Long-Term Efficacy of Dupilumab in Moderate-to-Severe Asthma Phenotyped by Blood Eosinophils and Exhaled Nitric Oxide

Authors: Wechsler, Michael E. ^{a, ∗}, Pavord, Ian D. ^b, Papi, Alberto ^c, Chapman, Kenneth R. ^d, Altincatal, Arman ^e, Pandit-Abid, Nami ^f, Jacob-Nara, Juby A. ^f, Rowe, Paul J. ^f, Deniz, Yamo ^g, Laws, Elizabeth ^f, Akinlade, Bolanle ^g, Amin, Nikhil ^g, Staudinger, Heribert W. ^f, Lederer, David J. ^g, Hardin, Megan ^e

Source: In CHEST Pulmonary March 2025 3(1)

Dupilumab Induces Long-Term On-Treatment Clinical Remission in Patients With Type 2 Asthma

Authors: Pavord, Ian D. ^{a, ∗}, Rabe, Klaus F. ^b, Israel, Elliot ^{c, d}, Szefler, Stanley J. ^e, Brusselle, Guy ^f, Pandit-Abid, Nami ^g, Altincatal, Arman ^h, Chen, Zhen ⁱ, Amin, Nikhil ^{i, ∗}, Khan, Asif H. ^j, Lederer, David J. ⁱ, Zhang, Yi ⁱ, Rowe, Paul J. ^g, Deniz, Yamo ⁱ, Radwan, Amr ⁱ, Jacob-Nara, Juby A. ^g, Busse, William W. ^k

Source: In The Journal of Allergy and Clinical Immunology: In Practice January 2025 13(1):132-142

Nasal brushing molecular endotyping distinguishes patients with chronic rhinosinusitis with nasal polyps with better response to dupilumab

Authors: Gayvert, Kaitlyn, Desrosiers, Martin, Laidlaw, Tanya M., Mannent, Leda P., Patel, Kiran, Horowitz, Julie, Amin, Nikhil, Jagerschmidt, Alexandre, Hamilton, Jennifer D., Lim, Wei Keat, Harel, Sivan

Source: In The Journal of Allergy and Clinical Immunology September 2024 154(3):619-630

Dupilumab in patients with chronic spontaneous urticaria (LIBERTY-CSU CUPID): Two randomized, double-blind, placebo-controlled, phase 3 trials

Authors: Maurer, Marcus, Casale, Thomas B., Saini, Sarbjit S., Ben-Shoshan, Moshe, Giménez-Arnau, Ana M., Bernstein, Jonathan A., Yagami, Akiko, Stjepanovic, Aleksandra, Radin, Allen, Staudinger, Heribert W., Patel, Naimish, Amin, Nikhil, Akinlade, Bolanle, Fan, Chunpeng, Bauer, Deborah, Yancopoulos, George D., Patel, Kiran, Mannent, Leda P., Laws, Elizabeth

Source: In The Journal of Allergy and Clinical Immunology July 2024 154(1):184-194

Blood eosinophils and fractional exhaled nitric oxide are prognostic and predictive biomarkers in childhood asthma

Authors: Bacharier, Leonard B., Pavord, Ian D., Maspero, Jorge F., Jackson, Daniel J., Fiocchi, Alessandro G., Mao, Xuezhou, Jacob-Nara, Juby A., Deniz, Yamo, Laws, Elizabeth, Mannent, Leda P., Amin, Nikhil, Akinlade, Bolanle, Staudinger, Heribert W., Lederer, David J., Hardin, Megan

Source: In The Journal of Allergy and Clinical Immunology July 2024 154(1):101-110

Dupilumab pharmacokinetics and effect on type 2 biomarkers in children with moderate-to-severe asthma

Authors: Jackson, Daniel J. ^*, Bacharier, Leonard B., Phipatanakul, Wanda, Sher, Lawrence, Domingo, Christian, Papadopoulos, Nikolaos, Modena, Brian, Li, Ning, Xia, Changming, Kamal, Mohamed A., Dillon, Myles, Wolfe, Kelley, Gall, Rebecca, Amin, Nikhil, Mannent, Leda P., Laws, Elizabeth, Rowe, Paul J., Jacob-Nara, Juby A., Deniz, Yamo, Lederer, David J., Hardin, Megan, Xu, Christine

Source: In Annals of Allergy, Asthma & Immunology July 2023 131(1):44-51

Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial

Authors: Pepper, Amber, Paller, Amy S, Lockshin, Benjamin, Cohen, David, Pariser, David, Siegfried, Elaine C, Simpson, Eric L, Leflein, Jeffrey, Weinberg, Jeffrey, Browning, John, Teng, Joyce, Wine Lee, Lara, Sher, Lawrence, Diaz, Lucia, Schneider, Lynda, Gonzalez, Mercedes E, Rupp, Ned, Ong, Peck, Cartwright, Robert, Sidbury, Robert, Soong, Weily, Pinter, Andreas, Wollenberg, Andreas, Schnopp, Christina, Cork, Michael J, Arkwright, Peter D, Korkosz, Anna, Bystrzanowska, Dorota, Sygula, Ewa, Zdybski, Jacek, Padlewska, Kamila, Schneider, Lynda C, Meltzer, Steven, Wang, Zhixiao, Mannent, Leda P, Amin, Nikhil, Sun, Yiping, Laws, Elizabeth, Akinlade, Bolanle, Dillon, Myles, Kosloski, Matthew P, Kamal, Mohamed A, Dubost-Brama, Ariane, Patel, Naimish, Weinreich, David M, Yancopoulos, George D, O’Malley, John T, Bansal, Ashish ^*

