Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts

Authors: Seyma Katrinli, Agaz H. Wani, Adam X. Maihofer, Andrew Ratanatharathorn, Nikolaos P. Daskalakis, Janitza Montalvo-Ortiz, Diana L. Núñez-Ríos, Anthony S. Zannas, Xiang Zhao, Allison E. Aiello, Allison E. Ashley-Koch, Diana Avetyan, Dewleen G. Baker, Jean C. Beckham, Marco P. Boks, Leslie A. Brick, Evelyn Bromet, Frances A. Champagne, Chia-Yen Chen, Shareefa Dalvie, Michelle F. Dennis, Segun Fatumo, Catherine Fortier, Sandro Galea, Melanie E. Garrett, Elbert Geuze, Gerald Grant, Michael A. Hauser, Jasmeet P. Hayes, Sian M. J. Hemmings, Bertrand Russel Huber, Aarti Jajoo, Stefan Jansen, Ronald C. Kessler, Nathan A. Kimbrel, Anthony P. King, Joel E. Kleinman, Nastassja Koen, Karestan C. Koenen, Pei-Fen Kuan, Israel Liberzon, Sarah D. Linnstaedt, Adriana Lori, Benjamin J. Luft, Jurjen J. Luykx, Christine E. Marx, Samuel A. McLean, Divya Mehta, William Milberg, Mark W. Miller, Mary S. Mufford, Clarisse Musanabaganwa, Jean Mutabaruka, Leon Mutesa, Charles B. Nemeroff, Nicole R. Nugent, Holly K. Orcutt, Xue-Jun Qin, Sheila A. M. Rauch, Kerry J. Ressler, Victoria B. Risbrough, Eugène Rutembesa, Bart P. F. Rutten, Soraya Seedat, Dan J. Stein, Murray B. Stein, Sylvanus Toikumo, Robert J. Ursano, Annette Uwineza, Mieke H. Verfaellie, Eric Vermetten, Christiaan H. Vinkers, Erin B. Ware, Derek E. Wildman, Erika J. Wolf, Ross McD Young, Ying Zhao, Leigh L. van den Heuvel, PGC-PTSD Epigenetics Workgroup, PsychENCODE PTSD Brainomics Project, Traumatic Stress Brain Research Group, Monica Uddin, Caroline M. Nievergelt, Alicia K. Smith, Mark W. Logue

Source: Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)

Subject Terms: PTSD, Trauma, DNA methylation, Postmortem brain, GWAS, Gene expression, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/e7c75d3d1d50416e99e94207e5bfc3e1

Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts

Authors: Agaz H. Wani, Seyma Katrinli, Xiang Zhao, Nikolaos P. Daskalakis, Anthony S. Zannas, Allison E. Aiello, Dewleen G. Baker, Marco P. Boks, Leslie A. Brick, Chia-Yen Chen, Shareefa Dalvie, Catherine Fortier, Elbert Geuze, Jasmeet P. Hayes, Ronald C. Kessler, Anthony P. King, Nastassja Koen, Israel Liberzon, Adriana Lori, Jurjen J. Luykx, Adam X. Maihofer, William Milberg, Mark W. Miller, Mary S. Mufford, Nicole R. Nugent, Sheila Rauch, Kerry J. Ressler, Victoria B. Risbrough, Bart P. F. Rutten, Dan J. Stein, Murray B. Stein, Robert J. Ursano, Mieke H. Verfaellie, Eric Vermetten, Christiaan H. Vinkers, Erin B. Ware, Derek E. Wildman, Erika J. Wolf, Caroline M. Nievergelt, Mark W. Logue, Alicia K. Smith, Monica Uddin

Source: BMC Medical Genomics, Vol 17, Iss 1, Pp 1-14 (2024)

Subject Terms: DNA methylation, Machine learning, PTSD, Risk scores, Internal medicine, RC31-1245, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1755-8794

Access URL: https://doaj.org/article/71292b89b7524386adcc89a2a04c6480

Emerging evidence linking stress and glucocorticoid signaling with cancer phenotypes

Authors: Anthony S. Zannas

Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-2 (2024)

Subject Terms: Cancer, Epigenetics, Glucocorticoids, Psychosocial stress, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/6c7f937d464e47c1a49f2a44b2d5cb44

Chronic early life stress alters the neuroimmune profile and functioning of the developing zebrafish gut

Authors: Christina L. Graves, Erik Norloff, Darius Thompson, Oksana Kosyk, Yingning Sang, Angela Chen, Anthony S. Zannas, Shannon M. Wallet

Source: Brain, Behavior, & Immunity - Health, Vol 31, Iss , Pp 100655- (2023)

Subject Terms: Early life stress, Chronic stress, Anxiety, Neuroimmune, Gut, Zebrafish, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666354623000698; https://doaj.org/toc/2666-3546

Access URL: https://doaj.org/article/8a305c5adbbf49ac95ef57700e17893f

An open access, machine learning pipeline for high-throughput quantification of cell morphology

Authors: Emma M. Welter, Oksana Kosyk, Anthony S. Zannas

Source: STAR Protocols, Vol 4, Iss 1, Pp 101947- (2023)

Subject Terms: Cell Biology, Cell culture, Microscopy, Computer sciences, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166722008279; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/7b94f8ec2c374fcabf7635e67be89805

