Loss or inhibition of lysosomal acid lipase in vitro leads to cholesteryl ester accumulation without affecting muscle formation or mitochondrial function

Authors: Akhmetshina, Alena ^{a, b}, Schooltink, Laszlo ^a, Amor, Melina ^a, Kuentzel, Katharina B. ^{a, 1}, Rainer, Silvia ^a, Nandy, Ananya ^{b, 2}, Habisch, Hansjoerg ^c, Madl, Tobias ^{c, d}, Rendina-Ruedy, Elizabeth ^{b, e}, Leithner, Katharina ^{d, f}, Vujić, Nemanja ^a, Kratky, Dagmar ^{a, d, ⁎}

Source: In BBA Advances 2025 7

The effect of long-chain n-3 PUFA on liver transcriptome in human obesity

Authors: Joerg, Rebeka ^a, Itariu, Bianca K. ^{b, g, ⁎}, Amor, Melina ^c, Bilban, Martin ^d, Langer, Felix ^a, Prager, Gerhard ^a, Joerg, Florian ^e, Stulnig, Thomas M. ^{b, f, 1}

Source: In Prostaglandins, Leukotrienes and Essential Fatty Acids April 2025 204

Limited Alleviation of Lysosomal Acid Lipase Deficiency by Deletion of Matrix Metalloproteinase 12.

Authors: Buerger, Martin¹ (AUTHOR) martin.buerger@medunigraz.at, Amor, Melina¹ (AUTHOR) melina.amor@medunigraz.at, Akhmetshina, Alena¹ (AUTHOR) alena.akhmetshina@medunigraz.at, Bianco, Valentina^1,2 (AUTHOR) valentina.bianco@medunigraz.at, Perfler, Bianca^3,4 (AUTHOR) bianca.perfler@medunigraz.at, Zebisch, Armin^3,4 (AUTHOR) armin.zebisch@medunigraz.at, Weichhart, Thomas⁵ (AUTHOR) thomas.weichhart@meduniwien.ac.at, Kratky, Dagmar^1,6 (AUTHOR) dagmar.kratky@medunigraz.at

Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 20, p11001. 13p.

Subject Terms: *MYELOID-derived suppressor cells, *LYSOSOMAL storage diseases, *MATRIX metalloproteinases, *MYELOID cells, *BONE marrow, *CHOLESTERYL ester transfer protein

Identification of regulatory networks and crosstalk factors in brown adipose tissue and liver of a cold-exposed cardiometabolic mouse model.

Authors: Amor, Melina¹ (AUTHOR), Diaz, Malena¹ (AUTHOR), Bianco, Valentina^1,2 (AUTHOR), Svecla, Monika^1,3 (AUTHOR), Schwarz, Birgit¹ (AUTHOR), Rainer, Silvia¹ (AUTHOR), Pirchheim, Anita¹ (AUTHOR), Schooltink, Laszlo¹ (AUTHOR), Mukherjee, Suravi¹ (AUTHOR), Grabner, Gernot F.¹ (AUTHOR), Beretta, Giangiacomo⁴ (AUTHOR), Lamina, Claudia⁵ (AUTHOR), Norata, Giuseppe Danilo⁶ (AUTHOR), Hackl, Hubert⁷ (AUTHOR), Kratky, Dagmar^1,8 (AUTHOR) dagmar.kratky@medunigraz.at

Source: Cardiovascular Diabetology. 8/14/2024, Vol. 23 Issue 1, p1-17. 17p.

Subject Terms: *BROWN adipose tissue, *ADIPOSE tissue diseases, *HEART metabolism disorders, *TRANSCRIPTION factors, *ENERGY metabolism, *HIGH cholesterol diet, *WESTERN diet

Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration

Authors: Bianco, Valentina, Korbelius, Melanie, Vujic, Nemanja, Akhmetshina, Alena, Amor, Melina, Kolb, Dagmar, Pirchheim, Anita, Bradic, Ivan, Kuentzel, Katharina B., Buerger, Martin, Schauer, Silvia, Phan, Huyen T.T., Bulfon, Dominik, Hoefler, Gerald, Zimmermann, Robert, Kratky, Dagmar

Source: In Molecular Metabolism July 2023 73

Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice.

