Safety Evaluation of the Combination with Dexrazoxane and Anthracyclines: A Disproportionality Analysis Based on the Food and Drug Administration Adverse Event Reporting System Database.

Authors: Liu, Danyi¹ (AUTHOR) yxy_liudanyi@gs.zzu.edu.cn, Liu, Junting¹ (AUTHOR), Xiao, Rui¹ (AUTHOR), Deng, Anqi¹ (AUTHOR), Liu, Wei¹ (AUTHOR) liuweiyxy@zzu.edu.cn

Source: Pharmaceuticals (14248247). Dec2024, Vol. 17 Issue 12, p1739. 18p.

Subject Terms: *DATABASES, *ANTHRACYCLINES, *FOOD chemistry, *HEART failure, *CARDIOTOXICITY

Diagnostics and Treatment of Extrameningeal Solitary Fibrous Tumors.

Authors: Janik, Anna Maria^1,2 (AUTHOR) anna.janik@wum.edu.pl, Terlecka, Anna^1,2 (AUTHOR) s080287@student.wum.edu.pl, Spałek, Mateusz J.^1,3 (AUTHOR) mateusz.spalek@pib-nio.pl, Boye, Kjetil⁴ (AUTHOR) kjetil.boye@rr-research.no, Szostakowski, Bartłomiej¹ (AUTHOR) bartlomiej.szostakowski@nio.gov.pl, Chmiel, Paulina¹ (AUTHOR) gp.chmiel@gmail.com, Szumera-Ciećkiewicz, Anna^5,6 (AUTHOR) anna.szumera-cieckiewicz@pib-nio.pl, Bobak, Klaudia¹ (AUTHOR) klaudia.bobak@pib-nio.pl, Świtaj, Tomasz¹ (AUTHOR) tomasz.switaj@nio.gov.pl, Rutkowski, Piotr¹ (AUTHOR) piotr.rutkowski@nio.gov.pl, Czarnecka, Anna M.^1,7 (AUTHOR) am.czarnecka@pib-nio.pl

Source: Cancers. Dec2023, Vol. 15 Issue 24, p5854. 25p.

Subject Terms: *ANTHRACYCLINES, *EXTREMITIES (Anatomy), *IMMUNOHISTOCHEMISTRY, *CANCER relapse, *METASTASIS, *SOFT tissue tumors, *TUMOR classification, *MEDICAL protocols, *GENETIC markers, *SYMPTOMS, *ERIBULIN, *BLOOD coagulation factors, *IMATINIB, *DISEASE management, *SARCOMA, CONNECTIVE tissue tumors

Digitoxose as powerful glycosyls for building multifarious glycoconjugates of natural products and un-natural products.

Authors: Kemeng Li^1,2, Zhengyan Guo^1,2 guozhengyan@imb.pumc.edu.cn, Liping Bai^1,2,3 bailiping@imb.pumc.edu.cn

Source: Synthetic & Systems Biotechnology. Dec2024, Vol. 9 Issue 4, p701-712. 12p.

Subject Terms: *NATURAL products, *ANTHRACYCLINES, *ENEDIYNES, *ANTINEOPLASTIC agents, *OLIGOSACCHARIDES

Systematic Assessment of Chinese Medicine Compounds for Mitigating AnthracyclineInduced Cardiotoxicity.

Authors: Jing Yang¹, Feng Wang¹, Zhirong Wang¹, Lixin Wang¹ Wlx006@163.com

Source: Alternative Therapies in Health & Medicine. Nov2024, Vol. 30 Issue 11, p404-409. 6p.

Subject Terms: *ANTHRACYCLINES, *CARDIOTOXICITY, *CHINESE medicine, *META-analysis, *TROPONIN

Comparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance.

Authors: Piska, Kamil¹ (AUTHOR) kamil.piska@uj.edu.pl, Koczurkiewicz-Adamczyk, Paulina¹ (AUTHOR), Jamrozik, Marek² (AUTHOR), Bucki, Adam² (AUTHOR), Kołaczkowski, Marcin² (AUTHOR), Pękala, Elżbieta¹ (AUTHOR)

Source: Xenobiotica. 2023, Vol. 53 Issue 6/7, p507-514. 8p.

