Data Nuggets: A Method for Reducing Big Data While Preserving Data Structure

Authors: Beavers, Traymon E., Cheng, Ge, Duan, Yajie, Cabrera, Javier, Lubomirski, Mariusz, Amaratunga, Dhammika, Teigler, Jeffrey E.

Subject Terms: Statistics - Methodology, Statistics - Computation, 62:0

Access URL: http://arxiv.org/abs/2403.03099

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Survey and Recommendations on the Use of P-Values Driving Decisions in Nonclinical Pharmaceutical Applications

Authors: Altan, Stan, Amaratunga, Dhammika, Cabrera, Javier, Garren, Jeonifer, Geys, Helena, Kolassa, John, LeBlond, David, Li, Dingzhou, Liao, Jason, Liu, Jia, Lubomirski, Mariusz, Miro-Quesada, Guillermo, Novick, Steven, Otava, Martin, Peterson, John, Reckermann, Katharina, Schofield, Tim, Tan, Charles, Tatikola, Kanaka, Tekle, Fetene, Thomas, Jennifer, Vukovinsky, Kim

Source: Statistics in biopharmaceutical research. 15(2):343-358

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184412737.0x000001&indx=1&recIds=ETOCvdc_100184412737.0x000001

Integrated genomic, proteomic and cognitive assessment in Duchenne Muscular Dystrophy suggest astrocyte centric pathology

Authors: Wijekoon, Nalaka ^{a, b}, Gonawala, Lakmal ^{a, b}, Ratnayake, Pyara ^c, Dissanayaka, Pulasthi ^a, Gunarathne, Isuru ^a, Amaratunga, Dhammika ^d, Liyanage, Roshan ^a, Senanayaka, Sunethra ^e, Wijesekara, Saraji ^{f, g}, Gunasekara, Hemal H. ^h, Vanarsa, Kamala ⁱ, Castillo, Jessica ⁱ, Hathout, Yetrib ^j, Dalal, Ashwin ^k, Steinbusch, Harry W.M. ^b, Hoffman, Eric ^j, Mohan, Chandra ^{i, 1}, de Silva, K. Ranil D. ^{a, b, l, 1, ∗}

Source: In Heliyon August 2023 9(8)

Serum metabolomic signatures of patients with rare neurogenetic diseases: an insight into potential biomarkers and treatment targets.

Authors: Wijekoon, Nalaka, Gonawala, Lakmal, Ratnayake, Pyara, Sirisena, Darshana, Gunasekara, Harsha, Dissanayake, Athula, Amaratunga, Dhammika, Steinbusch, Harry W. M., Hathout, Yetrib, Hoffman, Eric P., Dalal, Ashwin, Mohan, Chandra, de Silva, K. Ranil D.

Source: Frontiers in Molecular Neuroscience; 2025, p1-17, 17p

Subject Terms: LIPID metabolism, CARBOHYDRATE metabolism, METABOLISM, MUSCULAR dystrophy, PATHOLOGY

Uses and opportunities for machine learning in hypertension research

Authors: Amaratunga, Dhammika, Cabrera, Javier, Sargsyan, Davit, Kostis, John B., Zinonos, Stavros, Kostis, William J.

Source: In International Journal of Cardiology Hypertension June 2020 5

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Feature Selection With Weighted Importance Index in an Autism Spectrum Disorder Study

Authors: Sargsyan, Davit, Jagannatha, Shyla, Manyakov, Nikolay V., Skalkin, Andrew, Bangerter, Abigail, Ness, Seth, Durham, Kathryn, Amaratunga, Dhammika, Cabrera, Javier, Pandina, Gahan

Source: Statistics in biopharmaceutical research. 11(2):118-125

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100082029482.0x000001&indx=1&recIds=ETOCvdc_100082029482.0x000001

Analysis of Data from Viral DNA Microchips

Authors: Amaratunga, Dhammika, Cabrera, Javier

Source: Journal of the American Statistical Association, 2001 Dec 01. 96(456), 1161-1170.

Access URL: https://www.jstor.org/stable/3085879

Searching for the Right Sample Size

Authors: Amaratunga, Dhammika

Source: The American Statistician, 1999 Feb 01. 53(1), 52-55.