Source: In The Lancet 17-23 September 2022 400(10356):908-919

Dupilumab Demonstrates Rapid Onset of Response Across Three Type 2 Inflammatory Diseases

Authors: Canonica, G. Walter, Bourdin, Arnaud, Peters, Anju T., Desrosiers, Martin, Bachert, Claus, Weidinger, Stephan, Simpson, Eric L., Daizadeh, Nadia, Chen, Zhen, Kamat, Siddhesh, Khan, Asif H., Chao, Jingdong, Graham, Neil M.H., Laws, Elizabeth, Rossi, Ana B., Ardeleanu, Marius, Mannent, Leda P., Amin, Nikhil, Ortiz, Benjamin, Deniz, Yamo, Djandji, Michel, Rowe, Paul J.

Source: In The Journal of Allergy and Clinical Immunology: In Practice June 2022 10(6):1515-1526

Olfactory Outcomes With Dupilumab in Chronic Rhinosinusitis With Nasal Polyps

Authors: Mullol, Joaquim, Bachert, Claus, Amin, Nikhil, Desrosiers, Martin, Hellings, Peter W., Han, Joseph K., Jankowski, Roger, Vodicka, Jan, Gevaert, Philippe, Daizadeh, Nadia, Khan, Asif H., Kamat, Siddhesh, Patel, Naimish, Graham, Neil M.H., Ruddy, Marcella, Staudinger, Heribert, Mannent, Leda P.

Source: In The Journal of Allergy and Clinical Immunology: In Practice April 2022 10(4):1086-1095

Long-term safety and efficacy of dupilumab in patients with moderate-to-severe asthma (TRAVERSE): an open-label extension study

Authors: Wechsler, Michael E ^*, Ford, Linda B, Maspero, Jorge F, Pavord, Ian D, Papi, Alberto, Bourdin, Arnaud, Watz, Henrik, Castro, Mario, Nenasheva, Natalia M, Tohda, Yuji, Langton, David, Cardona, Guido, Domingo, Christian, Park, Hae Sim, Chapman, Kenneth R, Mao, Xuezhou, Zhang, Yi, Khan, Asif H, Deniz, Yamo, Rowe, Paul J, Kapoor, Upender, Khokhar, Faisal A, Mannent, Leda P, Ruddy, Marcella, Laws, Elizabeth, Amin, Nikhil, Hardin, Megan

Source: In The Lancet Respiratory Medicine January 2022 10(1):11-25

Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial

Authors: Rabe, Klaus F ^*, Celli, Bartolome R, Wechsler, Michael E, Abdulai, Raolat M, Luo, Xiaodong, Boomsma, Maarten M, Staudinger, Heribert, Horowitz, Julie E, Baras, Aris, Ferreira, Manuel A, Ruddy, Marcella K, Nivens, Michael C, Amin, Nikhil, Weinreich, David M, Yancopoulos, George D, Goulaouic, Helene

Source: In The Lancet Respiratory Medicine November 2021 9(11):1288-1298

Chronic Rhinosinusitis with Nasal Polyps and Asthma

Authors: Laidlaw, Tanya M., Mullol, Joaquim, Woessner, Katharine M., Amin, Nikhil, Mannent, Leda P.

Source: In The Journal of Allergy and Clinical Immunology: In Practice March 2021 9(3):1133-1141

Efficacy of dupilumab on clinical outcomes in patients with asthma and perennial allergic rhinitis

Authors: Busse, William W., Maspero, Jorge F., Lu, Yufang, Corren, Jonathan, Hanania, Nicola A., Chipps, Bradley E., Katelaris, Constance H., FitzGerald, J. Mark, Quirce, Santiago, Ford, Linda B., Rice, Megan S., Kamat, Siddhesh, Khan, Asif H., Jagerschmidt, Alexandre, Harel, Sivan, Rowe, Paul, Pirozzi, Gianluca, Amin, Nikhil, Ruddy, Marcella, Graham, Neil M.H., Teper, Ariel

Source: In Annals of Allergy, Asthma & Immunology November 2020 125(5):565-576

Dupilumab Efficacy in Patients with Uncontrolled, Moderate-to-Severe Allergic Asthma