Subject Terms: *ANTHRACYCLINES, *METABOLITES, *P-glycoprotein, *ENDOENZYMES, *MULTIDRUG resistance, *ANTINEOPLASTIC agents, *ATP-binding cassette transporters

Pathologic Response to Neoadjuvant Sequential Chemoradiation Therapy in Locally Advanced Breast Cancer: Preliminary, Translational Results from the French Neo-APBI-01 Trial.

Authors: To, Nhu Hanh^1,2,3 (AUTHOR) nhuhanh.to@aphp.fr, Gabelle-Flandin, Isabelle⁴ (AUTHOR), Luong, Thi My Hanh⁵ (AUTHOR), Loganadane, Gokoulakrichenane¹ (AUTHOR), Ouidir, Nabila⁶ (AUTHOR), Boukhobza, Chahrazed¹ (AUTHOR), Grellier, Noémie¹ (AUTHOR), Verry, Camille⁴ (AUTHOR), Thiolat, Allan² (AUTHOR), Cohen, José L.² (AUTHOR), Radosevic-Robin, Nina⁷ (AUTHOR), Belkacemi, Yazid^1,2,3 (AUTHOR) yazid.belkacemi@aphp.fr

Source: Cancers. Apr2023, Vol. 15 Issue 7, p2030. 14p.

Subject Terms: *ADJUVANT chemotherapy, *ANTHRACYCLINES, *CONFIDENCE intervals, *IMMUNOHISTOCHEMISTRY, *FISHER exact test, *TREATMENT effectiveness, *RANDOMIZED controlled trials, *NEUTROPHIL lymphocyte ratio, *LYMPHOCYTES, *RADIATION doses, *CHI-squared test, *DESCRIPTIVE statistics, *COMBINED modality therapy, *TUMOR markers, *STATISTICAL sampling, *TRANSLATIONAL research, *SENSITIVITY & specificity (Statistics), *RECEIVER operating characteristic curves, *LOGISTIC regression analysis, *ODDS ratio, *DATA analysis software, *BREAST tumors

Anthracyclines induce cardiotoxicity through a shared gene expression response signature.

Authors: Matthews, E. Renee¹, Johnson, Omar D.², Horn, Kandace J.³, Gutiérrez, José A.¹, Powell, Simon R.⁴, Ward, Michelle C.¹, miward@utmb.edu

Source: PLoS Genetics; 2/28/2024, Vol. 20 Issue 2, p1-36, 36p

Systemic Inflammatory Indices in Second-Line Soft Tissue Sarcoma Patients: Focus on Lymphocyte/Monocyte Ratio and Trabectedin.

Authors: Fausti, Valentina¹ (AUTHOR), De Vita, Alessandro² (AUTHOR) alessandro.devita@irst.emr.it, Vanni, Silvia² (AUTHOR), Ghini, Virginia¹ (AUTHOR), Gurrieri, Lorena¹ (AUTHOR), Riva, Nada¹ (AUTHOR), Casadei, Roberto³ (AUTHOR), Maraldi, Marco³ (AUTHOR), Ercolani, Giorgio⁴ (AUTHOR), Cavaliere, Davide⁴ (AUTHOR), Pacilio, Carlo Alberto⁴ (AUTHOR), Pieri, Federica⁵ (AUTHOR), Foca, Flavia⁶ (AUTHOR), Bongiovanni, Alberto¹ (AUTHOR), Ranallo, Nicoletta¹ (AUTHOR), Calpona, Sebastiano¹ (AUTHOR), Frassineti, Giovanni Luca⁷ (AUTHOR), Ibrahim, Toni⁸ (AUTHOR), Mercatali, Laura² (AUTHOR)

Source: Cancers. Feb2023, Vol. 15 Issue 4, p1080. 17p.

Subject Terms: *PLATELET lymphocyte ratio, *ANTHRACYCLINES, *SEQUENCE analysis, *INFLAMMATION, *ANTINEOPLASTIC agents, *RETROSPECTIVE studies, *ACQUISITION of data, *RNA, *SOFT tissue tumors, *NEUTROPHIL lymphocyte ratio, *RESEARCH funding, *MEDICAL records, *KAPLAN-Meier estimator, *PROGRESSION-free survival, *TUMOR markers, *SARCOMA, *MONOCYTE lymphocyte ratio, *OVERALL survival

Management and Outcomes of Older Patients (Age ≥ 70 Years) with Advanced Soft Tissue Sarcoma and Role of Geriatric Assessment and Oncological Multidimensional Prognostic Index (Onco-MPI) in a Real-World Setting.

