Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells

Authors: Wang, Kevin, Coutifaris, Paulina, Brocks, David, Wang, Guanning, Azar, Tarek, Solis, Sabrina, Nandi, Ajeya, Anderson, Shaneaka, Han, Nicholas, Manne, Sasikanth, Kiner, Evgeny, Sachar, Chirag, Lucas, Minke, George, Sangeeth, Yan, Patrick K., Kier, Melanie W., Laughlin, Amy I., Kothari, Shawn, Giles, Josephine, Mathew, Divij, Ghinnagow, Reem, Alanio, Cecile, Flowers, Ahron, Xu, Wei, Tenney, Daniel J., Xu, Xiaowei, Amaravadi, Ravi K., Karakousis, Giorgos C., Schuchter, Lynn M., Buggert, Marcus, Oldridge, Derek, Minn, Andy J., Blank, Christian, Weber, Jeffrey S., Mitchell, Tara C., Farwell, Michael D., Herati, Ramin S., Huang, Alexander C.

Source: In Cancer Cell 9 September 2024 42(9):1582-1597

Recent advances in targeting autophagy in cancer

Authors: Jain, Vaibhav, Singh, Mahendra Pal, Amaravadi, Ravi K.

Source: Trends in pharmacological sciences. 44(5):290-302

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187564437.0x000001&indx=1&recIds=ETOCvdc_100187564437.0x000001

Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy

Authors: Tcyganov, Evgenii N., Sanseviero, Emilio, Marvel, Douglas, Beer, Thomas, Tang, Hsin-Yao, Hembach, Peter, Speicher, David W., Zhang, Qianfei, Donthireddy, Laxminarasimha R., Mostafa, Ali, Tsyganova, Sabina, Pisarev, Vladimir, Laufer, Terri, Ignatov, Dmitriy, Ferrone, Soldano, Meyer, Christiane, Maby-El Hajjami, Hélène, Speiser, Daniel E., Altiok, Sooner, Antonia, Scott, Xu, Xiaowei, Xu, Wei, Zheng, Cathy, Schuchter, Lynn M., Amaravadi, Ravi K., Mitchell, Tara C., Karakousis, Giorgos C., Yuan, Zhe, Montaner, Luis J., Celis, Esteban, Gabrilovich, Dmitry I.

Source: In Cancer Cell 10 October 2022 40(10):1173-1189

Divergent effects of acute and chronic PPT1 inhibition in melanoma.

Authors: Crissey, Mary Ann S., Versace, Amanda, Bhardwaj, Monika, Jain, Vaibhav, Liu, Shujing, Singh, Arpana, Beer, Lynn A., Tang, Hsin-Yao, Villanueva, Jessie, Gimotty, Phyllis A., Xu, Xiaowei, Amaravadi, Ravi K.

Source: Autophagy; Feb2025, Vol. 21 Issue 2, p394-406, 13p

Subject Terms: LOW density lipoprotein receptors, TRANSCRIPTION factors, SMALL molecules, LIQUID chromatography-mass spectrometry, PTEN protein

Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers

Authors: Giles, Josephine R., Manne, Sasikanth, Freilich, Elizabeth, Oldridge, Derek A., Baxter, Amy E., George, Sangeeth, Chen, Zeyu, Huang, Hua, Chilukuri, Lakshmi, Carberry, Mary, Giles, Lydia, Weng, Nan-Ping P., Young, Regina M., June, Carl H., Schuchter, Lynn M., Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Huang, Alexander C., Shi, Junwei, Wherry, E. John

Source: In Immunity 8 March 2022 55(3):557-574

Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells

Authors: McLane, Laura M., Ngiow, Shin Foong, Chen, Zeyu, Attanasio, John, Manne, Sasikanth, Ruthel, Gordon, Wu, Jennifer E., Staupe, Ryan P., Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Huang, Alexander C., Freedman, Bruce D., Betts, Michael R., Wherry, E. John

Source: In Cell Reports 11 May 2021 35(6)

Compliance with sentinel lymph node biopsy guidelines for invasive melanomas treated with Mohs micrographic surgery

Authors: MacArthur, Kelly M., Baumann, Brian C., Sobanko, Joseph F., Etzkorn, Jeremy R., Shin, Thuzar M., Higgins, H. William, Giordano, Cerrene N., McMurray, Stacy L., Krausz, Aimee, Newman, Jason G., Rajasekaran, Karthik, Cannady, Steven B., Brody, Robert M., Karakousis, Giorgos C., Miura, John T., Cohen, Justine V., Amaravadi, Ravi K., Mitchell, Tara C., Schuchter, Lynn M., Miller, Christopher J.

Source: Cancer. 127(19):3591-3598

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128235351.0x000001&indx=1&recIds=ETOCvdc_100128235351.0x000001

The effect of sonidegib (LDE225) on the pharmacokinetics of bupropion and warfarin in patients with advanced solid tumours

Authors: Pooler, Darcy B., Ness, Dylan B., Sarantopoulos, John, Squittieri, Nicholas, Ravichandran, Shoba, Britten, Carolyn D., Amaravadi, Ravi K., Vaishampayan, Ulka, LoRusso, Patricia, Shapiro, Geoffrey I., Olszanski, Anthony J., Perez, Raymond, Gutierrez, Martin, O'Rourke, Mark Allen, Chung, Vincent, Lee, James J., Lewis, Lionel D.

Source: British journal of clinical pharmacology. 87(3):1291-1302

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115841602.0x000001&indx=1&recIds=ETOCvdc_100115841602.0x000001

Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer

Authors: Kwak, Taekyoung, Wang, Fang, Deng, Hui, Condamine, Thomas, Kumar, Vinit, Perego, Michela, Kossenkov, Andrew, Montaner, Luis J., Xu, Xiaowei, Xu, Wei, Zheng, Cathy, Schuchter, Lynn M., Amaravadi, Ravi K., Mitchell, Tara C., Karakousis, Giorgos C., Mulligan, Charles, Nam, Brian, Masters, Gregory, Hockstein, Neil, Bennett, Joseph, Nefedova, Yulia, Gabrilovich, Dmitry I.

