Biobank-wide association scan identifies risk factors for late-onset Alzheimer’s disease and endophenotypes

Authors: Donghui Yan, Bowen Hu, Burcu F Darst, Shubhabrata Mukherjee, Brian W Kunkle, Yuetiva Deming, Logan Dumitrescu, Yunling Wang, Adam Naj, Amanda Kuzma, Yi Zhao, Hyunseung Kang, Sterling C Johnson, Cruchaga Carlos, Timothy J Hohman, Paul K Crane, Corinne D Engelman, Alzheimer’s Disease Genetics Consortium (ADGC), Qiongshi Lu

Source: eLife, Vol 12 (2024)

Subject Terms: Alzheimer's disease, GWAS, UK-biobank, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/91360; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/70e5d04b97aa44e69655821a17499202

Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

Authors: Laura Heath, John C. Earls, Andrew T. Magis, Sergey A. Kornilov, Jennifer C. Lovejoy, Cory C. Funk, Noa Rappaport, Benjamin A. Logsdon, Lara M. Mangravite, Brian W. Kunkle, Eden R. Martin, Adam C. Naj, Nilüfer Ertekin-Taner, Todd E. Golde, Leroy Hood, Nathan D. Price, Alzheimer’s Disease Genetics Consortium

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/16f2fcd1b96e47098d8b9f2e9f36d3ec

Genetically regulated expression in late-onset Alzheimer’s disease implicates risk genes within known and novel loci

Authors: Hung-Hsin Chen, Lauren E. Petty, Jin Sha, Yi Zhao, Amanda Kuzma, Otto Valladares, Alzheimer’s Disease Genetics Consortium, International Genomics of Alzheimer’s Project, William Bush, Adam C. Naj, Eric R. Gamazon, Jennifer E. Below

Source: Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2158-3188

Access URL: https://doaj.org/article/0f502839818045e6bbdef11e4cc55717

Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study

Authors: Adam J. Dugan, Peter T. Nelson, Yuriko Katsumata, Lincoln M. P. Shade, Kevin L. Boehme, Merilee A. Teylan, Matthew D. Cykowski, Shubhabrata Mukherjee, John S. K. Kauwe, Timothy J. Hohman, Julie A. Schneider, Alzheimer’s Disease Genetics Consortium, David W. Fardo

Source: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)

Subject Terms: Dementia, Proteinopathy, Pleiotropy, Arteriolosclerosis, SNP, Mixed pathology, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/72aff6c422274975afc0f86f16c43120

Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes

Authors: Aamira J. Huq, Brian Fulton‐Howard, Moeen Riaz, Simon Laws, Robert Sebra, Joanne Ryan, Alzheimer's Disease Genetics Consortium, Alan E. Renton, Alison M. Goate, Colin L. Masters, Elsdon Storey, Raj C. Shah, Anne Murray, John McNeil, Ingrid Winship, Paul A. James, Paul Lacaze

Source: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)

Subject Terms: Alzheimer's disease, Alzheimer's disease dementia, apolipoprotein E, dementia resilience, genetic modifiers, polygenic risk score, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/2352-8729

Access URL: https://doaj.org/article/387760b7d6144ea9bf93f60133cee4dd

Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease

Authors: Jaeyoon Chung, Xiaoling Zhang, Mariet Allen, Xue Wang, Yiyi Ma, Gary Beecham, Thomas J. Montine, Steven G. Younkin, Dennis W. Dickson, Todd E. Golde, Nathan D. Price, Nilüfer Ertekin-Taner, Kathryn L. Lunetta, Jesse Mez, Alzheimer’s Disease Genetics Consortium, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak-Vance, Gerard Schellenberg, Gyungah R. Jun, Lindsay A. Farrer

Source: Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-12 (2018)

Subject Terms: Alzheimer’s disease, Neuropathological traits, Genome-wide association study, Pleiotropy analysis, HDAC9, ECRG4, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13195-018-0349-z; https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/a58607a50c8d49d3aa6af148bdb402bb

Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.

Authors: Celeste M Karch, Lubov A Ezerskiy, Sarah Bertelsen, Alzheimer’s Disease Genetics Consortium (ADGC), Alison M Goate

Source: PLoS ONE, Vol 11, Iss 2, p e0148717 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4769299?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/0272b8ef3d274ad5bdb6fb5379b4b5ae

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study.

Authors: Søren D Østergaard, Shubhabrata Mukherjee, Stephen J Sharp, Petroula Proitsi, Luca A Lotta, Felix Day, John R B Perry, Kevin L Boehme, Stefan Walter, John S Kauwe, Laura E Gibbons, Alzheimer’s Disease Genetics Consortium, GERAD1 Consortium, EPIC-InterAct Consortium, Eric B Larson, John F Powell, Claudia Langenberg, Paul K Crane, Nicholas J Wareham, Robert A Scott

Source: PLoS Medicine, Vol 12, Iss 6, p e1001841; discussion e1001841 (2015)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1549-1277; https://doaj.org/toc/1549-1676

Access URL: https://doaj.org/article/8e823bfa41d34758a47b666711191f25

Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.

