Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities

Authors: Quentin Haas, Nikita Markov, Lukas Muerner, Viviana Rubino, Andrej Benjak, Monika Haubitz, Gabriela M. Baerlocher, Charlotte K. Y. Ng, Christian Münz, Carsten Riether, Adrian F. Ochsenbein, Hans-Uwe Simon, Stephan von Gunten

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: Siglec-7, CD8+ T cells, acute myeloid leukemia, immune checkpoint, tumor immunity and immunotherapy, sialoglycans, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.996746/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ee365483dca647a5aef0a91df47591e6

Gene expression patterns associated with multidrug therapy in multibacillary leprosy

Authors: Helen Ferreira, Thyago Leal-Calvo, Mayara Abud Mendes, Charlotte Avanzi, Philippe Busso, Andrej Benjak, Anna Maria Sales, Cássio Porto Ferreira, Márcia de Berrêdo-Pinho, Stewart Thomas Cole, Euzenir Nunes Sarno, Milton Ozório Moraes, Roberta Olmo Pinheiro

Source: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Subject Terms: multibacillary leprosy, multidrug therapy, lipid metabolism, bacillary load, gene signature, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2022.917282/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/322b90006fe1492baddc5a9e4e25637a

Patient-derived xenografts and organoids model therapy response in prostate cancer

Authors: Sofia Karkampouna, Federico La Manna, Andrej Benjak, Mirjam Kiener, Marta De Menna, Eugenio Zoni, Joël Grosjean, Irena Klima, Andrea Garofoli, Marco Bolis, Arianna Vallerga, Jean-Philippe Theurillat, Maria R. De Filippo, Vera Genitsch, David Keller, Tijmen H. Booij, Christian U. Stirnimann, Kenneth Eng, Andrea Sboner, Charlotte K. Y. Ng, Salvatore Piscuoglio, Peter C. Gray, Martin Spahn, Mark A. Rubin, George N. Thalmann, Marianna Kruithof-de Julio

Source: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/74f8126482f64e7aa57d9156cdf767c0

Elimination of PknL and MSMEG_4242 in Mycobacterium smegmatis alters the character of the outer cell envelope and selects for mutations in Lsr2

Authors: Estalina Báez-Ramírez, Luis Querales, Carlos Andres Aranaga, Gustavo López, Elba Guerrero, Laurent Kremer, Séverine Carrère-Kremer, Albertus Viljoen, Mamadou Daffé, Françoise Laval, Stewart T. Cole, Andrej Benjak, Pedro Alzari, Gwenaëlle André-Leroux, William R. Jacobs, Jr., Catherine Vilcheze, Howard E. Takiff

Source: The Cell Surface, Vol 7, Iss , Pp 100060- (2021)

Subject Terms: Tuberculosis, Kinase, PknL, Lsr2, Biofilms, Mycobacterial envelope, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S246823302100013X; https://doaj.org/toc/2468-2330

Access URL: https://doaj.org/article/611ee645f9a642f8b53d9cbe636b8cf3

A new paradigm for leprosy diagnosis based on host gene expression

Authors: Thyago Leal-Calvo, Charlotte Avanzi, Mayara Abud Mendes, Andrej Benjak, Philippe Busso, Roberta Olmo Pinheiro, Euzenir Nunes Sarno, Stewart Thomas Cole, Milton Ozório Moraes

Source: PLoS Pathogens, Vol 17, Iss 10 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568100/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/ea7647be84d24cc2a8be5dccda278b62

A new paradigm for leprosy diagnosis based on host gene expression.

Authors: Thyago Leal-Calvo, Charlotte Avanzi, Mayara Abud Mendes, Andrej Benjak, Philippe Busso, Roberta Olmo Pinheiro, Euzenir Nunes Sarno, Stewart Thomas Cole, Milton Ozório Moraes

Source: PLoS Pathogens, Vol 17, Iss 10, p e1009972 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/1f59cb6727cc4942a3c60c07f6f4ad26

Genomic Characterization of Mycobacterium leprae to Explore Transmission Patterns Identifies New Subtype in Bangladesh

Authors: Maria Tió-Coma, Charlotte Avanzi, Els M. Verhard, Louise Pierneef, Anouk van Hooij, Andrej Benjak, Johan Chandra Roy, Marufa Khatun, Khorshed Alam, Paul Corstjens, Stewart T. Cole, Jan Hendrik Richardus, Annemieke Geluk

