Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma

Authors: Talal El Zarif, Karl Semaan, Marc Eid, Ji-Heui Seo, Simon Garinet, Matthew P. Davidsohn, Pranshu Sahgal, Brad Fortunato, John Canniff, Amin H. Nassar, Sarah Abou Alaiwi, Ziad Bakouny, Gitanjali Lakshminarayanan, Hunter Savignano, Kevin Lyons, Sayed Matar, Atef Ali, Eddy Saad, Renee Maria Saliby, Paulo Cordeiro, Ziwei Zhang, Nourhan El Ahmar, Yasmin Nabil Laimon, Chris Labaki, Valisha Shah, Dory Freeman, Jillian O’Toole, Gwo-Shu Mary Lee, Justin Hwang, Mark Pomerantz, Sabina Signoretti, Eliezer M. Van Allen, Wanling Xie, Jacob E. Berchuck, Srinivas R. Viswanathan, David A. Braun, Toni K. Choueiri, Matthew L. Freedman, Sylvan C. Baca

Source: Cell Reports, Vol 43, Iss 6, Pp 114350- (2024)

Subject Terms: CP: Cancer, CP: Genomics, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124724006788; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/a9e18e74ab10487c9c8418746dfe9c2a

Epigenomic charting and functional annotation of risk loci in renal cell carcinoma

Authors: Amin H. Nassar, Sarah Abou Alaiwi, Sylvan C. Baca, Elio Adib, Rosario I. Corona, Ji-Heui Seo, Marcos A. S. Fonseca, Sandor Spisak, Talal El Zarif, Viktoria Tisza, David A. Braun, Heng Du, Monica He, Abdallah Flaifel, Michel Alchoueiry, Thomas Denize, Sayed G. Matar, Andres Acosta, Sachet Shukla, Yue Hou, John Steinharter, Gabrielle Bouchard, Jacob E. Berchuck, Edward O’Connor, Connor Bell, Pier Vitale Nuzzo, Gwo-Shu Mary Lee, Sabina Signoretti, Michelle S. Hirsch, Mark Pomerantz, Elizabeth Henske, Alexander Gusev, Kate Lawrenson, Toni K. Choueiri, David J. Kwiatkowski, Matthew L. Freedman

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5c45bbe4ef1e4b0b9d9d760011ce2040

Editorial: Methods in genitourinary oncology

Authors: Albert Jang, Avishay Sella, Amin H. Nassar, Vadim S. Koshkin

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: prostate cancer, bladder cancer, kidney cancer, research methods, geriatric oncology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1274264/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/491b29e8e25a42138137b4ec9d5de417

Variation in targetable genomic alterations in non-small cell lung cancer by genetic ancestry, sex, smoking history, and histology

Authors: Elio Adib, Amin H. Nassar, Sarah Abou Alaiwi, Stefan Groha, Elie W. Akl, Lynette M. Sholl, Kesi S. Michael, Mark M. Awad, Pasi A. Jӓnne, Alexander Gusev, David J. Kwiatkowski

Source: Genome Medicine, Vol 14, Iss 1, Pp 1-10 (2022)

Subject Terms: Non-small cell lung cancer, Targeted therapies, Targetable genomic alterations, Genetic ancestry, Smoking, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/c4e87f114ea24bebb735210ae5f0e899

FGFR2/3 genomic alterations and response to Enfortumab Vedotin in metastatic urothelial carcinoma

Authors: Elio Adib, Talal El‐Zarif, Rohit K. Jain, William P. Skelton IV, Dory Freeman, Catherine Curran, Elie W. Akl, Amin H. Nassar, Praful Ravi, Charlene Mantia, David J. Kwiatkowski, Toni K. Choueiri, Guru P. Sonpavde

Source: BJUI Compass, Vol 3, Iss 2, Pp 169-172 (2022)

Subject Terms: biomarkers, bladder cancer, enfortumab vedotin, genomics, targeted therapy, Diseases of the genitourinary system. Urology, RC870-923

