MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design.

Authors: Cottrell, Kevin M., Whittington, Douglas A., Briggs, Kimberly J., Jahic, Haris, Ali, Janid A., Amor, Alvaro J., Gotur, Deepali, Tonini, Matthew R., Zhang, Wenhai, Huang, Alan, Maxwell, John P.

Source: Journal of Medicinal Chemistry; 2/27/2025, Vol. 68 Issue 4, p4217-4236, 20p

Roles of the ClpX IGF loops in ClpP association, dissociation, and protein degradation

Authors: Amor, Alvaro J., Schmitz, Karl R., Baker, Tania A., Sauer, Robert T.

Source: Protein science. 28(4):756-765

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100082960572.0x000001&indx=1&recIds=ETOCvdc_100082960572.0x000001

The ribosome-associated complex antagonizes prion formation in yeast

Authors: Amor, Alvaro J, Castanzo, Dominic T, Delany, Sean P, Selechnik, Daniel M, van Ooy, Alex, Cameron, Dale M

Source: Prion. 9(2):144-164

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCETOCvdc_100029009955.0x000001&indx=1&recIds=ETOCETOCvdc_100029009955.0x000001

Highly Dynamic Interactions Maintain Kinetic Stability of the ClpXP Protease During the ATP-Fueled Mechanical Cycle

Authors: Amor, Alvaro J., Schmitz, Karl R., Sello, Jason K., Baker, Tania A., Sauer, Robert T.

Source: ACS chemical biology. 11(6):1552-1560

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN606774720&indx=1&recIds=ETOCRN606774720

Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex.

Authors: Kwon, Jason J., Hajian, Behnoush, Bian, Yuemin, Young, Lucy C., Amor, Alvaro J., Fuller, James R., Fraley, Cara V., Sykes, Abbey M., So, Jonathan, Pan, Joshua, Baker, Laura, Lee, Sun Joo, Wheeler, Douglas B., Mayhew, David L., Persky, Nicole S., Yang, Xiaoping, Root, David E., Barsotti, Anthony M., Stamford, Andrew W., Perry, Charles K.

Source: Nature; Sep2022, Vol. 609 Issue 7926, p408-415, 8p

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