Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

Authors: Young Seok Ju, Ludmil B Alexandrov, Moritz Gerstung, Inigo Martincorena, Serena Nik-Zainal, Manasa Ramakrishna, Helen R Davies, Elli Papaemmanuil, Gunes Gundem, Adam Shlien, Niccolo Bolli, Sam Behjati, Patrick S Tarpey, Jyoti Nangalia, Charles E Massie, Adam P Butler, Jon W Teague, George S Vassiliou, Anthony R Green, Ming-Qing Du, Ashwin Unnikrishnan, John E Pimanda, Bin Tean Teh, Nikhil Munshi, Mel Greaves, Paresh Vyas, Adel K El-Naggar, Tom Santarius, V Peter Collins, Richard Grundy, Jack A Taylor, D Neil Hayes, David Malkin, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Christopher S Foster, Anne Y Warren, Hayley C Whitaker, Daniel Brewer, Rosalind Eeles, Colin Cooper, David Neal, Tapio Visakorpi, William B Isaacs, G Steven Bova, Adrienne M Flanagan, P Andrew Futreal, Andy G Lynch, Patrick F Chinnery, Ultan McDermott, Michael R Stratton, Peter J Campbell

Source: eLife, Vol 3 (2014)

Subject Terms: mitochondrial DNA, somatic mutation, mutational signature, cancer genome, evolution, sequencing, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/02935; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/a97bb2e0fa0f4eb19b17cd3f405b0385

Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia

Authors: Tobias Ronny Haage, Emmanouil Charakopoulos, Vikas Bhuria, Conny K. Baldauf, Mark Korthals, Juliane Handschuh, Peter Müller, Juan Li, Kunjan Harit, Gopala Nishanth, Stephanie Frey, Martin Böttcher, Klaus-Dieter Fischer, Jan Dudeck, Anne Dudeck, Daniel B. Lipka, Burkhart Schraven, Anthony R. Green, Andreas J. Müller, Dimitrios Mougiakakos, Thomas Fischer

Source: Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-23 (2024)

Subject Terms: MPN, Inflammation, Neutrophils, JAK2-V617F, CALR mutations, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/de0cb7b1744d4527b1c4f8287f2223f4

Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion.

Authors: David G Kent, Juan Li, Hinal Tanna, Juergen Fink, Kristina Kirschner, Dean C Pask, Yvonne Silber, Tina L Hamilton, Rachel Sneade, Benjamin D Simons, Anthony R Green

Source: PLoS Biology, Vol 11, Iss 6, p e1001576 (2013)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23750118/pdf/?tool=EBI; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/7dfd3a5ed19c436ab9d0cf6c7ee2e024

Mapping and functional characterisation of a CTCF-dependent insulator element at the 3' border of the murine Scl transcriptional domain.

Authors: George A Follows, Rita Ferreira, Mary E Janes, Dominik Spensberger, Francesco Cambuli, Amy F Chaney, Sarah J Kinston, Josette R Landry, Anthony R Green, Berthold Göttgens

Source: PLoS ONE, Vol 7, Iss 3, p e31484 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3291548?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/219d391f231e4819a2042524172edf46

DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH.

Authors: Rui Zhao, David Oxley, Trevor S Smith, George A Follows, Anthony R Green, Denis R Alexander

Source: PLoS Biology, Vol 5, Iss 1, p e1 (2007)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/e6366835a2514aa192141714bc499717

Longitudinal Cytokine Profiling Identifies GRO-α and EGF as Potential Biomarkers of Disease Progression in Essential Thrombocythemia

Authors: Nina F. Øbro, Jacob Grinfeld, Miriam Belmonte, Melissa Irvine, Mairi S. Shepherd, Tata Nageswara Rao, Axel Karow, Lisa M. Riedel, Oliva B. Harris, E. Joanna Baxter, Jyoti Nangalia, Anna Godfrey, Claire N. Harrison, Juan Li, Radek C. Skoda, Peter J. Campbell, Anthony R. Green, David G. Kent

Source: HemaSphere, Vol 4, Iss 3, p e371 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000371; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/43e4a632d24a477996c58eecfcde097c

Mutant Calreticulin in the Myeloproliferative Neoplasms

Authors: Daniel Prins, Carlos González Arias, Thorsten Klampfl, Jacob Grinfeld, Anthony R. Green

Source: HemaSphere, Vol 4, Iss 1, p e333 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000333; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/53c9e8fe26884ff39c6f1b1d035afdfb

Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms

Authors: Jacob Grinfeld, Jyoti Nangalia, Anthony R. Green

Source: Haematologica, Vol 102, Iss 1 (2017)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/7947; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/d353112843cc409fb94d779ba0f7c04e