Authors: Corren, Jonathan, Castro, Mario, O'Riordan, Thomas, Hanania, Nicola A., Pavord, Ian D., Quirce, Santiago, Chipps, Bradley E., Wenzel, Sally E., Thangavelu, Karthinathan, Rice, Megan S., Harel, Sivan, Jagerschmidt, Alexandre, Khan, Asif H., Kamat, Siddhesh, Maroni, Jaman, Rowe, Paul, Lu, Yufang, Amin, Nikhil, Pirozzi, Gianluca, Ruddy, Marcella, Graham, Neil M.H., Teper, Ariel

Source: In The Journal of Allergy and Clinical Immunology: In Practice February 2020 8(2):516-526

Dupilumab Efficacy in Uncontrolled, Moderate-to-Severe Asthma with Self-Reported Chronic Rhinosinusitis

Authors: Maspero, Jorge F., Katelaris, Constance H., Busse, William W., Castro, Mario, Corren, Jonathan, Chipps, Bradley E., Peters, Anju T., Pavord, Ian D., Ford, Linda B., Sher, Lawrence, Rabe, Klaus F., Rice, Megan S., Rowe, Paul, Lu, Yufang, Harel, Sivan, Jagerschmidt, Alexandre, Khan, Asif H., Kamat, Siddhesh, Pirozzi, Gianluca, Amin, Nikhil, Ruddy, Marcella, Graham, Neil M.H., Mannent, Leda P., Teper, Ariel

Source: In The Journal of Allergy and Clinical Immunology: In Practice February 2020 8(2):527-539

Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials

Authors: Bachert, Claus ^*, Han, Joseph K, Desrosiers, Martin, Hellings, Peter W, Amin, Nikhil, Lee, Stella E, Mullol, Joaquim, Greos, Leon S, Bosso, John V, Laidlaw, Tanya M, Cervin, Anders U, Maspero, Jorge F, Hopkins, Claire, Olze, Heidi, Canonica, G Walter, Paggiaro, Pierluigi, Cho, Seong H, Fokkens, Wytske J, Fujieda, Shigeharu, Zhang, Mei, Lu, Xin, Fan, Chunpeng, Draikiwicz, Steven, Kamat, Siddhesh A, Khan, Asif, Pirozzi, Gianluca, Patel, Naimish, Graham, Neil M H, Ruddy, Marcella, Staudinger, Heribert, Weinreich, David, Stahl, Neil, Yancopoulos, George D, Mannent, Leda P

Source: In The Lancet 2-8 November 2019 394(10209):1638-1650

Dupilumab efficacy across serum IgE and blood eosinophil levels in chronic rhinosinusitis with nasal polyposis.

Authors: Bachert, Claus, Gevaert, Philippe, Lipworth, Brian, Mustafa, Syed Shahzad, Lane, Andrew P., Mullol, Joaquim, Rowe, Paul, Deniz, Yamo, Kamat, Siddhesh, Khan, Asif H., Jacob‐Nara, Juby, Siddiqui, Shahid, Ruddy, Marcella, Laws, Elizabeth, Msihid, Jérôme, Harel, Sivan, Jagerschmidt, Alexandre, Amin, Nikhil, Mannent, Leda, Rout, Raj

Source: Allergy; Oct2024, Vol. 79 Issue 10, p2858-2861, 4p

Subject Terms: IMMUNOGLOBULIN E, STOCK options, OLFACTOMETRY, MEDICAL writing, ENDOSCOPIC surgery, NASAL polyps

AERIFY-1/2: two phase 3, randomised, controlled trials of itepekimab in former smokers with moderate-to-severe COPD.

Authors: Rabe, Klaus F., Martinez, Fernando J., Bhatt, Surya P., Tomotaka Kawayama, Cosio, Borja G., Mroz, Robert M., Boomsma, Maarten M., Goulaouic, Helene, Nivens, Michael C., Djandji, Michel, Soler, Xavier, Ying Liu, Kosloski, Matthew P., Xu, Christine R., Amin, Nikhil, Staudinger, Heribert, Lederer, David J., Abdulai, Raolat M.

Source: ERJ Open Research; Sep2024, Vol. 10 Issue 5, p1-11, 11p

Dupilumab improves symptoms, quality of life, and productivity in uncontrolled persistent asthma

Authors: Corren, Jonathan ^*, Castro, Mario, Chanez, Pascal, Fabbri, Leonardo, Joish, Vijay N., Amin, Nikhil, Graham, Neil M.H., Mastey, Vera, Abbé, Adeline, Taniou, Christine, Mahajan, Puneet, Teper, Ariel, Pirozzi, Gianluca, Eckert, Laurent

Source: In Annals of Allergy, Asthma & Immunology January 2019 122(1):41-49

Efficacy and safety of dupilumab in perennial allergic rhinitis and comorbid asthma

Authors: Weinstein, Steven F., Katial, Rohit, Jayawardena, Shyamalie, Pirozzi, Gianluca, Staudinger, Heribert, Eckert, Laurent, Joish, Vijay N., Amin, Nikhil, Maroni, Jaman, Rowe, Paul, Graham, Neil M.H., Teper, Ariel

Source: In The Journal of Allergy and Clinical Immunology July 2018 142(1):171-177