Authors: Chiusole, Benedetta¹ (AUTHOR) benedetta.chiusole@iov.veneto.it, Tortorelli, Ilaria^1,2 (AUTHOR), Galiano, Antonella¹ (AUTHOR), Murtas, Fabio¹ (AUTHOR), Ahcene-Djaballah, Selma³ (AUTHOR), Tierno, Giuseppina¹ (AUTHOR), Bergo, Eleonora¹ (AUTHOR), Banzato, Alberto⁴ (AUTHOR), Gatti, Maura¹ (AUTHOR), Di Maggio, Antonio⁵ (AUTHOR), Sergi, Giuseppe⁶ (AUTHOR), Rastrelli, Marco^2,7 (AUTHOR), Sbaraglia, Marta⁸ (AUTHOR), Zagonel, Vittorina¹ (AUTHOR), Brunello, Antonella¹ (AUTHOR) benedetta.chiusole@iov.veneto.it

Source: Cancers. Feb2023, Vol. 15 Issue 4, p1043. 13p.

Subject Terms: *ANTHRACYCLINES, *CONFIDENCE intervals, *CANCER chemotherapy, *MULTIVARIATE analysis, *GERIATRIC assessment, *RETROSPECTIVE studies, *SOFT tissue tumors, *CANCER patients, *TREATMENT effectiveness, *RESEARCH funding, *QUESTIONNAIRES, *DATA analysis software, *SARCOMA, *RARE diseases, *DISEASE management, *OVERALL survival, *OLD age

2,4-Dinitrophenol as an Uncoupler Augments the Anthracyclines Toxicity against Prostate Cancer Cells.

Authors: Adamczuk, Grzegorz¹ (AUTHOR) grzegorzadamczuk@umlub.pl, Humeniuk, Ewelina¹ (AUTHOR), Adamczuk, Kamila² (AUTHOR), Grabarska, Aneta² (AUTHOR), Dudka, Jarosław³ (AUTHOR)

Source: Molecules. Nov2022, Vol. 27 Issue 21, p7227. 14p.

Subject Terms: *ANTHRACYCLINES, *PROSTATE cancer, *CELL cycle, *CELL metabolism, *ENERGY metabolism, *CANCER cells, *DOCETAXEL

Is Electrocardiogram Helpful in Predicting a Rise in Troponin I as a Marker of Anthracycline Cardiotoxicity?

Authors: Muneer, Kader¹, Jose, Benny² drbennyjose@gmail.com, Dubey, Gajendra², T., Ajayakumar¹, C. G., Sajeev¹, M. N., Krishnan¹

Source: European Journal of Breast Health. Oct2022, Vol. 18 Issue 4, p299-305. 7p.

Subject Terms: *ELECTROCARDIOGRAPHY, *ANTHRACYCLINES, *CARDIOTOXICITY, *CANCER chemotherapy, *TROPONIN

BRCA Mutation Status in Triple-Negative Breast Cancer Patients Treated with Neoadjuvant Chemotherapy: A Pivotal Role for Treatment Decision-Making.

Authors: Pavese, Francesco¹ (AUTHOR), Capoluongo, Ettore Domenico^2,3 (AUTHOR), Muratore, Margherita¹ (AUTHOR), Minucci, Angelo⁴ (AUTHOR), Santonocito, Concetta⁴ (AUTHOR), Fuso, Paola¹ (AUTHOR), Concolino, Paola⁴ (AUTHOR), Di Stasio, Enrico⁴ (AUTHOR), Carbognin, Luisa¹ (AUTHOR), Tiberi, Giordana¹ (AUTHOR), Garganese, Giorgia^5,6 (AUTHOR), Corrado, Giacomo¹ (AUTHOR), Di Leone, Alba¹ (AUTHOR), Generali, Daniele⁷ (AUTHOR), Fragomeni, Simona Maria¹ (AUTHOR), D'Angelo, Tatiana¹ (AUTHOR), Franceschini, Gianluca¹ (AUTHOR), Masetti, Riccardo¹ (AUTHOR), Fabi, Alessandra⁸ (AUTHOR), Mulè, Antonino⁹ (AUTHOR)

Source: Cancers. Oct2022, Vol. 14 Issue 19, p4571. 14p.

