Synergistic anti‐depressive effect of combination treatment of Brexpiprazole and selective serotonin reuptake inhibitors on forced swimming test in mice

Authors: Amada, Naoki, Hirose, Tsuyoshi, Suzuki, Mikio, Kakumoto, Yusuke, Futamura, Takashi, Maeda, Kenji, Kikuchi, Tetsuro

Source: Neuropsychopharmacology reports. 43(1):132-136

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177728833.0x000001&indx=1&recIds=ETOCvdc_100177728833.0x000001

Prenatal methotrexate injection increases behaviors possibly associated with depression and/or autism in rat offspring; A new animal model for mental disorder, based on folate metabolism deficit during pregnancy

Authors: Amada, Naoki, Kakumoto, Yusuke, Futamura, Takashi, Maeda, Kenji

Source: Neuropsychopharmacology reports. 42(3):263-271

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165091471.0x000001&indx=1&recIds=ETOCvdc_100165091471.0x000001

Brexpiprazole: A new option in treating agitation in Alzheimer's dementia—Insights from transgenic mouse models.

Authors: Amada, Naoki¹ (AUTHOR) amada.naoki@otsuka.jp, Sato, Shinji² (AUTHOR), Ishikawa, Dai¹ (AUTHOR), Nakamura, Mai¹ (AUTHOR), Suzuki, Mikio¹ (AUTHOR), Futamura, Takashi¹ (AUTHOR), Maeda, Kenji² (AUTHOR)

Source: Neuropsychopharmacology Reports. Sep2024, Vol. 44 Issue 3, p557-568. 12p.

Subject Terms: *ALZHEIMER'S disease, *ANIMAL locomotion, *LABORATORY mice, *CLINICAL trials, *TREATMENT effectiveness, *MICE

Brexpiprazole has a low risk of dopamine D2 receptor sensitization and inhibits rebound phenomena related to D2 and serotonin 5‐HT2A receptors in rats

Authors: Amada, Naoki, Akazawa, Hitomi, Ohgi, Yuta, Maeda, Kenji, Sugino, Haruhiko, Kurahashi, Nobuyuki, Kikuchi, Tetsuro, Futamura, Takashi

Source: Neuropsychopharmacology reports. 39(4):279-288

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093716949.0x000001&indx=1&recIds=ETOCvdc_100093716949.0x000001

Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator

Authors: Maeda, Kenji ^*, Sugino, Haruhiko, Akazawa, Hitomi, Amada, Naoki, Shimada, Jun, Futamura, Takashi, Yamashita, Hiroshi, Ito, Nobuaki, McQuade, Robert D., Mørk, Arne, Pehrson, Alan L., Hentzer, Morten, Nielsen, Vibeke, Bundgaard, Christoffer, Arnt, Jørn, Stensbøl, Tine Bryan, Kikuchi, Tetsuro

Source: In The Journal of Pharmacology and Experimental Therapeutics September 2014 350(3):589-604

Brexpiprazole II: Antipsychotic-Like and Procognitive Effects of a Novel Serotonin-Dopamine Activity Modulator

Authors: Maeda, Kenji ^*, Lerdrup, Linda, Sugino, Haruhiko, Akazawa, Hitomi, Amada, Naoki, McQuade, Robert D., Stensbøl, Tine Bryan, Bundgaard, Christoffer, Arnt, Jørn, Kikuchi, Tetsuro

Source: In The Journal of Pharmacology and Experimental Therapeutics September 2014 350(3):605-614

N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors

Global Trends in Alzheimer Disease Clinical Development: Increasing the Probability of Success

Authors: Sugino, Haruhiko, Watanabe, Akihito, Amada, Naoki, Yamamoto, Miho, Ohgi, Yuta, Kostic, Dusan, Sanchez, Raymond

Source: Clinical therapeutics. 37(8):1632-1642

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100032601089.0x000001&indx=1&recIds=ETOCvdc_100032601089.0x000001

N-N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS

N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors

N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS

A Novel Rat Orthologue and Homologue for the Drosophila crooked neck Gene in Neural Stem Cells and Their Immediate Descendants.

Authors: Amada, Naoki¹ hnawa@bri.niigata-u.ac.jp, Tezuka, Tomoyuki², Mayeda, Akila³, Araki, Kazuaki¹, Takei, Nobuyuki¹, Todokoro, Kazuo⁴, Nawa, Hiroyuki¹ hnawa@bri.niigata-u.ac.jp

Source: Journal of Biochemistry. May2003, Vol. 133 Issue 5, p615-623. 9p.

Subject Terms: *LABORATORY rats, *NEURAL stem cells, *DROSOPHILA, *MESSENGER RNA, *CELL differentiation

Brexpiprazole has a low risk of dopamine D2 receptor sensitization and inhibits rebound phenomena related to D2 and serotonin 5‐HT2A receptors in rats.

Authors: Amada, Naoki¹ (AUTHOR) amada.naoki@otsuka.jp, Akazawa, Hitomi¹ (AUTHOR), Ohgi, Yuta¹ (AUTHOR), Maeda, Kenji² (AUTHOR), Sugino, Haruhiko³ (AUTHOR), Kurahashi, Nobuyuki⁴ (AUTHOR), Kikuchi, Tetsuro⁵ (AUTHOR), Futamura, Takashi¹ (AUTHOR)

Source: Neuropsychopharmacology Reports. Dec2019, Vol. 39 Issue 4, p279-288. 10p.

Subject Terms: *DOPAMINE antagonists, *APOMORPHINE, *SEROTONIN receptors, *DOPAMINE receptors, *RATS, *TARDIVE dyskinesia, *PEOPLE with schizophrenia

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Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour

Authors: Deiana, Serena, Watanabe, Akihito, Yamasaki, Yuki, Amada, Naoki, Arthur, Marlene, Fleming, Shona, Woodcock, Hilary, Dorward, Patricia, Pigliacampo, Barbara, Close, Steve, Platt, Bettina, Riedel, Gernot

Source: Psychopharmacology; Feb2012, Vol. 219 Issue 3, p859-873, 15p

Subject Terms: PHARMACODYNAMICS, PHARMACOKINETICS, CANNABINOIDS, BIOAVAILABILITY, CONSTIPATION, LABORATORY rats, LABORATORY mice

Reduction of NR1 and phosphorylated Ca2calmodulin-dependent protein kinase II levels in Alzheimer's disease

Authors: Amada, Naoki, Aihara, Koutoku, Ravid, Rivka, Horie, Masato

Source: NeuroReport; November 2005, Vol. 16 Issue: 16 p1809-1813, 5p

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