Subclonal TP53 and KRAS variants combined with poor treatment response identify ultrahigh-risk pediatric patients with T-ALL

Authors: Tamara Kempter, Paulina Richter-Pechańska, Katarzyna Michel, Tobias Rausch, Büşra Erarslan-Uysal, Cornelia Eckert, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Gunnar Cario, Stefan Köhrer, Andishe Attarbaschi, Jan O. Korbel, Joachim B. Kunz, Andreas E. Kulozik

Source: Blood Advances, Vol 9, Iss 6, Pp 1267-1279 (2025)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952925000151; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/926fbc018ab84c44ab4d39eb6cda033b

Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma

Authors: Yang Zhou, Partho Sarothi Ray, Jianguo Zhu, Frank Stein, Mandy Rettel, Thileepan Sekaran, Sudeep Sahadevan, Joel I. Perez-Perri, Eva K. Roth, Ola Myklebost, Leonardo A. Meza-Zepeda, Andreas von Deimling, Chuli Fu, Annika N. Brosig, Kjetil Boye, Michaela Nathrath, Claudia Blattmann, Burkhard Lehner, Matthias W. Hentze, Andreas E. Kulozik

Source: Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c8a044416b63443ebe99465720d460f3

Sarcoma classification by DNA methylation profiling

Authors: Christian Koelsche, Daniel Schrimpf, Damian Stichel, Martin Sill, Felix Sahm, David E. Reuss, Mirjam Blattner, Barbara Worst, Christoph E. Heilig, Katja Beck, Peter Horak, Simon Kreutzfeldt, Elke Paff, Sebastian Stark, Pascal Johann, Florian Selt, Jonas Ecker, Dominik Sturm, Kristian W. Pajtler, Annekathrin Reinhardt, Annika K. Wefers, Philipp Sievers, Azadeh Ebrahimi, Abigail Suwala, Francisco Fernández-Klett, Belén Casalini, Andrey Korshunov, Volker Hovestadt, Felix K. F. Kommoss, Mark Kriegsmann, Matthias Schick, Melanie Bewerunge-Hudler, Till Milde, Olaf Witt, Andreas E. Kulozik, Marcel Kool, Laura Romero-Pérez, Thomas G. P. Grünewald, Thomas Kirchner, Wolfgang Wick, Michael Platten, Andreas Unterberg, Matthias Uhl, Amir Abdollahi, Jürgen Debus, Burkhard Lehner, Christian Thomas, Martin Hasselblatt, Werner Paulus, Christian Hartmann, Ori Staszewski, Marco Prinz, Jürgen Hench, Stephan Frank, Yvonne M. H. Versleijen-Jonkers, Marije E. Weidema, Thomas Mentzel, Klaus Griewank, Enrique de Álava, Juan Díaz Martín, Miguel A. Idoate Gastearena, Kenneth Tou-En Chang, Sharon Yin Yee Low, Adrian Cuevas-Bourdier, Michel Mittelbronn, Martin Mynarek, Stefan Rutkowski, Ulrich Schüller, Viktor F. Mautner, Jens Schittenhelm, Jonathan Serrano, Matija Snuderl, Reinhard Büttner, Thomas Klingebiel, Rolf Buslei, Manfred Gessler, Pieter Wesseling, Winand N. M. Dinjens, Sebastian Brandner, Zane Jaunmuktane, Iben Lyskjær, Peter Schirmacher, Albrecht Stenzinger, Benedikt Brors, Hanno Glimm, Christoph Heining, Oscar M. Tirado, Miguel Sáinz-Jaspeado, Jaume Mora, Javier Alonso, Xavier Garcia del Muro, Sebastian Moran, Manel Esteller, Jamal K. Benhamida, Marc Ladanyi, Eva Wardelmann, Cristina Antonescu, Adrienne Flanagan, Uta Dirksen, Peter Hohenberger, Daniel Baumhoer, Wolfgang Hartmann, Christian Vokuhl, Uta Flucke, Iver Petersen, Gunhild Mechtersheimer, David Capper, David T. W. Jones, Stefan Fröhling, Stefan M. Pfister, Andreas von Deimling

Source: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c88e43d5043848c8bc27777e780e6d5b

Odisha Revisited: A Personal Account

Authors: Graham R. Serjeant, Andreas E. Kulozik, Beryl E. Serjeant

Source: Frontiers in Medicine, Vol 8 (2021)