Subject Terms: *GENETIC mutation, *ANTHRACYCLINES, *CONFIDENCE intervals, *BRCA genes, *CANCER chemotherapy, *RETROSPECTIVE studies, *ACQUISITION of data, *MEDICAL records, *DESCRIPTIVE statistics, *COMBINED modality therapy, *DECISION making in clinical medicine, *TUMOR markers, *ODDS ratio, *BREAST tumors, *PHENOTYPES

Protective Effect of Continuous Aerobic Training and Crocin on Doxorubicin-Induced Apoptosis in the Heart Tissue of Rats.

Authors: Shekarriz, Hekmat¹, Galedari, Mohammad² m.galedari@gmail.com, Nikbakht, Masoud³, Khorsandi, Layasadat^4,5

Source: Jentashapir Journal of Cellular & Molecular Biology. Sep2022, Vol. 13 Issue 3, p1-7. 7p.

Subject Terms: *DOXORUBICIN, *ANTHRACYCLINES, *AEROBIC exercises, *CROCIN, *AMINOGLYCOSIDES

Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity.

Authors: Shi, Hongwei^1,2 (AUTHOR), Yan, Yue³ (AUTHOR), Yang, Hong⁴ (AUTHOR), Pu, Peng⁵ (AUTHOR), Tang, Heng^5,6 (AUTHOR)

Source: BioMed Research International. 8/18/2022, p1-11. 11p.

Subject Terms: *HERBAL medicine, *ANTHRACYCLINES, *STAINS & staining (Microscopy), *ANIMAL experimentation, *WESTERN immunoblotting, *DIET, *OXIDATIVE stress, *HEPATOTOXICOLOGY, *RATS, *CELLULAR signal transduction, *PLANT extracts, *REACTIVE oxygen species, *CHINESE medicine, *CELL death, *LIPID peroxidation (Biology), *ALANINE aminotransferase, *ASPARTATE aminotransferase, *THERAPEUTICS

Grading Evaluation of Cardiotoxicity in Patients with Breast Cancer Treated with Adjuvant Paclitaxel Anthracycline/Cyclophosphamide Chemotherapy: A Meta-Analysis.

Authors: Hu, Weibao¹ (AUTHOR), Song, Mengli² (AUTHOR), Li, Linfeng³ (AUTHOR)

Source: Computational & Mathematical Methods in Medicine. 8/8/2022, p1-9. 9p.

Subject Terms: *ANTHRACYCLINES, *CANCER patients, *BREAST cancer, *CARDIOTOXICITY, *PACLITAXEL, *CANCER chemotherapy, *CONGESTIVE heart failure, *ALKALOIDS

The Therapeutic Potential of Carnosine as an Antidote against Drug-Induced Cardiotoxicity and Neurotoxicity: Focus on Nrf2 Pathway.

Authors: Caruso, Giuseppe^1,2 (AUTHOR) giuseppe.caruso2@unict.it, Privitera, Anna¹ (AUTHOR) fcaraci@unict.it, Antunes, Barbara Moura³ (AUTHOR) barbara.moura@uabc.edu.mx, Lazzarino, Giuseppe⁴ (AUTHOR) lazzarig@unict.it, Lunte, Susan Marie^5,6,7 (AUTHOR) slunte@ku.edu, Aldini, Giancarlo⁸ (AUTHOR) giancarlo.aldini@unimi.it, Caraci, Filippo^1,2 (AUTHOR)

Source: Molecules. Jul2022, Vol. 27 Issue 14, pN.PAG-N.PAG. 27p.

Subject Terms: *ANTHRACYCLINES, *NUCLEAR factor E2 related factor, *DRUG side effects, *CARNOSINE, *ANTIDOTES

Evolving Evidence for the Optimization of Neoadjuvant Therapy in Triple-Negative Breast Cancer.

Authors: Silva, Diogo¹ (AUTHOR) silvajddiogo@gmail.com, Mesquita, Alexandra¹ (AUTHOR)

Source: Breast Cancer: Basic & Clinical Research. 6/27/2022, p1-12. 12p.

Subject Terms: *CLINICAL trials, *ANTHRACYCLINES, *GENETIC mutation, *RESEARCH methodology, *PATIENT selection, *TREATMENT effectiveness, *GENOMICS, *COMBINED modality therapy, *BREAST tumors

A Fibrosis Biomarker Early Predicts Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy.

