Modeling Spinal Cord Injury in a Dish with Hyperosmotic Stress: Population-Specific Effects and the Modulatory Role of Mesenchymal Stromal Cell Secretome.

Authors: Campos, Jonas^1,2 (AUTHOR), Palha, Ana T.^1,2 (AUTHOR), Fernandes, Luís S.^1,2,3 (AUTHOR), Cibrão, Jorge R.^1,2 (AUTHOR), Pinho, Tiffany S.^1,2 (AUTHOR), Serra, Sofia C.^1,2,3 (AUTHOR), Silva, Nuno A.^1,2 (AUTHOR), Michael-Titus, Adina T.³ (AUTHOR), Salgado, António J.^1,2 (AUTHOR) asalgado@med.uminho.pt

Source: International Journal of Molecular Sciences. Apr2025, Vol. 26 Issue 7, p3298. 26p.

Subject Terms: *AMYLOID beta-protein precursor, *SPINAL cord injuries, *CELL cycle, *STEM cells, *SPINAL cord, *CELL culture

Exploration of small molecules as inhibitors of potential BACE1 protein to treat amyloid cerebrovascular disease by employing molecular modeling and simulation approaches.

Authors: Wang, Zhizhong^1,2 (AUTHOR), Li, Zhiyong² (AUTHOR), Lin, Ailong² (AUTHOR), Zhang, Qing² (AUTHOR), Chen, Yingchun² (AUTHOR), Bie, Bizhou² (AUTHOR) 18771032136@163.com, Feng, Juanjuan² (AUTHOR) 821305856@qq.com

Source: PLoS ONE. 3/21/2025, Vol. 20 Issue 3, p1-22. 22p.

Subject Terms: *AMYLOID beta-protein precursor, *VIRTUAL high-throughput screening (Drug development), *ALZHEIMER'S disease, *PROTEIN-ligand interactions, *PRINCIPAL components analysis, *SMALL molecules

Hesperetin-Enhanced Metformin to Alleviate Cognitive Impairment via Gut–Brain Axis in Type 2 Diabetes Rats.

Authors: Zhang, Danyang¹ (AUTHOR), He, Xiaoshi^1,2 (AUTHOR), Wang, Yinbo^2,3 (AUTHOR), Wang, Xiaoyu¹ (AUTHOR), Han, Xiao^1,2 (AUTHOR), Liu, Haodong^1,3 (AUTHOR), Xing, Yan¹ (AUTHOR), Jiang, Bo¹ (AUTHOR), Xiu, Zhilong¹ (AUTHOR), Bao, Yongming^1,3 (AUTHOR), Dong, Yuesheng¹ (AUTHOR) yshdong@dlut.edu.cn

Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 5, p1923. 23p.

Subject Terms: *AMYLOID beta-protein precursor, *TYPE 2 diabetes, *SHORT-chain fatty acids, *DISEASE risk factors, *INSULIN sensitivity

Inhibitory Effects of Gliadin Hydrolysates on BACE1 Expression and APP Processing to Prevent Aβ Aggregation.

Authors: Lin, Chin-Yu¹ (AUTHOR) geant@mail.tcu.edu.tw, Hsieh, Cheng-Hong^2,3 (AUTHOR) hyweuan@asia.edu.tw, Lai, Pei-Yu² (AUTHOR) azazmj2323@gmail.com, Huang, Ching-Wei² (AUTHOR) u112211002@cmu.edu.tw, Chung, Yung-Hui² (AUTHOR) carol510020@gmail.com, Huang, Shang-Ming² (AUTHOR) zxzxmj2323@mail.cmu.edu.tw, Hsu, Kuo-Chiang^2,3 (AUTHOR) zxzxmj2323@mail.cmu.edu.tw

Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 23, p13212. 16p.

Subject Terms: *AMYLOID beta-protein, *AMYLOID beta-protein precursor, *PEPTIDES, *NEUROPEPTIDES, *ALZHEIMER'S disease, *GLIADINS, *CASEINS

Circular RNA APP contributes to Alzheimer's disease pathogenesis by modulating microglial polarization via miR-1906/CLIC1 axis.

