Synthesis, testing, and computational modeling of pleuromutilin 1,2,3-triazole derivatives in the ribosome

Authors: Logan M. Breiner, Anthony J. Briganti, Jennifer P. McCord, Moriah E. Heifetz, Sophia Y. Philbrook, Carla Slebodnick, Anne M. Brown, Andrew N. Lowell

Source: Tetrahedron Chem, Vol 4, Iss , Pp 100034- (2022)

Subject Terms: Ribosome, Antibiotics, Pleuromutilin, Click-chemistry, In silico modeling, Molecular docking, Organic chemistry, QD241-441

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666951X22000304; https://doaj.org/toc/2666-951X

Access URL: https://doaj.org/article/7651b2cc772c4e9b8b5387abcee697df

Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase

Authors: Edward Kalkreuter, Kyle S. Bingham, Aaron M. Keeler, Andrew N. Lowell, Jennifer J. Schmidt, David H. Sherman, Gavin J. Williams

Source: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8ac2f471c63242d2830d7699ac214224