Chronic stress-driven glucocorticoid receptor activation programs key cell phenotypes and functional epigenomic patterns in human fibroblasts

Authors: Calvin S. Leung, Oksana Kosyk, Emma M. Welter, Nicholas Dietrich, Trevor K. Archer, Anthony S. Zannas

Source: iScience, Vol 25, Iss 9, Pp 104960- (2022)

Subject Terms: Biological sciences, Endocrinology, Molecular biology, Transcriptomics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222012329; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/7ec769d869d247528f5def784a303706

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

Authors: Nils C. Gassen, Daniela Niemeyer, Doreen Muth, Victor M. Corman, Silvia Martinelli, Alwine Gassen, Kathrin Hafner, Jan Papies, Kirstin Mösbauer, Andreas Zellner, Anthony S. Zannas, Alexander Herrmann, Florian Holsboer, Ruth Brack-Werner, Michael Boshart, Bertram Müller-Myhsok, Christian Drosten, Marcel A. Müller, Theo Rein

Source: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/173953915c6a47688637a8c938baf515

DNA methylation levels are associated with CRF1 receptor antagonist treatment outcome in women with post-traumatic stress disorder

Authors: Julius C. Pape, Tania Carrillo-Roa, Barbara O. Rothbaum, Charles B. Nemeroff, Darina Czamara, Anthony S. Zannas, Dan Iosifescu, Sanjay J. Mathew, Thomas C. Neylan, Helen S. Mayberg, Boadie W. Dunlop, Elisabeth B. Binder

Source: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-11 (2018)

Subject Terms: CRF1 receptor antagonist, DNA methylation, Epigenetics, PTSD, CRHR1, NR3C1, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13148-018-0569-x; https://doaj.org/toc/1868-7075; https://doaj.org/toc/1868-7083

Access URL: https://doaj.org/article/1be6c64356324c6199a80ce93fd0d69b

Editorial: Molecular Mechanisms in Stress and Trauma Related Disorders

Authors: Anthony S. Zannas, Murray B. Stein, George P. Chrousos

Source: Frontiers in Psychiatry, Vol 11 (2020)

Subject Terms: autophagy, circadian biology, epigenetics, inflammation, major depression, posttraumatic stress disorder, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fpsyt.2020.00103/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/ffc2d3545fe74610847f1f508c1c4854

Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress

Authors: Naama Volk, Julius C. Pape, Mareen Engel, Anthony S. Zannas, Nadia Cattane, Annamaria Cattaneo, Elisabeth B. Binder, Alon Chen

Source: Cell Reports, Vol 17, Iss 7, Pp 1882-1891 (2016)

Subject Terms: amygdala, FKBP5, microRNA-15a, chronic stress, anxiety, early life stress, Ago2, stress-related psychopathologies, stress adaption, childhood trauma, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716314437; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/7b5336b76ffa4b99a813fcd00b298797

Correction to: Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling

Authors: Anthony S. Zannas, Janine Arloth, Tania Carrillo-Roa, Stella Iurato, Simone Röh, Kerry J. Ressler, Charles B. Nemeroff, Alicia K. Smith, Bekh Bradley, Christine Heim, Andreas Menke, Jennifer F. Lange, Tanja Brückl, Marcus Ising, Naomi R. Wray, Angelika Erhardt, Elisabeth B. Binder, Divya Mehta

Source: Genome Biology, Vol 19, Iss 1, Pp 1-1 (2018)

Subject Terms: Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13059-018-1441-1; https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/18a08ae6a8eb493d952c90c7d2cc5855

How Much Is a Picture Worth Putting Amyloid Imaging to the Test

Authors: Anthony S. Zannas, Terence Z. Wong, P. Murali Doraiswamy

Source: Dementia and Geriatric Cognitive Disorders Extra, Vol 2, Iss 1, Pp 649-651 (2012)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: http://www.karger.com/Article/FullText/345982; https://doaj.org/toc/1664-5464

Access URL: https://doaj.org/article/0d00f3ac91ae48749e0c41cb89b37444

Influence of occupational stress on breast cancer incidence in the Women’s Health Initiative.

Authors: Ingram, Sarah H., ORCID 0009-0004-0006-1345. College of Medicine, Drexel University, Chestnut Hill, MA, US, shi26@drexel.edu, De Roos, Anneclaire J., ORCID 0000-0002-2811-2405. Department of Environmental and Occupational Health, Drexel University, Chestnut Hill, MA, US, Wallace, Robert B.. Department of Epidemiology, University of Iowa, Iowa City, IA, US, Parks, Christine G.. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, US, Lane, Dorothy S.. Department of Family, Population and Preventative Medicine, Stony Brook University, NY, US, Martin, Lisa W.. School of Medicine & Health Sciences, George Washington University, Washington, DC, US, Zannas, Anthony S.. Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, US, Mouton, Charles P.. John Sealy School of Medicine, University of Texas Medical Branch, Galveston, TX, US, Michael, Yvonne L.. College of Medicine, Drexel University, Chestnut Hill, MA, US

Source: Health Psychology, Vol 44(4), Apr, 2025. pp. 335-344.

NLM Title Abbreviation: Health Psychol

Publisher: US : American Psychological Association

Other Publishers: US : Lawrence Erlbaum Associates

Supplemental Data: Tables and Figures Internet

Publication Type: Journal; Peer Reviewed Journal

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