STAT1 activation in association with JAK2 exon 12 mutations

Authors: Anna L. Godfrey, Edwin Chen, Charles E. Massie, Yvonne Silber, Francesca Pagano, Beatriz Bellosillo, Paola Guglielmelli, Claire N. Harrison, John T. Reilly, Frank Stegelmann, Fontanet Bijou, Eric Lippert, Jean-Michel Boiron, Konstanze Döhner, Alessandro M. Vannucchi, Carlos Besses, Anthony R. Green

Source: Haematologica, Vol 101, Iss 1 (2016)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/7614; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/f7c4fd6dbc7a4646b7a2fe6c74bbcf93

DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype

Authors: Jyoti Nangalia, Francesca L. Nice, David C. Wedge, Anna L Godfrey, Jacob Grinfeld, Clare Thakker, Charlie E. Massie, Joanna Baxter, David Sewell, Yvonne Silber, Peter J. Campbell, Anthony R. Green

Source: Haematologica, Vol 100, Iss 11 (2015)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/7564; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/c5a89da653794239b41d62c8a24c8daf

Clonal analyses reveal associations of JAK2V617F homozygosity with hematologic features, age and gender in polycythemia vera and essential thrombocythemia

Authors: Anna L. Godfrey, Edwin Chen, Francesca Pagano, Yvonne Silber, Peter J. Campbell, Anthony R. Green

Source: Haematologica, Vol 98, Iss 5 (2013)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/6659; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/0958de92e9b04d2da1b0e421ce5d1505

Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms

Authors: Philip A. Beer, Christina A. Ortmann, Frank Stegelmann, Paola Guglielmelli, John T. Reilly, Thomas S. Larsen, Hans C. Hasselbalch, Alessandro M. Vannucchi, Peter Möller, Konstanze Döhner, Anthony R. Green

Source: Haematologica, Vol 95, Iss 12 (2010)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/5825; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/5c8198e5074f4243b681fb61513dc830

Comparison of different criteria for the diagnosis of primary myelofibrosis reveals limited clinical utility for measurement of serum lactate dehydrogenase

Authors: Philip A. Beer, Peter J. Campbell, Anthony R. Green

Source: Haematologica, Vol 95, Iss 11 (2010)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/5794; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/80c20f23bc3544bcbb3b71e2548e767f

SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases

Authors: Joanne Elliott, Yvonne Suessmuth, Linda M. Scott, Krystyna Nahlik, Mary Frances McMullin, Stefan N. Constantinescu, Anthony R. Green, James A. Johnston

Source: Haematologica, Vol 94, Iss 4 (2009)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/5226; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/b625228538024578b99f1d82071dd475

Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders

Authors: Nasios Fourouclas, Juan Li, Daniel C. Gilby, Peter J. Campbell, Philip A. Beer, Elaine M. Boyd, Anne C. Goodeve, David Bareford, Claire N. Harrison, John T. Reilly, Anthony R. Green, Anthony J. Bench

Source: Haematologica, Vol 93, Iss 11 (2008)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/5067; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/37dab90e88ce4965aefef73f01418a5f

Rapid identification of JAK2 exon 12 mutations using high resolution melting analysis

Authors: Amy V. Jones, Nicholas C.P. Cross, Helen E. White, Anthony R. Green, Linda M. Scott

Source: Haematologica, Vol 93, Iss 10 (2008)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/5039; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/9e3ea614440549e1bc2d78f9268127cc

The frequency of JAK2 exon 12 mutations in idiopathic erythrocytosis patients with low serum erythropoietin levels

Authors: Melanie J. Percy, Linda M. Scott, Wendy N. Erber, Claire N. Harrison, John T. Reilly, Frank G.C. Jones, Anthony R. Green, Mary Frances McMullin

Source: Haematologica, Vol 92, Iss 12 (2007)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/4660; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/d674209c805f46e2bd06e3e2266e448f

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Genomic imbalances in CML blast crisis: 8q24.12–q24.13 Segment identified as a common region of over-representation.

Authors: Susan M. Gribble, Alistair G. Reid, Ian Roberts, Colin Grace, Anthony R. Green, Elizabeth P. Nacheva

Source: Genes, Chromosomes & Cancer; Aug2003, Vol. 37 Issue 4, p346, 13p

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment

Authors: Kristina Kirschner, Tamir Chandra, Vladimir Kiselev, David Flores-Santa Cruz, Iain C. Macaulay, Hyun Jun Park, Juan Li, David G. Kent, Rupa Kumar, Dean C. Pask, Tina L. Hamilton, Martin Hemberg, Wolf Reik, Anthony R. Green

Source: Cell Reports, Vol 19, Iss 8, Pp 1503-1511 (2017)

Subject Terms: aging, scRNA-seq, hematology, JAK2, p53, stem cells, cellular aging, cancer, leukemia, genomics, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124717306034; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/8b76b64798534b639419288a43fe51f3