Authors: Gary W Beecham, Kara Hamilton, Adam C Naj, Eden R Martin, Matt Huentelman, Amanda J Myers, Jason J Corneveaux, John Hardy, Jean-Paul Vonsattel, Steven G Younkin, David A Bennett, Philip L De Jager, Eric B Larson, Paul K Crane, M Ilyas Kamboh, Julia K Kofler, Deborah C Mash, Linda Duque, John R Gilbert, Harry Gwirtsman, Joseph D Buxbaum, Patricia Kramer, Dennis W Dickson, Lindsay A Farrer, Matthew P Frosch, Bernardino Ghetti, Jonathan L Haines, Bradley T Hyman, Walter A Kukull, Richard P Mayeux, Margaret A Pericak-Vance, Julie A Schneider, John Q Trojanowski, Eric M Reiman, Alzheimer's Disease Genetics Consortium (ADGC), Gerard D Schellenberg, Thomas J Montine

Source: PLoS Genetics, Vol 10, Iss 9, p e1004606 (2014)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25188341/?tool=EBI; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/16fab959c9274eda9e554f003340125a

Alzheimer's disease: analyzing the missing heritability.

Authors: Perry G Ridge, Shubhabrata Mukherjee, Paul K Crane, John S K Kauwe, Alzheimer’s Disease Genetics Consortium

Source: PLoS ONE, Vol 8, Iss 11, p e79771 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244562/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/587e51c7b17945c7b0be9847d701f96c

Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.

Authors: Fanggeng Zou, High Seng Chai, Curtis S Younkin, Mariet Allen, Julia Crook, V Shane Pankratz, Minerva M Carrasquillo, Christopher N Rowley, Asha A Nair, Sumit Middha, Sooraj Maharjan, Thuy Nguyen, Li Ma, Kimberly G Malphrus, Ryan Palusak, Sarah Lincoln, Gina Bisceglio, Constantin Georgescu, Naomi Kouri, Christopher P Kolbert, Jin Jen, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg, Alzheimer's Disease Genetics Consortium, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Taner

Source: PLoS Genetics, Vol 8, Iss 6, p e1002707 (2012)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3369937?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/a148bd6289944186a3a7dd01c3a33cac

Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90.

Authors: Heath, Laura, Earls, John C., Magis, Andrew T., Kornilov, Sergey A., Lovejoy, Jennifer C., Funk, Cory C., Rappaport, Noa, Logsdon, Benjamin A., Mangravite, Lara M., Kunkle, Brian W., Martin, Eden R., Naj, Adam C., Ertekin-Taner, Nilüfer, Golde, Todd E., Hood, Leroy, Price, Nathan D., Alzheimer's Disease Genetics Consortium, Abner, Erin, Adams, Perrie M., Albert, Marilyn S.

Source: Scientific Reports; 4/12/2022, Vol. 12 Issue 1, p1-17, 17p

Subject Terms: DISEASE risk factors, METABOLOMICS, GENETIC variation, SEX (Biology), MONOGENIC & polygenic inheritance (Genetics)

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Genome-wide association studies of CSF biomarkers

Authors: Kauwe, John, Cruchaga, Carlos, McKean, David, Bailey, Matthew, Patty, David, Mayo, Kevin, Bertelsen, Sarah, Hinrichs, Anthony, the Alzheimer's Disease Neuroimaging Initiative, The Alzheimer's Disease Genetics Consortium, Fagan, Anne, Holtzman, David, Goate, Alison

Source: In Alzheimer's & Dementia: The Journal of the Alzheimer's Association July 2011 7(4) Supplement:S85-S85

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TREM2 and neurodegenerative disease.

Authors: Reitz, Christiane, Mayeux, Richard, Alzheimer's Disease Genetics Consortium, Alzheimer’s Disease Genetics Consortium

Source: New England Journal of Medicine; 10/17/2013, Vol. 369 Issue 16, p1564-1565, 2p

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Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease.

Authors: Chung, Jaeyoon, Zhang, Xiaoling, Allen, Mariet, Wang, Xue, Ma, Yiyi, Beecham, Gary, Montine, Thomas J., Younkin, Steven G., Dickson, Dennis W., Golde, Todd E., Price, Nathan D., Ertekin-Taner, Nilüfer, Lunetta, Kathryn L., Mez, Jesse, Alzheimer’s Disease Genetics Consortium, Mayeux, Richard, Haines, Jonathan L., Pericak-Vance, Margaret A., Schellenberg, Gerard, Jun, Gyungah R.

Source: Alzheimer's Research & Therapy; 2/20/2018, Vol. 10, p1-1, 1p

Subject Terms: ALZHEIMER'S disease treatment, CEREBRAL amyloid angiopathy, SINGLE nucleotide polymorphisms, NEUROFIBRILLARY tangles, QUANTITATIVE research, GENE expression