File Description: electronic resource

Relation: https://doaj.org/toc/2688-4526

Access URL: https://doaj.org/article/76522c21149d4e469e8745761faf5c58

Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma

Authors: Ziad Bakouny, David A. Braun, Sachet A. Shukla, Wenting Pan, Xin Gao, Yue Hou, Abdallah Flaifel, Stephen Tang, Alice Bosma-Moody, Meng Xiao He, Natalie Vokes, Jackson Nyman, Wanling Xie, Amin H. Nassar, Sarah Abou Alaiwi, Ronan Flippot, Gabrielle Bouchard, John A. Steinharter, Pier Vitale Nuzzo, Miriam Ficial, Miriam Sant’Angelo, Juliet Forman, Jacob E. Berchuck, Shaan Dudani, Kevin Bi, Jihye Park, Sabrina Camp, Maura Sticco-Ivins, Laure Hirsch, Sylvan C. Baca, Megan Wind-Rotolo, Petra Ross-Macdonald, Maxine Sun, Gwo-Shu Mary Lee, Steven L. Chang, Xiao X. Wei, Bradley A. McGregor, Lauren C. Harshman, Giannicola Genovese, Leigh Ellis, Mark Pomerantz, Michelle S. Hirsch, Matthew L. Freedman, Michael B. Atkins, Catherine J. Wu, Thai H. Ho, W. Marston Linehan, David F. McDermott, Daniel Y. C. Heng, Srinivas R. Viswanathan, Sabina Signoretti, Eliezer M. Van Allen, Toni K. Choueiri

Source: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/65b689f6ed0042b1ab0807dd0eb2f0de

Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant

Authors: Tarek H. Mouhieddine, Adam S. Sperling, Robert Redd, Jihye Park, Matthew Leventhal, Christopher J. Gibson, Salomon Manier, Amin H. Nassar, Marzia Capelletti, Daisy Huynh, Mark Bustoros, Romanos Sklavenitis-Pistofidis, Sabrin Tahri, Kalvis Hornburg, Henry Dumke, Muhieddine M. Itani, Cody J. Boehner, Chia-Jen Liu, Saud H. AlDubayan, Brendan Reardon, Eliezer M. Van Allen, Jonathan J. Keats, Chip Stewart, Shaadi Mehr, Daniel Auclair, Robert L. Schlossman, Nikhil C. Munshi, Kenneth C. Anderson, David P. Steensma, Jacob P. Laubach, Paul G. Richardson, Jerome Ritz, Benjamin L. Ebert, Robert J. Soiffer, Lorenzo Trippa, Gad Getz, Donna S. Neuberg, Irene M. Ghobrial

Source: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/26a4f18ed00849e6bce820eacad6b32d

Trans-ethnic variation in germline variants of patients with renal cell carcinoma

Authors: Sarah Abou Alaiwi, Amin H. Nassar, Elio Adib, Stefan M. Groha, Elie W. Akl, Bradley A. McGregor, Edward D. Esplin, Shan Yang, Kathryn Hatchell, Vincent Fusaro, Sarah Nielsen, David J. Kwiatkowski, Guru P. Sonpavde, Mark Pomerantz, Judy E. Garber, Matthew L. Freedman, Huma Q. Rana, Alexander Gusev, Toni K. Choueiri

Source: Cell Reports, Vol 34, Iss 13, Pp 108926- (2021)

Subject Terms: renal cell carcinoma, kidney cancer, germline variants, DNA damage repair, clinical genetics, Ancestry, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124721002400; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/56159126e4444fb695cba37e80648755

The emerging landscape of germline variants in urothelial carcinoma: Implications for genetic testing

Authors: Panagiotis J. Vlachostergios, M.D., Ph.D., Bishoy M. Faltas, M.D., Maria I. Carlo, M.D., Amin H. Nassar, M.D., Sarah Abou Alaiwi, M.D., Guru Sonpavde, M.D.

