Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse models.

Authors: Ziółkowska, Ewa A., Jansen, Matthew J., Williams, Letitia L., Wang, Sophie H., Eultgen, Elizabeth M., Takahashi, Keigo, Le, Steven Q., Nelvagal, Hemanth R., Sharma, Jaiprakash, Sardiello, Marco, DeBosch, Brian J., Dickson, Patricia I., Anderson, Jessica B., Sax, Sophie E., Wright, Christina M., Bradley, Rebecca P., Whiteman, Ineka T., Makita, Takako, Grider, John R., Sands, Mark S.

Source: Science Translational Medicine; 1/15/2025, Vol. 17 Issue 781, p1-17, 17p

Subject Terms: ENTERIC nervous system, NEURONAL ceroid-lipofuscinosis, LYSOSOMAL storage diseases, NEURAL development, NEURODEGENERATION

scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3

Authors: Wright, Christina M., Schneider, Sabine, Smith-Edwards, Kristen M., Mafra, Fernanda, Leembruggen, Anita J.L., Gonzalez, Michael V., Kothakapa, Deepika R., Anderson, Jessica B., Maguire, Beth A., Gao, Tao, Missall, Tricia A., Howard, Marthe J., Bornstein, Joel C., Davis, Brian M., Heuckeroth, Robert O.

Source: In Cellular and Molecular Gastroenterology and Hepatology 2021 11(5):1548-1592

The Impact of Legalizing Medical Aid in Dying on Patient Trust: A Randomized Controlled Survey Study.

Authors: Anderson, Jessica B.¹, Cacciapuoti, Maria², Day, Hannah³, Hashemzadeh, Taymour⁴, Krohmal, Benjamin J.^5,6 benjamin.j.krohmal@medstar.net

Source: Journal of Palliative Medicine. Nov2024, Vol. 27 Issue 11, p1459-1466. 8p.

Subject Terms: *ASSISTED suicide laws, *ASSISTED suicide, *AFRICAN Americans, *STATISTICAL sampling, *RANDOMIZED controlled trials, *DESCRIPTIVE statistics, *PHYSICIAN-patient relations, *TRUST, *MINORITIES, *PEOPLE with disabilities

Geographic Terms: WASHINGTON (D.C.)

BAP1 is required prenatally for differentiation and maintenance of postnatal murine enteric nervous system.

Authors: Schneider, Sabine^1,2,3, Anderson, Jessica B.^1,2, Bradley, Rebecca P.¹, Beigel, Katherine^1,4, Wright, Christina M.^1,2, Maguire, Beth A.¹, Guang Yan¹, Taylor, Deanne M.^1,4,5, Harbour, J. William⁶, Heuckeroth, Robert O.^1,5 Heuckerothr@chop.edu

Source: Journal of Clinical Investigation. 5/1/2024, Issue 9, p1-17. 17p.

Subject Terms: *ENTERIC nervous system, *NEURONAL differentiation, *LARGE intestine, *RNA sequencing, *EARLY death

Amelioration of enteric nervous system defects via gene therapy in CLN1 disease mice

Authors: Cooper, Jonathan D., Wang, Sophie H., Williams, Letitia L., Eultgen, Elizabeth M., Takahashi, Keigo, Nelvagal, Hemanth R., Anderson, Jessica B., Makita, Takako, DeBosch, Brian, Sands, Mark S., Heuckeroth, Robert O.

Source: Molecular genetics and metabolism. 135(2):S33-S33

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154953942.0x000001&indx=1&recIds=ETOCvdc_100154953942.0x000001