Authors: Wu, Deng-Pan^1,2 (AUTHOR), Wei, Yan-Su¹ (AUTHOR), Hou, Li-Xiang¹ (AUTHOR), Du, Yu-Xuan¹ (AUTHOR), Yan, Qiu-Qing¹ (AUTHOR), Liu, Ling-Ling¹ (AUTHOR), Zhao, Yuan-Dan¹ (AUTHOR), Yan, Ru-Yu³ (AUTHOR), Yu, Chao⁴ (AUTHOR), Zhong, Zhen-Guo⁵ (AUTHOR), Huang, Jin-Lan^1,2 (AUTHOR) jinlanhuang@xzhmu.edu.cn

Source: Alzheimer's Research & Therapy. 2/14/2025, Vol. 17 Issue 1, p1-17. 17p.

Subject Terms: *AMYLOID beta-protein precursor, *RECOGNITION (Psychology), *MEDICAL sciences, *ALZHEIMER'S disease, *CHLORIDE channels

Integrated Clinomics and Molecular Dynamics Simulation Approaches Reveal the SAA1.1 Allele as a Biomarker in Alkaptonuria Disease Severity.

Authors: Trezza, Alfonso¹ (AUTHOR) alfonso.trezza2@unisi.it, Roncaglia, Bianca¹ (AUTHOR) bianca.roncaglia@unisi.it, Visibelli, Anna¹ (AUTHOR) anna.visibelli2@unisi.it, Barletta, Roberta¹ (AUTHOR) r.barletta@student.unisi.it, Peruzzi, Luana¹ (AUTHOR) luana.peruzzi@unisi.it, Marzocchi, Barbara¹ (AUTHOR) barbara.marzocchi@unisi.it, Braconi, Daniela¹ (AUTHOR) daniela.braconi@unisi.it, Spiga, Ottavia¹ (AUTHOR) ottavia.spiga@unisi.it, Santucci, Annalisa^1,2 (AUTHOR) annalisa.santucci@unisi.it

Source: Biomolecules (2218-273X). Feb2025, Vol. 15 Issue 2, p194. 16p.

Subject Terms: *AMYLOID beta-protein, *AMYLOIDOSIS, *STRUCTURAL dynamics, *INFLAMMATORY mediators, *DATA integration, *MOLECULAR dynamics

Deletion of Murine APP Aggravates Tau and Amyloid Pathologies in the 5xFADXTg30 Alzheimer's Disease Model.

Authors: Ando, Kunie¹ (AUTHOR) kunie.ando.alzheimer.research@gmail.com, Kosa, Andreea-Claudia¹ (AUTHOR), Mehadji, Yasmina¹ (AUTHOR), Lasri, Hinde¹ (AUTHOR) andreea-claudia.kosa@ulb.be, Lopez-Gutierrez, Lidia¹ (AUTHOR), Quintanilla-Sánchez, Carolina¹ (AUTHOR), Aydin, Emmanuel¹ (AUTHOR), Doeraene, Emilie¹ (AUTHOR), Wathelet-Depauw, Alain¹ (AUTHOR), Nagaraj, Siranjeevi¹ (AUTHOR), Brion, Jean-Pierre¹ (AUTHOR), Leroy, Karelle¹ (AUTHOR) karelle.leroy@ulb.be

Source: Biomolecules (2218-273X). Feb2025, Vol. 15 Issue 2, p159. 16p.

Subject Terms: *AMYLOID beta-protein precursor, *ALZHEIMER'S disease, *AMYLOID plaque, *TAU proteins, *AMYLOID, *NEUROFIBRILLARY tangles

Synthesis and Characterization of Memantine-Loaded Niosomes for Enhanced Alzheimer's Disease Targeting.

