Leveraging multiple data types for improved compound-kinase bioactivity prediction

Authors: Ryan Theisen, Tianduanyi Wang, Balaguru Ravikumar, Rayees Rahman, Anna Cichońska

Source: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4d18f6b76b8e4d209b0b977e65748d7a

Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank

Authors: Heli Julkunen, Anna Cichońska, Mika Tiainen, Harri Koskela, Kristian Nybo, Valtteri Mäkelä, Jussi Nokso-Koivisto, Kati Kristiansson, Markus Perola, Veikko Salomaa, Pekka Jousilahti, Annamari Lundqvist, Antti J. Kangas, Pasi Soininen, Jeffrey C. Barrett, Peter Würtz

Source: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c89fd57120ab4597ba0f4b23f68d1f68

Crowdsourced mapping of unexplored target space of kinase inhibitors

Authors: Anna Cichońska, Balaguru Ravikumar, Robert J. Allaway, Fangping Wan, Sungjoon Park, Olexandr Isayev, Shuya Li, Michael Mason, Andrew Lamb, Ziaurrehman Tanoli, Minji Jeon, Sunkyu Kim, Mariya Popova, Stephen Capuzzi, Jianyang Zeng, Kristen Dang, Gregory Koytiger, Jaewoo Kang, Carrow I. Wells, Timothy M. Willson, The IDG-DREAM Drug-Kinase Binding Prediction Challenge Consortium, Tudor I. Oprea, Avner Schlessinger, David H. Drewry, Gustavo Stolovitzky, Krister Wennerberg, Justin Guinney, Tero Aittokallio

Source: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f21e267a1ae047ee9c1ecdf221b76214

Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation

Authors: Courtney J Smith, Nasa Sinnott-Armstrong, Anna Cichońska, Heli Julkunen, Eric B Fauman, Peter Würtz, Jonathan K Pritchard

Source: eLife, Vol 11 (2022)

Subject Terms: GWAS, genetic architecture, metabolites, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/79348; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/93c24e8d6a9e4e24a0498f5ad88bc407

Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

Authors: Heli Julkunen, Anna Cichońska, P Eline Slagboom, Peter Würtz, Nightingale Health UK Biobank Initiative

Source: eLife, Vol 10 (2021)

Subject Terms: biomarkers, pneumonia, covid-19, Medicine, Science, Biology (General), QH301-705.5

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Relation: https://elifesciences.org/articles/63033; https://doaj.org/toc/2050-084X

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Effects of general and central adiposity on circulating lipoprotein, lipid, and metabolite levels in UK Biobank: A multivariable Mendelian randomization study

Authors: Joshua A. Bell, Tom G. Richardson, Qin Wang, Eleanor Sanderson, Tom Palmer, Venexia Walker, Linda M. O'Keeffe, Nicholas J. Timpson, Anna Cichonska, Heli Julkunen, Peter Würtz, Michael V. Holmes, George Davey Smith

Source: The Lancet Regional Health. Europe, Vol 21, Iss , Pp 100457- (2022)

Subject Terms: Adiposity, BMI, WHR, Metabolism, NMR, Mendelian randomization, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S266677622200151X; https://doaj.org/toc/2666-7762

Access URL: https://doaj.org/article/0109e225c9814daebc7a73d4d765b914

Leveraging multi-way interactions for systematic prediction of pre-clinical drug combination effects

Authors: Heli Julkunen, Anna Cichonska, Prson Gautam, Sandor Szedmak, Jane Douat, Tapio Pahikkala, Tero Aittokallio, Juho Rousu

Source: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1dbe0a68db6948d0bdbef3a4f57cf4b3

Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors.

Authors: Anna Cichonska, Balaguru Ravikumar, Elina Parri, Sanna Timonen, Tapio Pahikkala, Antti Airola, Krister Wennerberg, Juho Rousu, Tero Aittokallio

Source: PLoS Computational Biology, Vol 13, Iss 8, p e1005678 (2017)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005678&type=printable; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/7279e5f8bd5b43b087551e17292e5595