Subject Terms: sickle cell, India, Jamaica, cohort study, haplotype comparison, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2021.745337/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/865be4b4bd24482ca7564c65522fc71d

Genetic modifiers of fetal hemoglobin affect the course of sickle cell disease in patients treated with hydroxyurea

Authors: Pierre Allard, Nareen Alhaj, Stephan Lobitz, Holger Cario, Andreas Jarisch, Regine Grosse, Lena Oevermann, Dani Hakimeh, Laura Tagliaferri, Elisabeth Kohne, Annette Kopp-Schneider, Andreas E. Kulozik, Joachim B. Kunz

Source: Haematologica, Vol 107, Iss 7 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10440; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/6917040d732d4b14a269d5e926b9d34b

Does the world need germline editing for β-thalassemia?

Authors: Andreas E. Kulozik

Source: Haematologica, Vol 107, Iss 6 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10443; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/3a2970f67d104e46b8a776a05e2e09a1

NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes

Authors: Jonas P. Becker, Dominic Helm, Mandy Rettel, Frank Stein, Alejandro Hernandez-Sanchez, Katharina Urban, Johannes Gebert, Matthias Kloor, Gabriele Neu-Yilik, Magnus von Knebel Doeberitz, Matthias W. Hentze, Andreas E. Kulozik

Source: iScience, Vol 24, Iss 4, Pp 102389- (2021)

Subject Terms: Biological Sciences, Immunology, Cancer, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004221003576; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/0d94a763505d49eea81e8b4ab2caa7f3

Gene Therapy of the Hemoglobinopathies

Authors: Joachim B. Kunz, Andreas E. Kulozik

Source: HemaSphere, Vol 4, Iss 5, p e479 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000479; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/24e710b7d0214bec8aac926d55679932

Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility

Authors: Mitchell J. Machiela, Thomas G. P. Grünewald, Didier Surdez, Stephanie Reynaud, Olivier Mirabeau, Eric Karlins, Rebeca Alba Rubio, Sakina Zaidi, Sandrine Grossetete-Lalami, Stelly Ballet, Eve Lapouble, Valérie Laurence, Jean Michon, Gaelle Pierron, Heinrich Kovar, Nathalie Gaspar, Udo Kontny, Anna González-Neira, Piero Picci, Javier Alonso, Ana Patino-Garcia, Nadège Corradini, Perrine Marec Bérard, Neal D. Freedman, Nathaniel Rothman, Casey L. Dagnall, Laurie Burdett, Kristine Jones, Michelle Manning, Kathleen Wyatt, Weiyin Zhou, Meredith Yeager, David G. Cox, Robert N. Hoover, Javed Khan, Gregory T. Armstrong, Wendy M. Leisenring, Smita Bhatia, Leslie L. Robison, Andreas E. Kulozik, Jennifer Kriebel, Thomas Meitinger, Markus Metzler, Wolfgang Hartmann, Konstantin Strauch, Thomas Kirchner, Uta Dirksen, Lindsay M. Morton, Lisa Mirabello, Margaret A. Tucker, Franck Tirode, Stephen J. Chanock, Olivier Delattre

Source: Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0ac8edbb89d948f498acb3404c1156e8

MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB

Authors: David M. Cordas dos Santos, Juliane Eilers, Alfonso Sosa Vizcaino, Elena Orlova, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Kathleen Börner, Dirk Grimm, Martina U. Muckenthaler, Andreas E. Kulozik, Joachim B. Kunz

Source: BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)

Subject Terms: T-cell acute lymphoblastic leukemia, T-ALL, TGF-beta activated kinase 1, MAP3K7, chr6q15 deletion, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-018-4525-0; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/ac458288d78b4b4582603ced482bd3c3

The German National Registry of Primary Immunodeficiencies (2012–2017)