Authors: Turkez, Hasan¹ (AUTHOR) hturkez@atauni.edu.tr, Oner, Sena² (AUTHOR) sena.oner66@erzurum.edu.tr, Yıldırım, Ozge Caglar² (AUTHOR) ozge.caglar@erzurum.edu.tr, Arslan, Mehmet Enes^2,3 (AUTHOR) enes.aslan@erzurum.edu.tr, Dimmito, Marilisa Pia⁴ (AUTHOR) marilisa.dimmito@unich.it, Kahraman, Çigdem Yuce⁵ (AUTHOR) cigdem.kahraman@atauni.edu.tr, Marinelli, Lisa⁴ (AUTHOR) l.marinelli@unich.it, Sonmez, Erdal⁶ (AUTHOR) esonmez@atauni.edu.tr, Kiki, Özlem⁷ (AUTHOR) ozlem.kiki@saglik.gov.tr, Tatar, Abdulgani⁵ (AUTHOR) abdulgani@atauni.edu.tr, Cacciatore, Ivana⁴ (AUTHOR) ivana.cacciatore@unich.it, Di Stefano, Antonio⁴ (AUTHOR) antonio.distefano@unich.it, Mardinoglu, Adil^8,9 (AUTHOR) adilm@kth.se

Source: Pharmaceutics. Feb2025, Vol. 17 Issue 2, p267. 19p.

Subject Terms: *AMYLOID beta-protein, *ALZHEIMER'S disease, *BIOMOLECULES, *DRUG derivatives, *THERAPEUTICS, *BLOOD-brain barrier, *NEUROTROPHIN receptors

Overexpression of SFPQ Improves Cognition and Memory in AD Mice.

Authors: Tie, Jinshan^1,2 (AUTHOR), Wu, Hongxiang¹ (AUTHOR), Liu, Wei¹ (AUTHOR), Li, Yuying¹ (AUTHOR), Li, Lu¹ (AUTHOR), Zhao, Suju¹ (AUTHOR), Yuan, Zhijiao¹ (AUTHOR), Mahmood, Khan¹ (AUTHOR), Chen, Shaochun¹ (AUTHOR) chenshaochun@kmmu.edu.cn, Wu, Huidong¹ (AUTHOR) wuhuidong@kmmu.edu.cn, Walker, Tara (AUTHOR) t.walker1@uq.edu.au

Source: Neural Plasticity. 1/28/2025, Vol. 2025, p1-11. 11p.

Subject Terms: *AMYLOID beta-protein precursor, *PROTEIN kinase B, *ALZHEIMER'S disease, *PI3K/AKT pathway, *BAX protein

Diverse Interactions of Sterols with Amyloid Precursor Protein Transmembrane Domain Can Shift Distribution Between Alternative Amyloid-β Production Cascades in Manner Dependent on Local Lipid Environment.

Authors: Volynsky, Pavel E.¹ (AUTHOR) volynski@yandex.ru, Urban, Anatoly S.¹ (AUTHOR) anatoly.urban@gmail.com, Pavlov, Konstantin V.² (AUTHOR) qpavlov@mail.ru, Bershatsky, Yaroslav V.¹ (AUTHOR) bershackyjaroslav@gmail.com, Bocharova, Olga V.¹ (AUTHOR) o.bocharova@gmail.com, Kryuchkova, Anastasia K.² (AUTHOR) anastasiakruckova44@gmail.com, Zlobina, Veronika V.^1,2 (AUTHOR) garaewa.nika@yandex.ru, Gavrilenkova, Alina A.^1,2 (AUTHOR) alycat1008@gmail.com, Dolotova, Sofya M.^1,2 (AUTHOR) sm.dolotova@gmail.com, Kamynina, Anna V.^1,2 (AUTHOR) aneskaminina@mail.ru, Zangieva, Olga T.³ (AUTHOR) zolgat@yandex.ru, Taldaev, Amir^2,4 (AUTHOR), Batishchev, Oleg V.⁵ (AUTHOR) olegbati@gmail.com, Okhrimenko, Ivan S.² (AUTHOR), Rakitina, Tatiana V.¹ (AUTHOR) r-efremov@yandex.ru, Efremov, Roman G.^1,6 (AUTHOR), Bocharov, Eduard V.^1,2 (AUTHOR) taniarakitina@yahoo.com

Source: International Journal of Molecular Sciences. Jan2025, Vol. 26 Issue 2, p553. 18p.

