Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein

Authors: Laura García-Pupo, Lucie Crouzier, Alberto Bencomo-Martínez, Johann Meunier, Axelle Morilleau, Benjamin Delprat, Marquiza Sablón Carrazana, Roberto Menéndez Soto del Valle, Tangui Maurice, Chryslaine Rodríguez-Tanty

Source: Acta Pharmaceutica Sinica B, Vol 14, Iss 10, Pp 4345-4359 (2024)

Subject Terms: Alzheimer's disease, Amyloid-β aggregation, Neuroprotection, σ1 receptor, Drug discovery, Molecular modelisation, Therapeutics. Pharmacology, RM1-950

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Relation: http://www.sciencedirect.com/science/article/pii/S2211383524002442; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/26f1239b7fa54d17870873e42f89e4c4

Revealing the mechanism of two rimantadine derivatives inhibiting Aβ aggregation and destabilizing Aβ protofibrils by molecular dynamics simulation

Authors: Zhang, Jiaxing ^{a, 1}, Yang, Yufan ^{b, 1}, Zhang, Chengyu ^{b, ⁎}, Wang, Yuefei ^b, Su, Rongxin ^{a, c, d}, Qi, Wei ^{a, c, d, ⁎⁎}

Source: In Colloids and Surfaces B: Biointerfaces June 2025 250

Quantification of amyloid-β aggregation inhibitors gallic acid and rosmarinic acid in biological samples by LC-MS/MS

Authors: Ştefănescu, Raluca

Source: In Analytical Biochemistry May 2025 700

Guluronic acid disaccharide inhibits reactive oxygen species production and amyloid-β oligomer formation

Authors: Shen, Hangyu ^a, Liu, Wenhui ^a, Dou, Yun ^a, Lu, Yongxin ^a, Zhang, Chunling ^b, Wang, Xiaoying ^{a, c, ⁎}, Kong, Fangong ^a, Wang, Shoujuan ^{a, ⁎⁎}

Source: In Biochemical and Biophysical Research Communications 10 December 2024 737

Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults

Authors: Samarelli, Francesco ^{a, 2}, Purgatorio, Rosa ^{a, 2}, Lopopolo, Gianfranco ^{a, 1}, Deruvo, Caterina ^a, Catto, Marco ^a, Andresini, Michael ^a, Carrieri, Antonio ^a, Nicolotti, Orazio ^a, De Palma, Annalisa ^b, Miniero, Daniela Valeria ^b, de Candia, Modesto ^{a, ⁎}, Altomare, Cosimo D. ^a

Source: In European Journal of Medicinal Chemistry 15 April 2024 270

Novel Analytical Methods in Food Analysis

Contributors: Delahaut, Philippe, Marega, Riccardo

Subject Terms: truffle, T. melanosporum, T. indicum, real-time PCR, RFLP, quantitative evaluation, Alzheimer’s disease, Amyloid β, amyloid β aggregation inhibitor, quantum dot, soy sauce, doping, sport, contamination, SARMs, diuretics, honey, vibrational spectroscopy, geographical origin, chemometrics, data fusion, frequency mixing technology, immunofiltration, magnetic beads, pesticide residues, optical detection, screening methods, point-of-care diagnostics, smartphones, biosensors, bioassays, food, routine testing, high-resolution mass spectrometry, feed, water, veterinary drug residues, natural toxins, pesticides, food authenticity, food microbiology, immunoaffinity assays, immunoagglutination, immunosensors, immunochromatographic testing, immunomagnetic separation, one health, pathogenic micro-organisms, responsive monitoring, review, serum, lipidomics, Lipidyzer™, LC-HRMS, ractopamine, β-agonist, food safety, portable food analyzer, point-of-need, ASSURED criteria, portable mass spectrometer, optical biosensor, electrochemical biosensor, microfluidic device, lab-on-a-chip, smartphone-based biosensor, Research and information: general, Biology, life sciences

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Access URL: https://directory.doabooks.org/handle/20.500.12854/95773
https://mdpi.com/books/pdfview/book/6429

New Multitarget Rivastigmine–Indole Hybrids as Potential Drug Candidates for Alzheimer’s Disease

