Polar-Radical Cyclization Cascades with Magnesiated Nitriles

Authors: Bolgunas, Stephen, Paleo, Ehecatl, Alwedi, Embarek, Wei, Yunjing, Keller, Taylor M., Fleming, Fraser F.

Source: Organic letters. 25(19):3512-3516

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Manufacturing Process Development for Belzutifan, Part 5: A Streamlined Fluorination—Dynamic Kinetic Resolution Process

Authors: Wang, Tao, Phillips, Eric M., Dalby, Stephen M., Sirota, Eric, Axnanda, Stephanus, Shultz, C. Scott, Patel, Pratiq, Waldman, Jacob H., Alwedi, Embarek, Wang, Xiao

Source: Organic process research & development. 26(3):543-550

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Development and Demonstration of a Co-feed Process to Address Form and Physical Attribute Control of the Gefapixant (MK-7264) Citrate Active Pharmaceutical Ingredient

Authors: Mohan, Anne E., DiBenedetto, Michael, Alwedi, Embarek, Ang, Yee Swan, Sihombing, Muhammad Sofian Bin Asi, Chang, Hsieh Yao D., Cote, Aaron, Desmond, Richard, Diaz-Santana, Anthony, Khong, Eric

Source: Organic process research & development. 25(3):541-551

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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 5: Completion of the API Free Base via a Direct Chlorosulfonylation Process

Authors: Di Maso, Michael J., Ren, Hong, Zhang, Si-Wei, Liu, Wenjun, Desmond, Richard, Alwedi, Embarek, Narsimhan, Karthik, Kalinin, Alexei, Larpent, Patrick, Lee, Alfred Y.

Source: Organic process research & development. 24(11):2491-2497

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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview

Authors: Ren, Hong, Maloney, Kevin M., Basu, Kallol, Di Maso, Michael J., Humphrey, Guy R., Peng, Feng, Desmond, Richard, Otte, Douglas A. L., Alwedi, Embarek, Liu, Wenjun

Source: Organic process research & development. 24(11):2445-2452

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Isocyanide Purification: C-2 Silica Cleans Up a Dirty Little Secret

Authors: Chao, Allen, Alwedi, Embarek, Fleming, Fraser

Source: Synthesis. 51(10):2122-2127

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Development of a derivatization RP-HPLC method for determination of sulfuryl chloride in chlorosulfonic acid for gefapixant citrate manufacture

Authors: Huang, Chunli, Song, Siqing, Liu, Wenjun, Parganiha, Priya, Zhuang, Ping, Lohani, Sachin, Alwedi, Embarek, Ren, Hong, Bishara, Daniel, Chang, Hsieh Yao D.

Source: Journal of pharmaceutical and biomedical analysis. 215

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Exploration of the utility of CF3+ as a reagent for chemical ionisation reaction mass spectrometry

Authors: Blake, Robert S., Ouheda, Saleh A., Alwedi, Embarek F., Monks, Paul S.

Source: In International Journal of Mass Spectrometry October 2017 421:224-233

Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation as a Batch–Flow Process.

Authors: Otte, Douglas A. L., Larson, Reed T., Alwedi, Embarek, Armiger, Travis, Chen, Yonggang, Chung, Cheol K., Corry, James, Desmond, Richard, Fier, Patrick S., Franklin, Robert D., Guetschow, Erik D., Hall, Jackson R., Halsey, Holst M., Hartmanshenn, Clara, Jellett, Lisa, Kuhl, Nadine, Lévesque, François, McMullen, Jonathan P., Patel, Pratiq A., Paulines, Mellie June

Source: Organic Process Research & Development; 5/17/2024, Vol. 28 Issue 5, p1402-1410, 9p

Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan.

Authors: Cheung‐Lee, Wai Ling¹, wai.ling.cheung-lee@merck.com, Kolev, Joshua N.¹, joshua.kolev@merck.com, McIntosh, John A.¹, Gil, Agnieszka A.¹, Pan, Weilan¹, Xiao, Li², Velásquez, Juan E.¹, Gangam, Rekha³, Winston, Matthew S.¹, Li, Shasha³, Abe, Kotoe⁴, Alwedi, Embarek¹, Dance, Zachary E. X.³, Fan, Haiyang⁵, Hiraga, Kaori¹, Kim, Jungchul¹, Kosjek, Birgit¹, Le, Diane N.¹, Marzijarani, Nastaran Salehi¹, Mattern, Keith¹

Source: Angewandte Chemie International Edition; 3/22/2024, Vol. 63 Issue 13, p1-9, 9p

Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 5Chemoenzymatic Diastereoselective Fluorination/DKR.

Authors: McCann, Scott D., Dubina, Sean H., Kosjek, Birgit, Alwedi, Embarek, Behre, Taylor, Burgess, Samantha A., Dal Poggetto, Guilherme, DiRocco, Daniel A., Hartmanshenn, Clara, McMullen, Jonathan P., Padivitage, Nilusha, Sun, Alexandra C.

Source: Organic Process Research & Development; 2/16/2024, Vol. 28 Issue 2, p441-450, 10p

Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 6Development of a Nucleophilic Aromatic Substitution in Water.

Authors: Le, Diane N., Wright, Timothy J., Alwedi, Embarek, Hartmanshenn, Clara, Li, Hong, McMullen, Jonathan P., DiRocco, Daniel A.

Source: Organic Process Research & Development; 2/16/2024, Vol. 28 Issue 2, p451-459, 9p

Dearomatization of aromatic asmic isocyanides to complex cyclohexadienes.

Authors: Altundas, Bilal, Alwedi, Embarek, Song, Zhihui, Gogoi, Achyut Ranjan, