Analysis of the Porphyrin Peak Shift and Fluorescence Lifetime in Gliomas with Different Tumor Grades, Intratumoral Regions, and Visible Fluorescence Status

Authors: Lisa Irina Körner, David Reichert, Marco Andreana, Angelika Unterhuber, Mikael T. Erkkilae, Jessica Makolli, Barbara Kiesel, Mario Mischkulnig, Thomas Rötzer-Pejrimovsky, Adelheid Wöhrer, Mitchel S. Berger, Rainer Leitgeb, Georg Widhalm

Source: Diagnostics, Vol 14, Iss 23, p 2651 (2024)

Subject Terms: protoporphyrin IX, 5-ALA, fluorescence lifetime, glioma, intraoperative visualization, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/2075-4418/14/23/2651; https://doaj.org/toc/2075-4418

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Detection of a Water-Soluble Hypericin Formulation in Glioblastoma Tissue with Fluorescence Lifetime and Intensity Using a Dual-Tap CMOS Camera System

Authors: Mario Mischkulnig, David Reichert, Lionel Wightman, Vanessa Roth, Marijke Hölz, Lisa I. Körner, Barbara Kiesel, Djenana Vejzovic, Gabriel A. Giardina, Mikael T. Erkkilae, Angelika Unterhuber, Marco Andreana, Beate Rinner, Andreas Kubin, Rainer Leitgeb, Georg Widhalm

Source: Diagnostics, Vol 14, Iss 21, p 2423 (2024)

Subject Terms: hypericin, HHL-PVP, glioblastoma, fluorescence, visualization, fluorescence lifetime, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/2075-4418/14/21/2423; https://doaj.org/toc/2075-4418

Access URL: https://doaj.org/article/52e0bbcef60148cb9fd2545701826426

Editorial: Advanced imaging and its application in biology and medicine

Authors: Veronika Huntosova, Marco Andreana, Angelika Unterhuber

Source: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Subject Terms: live imaging, spectroscopy, molecular biolgy, biophysics, artificial inteligence-AI, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2023.1163210/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/a108008275fe4db498eca1711d8edc71

Flavin fluorescence lifetime and autofluorescence optical redox ratio for improved visualization and classification of brain tumors

Authors: David Reichert, Lisa I. Wadiura, Mikael T. Erkkilae, Johanna Gesperger, Alexandra Lang, Thomas Roetzer-Pejrimovsky, Jessica Makolli, Adelheid Woehrer, Marco Wilzbach, Christoph Hauger, Barbara Kiesel, Marco Andreana, Angelika Unterhuber, Wolfgang Drexler, Georg Widhalm, Rainer A. Leitgeb

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: fluorescence guided surgery, fluorescence lifetime imaging, fluorescence spectroscopy, optical redox ratio, flavin mononucleotide, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1105648/full; https://doaj.org/toc/2234-943X

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Macroscopic fluorescence-lifetime imaging of NADH and protoporphyrin IX improves the detection and grading of 5-aminolevulinic acid-stained brain tumors

Authors: Mikael T. Erkkilä, David Reichert, Johanna Gesperger, Barbara Kiesel, Thomas Roetzer, Petra A. Mercea, Wolfgang Drexler, Angelika Unterhuber, Rainer A. Leitgeb, Adelheid Woehrer, Angelika Rueck, Marco Andreana, Georg Widhalm

Source: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3db3992c1c224e26a3d16b40e28f6931

Diagnosis of Pituitary Adenoma Biopsies by Ultrahigh Resolution Optical Coherence Tomography Using Neuronal Networks

Authors: Alexander Micko, Fabian Placzek, Roger Fonollà, Michael Winklehner, Ryan Sentosa, Arno Krause, Greisa Vila, Romana Höftberger, Marco Andreana, Wolfgang Drexler, Rainer A. Leitgeb, Angelika Unterhuber, Stefan Wolfsberger

Source: Frontiers in Endocrinology, Vol 12 (2021)

Subject Terms: Optical coherence tomography, pituitary gland, pituitary adenoma (PA), transition zone (TZ), convolutional neural network (CNN), Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2021.730100/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/a41c0dced29e43a5a5150f9df3269528

Fluorescence Lifetime Imaging and Spectroscopic Co-Validation for Protoporphyrin IX-Guided Tumor Visualization in Neurosurgery

Authors: David Reichert, Mikael T. Erkkilae, Johanna Gesperger, Lisa I. Wadiura, Alexandra Lang, Thomas Roetzer, Adelheid Woehrer, Marco Andreana, Angelika Unterhuber, Marco Wilzbach, Christoph Hauger, Wolfgang Drexler, Barbara Kiesel, Georg Widhalm, Rainer A. Leitgeb

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: fluorescence-guided surgery, fluorescence lifetime imaging (FLIM), fluorescence spectroscopy, protoporphyrin IX, surgical microscope, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.741303/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/b4796f9625d84d938d15fc8f4b813179

Toward Quantitative in vivo Label-Free Tracking of Lipid Distribution in a Zebrafish Cancer Model

Authors: Marco Andreana, Caterina Sturtzel, Clemens P. Spielvogel, Laszlo Papp, Rainer Leitgeb, Wolfgang Drexler, Martin Distel, Angelika Unterhuber

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: zebrafish, cancer model, lipid metabolism, label-free microscopy, coherent anti-Stokes Raman scattering, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.675636/full; https://doaj.org/toc/2296-634X

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Correlated Multimodal Imaging in Life Sciences: Expanding the Biomedical Horizon

Authors: Andreas Walter, Perrine Paul-Gilloteaux, Birgit Plochberger, Ludek Sefc, Paul Verkade, Julia G. Mannheim, Paul Slezak, Angelika Unterhuber, Martina Marchetti-Deschmann, Manfred Ogris, Katja Bühler, Dror Fixler, Stefan H. Geyer, Wolfgang J. Weninger, Martin Glösmann, Stephan Handschuh, Thomas Wanek

Source: Frontiers in Physics, Vol 8 (2020)

Subject Terms: bioimaging, correlated multimodal imaging, CMI, COMULIS, CLEM, correlative microscopy, Physics, QC1-999

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphy.2020.00047/full; https://doaj.org/toc/2296-424X

Access URL: https://doaj.org/article/b351d43f762e4b51bf0b5203308a8644

Improved Protoporphyrin IX-Guided Neurosurgical Tumor Detection with Frequency-Domain Fluorescence Lifetime Imaging

Authors: David Reichert, Mikael T. Erkkilae, Johanna Gesperger, Lisa I. Wadiura, Alexandra Lang, Thomas Roetzer-Pejrimovsky, Adelheid Woehrer, Marco Wilzbach, Christoph Hauger, Wolfgang Drexler, Barbara Kiesel, Georg Widhalm, Rainer A. Leitgeb, Angelika Unterhuber, Marco Andreana

Source: Applied Sciences, Vol 12, Iss 3, p 1002 (2022)

Subject Terms: fluorescence-guided surgery, fluorescence lifetime imaging, fluorescence spectroscopy, protoporphyrin IX, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3417/12/3/1002; https://doaj.org/toc/2076-3417

Access URL: https://doaj.org/article/d68975281ea04e398d3a8ecc2dd5a4d4

Integrated single- and two-photon light sheet microscopy using accelerating beams

Authors: Peeter Piksarv, Dominik Marti, Tuan Le, Angelika Unterhuber, Lindsey H. Forbes, Melissa R. Andrews, Andreas Stingl, Wolfgang Drexler, Peter E. Andersen, Kishan Dholakia

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/274bf661225845a69183481f7c6f19ab

Line Scan Raman Microspectroscopy for Label-Free Diagnosis of Human Pituitary Biopsies

Authors: Daniela Bovenkamp, Alexander Micko, Jeremias Püls, Fabian Placzek, Romana Höftberger, Greisa Vila, Rainer Leitgeb, Wolfgang Drexler, Marco Andreana, Stefan Wolfsberger, Angelika Unterhuber

Source: Molecules, Vol 24, Iss 19, p 3577 (2019)

Subject Terms: raman spectroscopy, line scan raman microspectroscopy, pituitary gland, pituitary adenoma, principal component analysis, k-nearest neighbor classifier, texture analysis, grey level cooccurrence matrix, correlation coefficients, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/24/19/3577; https://doaj.org/toc/1420-3049

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Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

Authors: Daniela Bovenkamp, Ryan Sentosa, Elisabet Rank, Mikael T. Erkkilä, Fabian Placzek, Jeremias Püls, Wolfgang Drexler, Rainer A. Leitgeb, Nathalie Garstka, Shahrokh F. Shariat, Clara Stiebing, Iwan W. Schie, Jürgen Popp, Marco Andreana, Angelika Unterhuber

Source: Applied Sciences, Vol 8, Iss 12, p 2371 (2018)

Subject Terms: optical coherence tomography (OCT), Raman spectroscopy (RS), principal component analysis (PCA), k-nearest neighbor classification (kNN), bladder cancer, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3417/8/12/2371; https://doaj.org/toc/2076-3417

Access URL: https://doaj.org/article/d51231b349c146a2ab75e09f32731d5e

Imaging ex vivo and in vitro brain morphology in animal models with ultrahigh resolution optical coherence tomography.

Authors: Kostadinka Bizheva, Angelika Unterhuber, Boris Hermann, Boris Povazˇay, Harald Sattmann, Wolfgang Drexler

Source: Journal of Biomedical Optics; Jul2004, Vol. 9 Issue 4, p719-724, 6p

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Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients.

Authors: Boris Povazˇay, Boris Hermann, Angelika Unterhuber, Bernd Hofer, Harald Sattmann, Florian Zeiler, James E. Morgan, Christiane Falkner-Radler, Carl Glittenberg, Susanne Blinder, Wolfgang Drexler

Source: Journal of Biomedical Optics; Jul2007, Vol. 12 Issue 4, p41211-41211, 1p

Subject Terms: CATARACT, DIAGNOSIS of eye diseases, OPTICAL coherence tomography, MEDICAL radiography

Minimum distance mapping using three-dimensional optical coherence tomography for glaucoma diagnosis.

Authors: Boris Povazˇay, Bernd Hofer, Boris Hermann, Angelika Unterhuber, James E. Morgan, Carl Glittenberg, Susanne Binder, Wolfgang Drexler

Source: Journal of Biomedical Optics; Jul2007, Vol. 12 Issue 4, p41204-41204, 1p

Subject Terms: DIAGNOSIS of eye diseases, VISUAL pathways, MEDICAL radiography, TOMOGRAPHY