Source: Frontiers in Microbiology, Vol 11 (2020)

Subject Terms: diagnosis, genotypes, strain subtype, WGS, leprosy, M. leprae, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmicb.2020.01220/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/c47091e1a30d49cf8989dac6c589aea0

Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros

Authors: Charlotte Avanzi, Emmanuel Lécorché, Fetra Angelot Rakotomalala, Andrej Benjak, Fahafahantsoa Rapelanoro Rabenja, Lala S. Ramarozatovo, Bertrand Cauchoix, Mala Rakoto-Andrianarivelo, Maria Tió-Coma, Thyago Leal-Calvo, Philippe Busso, Stefanie Boy-Röttger, Aurélie Chauffour, Tahinamandrato Rasamoelina, Aina Andrianarison, Fandresena Sendrasoa, John S. Spencer, Pushpendra Singh, Digambar Ramchandra Dashatwar, Rahul Narang, Jean-Luc Berland, Vincent Jarlier, Claudio G. Salgado, Milton O. Moraes, Annemieke Geluk, Andriamira Randrianantoandro, Emmanuelle Cambau, Stewart T. Cole

Source: Frontiers in Microbiology, Vol 11 (2020)

Subject Terms: leprosy, Mycobacterium leprae, Madagascar, Comoros, genomics, phylogeography, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmicb.2020.00711/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/a4751af38b644d63924f89fef83775be

Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae

Authors: Andrej Benjak, Charlotte Avanzi, Pushpendra Singh, Chloé Loiseau, Selfu Girma, Philippe Busso, Amanda N. Brum Fontes, Yuji Miyamoto, Masako Namisato, Kidist Bobosha, Claudio G. Salgado, Moisés B. da Silva, Raquel C. Bouth, Marco A. C. Frade, Fred Bernardes Filho, Josafá G. Barreto, José A. C. Nery, Samira Bührer-Sékula, Andréanne Lupien, Abdul R. Al-Samie, Yasin Al-Qubati, Abdul S. Alkubati, Gisela Bretzel, Lucio Vera-Cabrera, Fatoumata Sakho, Christian R. Johnson, Mamoudou Kodio, Abdoulaye Fomba, Samba O. Sow, Moussa Gado, Ousmane Konaté, Mariane M. A. Stefani, Gerson O. Penna, Philip N. Suffys, Euzenir Nunes Sarno, Milton O. Moraes, Patricia S. Rosa, Ida M. F. Dias Baptista, John S. Spencer, Abraham Aseffa, Masanori Matsuoka, Masanori Kai, Stewart T. Cole

Source: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d0872b16248e40f0a1f5adae60f93176

New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis.

Authors: Andréanne Lupien, Caroline Shi-Yan Foo, Svetlana Savina, Anthony Vocat, Jérémie Piton, Natalia Monakhova, Andrej Benjak, Dirk A Lamprecht, Adrie J C Steyn, Kevin Pethe, Vadim A Makarov, Stewart T Cole

Source: PLoS Pathogens, Vol 16, Iss 1, p e1008270 (2020)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/b7f8b7461a4442bc8a002d6f37ec16b1

Multicenter analysis of sputum microbiota in tuberculosis patients.

Authors: Claudia Sala, Andrej Benjak, Delia Goletti, Sayera Banu, Jesica Mazza-Stadler, Katia Jaton, Philippe Busso, Sille Remm, Marion Leleu, Jacques Rougemont, Fabrizio Palmieri, Gilda Cuzzi, Ornella Butera, Valentina Vanini, Senjuti Kabir, S M Mazidur Rahman, Laurent Nicod, Stewart T Cole

Source: PLoS ONE, Vol 15, Iss 10, p e0240250 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b8f8745ccd7c497c9b50097ad1c20d6c

EspL is essential for virulence and stabilizes EspE, EspF and EspH levels in Mycobacterium tuberculosis.