Source: Cancer Treatment and Research Communications, Vol 23, Iss , Pp 100165- (2020)

Subject Terms: Bladder cancer, Genetic testing, Germline variants, Urothelial carcinoma, Lynch syndrome, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2468294220300022; https://doaj.org/toc/2468-2942

Access URL: https://doaj.org/article/d1c4454e60f7474586e2b349e36fe4f7

Safety and efficacy of immune checkpoint therapy for the treatment of patients with cardiac metastasis: a multicenter international retrospective study

Authors: Nicholas Jones, Tarek Haykal, Noha Abdel-Wahab, Abdul Rafeh Naqash, Alessio Cortellini, Rana R McKay, Toni K Choueiri, Georgina V Long, Pauline Funchain, Sarah Abou Alaiwi, Amin H Nassar, Douglas B Johnson, Chul Kim, David J Pinato, Jonathan Trent, Vishal Navani, Alexandra Drakaki, Tomas G Neilan, Kaushal Parikh, Frank Aboubakar Nana, Eric H Yang, Elizabeth Anderson, Gavin Hui, Mingjia Li, Paul Sackstein, Shirly Grynberg, Jesus Antonio Ocejo Gallegos, Susan Dent, Ahmad Al-Hader, Ankita Tandon, Javier Baena, Yuki Kojima, Aakash P Desai, Arjun Mittra, Edward El-Am, Elie Kozaily, Rachel Woodford, Dory Freeman, Caleb Smith, Nausheen Akhter, Talal El Zarif, Ryan Denu, Walid Macaron, Alexi Vasbinder, Salim Hayeck, Rachel S Goodman, Ronnie Shapira, Jennifer M Kwan, Kan Yonemor, Alexandra Trevino, Elias Bou Farhat, Priyanka Babu, Mercedes Juarez Herrera, Simone Foderaro, James Korolewicz, Nerea Lopetegui-Lia, Arrush Choudhary, Aarti Asnani, Daniel Meyers, Igor Stukalin, Sanober Nusrat, Carmel Malvar

Source: Journal for ImmunoTherapy of Cancer, Vol 13, Iss 3 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/13/3/e009364.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/05d7ec16358045a28f21537e15841ed9

Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y global registry

Authors: Mieke Van Hemelrijck, Salvatore Grisanti, Avinash Aujayeb, Martin Forster, Giannis Mountzios, Andrea Napolitano, Bruno Vincenzi, Joachim G J V Aerts, Marina Garassino, Valter Torri, Solange Peters, Alex Friedlaender, Alfredo Addeo, Giuseppe Lo Russo, Roberto Ferrara, Diego Signorelli, Alessandro Russo, So Yeon Kim, Jarushka Naidoo, Scott Gettinger, Heather Wakelee, Martin Sebastian, Mark Awad, Abdul Rafeh Naqash, Alessio Cortellini, Raffaele Giusti, Michele De Tursi, Federica Zoratto, Marco Russano, Rita Chiari, Biagio Ricciuti, Andrea De Giglio, Alain Gelibter, Giuseppe Tonini, Amin H Nassar, Alessandra Curioni-Fontecedro, Eleni Karapanagiotou, Emilio Bria, Jack Bell, Paolo Bironzo, Joao V Alessi, Alessandro Morabito, David J Pinato, Francesco Passiglia, Carlo Genova, Francesca Mazzoni, Alessandro Inno, Francesco Grossi, Luca Cantini, Lorenza Landi, Luigi Della Gravara, Margarita Majem, Uma Mukherjee, Federica Biello, Alessandro Leonetti, Annalisa Guida, Marianna Macerelli, Gabriele Minuti, Giulio Metro, Thomas Newsom-Davis, Eleni Josephides, Andrea Camerini, Elisa Roca, David O’Reilly, Mingjia Li, Laura Mezquita, Teresa Gorría, Claudia A M Fulgenzi, Lauren Young, Joel W Neal, Javier Baena, Francesco Pantano, Jacobo Rogado, Mary Jo Fidler, Teresa Beninato, Federica Pecci, Alessandro Di Federico, Kazuki Takada, Leonardo Brunetti, Talal El Zarif, Laura Moliner, Alberto Servetto, Sukumar Kalvapudi, Sai Yendamuri, Edoardo Garbo, Giuseppina Rita Di Fazio, Monica Loza, Ritujith Jayakrishnan, Michele Montrone, Nichola O Awosika, Bartlomiej Tomasik, Maximilian Rost, Isabelle Monnet, Francesco Agustoni, Artur Katz, Dwight Hall Owen, Michele Ghidini, Armida D’Incecco, Gianpaolo Spinelli, Monica Verrico, Manuel Dupont, Rafael Di Marco Barros, Diego Luigi Cortinovis, Chiara Bennati, Frank Aboubakar Nana, Anne-Marie Dingemans, Taher Abu Hejleh