Authors: Leo Bon, Angelika Banaś, Inês Dias, Inês Melo-Marques, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos

Source: Pharmaceutics, Vol 16, Iss 2, p 281 (2024)

Subject Terms: Alzheimer´s disease, multitarget drugs, rivastigmine–indole, antioxidants, cholinesterases, amyloid-β aggregation, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/2/281; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/6f923be9007c40599210a36b8a0e3721

Preparation and study of the inhibitory effect of nano-niosomes containing essential oil from artemisia absinthium on amyloid fibril formation

Authors: Mojtaba Ansari, Hossein Eslami

Source: Nanomedicine Journal, Vol 7, Iss 3, Pp 243-250 (2020)

Subject Terms: alzheimer’s disease, amyloid-β aggregation, niosome, artemisia absinthium, drug delivery, Medicine (General), R5-920

File Description: electronic resource

Relation: http://nmj.mums.ac.ir/article_15573_50d11252158fdaf85b199081a787c4ec.pdf; https://doaj.org/toc/2322-3049; https://doaj.org/toc/2322-5904

Access URL: https://doaj.org/article/de354bd9f5cf4ca783cbd1e9035a557a

Gallic acid disruption of Aβ1–42 aggregation rescues cognitive decline of APP/PS1 double transgenic mouse

Authors: Mei Yu, Xuwei Chen, Jihong Liu, Quan Ma, Zhan Zhuo, Hao Chen, Lin Zhou, Sen Yang, Lifeng Zheng, Chengqing Ning, Jing Xu, Tianming Gao, Sheng-Tao Hou

Source: Neurobiology of Disease, Vol 124, Iss , Pp 67-80 (2019)

Subject Terms: Alzheimer's disease, Gallic acid, Amyloid-β-aggregation, Morris water maze, Novel object recognition test, Y-maze, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: http://www.sciencedirect.com/science/article/pii/S0969996118302067; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/dba616531d7643fb9bbe0034efe42106

Small-Molecule Amyloid Beta-Aggregation Inhibitors in Alzheimer's Disease Drug Development

Authors: Sharmin Reza Chowdhury, Fangzhou Xie, Jinxin Gu, Lei Fu

Source: Pharmaceutical Fronts, Vol 01, Iss 01, Pp e22-e32 (2019)

Subject Terms: alzheimer's disease, small molecule amyloid β-aggregation inhibitors, drug design, Pharmacy and materia medica, RS1-441

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Relation: https://doaj.org/toc/2628-5088; https://doaj.org/toc/2628-5096

Access URL: https://doaj.org/article/716f27ff98d245c98ce8e6834e97b28c

Evaluation of Amyloid β42 Aggregation Inhibitory Activity of Commercial Dressings by A Microliter-Scale High-Throughput Screening System Using Quantum-Dot Nanoprobes

Authors: Masahiro Kuragano, Wataru Yoshinari, Xuguang Lin, Keiya Shimamori, Koji Uwai, Kiyotaka Tokuraku

Source: Foods, Vol 9, Iss 6, p 825 (2020)

Subject Terms: Alzheimer’s disease, Amyloid β, amyloid β aggregation inhibitor, quantum dot, soy sauce, Chemical technology, TP1-1185

File Description: electronic resource

Relation: https://www.mdpi.com/2304-8158/9/6/825; https://doaj.org/toc/2304-8158

Access URL: https://doaj.org/article/3ba7c221d7284f2a9d6a5a09955945df

Identifying Phlorofucofuroeckol-A as a Dual Inhibitor of Amyloid-β25-35 Self-Aggregation and Insulin Glycation: Elucidation of the Molecular Mechanism of Action

Authors: Su Hui Seong, Pradeep Paudel, Hyun Ah Jung, Jae Sue Choi

Source: Marine Drugs, Vol 17, Iss 11, p 600 (2019)

Subject Terms: phlorotannin, amyloid-β aggregation, insulin glycation, dynamic simulation, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1660-3397/17/11/600; https://doaj.org/toc/1660-3397

Access URL: https://doaj.org/article/21703ea26d7a42d38ccb9af4c6f5f8ca