Subject Terms: *AMYLOID beta-protein precursor, *TRANSMEMBRANE domains, *MEMBRANE lipids, *ALZHEIMER'S disease, *MEMBRANE proteins, *PRESENILINS

Molecular Mechanisms of Alzheimer's Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for Neuronal Therapy.

Authors: Ahn, Eun Hee^1,2 (AUTHOR) eunhee.ahn@hallym.ac.kr, Park, Jae-Bong^3,4,5 (AUTHOR) jbpark@hallym.ac.kr

Source: Cells (2073-4409). Jan2025, Vol. 14 Issue 2, p89. 46p.

Subject Terms: *TAU proteins, *AMYLOID beta-protein precursor, *CELL morphology, *ALZHEIMER'S disease, *RHO GTPases

Evaluation of the Anti-Amyloid and Anti-Inflammatory Properties of a Novel Vanadium(IV)–Curcumin Complex in Lipopolysaccharides-Stimulated Primary Rat Neuron-Microglia Mixed Cultures.

Authors: Katsipis, Georgios^1,2 (AUTHOR) gkatsipis@chem.auth.gr, Lavrentiadou, Sophia N.^2,3 (AUTHOR) slavrent@vet.auth.gr, Geromichalos, George D.^2,4 (AUTHOR), Tsantarliotou, Maria P.³ (AUTHOR), Halevas, Eleftherios^1,5 (AUTHOR) lefterishalevas@gmail.com, Litsardakis, George⁶ (AUTHOR) lits@eng.auth.gr, Pantazaki, Anastasia A.^1,2 (AUTHOR) slavrent@vet.auth.gr

Source: International Journal of Molecular Sciences. Jan2025, Vol. 26 Issue 1, p282. 27p.

Subject Terms: *AMYLOID beta-protein precursor, *NITRIC-oxide synthases, *ALZHEIMER'S disease, *PATHOLOGY, *CURCUMIN

CD4‐Derived Double‐Negative T Cells Ameliorate Alzheimer's Disease‐Like Phenotypes in the 5×FAD Mouse Model.

Authors: Xie, Yuanzhi^1,2 (AUTHOR), Liu, Jing¹ (AUTHOR), Hou, Zongren^2,3 (AUTHOR), Wang, Huan^4,5 (AUTHOR), Liu, Kailun¹ (AUTHOR), Chen, Xiaowei⁶ (AUTHOR), Fan, Zhen⁶ (AUTHOR), Li, Da¹ (AUTHOR), Li, Can^1,2 (AUTHOR), Pan, Yuhualei^4,5 (AUTHOR), Zhao, Yushang^4,5 (AUTHOR), Zhu, Yanbing^4,5 (AUTHOR) zhuyanbing@ccmu.edu.cn, Hu, Baoyang^1,2,3,7,8 (AUTHOR) byhu@ioz.ac.cn

Source: CNS Neuroscience & Therapeutics. Jan2025, Vol. 31 Issue 1, p1-14. 14p.

Subject Terms: *ALZHEIMER'S disease, *AMYLOID beta-protein, *IMMUNOREGULATION, *NEURODEGENERATION, *TAUOPATHIES, *T helper cells, *LABORATORY mice, *T cells

Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer's drug discovery.

Authors: Alrouji, Mohammed¹ (AUTHOR), Yasmin, Sabina² (AUTHOR), Alshammari, Mohammed S.³ (AUTHOR), Alhumaydhi, Fahad A.⁴ (AUTHOR), Sharaf, Sharaf E.⁵ (AUTHOR), Shahwan, Moyad⁶ (AUTHOR), Shamsi, Anas⁶ (AUTHOR) anas.shamsi18@gmail.com

Source: PLoS ONE. 12/19/2024, Vol. 19 Issue 12, p1-19. 19p.

Subject Terms: *AMYLOID beta-protein precursor, *CATHEPSIN B, *DRUG discovery, *PROTEOLYSIS, *VIRTUAL high-throughput screening (Drug development)

Pathology and Treatments of Alzheimer's Disease Based on Considering Changes in Brain Energy Metabolism Due to Type 2 Diabetes.

