Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Authors: Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, C. David Owen, Efrat Resnick, Claire Strain-Damerell, Anthony Aimon, Péter Ábrányi-Balogh, José Brandão-Neto, Anna Carbery, Gemma Davison, Alexandre Dias, Thomas D. Downes, Louise Dunnett, Michael Fairhead, James D. Firth, S. Paul Jones, Aaron Keeley, György M. Keserü, Hanna F. Klein, Mathew P. Martin, Martin E. M. Noble, Peter O’Brien, Ailsa Powell, Rambabu N. Reddi, Rachael Skyner, Matthew Snee, Michael J. Waring, Conor Wild, Nir London, Frank von Delft, Martin A. Walsh

Source: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d499338758524d99942f9963faf75661

Synthesis of the Core Framework of the Cornexistins by Intramolecular Nozaki-Hiyama-Kishi Coupling

Authors: Anthony Aimon, Louis J. Farrugia, J. Stephen Clark

Source: Molecules, Vol 24, Iss 14, p 2654 (2019)

Subject Terms: cornexistins, nonadride, natural product, herbicide, nine-membered carbocycle, Nozaki-Hiyama-Kishi reaction, cyclisation, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/24/14/2654; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/4c95fe338d0140d683bc49518da90480

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Authors: Alice Douangamath, author^{1, 2}, Ailsa Powell, author^{1, 2}, Daren Fearon, author^{1, 2}, Patrick M. Collins, author^{1, 2}, Romain Talon, author^{1, 2, 3}, Tobias Krojer, author^{3, 4}, Rachael Skyner, author^{1, 2}, Jose Brandao-Neto, author^{1, 2}, Louise Dunnett, author^{1, 2}, Alexandre Dias, author^{1, 2}, Anthony Aimon, author^{1, 2, 3}, Nicholas M. Pearce, author^{1, 3}, Conor Wild, author^{3, 5}, Tyler Gorrie-Stone, author¹, Frank von Delft, author^{1, 2, 3, 4, 6}

Source: Journal of Visualized Experiments. (171)

Availability: http://www.jove.com/video/62414