Authors: Fuente, Ana de la¹ (AUTHOR) adelafuente.1@unav.es, Santisteban, Marta^2,3 (AUTHOR) blopez@unav.es, Lupón, Josep^4,5,6 (AUTHOR) gecediel@yahoo.com, Aramendía, José Manuel^2,3 (AUTHOR) jmaramen@unav.es, Díaz, Agnes^1,3 (AUTHOR) adiazdo@unav.es, Santaballa, Ana⁷ (AUTHOR) santaballa_ana@gva.es, Hernándiz, Amparo⁸ (AUTHOR) hernandiz_amp@gva.es, Sepúlveda, Pilar^4,8 (AUTHOR) pilar.sepulveda.sanchis@gmail.com, Cediel, Germán⁵ (AUTHOR), López, Begoña^3,4,9 (AUTHOR) abayesgenis@gmail.com, Picazo, José María López² (AUTHOR) jlpicazo@unav.es, Mazo, Manuel M.^3,10 (AUTHOR), Rábago, Gregorio¹ (AUTHOR) grabago@unav.es, Gavira, Juan José^1,3 (AUTHOR) jjgavira@unav.es, García-Bolao, Ignacio^1,3 (AUTHOR) igarciab@unav.es, Díez, Javier^1,3,4,9 (AUTHOR) jadimar@unav.es, González, Arantxa^3,4,9 (AUTHOR), Bayés-Genís, Antoni^4,5,6,11 (AUTHOR), Ravassa, Susana^3,4,9 (AUTHOR) sravassa@unav.es

Source: Cancers. Jun2022, Vol. 14 Issue 12, p2941-N.PAG. 21p.

Subject Terms: *CARDIOTOXICITY, *ANTHRACYCLINES, *CANCER chemotherapy, *FIBROSIS, *CANCER patients, *DESCRIPTIVE statistics, *TUMOR markers, *BREAST tumors, *EARLY medical intervention, *MEDICAL needs assessment

Induction of Fatigue by Specific Anthracycline Cancer Drugs through Disruption of the Circadian Pacemaker.

Authors: Wang, Yumeng¹ (AUTHOR) y.wang.mcb@lumc.nl, Zanden, Sabina Y. van der² (AUTHOR) s.y.van_der_zanden@lumc.nl, van Leerdam, Suzanne¹ (AUTHOR) suzannevanleerdam@hotmail.com, Tersteeg, Mayke M. H.¹ (AUTHOR) m.m.h.tersteeg@lumc.nl, Kastelein, Anneke¹ (AUTHOR) a.kastelein@lumc.nl, Michel, Stephan¹ (AUTHOR) s.h.michel@lumc.nl, Neefjes, Jacques² (AUTHOR) j.j.c.neefjes@lumc.nl, Meijer, Johanna H.¹ (AUTHOR) j.h.meijer@lumc.nl, Deboer, Tom¹ (AUTHOR) t.de_boer@lumc.nl

Source: Cancers. May2022, Vol. 14 Issue 10, p2421-N.PAG. 14p.

Subject Terms: *BIOLOGICAL models, *ANTHRACYCLINES, *SOCIAL support, *DNA, *ANIMAL experimentation, *ANTINEOPLASTIC agents, *CIRCADIAN rhythms, *CANCER patients, *CANCER fatigue, *QUALITY of life

Myocardial extracellular volume derived from contrast-enhanced chest computed tomography for longitudinal evaluation of cardiotoxicity in patients with breast cancer treated with anthracyclines.

Authors: Tu, Chunrong¹ (AUTHOR), Shen, Hesong¹ (AUTHOR), Liu, Renwei¹ (AUTHOR), Wang, Xing¹ (AUTHOR), Li, Xiaoqin¹ (AUTHOR), Yuan, Xiaoqian¹ (AUTHOR), Chen, Qiuzhi¹ (AUTHOR), Wang, Yu¹ (AUTHOR), Ran, Zijuan¹ (AUTHOR), Lan, Xiaosong¹ (AUTHOR), Zhang, Xiaoyue² (AUTHOR), Lin, Meng¹ (AUTHOR) 15823113338@139.com, Zhang, Jiuquan¹ (AUTHOR) zhangjq_radiol@foxmail.com

Source: Insights into Imaging. 5/4/2022, Vol. 13 Issue 1, p1-10. 10p.

Subject Terms: *ANTHRACYCLINES, *CHEST examination, *CANCER patients, *CARDIOTOXICITY, *BREAST cancer, *HEART septum