Authors: Yanai, Hidekatsu¹ (AUTHOR) dadachidm@hospk.ncgm.go.jp, Adachi, Hiroki¹ (AUTHOR), Hakoshima, Mariko¹ (AUTHOR), Katsuyama, Hisayuki¹ (AUTHOR)

Source: Molecules. Dec2024, Vol. 29 Issue 24, p5936. 28p.

Subject Terms: *TYPE 2 diabetes, *AMYLOID beta-protein, *GLUCAGON-like peptide 1, *ALZHEIMER'S disease, BRAIN metabolism

Identifying Hub Genes and miRNAs Associated with Alzheimer's Disease: A Bioinformatics Pathway to Novel Therapeutic Strategies.

Authors: Gascón, Elisa^1,2,3,4 (AUTHOR) egascon@unizar.es, Calvo, Ana Cristina^1,2,3,4 (AUTHOR) accalvo@unizar.es, Molina, Nora^1,2,3,4 (AUTHOR) pilarzar@unizar.es, Zaragoza, Pilar^1,2,3,4 (AUTHOR), Osta, Rosario^1,2,3,4 (AUTHOR) osta@unizar.es

Source: Biomolecules (2218-273X). Dec2024, Vol. 14 Issue 12, p1641. 14p.

Subject Terms: *AMYLOID beta-protein, *ALZHEIMER'S disease, *GENE regulatory networks, *OLDER people, *SENSORY perception

Targeting Iron Responsive Elements (IREs) of APP mRNA into Novel Therapeutics to Control the Translation of Amyloid-β Precursor Protein in Alzheimer's Disease.

Authors: Khan, Mateen A.¹ (AUTHOR) matkhan@alfaisal.edu

Source: Pharmaceuticals (14248247). Dec2024, Vol. 17 Issue 12, p1669. 24p.

Subject Terms: *AMYLOID beta-protein precursor, *ALZHEIMER'S disease, *PROTEIN precursors, *IRON proteins, *GENE expression

Catalpol alleviates amyloid-B generation and neuronal oxidative stress injury via activating the Keap1-N rf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model.

Authors: Caixia Xiang^1,2, Yunwei Lu^1,3, Renjuan Hao¹, Yuyan Wei¹, Yingchao Hu¹, Guran Yu¹ yushengzh@126.com

Source: Iranian Journal of Basic Medical Sciences. Dec2024, Vol. 27 Issue 12, p1547-1557. 11p.

Subject Terms: *AMYLOID beta-protein precursor, *LYMPHOBLASTOID cell lines, *ALZHEIMER'S patients, *ALZHEIMER'S disease, *OXIDANT status

An eye's look unmasks the mystery: correlation between serum amyloid beta peptide, hippocampal volume and retinal thickness in Alzheimer's disease.

Authors: Abou Elmaaty, Ali Ahmed¹ (AUTHOR) carmenali042@gmail.com, Eissa, Mona Ali² (AUTHOR), Elrashedy, Shady³ (AUTHOR), Zehry, Hamada Ibrahim⁴ (AUTHOR), Mosa, Ahmed Abdulatif³ (AUTHOR), Zarad, Carmen Ali⁵ (AUTHOR), Abdel-dayem, Marwa Ahmad⁶ (AUTHOR), Elnokrashy, Amgad⁷ (AUTHOR), Elsherifi, Saad Shawki⁸ (AUTHOR)

Source: Egyptian Journal of Neurology, Psychiatry & Neurosurgery. 11/21/2024, Vol. 60 Issue 1, p1-16. 16p.

Subject Terms: *AMYLOID beta-protein, *ALZHEIMER'S disease, *OPTICAL coherence tomography, *NERVE fibers, *HIPPOCAMPUS diseases

Haploinsufficiency and Alzheimer's Disease: The Possible Pathogenic and Protective Genetic Factors.

Authors: Bagyinszky, Eva¹ (AUTHOR) eva85@gachon.ac.kr, An, Seong Soo A.² (AUTHOR) eva85@gachon.ac.kr

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p11959. 26p.

Subject Terms: *AMYLOID beta-protein precursor, *MEMBRANE proteins, *ALZHEIMER'S disease, *GENE expression, *MYELOID cells, *RECESSIVE genes