Use of Melatonin in the In Vitro Production of Bovine Embryos

Authors: LIRA, Alan da Silva, CHAVES, Ricardo de Macedo, MORAES JUNIOR, Felipe de Jesus, COSTA JUNIOR, Sergio Henrique, AMARAL, Brenda Karine Lima do, TROVÃO, Hallef Mithchel Pereira

Source: Revista Brasileira de Saúde e Produção Animal. January 2020 21

Subject Terms: COC, Melatonin, IVP, Follicular Aspiration

File Description: text/html

Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-99402020000101000

Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors.

Authors: Amaral, Brenda, Capacci, Andrew, Anderson, Trip, Tezer, Ceren, Bajrami, Bekim, Lulla, Mukesh, Lucas, Brian, Chodaparambil, Jayanth V., Marcotte, Douglas, Kumar, P. Rajesh, Murugan, Paramasivam, Spilker, Kerri, Cullivan, Mike, Wang, Ti, Peterson, Anton C., Enyedy, Istvan, Ma, Bin, Chen, TeYu, Yousaf, Zain, Calhoun, Michael

Source: ACS Chemical Neuroscience; 3/15/2023, Vol. 14 Issue 6, p1080-1094, 15p

Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites.

Authors: Dillon, Gregory M., Henderson, Jaclyn L., Bao, Channa, Joyce, John A., Calhoun, Michael, Amaral, Brenda, King, Kristopher W., Bajrami, Bekim, Rabah, Dania

Source: PLoS ONE; 4/7/2020, Vol. 15 Issue 4, p1-22, 22p

Subject Terms: TAU proteins, TUBULINS, PHOSPHORYLATION, COGNITION disorders, SMALL molecules, NEURODEGENERATION, KINASE inhibitors

Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery

Authors: Bernard-Gauthier, Vadim, Mossine, Andrew V., Knight, Ashley, Patnaik, Debasis, Zhao, Wen-Ning, Cheng, Chialin, Krishnan, Hema S., Xuan, Lucius L., Chindavong, Peter S., Reis, Surya A., Chen, Jinshan Michael, Shao, Xia, Stauff, Jenelle, Arteaga, Janna, Sherman, Phillip, Salem, Nicolas, Bonsall, David, Amaral, Brenda, Varlow, Cassis, Wells, Lisa, Martarello, Laurent, Patel, Shil, Liang, Steven H., Kurumbail, Ravi G., Haggarty, Stephen J., Scott, Peter J. H., Vasdev, Neil

Source: Journal of Medicinal Chemistry; November 2019, Vol. 62 Issue: 21 p9600-9617, 18p

Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo

Authors: Halkina, Tamara, Henderson, Jaclyn L., Lin, Edward Y., Himmelbauer, Martin K., Jones, J. Howard, Nevalainen, Marta, Feng, Jun, King, Kristopher, Rooney, Michael, Johnson, Joshua L., Marcotte, Douglas J., Chodaparambil, Jayanth V., Kumar, P. Rajesh, Patterson, Thomas A., Murugan, Paramasivam, Schuman, Eli, Wong, LaiYee, Hesson, Thomas, Lamore, Sarah, Bao, Channa, Calhoun, Michael, Certo, Hannah, Amaral, Brenda, Dillon, Gregory M., Gilfillan, Rab, de Turiso, Felix Gonzalez-Lopez

Source: Journal of Medicinal Chemistry; 20210101, Issue: Preprints