Authors: Sabine M. El-Helou, Anika-Kerstin Biegner, Sebastian Bode, Stephan R. Ehl, Maximilian Heeg, Maria E. Maccari, Henrike Ritterbusch, Carsten Speckmann, Stephan Rusch, Raphael Scheible, Klaus Warnatz, Faranaz Atschekzei, Renata Beider, Diana Ernst, Stev Gerschmann, Alexandra Jablonka, Gudrun Mielke, Reinhold E. Schmidt, Gesine Schürmann, Georgios Sogkas, Ulrich H. Baumann, Christian Klemann, Dorothee Viemann, Horst von Bernuth, Renate Krüger, Leif G. Hanitsch, Carmen M. Scheibenbogen, Kirsten Wittke, Michael H. Albert, Anna Eichinger, Fabian Hauck, Christoph Klein, Anita Rack-Hoch, Franz M. Sollinger, Anne Avila, Michael Borte, Stephan Borte, Maria Fasshauer, Anja Hauenherm, Nils Kellner, Anna H. Müller, Anett Ülzen, Peter Bader, Shahrzad Bakhtiar, Jae-Yun Lee, Ursula Heß, Ralf Schubert, Sandra Wölke, Stefan Zielen, Sujal Ghosh, Hans-Juergen Laws, Jennifer Neubert, Prasad T. Oommen, Manfred Hönig, Ansgar Schulz, Sandra Steinmann, Klaus Schwarz, Gregor Dückers, Beate Lamers, Vanessa Langemeyer, Tim Niehues, Sonu Shai, Dagmar Graf, Carmen Müglich, Marc T. Schmalzing, Eva C. Schwaneck, Hans-Peter Tony, Johannes Dirks, Gabriele Haase, Johannes G. Liese, Henner Morbach, Dirk Foell, Antje Hellige, Helmut Wittkowski, Katja Masjosthusmann, Michael Mohr, Linda Geberzahn, Christian M. Hedrich, Christiane Müller, Angela Rösen-Wolff, Joachim Roesler, Antje Zimmermann, Uta Behrends, Nikolaus Rieber, Uwe Schauer, Rupert Handgretinger, Ursula Holzer, Jörg Henes, Lothar Kanz, Christoph Boesecke, Jürgen K. Rockstroh, Carolynne Schwarze-Zander, Jan-Christian Wasmuth, Dagmar Dilloo, Brigitte Hülsmann, Stefan Schönberger, Stefan Schreiber, Rainald Zeuner, Tobias Ankermann, Philipp von Bismarck, Hans-Iko Huppertz, Petra Kaiser-Labusch, Johann Greil, Donate Jakoby, Andreas E. Kulozik, Markus Metzler, Nora Naumann-Bartsch, Bettina Sobik, Norbert Graf, Sabine Heine, Robin Kobbe, Kai Lehmberg, Ingo Müller, Friedrich Herrmann, Gerd Horneff, Ariane Klein, Joachim Peitz, Nadine Schmidt, Stefan Bielack, Ute Groß-Wieltsch, Carl F. Classen, Jessica Klasen, Peter Deutz, Dirk Kamitz, Lisa Lassay, Klaus Tenbrock, Norbert Wagner, Benedikt Bernbeck, Bastian Brummel, Eusebia Lara-Villacanas, Esther Münstermann, Dominik T. Schneider, Nadine Tietsch, Marco Westkemper, Michael Weiß, Christof Kramm, Ingrid Kühnle, Silke Kullmann, Hermann Girschick, Christof Specker, Elisabeth Vinnemeier-Laubenthal, Henriette Haenicke, Claudia Schulz, Lothar Schweigerer, Thomas G. Müller, Martina Stiefel, Bernd H. Belohradsky, Veronika Soetedjo, Gerhard Kindle, Bodo Grimbacher

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: registry for primary immunodeficiency, primary immunodeficiency (PID), German PID-NET registry, PID prevalence, European Society for Immunodeficiencies (ESID), IgG substitution therapy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.01272/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e9075140b79b4c8c90ad31f540d2800a

Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins

Authors: Christian Hauer, Jana Sieber, Thomas Schwarzl, Ina Hollerer, Tomaz Curk, Anne-Marie Alleaume, Matthias W. Hentze, Andreas E. Kulozik

Source: Cell Reports, Vol 16, Iss 6, Pp 1588-1603 (2016)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716308658; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/55c4f6dafa4a4fb68e162596c8e9bec5

Introduction of Universal Newborn Screening for Sickle Cell Disease in Germany—A Brief Narrative Review

Authors: Stephan Lobitz, Joachim B. Kunz, Holger Cario, Dani Hakimeh, Andrea Jarisch, Andreas E. Kulozik, Lena Oevermann, Regine Grosse

Source: International Journal of Neonatal Screening, Vol 7, Iss 1, p 7 (2021)

Subject Terms: n/a, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.mdpi.com/2409-515X/7/1/7; https://doaj.org/toc/2409-515X

