Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment

Authors: Anne-Sophie Rebstock, Mareike Wiedmann, Beatrix Stelte-Ludwig, Harvey Wong, Amy J. Johnson, Raquel Izumi, Ahmed Hamdy, Hans-Georg Lerchen

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: αvβ3 integrin, tumor microenvironment, neutrophil elastase (NE), small molecule drug conjugate, camptothecin, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1358393/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/48196de27ca84870b273d09b3f4c3f6d