A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants

Authors: Jimena Pérez-Vargas, Liam J. Worrall, Andrea D. Olmstead, Anh-Tien Ton, Jaeyong Lee, Ivan Villanueva, Connor A. H. Thompson, Svenja Dudek, Siobhan Ennis, Jason R. Smith, Tirosh Shapira, Joshua De Guzman, Shutong Gang, Fuqiang Ban, Marija Vuckovic, Michael Bielecki, Suzana Kovacic, Calem Kenward, Christopher Yee Hong, Danielle G. Gordon, Paul N. Levett, Mel Krajden, Richard Leduc, Pierre-Luc Boudreault, Masahiro Niikura, Mark Paetzel, Robert N. Young, Artem Cherkasov, Natalie C. J. Strynadka, François Jean

Source: Emerging Microbes and Infections, Vol 12, Iss 2 (2023)

Subject Terms: SARS-CoV-2 Omicron subvariants, SARS-CoV-2 3CLpro, 3CLpro inhibitor, combination therapy, computer-aided drug design, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/af2615cbac4f4e1583d54bc3e7ff1625

Intra-host evolutionary dynamics of the hepatitis C virus among people who inject drugs

Authors: Vincent Montoya, Anita Y. M. Howe, Weiyan Y. Dong, Winnie Dong, Chanson J. Brumme, Andrea D. Olmstead, Kanna Hayashi, P. Richard Harrigan, Jeffrey B. Joy

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9897a6ee8ee742759ddb6f3d56a742fb

Characterizing Longitudinal Antibody Responses in Recovered Individuals Following COVID-19 Infection and Single-Dose Vaccination: A Prospective Cohort Study

Authors: Andrea D. Olmstead, Aidan M. Nikiforuk, Sydney Schwartz, Ana Citlali Márquez, Tahereh Valadbeigy, Eri Flores, Monika Saran, David M. Goldfarb, Althea Hayden, Shazia Masud, Shannon L. Russell, Natalie Prystajecky, Agatha N. Jassem, Muhammad Morshed, Inna Sekirov

Source: Viruses, Vol 14, Iss 11, p 2416 (2022)

Subject Terms: SARS-CoV-2, COVID-19, cohort study, antibody waning, seroreactivity, electrochemiluminescence assay, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/14/11/2416; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/833f31504b68400b90a59e90967be2e2

Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9

Authors: Anastasia Hyrina, Andrea D. Olmstead, Paul Steven, Mel Krajden, Edward Tam, François Jean

Source: EBioMedicine, Vol 23, Iss C, Pp 68-78 (2017)

Subject Terms: Hepatitis C virus, Antiviral therapy, miR-24, miR-122, miR-223, Proprotein convertase subtilisin/kexin type 9, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396417303377; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/caa5f4c18f7441c4873a070f92ecc254

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Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents.

Authors: Andrea D Olmstead, Wolfgang Knecht, Ina Lazarov, Surjit B Dixit, François Jean

Source: PLoS Pathogens, Vol 8, Iss 1, p e1002468 (2012)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3252376?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/041269435179438981ff0022f4d05683