A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases.

Authors: Yashar Zeighami, Trygve E Bakken, Thomas Nickl-Jockschat, Zeru Peterson, Anil G Jegga, Jeremy A Miller, Jay Schulkin, Alan C Evans, Ed S Lein, Michael Hawrylycz

Source: PLoS Biology, Vol 21, Iss 4, p e3002058 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002058&type=printable; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/e3161a5782d644bfb0511f353e3e4f28

Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity

Authors: Yuan Li, Yi Zheng, Phuong Nguyen, Ting Wen, Anil G Jegga, Khalid W Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Fukun Guo

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/11/e004806.full; https://doaj.org/toc/2051-1426

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Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis

Authors: Rajesh K Kasam, Sudhir Ghandikota, Divyalakshmi Soundararajan, Geereddy B Reddy, Steven K Huang, Anil G Jegga, Satish K Madala

Source: EMBO Molecular Medicine, Vol 12, Iss 9, Pp 1-16 (2020)

Subject Terms: Aurora Kinase B, Barasertib, fibroproliferation, pulmonary fibrosis, Wilms’ tumor 1, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/2a97e233e5134721ba0d532a1b18172e

Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases

Authors: Van N Huynh, Sheng Wang, Xiaosen Ouyang, Willayat Y Wani, Michelle S Johnson, Balu K Chacko, Anil G Jegga, Wei-Jun Qian, John C Chatham, Victor M Darley-Usmar, Jianhua Zhang

Source: Frontiers in Aging, Vol 2 (2021)

Subject Terms: OGA, O-GlcNAc, thiamet G, mass spectrometry, PICALM, DnaJC6, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fragi.2021.757801/full; https://doaj.org/toc/2673-6217

Access URL: https://doaj.org/article/1e1ae2e0cbe84e84ba61486e69e70e74

Correction: IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function.

Authors: Brijendra Singh, Anil G Jegga, Kumar S Shanmukhappa, Ramakrishna Edukulla, Gurjit Kaur Khurana Hershey, Mario Medvedovic, Stacey R Dillon, Satish K Madala

Source: PLoS ONE, Vol 12, Iss 1, p e0170446 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5256880?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/42749d9088f54048834c96533886ade3

IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function.

Authors: Brijendra Singh, Anil G Jegga, Kumar S Shanmukhappa, Ramakrishna Edukulla, Gurjit H Khurana Hershey, Mario Medvedovic, Stacey R Dillon, Satish K Madala

Source: PLoS ONE, Vol 11, Iss 8, p e0161877 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4996532?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ea32bb4149e947fc8fc884016771bf35

Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case study.

Authors: Lun Yang, Kejian Wang, Jian Chen, Anil G Jegga, Heng Luo, Leming Shi, Chunling Wan, Xizhi Guo, Shengying Qin, Guang He, Guoyin Feng, Lin He

Source: PLoS Computational Biology, Vol 7, Iss 3, p e1002016 (2011)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3068927?pdf=render; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/3272010b712f4b77a742357fa97500fc

Decidual cell polyploidization necessitates mitochondrial activity.

Authors: Xinghong Ma, Fei Gao, Allison Rusie, Jennifer Hemingway, Alicia B Ostmann, Julie M Sroga, Anil G Jegga, Sanjoy K Das

Source: PLoS ONE, Vol 6, Iss 10, p e26774 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3201964?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/0c0f99ee409e4aec967024fb1228ff33

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Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice

Authors: S’Dravious A. DeVeaux, Sofiya Vyshnya, Katherine Propsom, Oluwabukola T. Gbotosho, Asem S. Singh, Robert Z. Horning, Mihika Sharma, Anil G. Jegga, Liang Niu, Edward A. Botchwey, Hyacinth I. Hyacinth

Source: Experimental Biology and Medicine, Vol 249 (2024)

Subject Terms: sickle cell disease, neuroinflammation, cognitive function, social stress, minocycline, Biology (General), QH301-705.5, Medicine

File Description: electronic resource

Relation: https://www.ebm-journal.org/articles/10.3389/ebm.2024.10361/full; https://doaj.org/toc/1535-3699

Access URL: https://doaj.org/article/cf60ae327363473aad9f9b4733f4237f

Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction in db/db mice

Authors: Darshini A. Desai, Akhil Baby, Kalyani Ananthamohan, Lisa C. Green, Mohammed Arif, Brittany C. Duncan, Mohit Kumar, Rohit R. Singh, Sheryl E. Koch, Sankar Natesan, Jack Rubinstein, Anil G. Jegga, Sakthivel Sadayappan

Source: Journal of Molecular and Cellular Cardiology Plus, Vol 8, Iss , Pp 100075- (2024)

Subject Terms: cMyBP-C, Diabetes, HFpEF, MYBPC3, Mavacamten, Phosphorylation, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772976124000151; https://doaj.org/toc/2772-9761

Access URL: https://doaj.org/article/dfbdc26c598344ae941d40c3723cf9bd

Elucidating a genomic signature associated with behavioral and executive function after moderate to severe pediatric TBI: a systems biology informed approach