Access URL: https://doaj.org/article/939b37f4f3954d0e804c02ff79a7e51d

HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA

Authors: Lara Ajamian, Karen Abel, Shringar Rao, Kishanda Vyboh, Francisco García-de-Gracia, Ricardo Soto-Rifo, Andreas E. Kulozik, Niels H. Gehring, Andrew J. Mouland

Source: Biomolecules, Vol 5, Iss 4, Pp 2808-2839 (2015)

Subject Terms: HIV-1, UPF1, ribonucleoprotein, nuclear RNA export, viral evasion, nonsense mediated decay, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.mdpi.com/2218-273X/5/4/2808; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/c3766bdb1e4348ddbe1c4472c2fd0475

NOTCH1 mutation, TP53 alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of T-cell acute lymphoblastic leukemia

Authors: Jana Hof, Corinne Kox, Stefanie Groeneveld-Krentz, Obul R. Bandapalli, Leonid Karawajew, Katharina Schedel, Joachim B. Kunz, Cornelia Eckert, Wolf-Dieter Ludwig, Richard Ratei, Peter Rhein, Günter Henze, Martina U. Muckenthaler, Andreas E. Kulozik, Arend von Stackelberg, Renate Kirschner-Schwabe

Source: Haematologica, Vol 102, Iss 7 (2017)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8139; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/987d27552bb84979998f86731dd7813b

Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation

Authors: Johann Greil, Maria V. Verga-Falzacappa, Nicole E. Echner, Wolfgang Behnisch, Obul R. Bandapalli, Paulina Pechanska, Stephan Immenschuh, Vijith Vijayan, Jozsef Balla, Hirokatsu Tsukahara, Marion Schneider, Gritta Janka, Maren Claus, Thomas Longerich, Martina U. Muckenthaler, Andreas E. Kulozik

Source: Haematologica, Vol 101, Iss 11 (2016)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/7890; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/894e78a3117c41ca8ea07ae46102437e

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation

Authors: Joachim B. Kunz, Tobias Rausch, Obul R. Bandapalli, Juliane Eilers, Paulina Pechanska, Stephanie Schuessele, Yassen Assenov, Adrian M. Stütz, Renate Kirschner-Schwabe, Jana Hof, Cornelia Eckert, Arend von Stackelberg, Martin Schrappe, Martin Stanulla, Rolf Koehler, Smadar Avigad, Sarah Elitzur, Rupert Handgretinger, Vladimir Benes, Joachim Weischenfeldt, Jan O. Korbel, Martina U. Muckenthaler, Andreas E. Kulozik

Source: Haematologica, Vol 100, Iss 11 (2015)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/7557; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/46500b812ed74866a1f64e67d1035354

Erratum to: Insights into the design and interpretation of iCLIP experiments

Authors: Nejc Haberman, Ina Huppertz, Jan Attig, Julian König, Zhen Wang, Christian Hauer, Matthias W. Hentze, Andreas E. Kulozik, Hervé Le Hir, Tomaž Curk, Christopher R. Sibley, Kathi Zarnack, Jernej Ule

Source: Genome Biology, Vol 18, Iss 1, Pp 1-1 (2017)

Subject Terms: Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13059-017-1294-z; https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/8bb830280be149adbf06245c00271dd6

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

Authors: Obul R. Bandapalli, Stephanie Schuessele, Joachim B. Kunz, Tobias Rausch, Adrian M. Stütz, Noa Tal, Ifat Geron, Nava Gershman, Shai Izraeli, Juliane Eilers, Nina Vaezipour, Renate Kirschner-Schwabe, Jana Hof, Arend von Stackelberg, Martin Schrappe, Martin Stanulla, Martin Zimmermann, Rolf Koehler, Smadar Avigad, Rupert Handgretinger, Viktoras Frismantas, Jean Pierre Bourquin, Beat Bornhauser, Jan O. Korbel, Martina U. Muckenthaler, Andreas E. Kulozik

Source: Haematologica, Vol 99, Iss 10 (2014)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/7180; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/b89e97b78d674971ac30a7cc3964535a

High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol

Authors: Gunnar Cario, Peter Rhein, Rita Mitlöhner, Martin Zimmermann, Obul R. Bandapalli, Renja Romey, Anja Moericke, Wolf-Dieter Ludwig, Richard Ratei, Martina U. Muckenthaler, Andreas E. Kulozik, Martin Schrappe, Martin Stanulla, Leonid Karawajew

Source: Haematologica, Vol 99, Iss 1 (2014)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/6885; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/c748f5a4784c47bb8ac8f5f266796a2d