Source: Journal for ImmunoTherapy of Cancer, Vol 13, Iss 2 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/13/2/e010674.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/cfc4d8473e7c465aa0bb0b93092e1b13

Mismatch repair deficiency and microsatellite instability in urothelial carcinoma: a systematic review and meta-analysis

Authors: Ninet Sinaii, Guru Sonpavde, Amin H Nassar, Min Yuen Teo, Andrea B Apolo, Jonathan E Rosenberg, Giovanni Maria Iannantuono, Elias B A Chandran, Saad O Atiq, Dilara Akbulut, Nicholas I Simon, Abdul Rouf Banday, Salah Boudjadi, Sandeep Gurram, Gisela Butera, Jonathan A Coleman

Source: BMJ Oncology, Vol 3, Iss 1 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://bmjoncology.bmj.com/content/3/1/e000335.full; https://doaj.org/toc/2752-7948

Access URL: https://doaj.org/article/d3920c29bad4423893885de5201f3040

Clinical outcomes and safety of immune checkpoint inhibitors in patients with solid tumors and paraneoplastic syndromes

Authors: Lucia Kwak, So Yeon Kim, Guru Sonpavde, Elad Sharon, Abdul Rafeh Naqash, Alessio Cortellini, Rana R McKay, Toni K Choueiri, Thomas Marron, Amin H Nassar, Jeffrey A Sparks, Kaushal Parikh, Frank Aboubakar Nana, Jenny Linnoila, Shruti Gupta, Nicole R LeBoeuf, Elio Adib, Ahmad Al-Hader, Edward El-Am, Dory Freeman, Ahmed Bilal Khalid, Marita Salame, Elias Bou Farhat, Arjun Ravishankar, Bachar Ahmad, David Kaldas, Andrea Malgeri, Ole-Petter R Hamnvik, Thomas Dilling, Elie Najem, Talal El Zarif, Serena Rahme, Caiwei Zhong, Tarek H Mouhieddine

Source: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/12/3/e008724.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/e3a36a44dc60429b90c5ae6bfb360660

Safety and efficacy of immune checkpoint inhibitors in advanced urological cancers with pre-existing autoimmune disorders: a retrospective international multicenter study

Authors: Elaine Lam, Marina D Kaymakcalan, Wanling Xie, Sarah Abou Alaiwi, Amin H Nassar, Pier Vitale Nuzzo, Nieves Martinez Chanza, Majd Issa, Hannah Dzimitrowicz, Abhishek Tripathi, Benoit Beuselinck, Yousef Zakharia, Rana Mckay, Sumit Shah, Amir Mortazavi, Michael R. Harrison, Spyridon Sideris, Anis Hamid, Toni K Choueiri, Lauren C Harshman

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/1/e000538.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/6224446d7b454cfaa7f257f5c8b240db

Safety and efficacy of restarting immune checkpoint inhibitors after clinically significant immune-related adverse events in metastatic renal cell carcinoma

Authors: Xiao Wei, Marina D Kaymakcalan, Toni K Choueiri, Daniel Y C Heng, Wanling Xie, Sarah Abou Alaiwi, Amin H Nassar, Shaan Dudani, Dylan Martini, Ziad Bakouny, John A Steinharter, Pier Vitale Nuzzo, Ronan Flippot, Nieves Martinez-Chanza, Bradley A McGregor, Mehmet A Bilen, Lauren C Harshman

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/1/e000144.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/cddad0a5c98242358042f98cc6c1686d

Conditional immune toxicity rate in patients with metastatic renal and urothelial cancer treated with immune checkpoint inhibitors

Authors: Guru Sonpavde, Sarah Abou Alaiwi, Amin H Nassar, Pier Vitale Nuzzo, Ronan Flippot, Bradley A McGregor, Lauren C Harshman, Gregory R Pond, Catherine Curran, Kerry L Kilbridge, Xiao X Wei, Toni Choueiri

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/1/e000371.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/f9a53e784a40492e874a776edb028735