Authors: Brad G. Kurowski, Amery Treble-Barna, Valentina Pilipenko, Lisa J. Martin, Anil G. Jegga, Aimee E. Miley, Nanhua Zhang, Anthony Fabio, Ranjit S. Chima, Anna-Lynne R. Adlam, Kenneth Kaufman, Michael J. Bell, Sue R. Beers, Stephen R. Wisniewski, Shari L. Wade, TBI Genetics and Environment Study Team

Source: Frontiers in Systems Biology, Vol 4 (2024)

Subject Terms: traumatic brain injury, genomics, systems biology, pediatrics, long-term, behavior, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fsysb.2024.1293265/full; https://doaj.org/toc/2674-0702

Access URL: https://doaj.org/article/ef70d6c38f6e4c31b24d60c6d0614514

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Combination of esomeprazole and pirfenidone enhances antifibrotic efficacy in vitro and in a mouse model of TGFβ-induced lung fibrosis

Authors: Afshin Ebrahimpour, Manisha Ahir, Min Wang, Anil G. Jegga, Mark D. Bonnen, N. Tony Eissa, Sydney B. Montesi, Ganesh Raghu, Yohannes T. Ghebre

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3ce6a0a83e064759a2ff579276fe6229

Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn’s disease, and celiac disease

Authors: Tzipi Braun, Katya E. Sosnovski, Amnon Amir, Marina BenShoshan, Kelli L. VanDussen, Rebekah Karns, Nina Levhar, Haya Abbas-Egbariya, Rotem Hadar, Gilat Efroni, David Castel, Camila Avivi, Michael J. Rosen, Anne M. Grifiths, Thomas D. Walters, David R. Mack, Brendan M. Boyle, Syed Asad Ali, Sean R. Moore, Melanie Schirmer, Ramnik J. Xavier, Subra Kugathasan, Anil G. Jegga, Batya Weiss, Chen Mayer, Iris Barshack, Shomron Ben-Horin, Igor Ulitsky, Anthony Beucher, Jorge Ferrer, Jeffrey S. Hyams, Lee A. Denson, Yael Haberman

Source: JCI Insight, Vol 8, Iss 14 (2023)

Subject Terms: Gastroenterology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/175d48f8e9c64094a115fe7ffb8e26b5

Transcriptome analysis in acute gastrointestinal graft-versus host disease reveals a unique signature in children and shared biology with pediatric inflammatory bowel disease

Authors: Pooja Khandelwal, Dana T Lounder, Allison Bartlett, Yael Haberman, Anil G. Jegga, Sudhir Ghandikota, Jane Koo, Nathan Luebbering, Daniel Leino, Sheyar Abdullah, Michaela Loveless, Phillip Minar, Kelly Lake, Bridget Litts, Rebekah Karns, Adam S. Nelson, Lee A. Denson, Stella M. Davies

Source: Haematologica, Vol 108, Iss 7 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10967; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/4fe814e572894a2582f0fd589687275a

Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells

Authors: Vi Nguyen, Jacob Kravitz, Chao Gao, Marcelo L. Hochman, Dehao Meng, Dongbao Chen, Yunguan Wang, Anil G. Jegga, J Stuart Nelson, Wenbin Tan

Source: Metabolites, Vol 13, Iss 9, p 983 (2023)

Subject Terms: Port Wine Birthmark, induced pluripotent stem cells, metabolome, glutathione, sphingolipid, sphingosine, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/13/9/983; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/fb97ec88e52e441c8999d13348cecb6c

Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway

Authors: Afshin Ebrahimpour, Min Wang, Li Li, Anil G. Jegga, Mark D. Bonnen, N. Tony Eissa, Ganesh Raghu, Soma Jyothula, Farrah Kheradmand, Nicola A. Hanania, Ivan O. Rosas, Yohannes T. Ghebre

Source: Journal of Inflammation, Vol 18, Iss 1, Pp 1-14 (2021)

Subject Terms: Esomeprazole, Proton pump inhibitors, Inflammation, Fibrosis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1476-9255

Access URL: https://doaj.org/article/e4e7d799ccab4aaabac4af93292863d5

Ileal Derived Organoids From Crohn’s Disease Patients Show Unique Transcriptomic and Secretomic SignaturesSummary

Authors: Barbara Joanna Niklinska-Schirtz, Suresh Venkateswaran, Murugadas Anbazhagan, Vasantha L. Kolachala, Jarod Prince, Anne Dodd, Raghavan Chinnadurai, Gregory Gibson, Lee A. Denson, David J. Cutler, Anil G. Jegga, Jason D. Matthews, Subra Kugathasan

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1267-1280 (2021)

Subject Terms: Inflammatory Bowel Disease, Human Intestinal Organoids, Children, Epigenetics, Intestinal Epithelium, Secretome, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X21001338; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/138e1bb610ec4c1a92016aaad7d4e59a

Heterogeneous Distribution of Genetic Mutations in Myosin Binding Protein-C Paralogs

Authors: Darshini A. Desai, Vinay J. Rao, Anil G. Jegga, Perundurai S. Dhandapany, Sakthivel Sadayappan

Source: Frontiers in Genetics, Vol 13 (2022)

Subject Terms: MYBPC1, MYBPC2, MYBPC3, hypertrophic cardiomyopathy, distal arthrogryposis, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2022.896117/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/864e01194e4f4bffa6a86b5a7b3b1d16