Source: In Cell Reports 29 December 2020 33(13)

Regulation of autophagy by canonical and non-canonical ER stress responses

Authors: Bhardwaj, Monika, Leli, Nektaria Maria, Koumenis, Constantinos, Amaravadi, Ravi K. ^*

Source: In Seminars in Cancer Biology November 2020 66:116-128

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

Authors: Beltra, Jean-Christophe, Manne, Sasikanth, Abdel-Hakeem, Mohamed S., Kurachi, Makoto, Giles, Josephine R., Chen, Zeyu, Casella, Valentina, Ngiow, Shin Foong, Khan, Omar, Huang, Yinghui Jane, Yan, Patrick, Nzingha, Kito, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Huang, Alexander C., Wherry, E. John

Source: In Immunity 19 May 2020 52(5):825-841

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma

Authors: Webster, Marie R., Fane, Mitchell E., Alicea, Gretchen M., Basu, Subhasree, Kossenkov, Andrew V., Marino, Gloria E., Douglass, Stephen M., Kaur, Amanpreet, Ecker, Brett L., Gnanapradeepan, Keerthana, Ndoye, Abibatou, Kugel, Curtis, Valiga, Alexander, Palmer, Jessica, Liu, Qin, Xu, Xiaowei, Morris, Jessicamarie, Yin, Xiangfan, Wu, Hong, Xu, Wei, Zheng, Cathy, Karakousis, Giorgos C., Amaravadi, Ravi K., Mitchell, Tara C., Almeida, Filipe V., Xiao, Min, Rebecca, Vito W., Wang, Ying-Jie, Schuchter, Lynn M., Herlyn, Meenhard, Murphy, Maureen E., Weeraratna, Ashani T.

Source: In Molecular Cell 6 February 2020 77(3):633-644

Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy‐mediated drug resistance in ovarian cancer cells, xenografts, and patient‐derived xenograft models

Authors: Santiago‐O'Farrill, Janice M., Weroha, S. John, Hou, Xiaonan, Oberg, Ann L., Heinzen, Ethan P., Maurer, Matthew J., Pang, Lan, Rask, Philip, Amaravadi, Ravi K., Becker, Sarah E., Romero, Ignacio, Rubio, Ma Jesús, Matias‐Guiu, Xavier, Santacana, Maria, Llombart‐Cussac, Antonio, Poveda, Andrés, Lu, Zhen, Bast, Robert C.

Source: Cancer. 126(4):894-907

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097872703.0x000001&indx=1&recIds=ETOCvdc_100097872703.0x000001

Neoadjuvant Versus Adjuvant Immune Checkpoint Blockade in the Treatment of Clinical Stage III Melanoma

Authors: Song, Yun, Straker, Richard J., Xu, Xiaowei, Elder, David E., Gimotty, Phyllis A., Huang, Alexander C., Mitchell, Tara C., Amaravadi, Ravi K., Schuchter, Lynn M., Karakousis, Giorgos C.

Source: Annals of surgical oncology. 27(8):2915-2926

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168245179.0x000001&indx=1&recIds=ETOCvdc_100168245179.0x000001

Lysosomes Support the Degradation, Signaling, and Mitochondrial Metabolism Necessary for Human Epidermal Differentiation

Authors: Monteleon, Christine L., Agnihotri, Tanvir, Dahal, Ankit, Liu, Mingen, Rebecca, Vito W., Beatty, Gregory L., Amaravadi, Ravi K., Ridky, Todd W.

Source: In Journal of Investigative Dermatology September 2018 138(9):1945-1954

Survival Outcomes of Patients with Clinical Stage III Melanoma in the Era of Novel Systemic Therapies

Authors: Song, Yun, Tieniber, Andrew D., Gimotty, Phyllis A., Mitchell, Tara C., Amaravadi, Ravi K., Schuchter, Lynn M., Fraker, Douglas L., Karakousis, Giorgos C.

Source: Annals of surgical oncology. 26(13):4621-4630

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100118554672.0x000001&indx=1&recIds=ETOCvdc_100118554672.0x000001

Targeting the unfolded protein response in cancer

Authors: Ojha, Rani, Amaravadi, Ravi K.

Source: In Pharmacological Research June 2017 120:258-266

Methods for Studying Autophagy Within the Tumor Microenvironment
Tumor microenvironment and Cellular stress (International conference)

Authors: Murugan, Sengottuvelan, Amaravadi, Ravi K.

Source: Advances in experimental medicine and biology. 899:145-166

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN601412493&indx=1&recIds=ETOCCN601412493

Targeting autophagy in cancer

Authors: Onorati, Angelique V., Dyczynski, Matheus, Ojha, Rani, Amaravadi, Ravi K.

Source: Cancer. 124(16):3307-3318

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123829313.0x000001&indx=1&recIds=ETOCvdc_100123829313.0x000001

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

Authors: Benci, Joseph L., Xu, Bihui, Qiu, Yu, Wu, Tony J., Dada, Hannah, Twyman-Saint Victor, Christina, Cucolo, Lisa, Lee, David S.M., Pauken, Kristen E., Huang, Alexander C., Gangadhar, Tara C., Amaravadi, Ravi K., Schuchter, Lynn M., Feldman, Michael D., Ishwaran, Hemant, Vonderheide, Robert H., Maity, Amit, Wherry, E. John, Minn, Andy J.

Source: In Cell 1 December 2016 167(6):1540-1554