Authors: Claudia Sala, Nina T Odermatt, Paloma Soler-Arnedo, Muhammet F Gülen, Sofia von Schultz, Andrej Benjak, Stewart T Cole

Source: PLoS Pathogens, Vol 14, Iss 12, p e1007491 (2018)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/06f809a536ae4b8f9028346a204f13bf

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

Authors: Caroline S. Foo, Andréanne Lupien, Maryline Kienle, Anthony Vocat, Andrej Benjak, Raphael Sommer, Dirk A. Lamprecht, Adrie J. C. Steyn, Kevin Pethe, Jérémie Piton, Karl-Heinz Altmann, Stewart T. Cole

Source: mBio, Vol 9, Iss 5 (2018)

Subject Terms: QcrB inhibitor, cytochrome bc1 oxidase, cytochrome bd oxidase, mycobacterial diseases, mycobacterial respiration, tuberculosis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/adb9ac67e2c14c6b855d0f2b8719a48c

Highly Reduced Genome of the New Species Mycobacterium uberis, the Causative Agent of Nodular Thelitis and Tuberculoid Scrotitis in Livestock and a Close Relative of the Leprosy Bacilli

Authors: Andrej Benjak, Charlotte Avanzi, Yvonne Benito, Franck Breysse, Christophe Chartier, Maria-Laura Boschiroli, Christine Fourichon, Lorraine Michelet, Didier Pin, Jean-Pierre Flandrois, Pierre Bruyere, Oana Dumitrescu, Stewart T. Cole, Gerard Lina

Source: mSphere, Vol 3, Iss 5 (2018)

Subject Terms: Mycobacterium uberis, evolutionary biology, genome analysis, granulomatous dermatitis, veterinary pathogens, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/8650c37ec1dd41949fddeacac30f9ebe

Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe.

Authors: Verena J Schuenemann, Charlotte Avanzi, Ben Krause-Kyora, Alexander Seitz, Alexander Herbig, Sarah Inskip, Marion Bonazzi, Ella Reiter, Christian Urban, Dorthe Dangvard Pedersen, G Michael Taylor, Pushpendra Singh, Graham R Stewart, Petr Velemínský, Jakub Likovsky, Antónia Marcsik, Erika Molnár, György Pálfi, Valentina Mariotti, Alessandro Riga, M Giovanna Belcastro, Jesper L Boldsen, Almut Nebel, Simon Mays, Helen D Donoghue, Sonia Zakrzewski, Andrej Benjak, Kay Nieselt, Stewart T Cole, Johannes Krause

Source: PLoS Pathogens, Vol 14, Iss 5, p e1006997 (2018)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/1d2b1eeff903483cbb6c16855a091083

Insights from the Genome Sequence of Mycobacterium lepraemurium: Massive Gene Decay and Reductive Evolution

Authors: Andrej Benjak, Tanvi P. Honap, Charlotte Avanzi, Enrique Becerril-Villanueva, Iris Estrada-García, Oscar Rojas-Espinosa, Anne C. Stone, Stewart T. Cole

Source: mBio, Vol 8, Iss 5 (2017)

Subject Terms: Mycobacterium lepraemurium, comparative genomics, genome sequencing, murine leprosy, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/a69604838d0343efa4b9f56cc5903a8c

Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy cases.

Authors: Mariane M A Stefani, Charlotte Avanzi, Samira Bührer-Sékula, Andrej Benjak, Chloé Loiseau, Pushpendra Singh, Maria A A Pontes, Heitor S Gonçalves, Emerith M Hungria, Philippe Busso, Jérémie Piton, Maria I S Silveira, Rossilene Cruz, Antônio Schetinni, Maurício B Costa, Marcos C L Virmond, Suzana M Diorio, Ida M F Dias-Baptista, Patricia S Rosa, Masanori Matsuoka, Maria L F Penna, Stewart T Cole, Gerson O Penna

Source: PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005598 (2017)

Subject Terms: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5498066?pdf=render; https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

Access URL: https://doaj.org/article/91540a58ac934e209d0d7e74859d55f7

The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis.

Authors: Luis Solans, Jesús Gonzalo-Asensio, Claudia Sala, Andrej Benjak, Swapna Uplekar, Jacques Rougemont, Christophe Guilhot, Wladimir Malaga, Carlos Martín, Stewart T Cole

Source: PLoS Pathogens, Vol 10, Iss 5, p e1004183 (2014)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24874799/pdf/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/ac0b6184c8934c1cb51230f9313de08e

Genome-wide analysis of the 'cut-and-paste' transposons of grapevine.

Authors: Andrej Benjak, Astrid Forneck, Josep M Casacuberta

Source: PLoS ONE, Vol 3, Iss 9, p e3107 (2008)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18769592/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f0aa90b6bcf64fac891eeee61750abad