Access URL: https://www.jstor.org/stable/2685652

ABC gene-ranking for prediction of drug-induced cholestasis in rats

Authors: Cherkas, Yauheniya, McMillian, Michael K., Amaratunga, Dhammika, Raghavan, Nandini, Sasaki, Jennifer C.

Source: In Toxicology Reports 2016 3:252-261

Title-molecular diagnostics of dystrophinopathies in Sri Lanka towards phenotype predictions: an insight from a South Asian resource limited setting.

Authors: Wijekoon, Nalaka, Gonawala, Lakmal, Ratnayake, Pyara, Liyanage, Roshan, Amaratunga, Dhammika, Hathout, Yetrib, Steinbusch, Harry W. M., Dalal, Ashwin, Hoffman, Eric P., de Silva, K. Ranil D.

Source: European Journal of Medical Research; 1/9/2024, Vol. 29 Issue 1, p1-16, 16p

Subject Terms: RESOURCE-limited settings, BECKER muscular dystrophy, DUCHENNE muscular dystrophy, PHENOTYPES, DELETION mutation, CHROMOSOME duplication, MOLECULAR diagnosis

Geographic Terms: SRI Lanka, SOUTH Asia

Early stages of Alzheimer's disease are alarming signs in injury deaths caused by traffic accidents in elderly people (≥60 years of age): A neuropathological study

Authors: Wijesinghe, Printha, Gorrie, Catherine, Shankar, S, Chickabasaviah, Yasha, Amaratunga, Dhammika, Hulathduwa, Sanjayah, Kumara, K, Samarasinghe, Kamani, Suh, Yoo-Hun, M. Steinbusch, H, D. De Silva, K

Source: Indian journal of psychiatry. 59(4):471-477

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100088401643.0x000001&indx=1&recIds=ETOCvdc_100088401643.0x000001

Quality control of Platinum Spike dataset by probe-level mixed models

Authors: Khamiakova, Tatsiana, Shkedy, Ziv, Amaratunga, Dhammika, Talloen, Willem, Göhlmann, Hinrich, Bijnens, Luc, Kasim, Adetayo

Source: In Mathematical Biosciences February 2014 248:1-10

Release of (and lessons learned from mining) a pioneering large toxicogenomics database

Authors: Sandhu, Komal S, Veeramachaneni, Vamsi, Yao, Xiang, Nie, Alex, Lord, Peter, Amaratunga, Dhammika, McMillian, Michael K, Verheyen, Geert R

Source: Pharmacogenomics. 16(8):779-801

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123906390.0x000001&indx=1&recIds=ETOCvdc_100123906390.0x000001

Duchenne Muscular Dystrophy from Brain to Muscle: The Role of Brain Dystrophin Isoforms in Motor Functions.

Authors: Wijekoon, Nalaka, Gonawala, Lakmal, Ratnayake, Pyara, Amaratunga, Dhammika, Hathout, Yetrib, Mohan, Chandra, Steinbusch, Harry W. M., Dalal, Ashwin, Hoffman, Eric P., de Silva, K. Ranil D.

Source: Journal of Clinical Medicine; Sep2023, Vol. 12 Issue 17, p5637, 15p

Subject Terms: DUCHENNE muscular dystrophy, DYSTROPHIN, MUSCLE strength, NATURAL history, DEVELOPMENTAL delay, KNEE muscles

Geographic Terms: SRI Lanka

Company/Entity: MEDICAL Research Council (Great Britain), SOUTH Asian Association for Regional Cooperation

IRINI: Random group allocation of multiple prognostic factors

Authors: Kasturi, Jyotsna, Geisler, John G., Liu, Jianying, Kirchner, Thomas, Amaratunga, Dhammika, Lubomirski, Mariusz

Source: In Contemporary Clinical Trials 2011 32(3):372-381

Using Fisher's Method to Identify Enriched Gene Sets

Authors: Tryputsen, Volha, Cabrera, Javier, De Bondt, An, Amaratunga, Dhammika

Source: Statistics in biopharmaceutical research. 6(2):154-162

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100032988784.0x000001&indx=1&recIds=ETOCvdc_100032988784.0x000001

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Modeling of systemic inflammatory response to infection