Authors: Amor, Melina¹ (AUTHOR), Bianco, Valentina¹ (AUTHOR), Buerger, Martin¹ (AUTHOR), Lechleitner, Margarete¹ (AUTHOR), Vujić, Nemanja¹ (AUTHOR), Dobrijević, Anja^1,2 (AUTHOR), Akhmetshina, Alena¹ (AUTHOR), Pirchheim, Anita¹ (AUTHOR), Schwarz, Birgit¹ (AUTHOR), Pessentheiner, Ariane R.^1,3 (AUTHOR), Baumgartner, Franziska⁴ (AUTHOR), Rampitsch, Katharina⁴ (AUTHOR), Schauer, Silvia⁵ (AUTHOR), Klobučar, Iva⁶ (AUTHOR), Degoricija, Vesna^7,8 (AUTHOR), Pregartner, Gudrun⁹ (AUTHOR), Kummer, Daniel¹⁰ (AUTHOR), Svecla, Monika¹¹ (AUTHOR), Sommer, Gerhard^4,12 (AUTHOR), Kolb, Dagmar^10,12,13 (AUTHOR)

Source: Cardiovascular Diabetology. 11/28/2023, Vol. 22 Issue 1, p1-18. 18p.

Subject Terms: *WESTERN diet, *ATHEROSCLEROTIC plaque, *MATRIX metalloproteinases, *INSULIN sensitivity, *HEART metabolism disorders, *WHITE adipose tissue, *LIPOPROTEIN receptors

Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance

Authors: Xia, Wenmin, Pessentheiner, Ariane R., Hofer, Dina C., Amor, Melina, Schreiber, Renate, Schoiswohl, Gabriele, Eichmann, Thomas O., Walenta, Evelyn, Itariu, Bianca, Prager, Gerhard, Hackl, Hubert, Stulnig, Thomas, Kratky, Dagmar, Rülicke, Thomas, Bogner-Strauss, Juliane G.

Source: In Cell Reports 15 May 2018 23(7):1948-1961

Serum Myostatin is Upregulated in Obesity and Correlates with Insulin Resistance in Humans

Authors: Amor, Melina, Itariu, Bianca, Moreno-Viedma, Veronica, Keindl, Magdalena, Jürets, Alexander, Prager, Gerhard, Langer, Felix, Grablowitz, Viktor, Zeyda, Maximilian, Stulnig, Thomas

Source: Experimental and clinical endocrinology and diabetes. 127(8):550-556

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186818760.0x000001&indx=1&recIds=ETOCvdc_100186818760.0x000001

Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape.

Authors: Reinisch, Isabel, Michenthaler, Helene, Sulaj, Alba, Moyschewitz, Elisabeth, Krstic, Jelena, Galhuber, Markus, Xu, Ruonan, Riahi, Zina, Wang, Tongtong, Vujic, Nemanja, Amor, Melina, Zenezini Chiozzi, Riccardo, Wabitsch, Martin, Kolb, Dagmar, Georgiadi, Anastasia, Glawitsch, Lisa, Heitzer, Ellen, Schulz, Tim J., Schupp, Michael, Sun, Wenfei

Source: Nature Communications; 2/15/2024, Vol. 15 Issue 1, p1-21, 21p

Subject Terms: INTERMITTENT fasting, WEIGHT loss, FAT cells, OBESOGENIC environment, ADIPOSE tissues, INSULIN sensitivity, BARIATRIC surgery, MACROPHAGES

Identification of Matrix Metalloproteinase-12 as a Candidate Molecule for Prevention and Treatment of Cardiometabolic Disease

Authors: Amor, Melina, Moreno-Viedma, Veronica, Sarabi, Alisina, Grün, Nicole, Itariu, Bianca, Leitner, Lukas, Steiner, Irene, Bilban, Martin, Kodama, Keiichi, Butte, Atul, Staffler, Guenther, Zeyda, Maximilian, Stulnig, Thomas

Source: Molecular medicine. 22(1):487-496

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185411684.0x000001&indx=1&recIds=ETOCvdc_100185411684.0x000001

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