doaj.org/article/b47864c5af2e4167adbb08566aff8bc0

The prominent role of a CDR1 somatic hypermutation for convergent IGHV3-53/3-66 antibodies in binding to SARS-CoV-2

Authors: Xiaolong Tian, Xiaoyi Zhu, Wenping Song, Zhenlin Yang, Yanling Wu, Tianlei Ying

Source: Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1186-1190 (2022)

Subject Terms: SARS-CoV-2, monoclonal antibody, somatic hypermutation, IGHV3-53/3-66, antibody affinity, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/9de7e7ece569421fa99e6498abdaed45

Immunogenicity after outbreak response immunization activities among young healthcare workers with secondary vaccine failure during the measles epidemic in Korea, 2019

Authors: Hyeri Seok, Erica Españo, Jooyun Kim, Ji Hoon Jeon, Won Suk Choi, Yun-Kyung Kim, Jeong-Ki Kim, Dae Won Park

Source: BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-9 (2022)

Subject Terms: Measles, Measles-Mumps-Rubella Vaccine, Vaccine immunogenicity, Antibody affinity, Neutralization tests, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2334

Access URL: https://doaj.org/article/ca66b7af1a174888861e9281d1847189

Solvated interaction energy: from small-molecule to antibody drug design

Authors: Enrico O. Purisima, Christopher R. Corbeil, Francis Gaudreault, Wanlei Wei, Christophe Deprez, Traian Sulea

Source: Frontiers in Molecular Biosciences, Vol 10 (2023)

Subject Terms: binding affinity, solvation, protein-ligand interaction, scoring function, antibody affinity maturation, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2023.1210576/full; https://doaj.org/toc/2296-889X

Access URL: https://doaj.org/article/6af386baeb524da2aa8fe61f44a00bc2

Immunoglobulin VDJ repertoires reveal hallmarks of germinal centers in unique cell clusters isolated from zebrafish (Danio rerio) lymphoid tissues

Authors: Doaa Waly, Aradana Muthupandian, Chia-Wei Fan, Harrison Anzinger, Brad G. Magor

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: antibody affinity maturation, VDJ repertoires, germinal center, evolution, somatic hypermutation, fish, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1058877/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5ad4967b9135449bae5eb4b92f6d3464

Corrigendum: Higher Affinity Antibodies Bind With Lower Hydration and Flexibility in Large Scale Simulations

Authors: Mabel T. Y. Wong, Sebastian Kelm, Xiaofeng Liu, Richard D. Taylor, Terry Baker, Jonathan W. Essex

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: antibody-antigen interactions, antibody binding, antibody affinity, antibody interface hydration, CDR flexibility, molecular dynamics, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.969176/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9c003273c04047e885cde25b39cf0c43

Effect of β-alanine on humoral immune response in low-dose allergy model

Authors: D. B. Chudakov, O. D. Kotsareva, D. S. Tsaregorotseva, E. I. Kashirina, G. V. Fattakhova

Source: Медицинская иммунология, Vol 23, Iss 1, Pp 127-136 (2021)

Subject Terms: β-alanine, ige, low doses, antibody affinity, immunogenicity, mrgd receptor, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.mimmun.ru/mimmun/article/view/2008; https://doaj.org/toc/1563-0625; https://doaj.org/toc/2313-741X

Access URL: https://doaj.org/article/34798a48bc424ec6a07b9abd757e68be

Computational modeling of microfluidic data provides high-throughput affinity estimates for monoclonal antibodies

Authors: Sonia Budroni, Francesca Buricchi, Andrea Cavallone, Gianfranco Volpini, Alessandra Mariani, Paola Lo Surdo, Christoph J. Blohmke, Giuseppe Del Giudice, Duccio Medini, Oretta Finco

Source: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3664-3672 (2021)

Subject Terms: Microfluidic, Antibody affinity, Landau distribution, Gyrolab, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037021002622; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/23582833267946899d70dc3179517435

Higher Affinity Antibodies Bind With Lower Hydration and Flexibility in Large Scale Simulations

Authors: Mabel T. Y. Wong, Sebastian Kelm, Xiaofeng Liu, Richard D. Taylor, Terry Baker, Jonathan W. Essex

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: antibody-antigen interactions, antibody binding, antibody affinity, antibody interface hydration, CDR flexibility, molecular dynamics, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.884110/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9c8442dbe84e4fc28e2f66dd4fdc1822

Rapid Determination of Antibody-Antigen Affinity by Mass Photometry

Authors: Di Wu, author¹, Grzegorz Piszczek, author¹

Source: Journal of Visualized Experiments. (168)

Availability: http://www.jove.com/video/61784

Affinity of anti-spike antibodies in SARS-CoV-2 patient plasma and its effect on COVID-19 antibody assays

Authors: Patrick J. Macdonald, Qiaoqiao Ruan, Jessica L. Grieshaber, Kerry M. Swift, Russell E. Taylor, John C. Prostko, Sergey Y. Tetin

Source: EBioMedicine, Vol 75, Iss , Pp 103796- (2022)

Subject Terms: Antibody affinity, Immunoassays, HDIA, SARS-CoV-2 vaccination, Diagnostics, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396421005909; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/9dde7569e76f4af18d800e257c48d67e

EASINESS: E. coli Assisted Speedy affINity-maturation Evolution SyStem

Authors: Hai-nan Zhang, Jun-biao Xue, Aru Ze-ling Wang, He-wei Jiang, Siva Bhararth Merugu, Da-wei Li, Sheng-ce Tao

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: antibody affinity improvement, directed evolution, 18A4Hu, error-prone DNA polymerase I, protein-fragment complementation assay, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.747267/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9733a6ddde754c66b8518f3ccfab7729

Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies

Authors: Jalili, Roxana, Horecka, Joe, Swartz, James R., Davis, Ronald W., Persson, Henrik H. J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Jan . 115(5), E925-E933.

Access URL: https://www.jstor.org/stable/26507296

Effect of trifluoroethanol on antibody reactivity against corresponding and nonrelated antigens

Authors: S. A. Bobrovnik, M. O. Demchenko, S. V. Komisarenko

Source: The Ukrainian Biochemical Journal, Vol 90, Iss 4, Pp 80-89 (2018)

Subject Terms: antibody affinity, antibody-antigen interaction, polyreactive immunoglobulins, specific monoclonal antibodies, trifluoroethanol, Biochemistry, QD415-436, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://ukrbiochemjournal.org/wp-content/uploads/2018/06/Bobrovnik_4_18.pdf; https://doaj.org/toc/2409-4943; https://doaj.org/toc/2413-5003

Access URL: https://doaj.org/article/381ba7195afd4c07ab606de84dc42a40

Primary Human Herpesvirus-6 and -7 Infections, Often Coinciding, Misdiagnosed as Measles in Children from a Tropical Region of Brazil

Authors: Oliveira, S. A., Turner, D. J., Knowles, W., Nascimento, J. P., Brown, D. W. G., Ward, K. N.

Source: Epidemiology and Infection, 2003 Oct 01. 131(2), 873-879.

Access URL: https://www.jstor.org/stable/3865299

Concentration and Avidity of Anti-Haemophilus influenzae Type b (Hib) Antibodies in Serum Samples Obtained from Patients for Whom Hib Vaccination Failed

Authors: Rijkers, Ger T.

Source: Clinical Infectious Diseases, 2002 Jan . 34(2), 191-197.

Access URL: https://www.jstor.org/stable/4461836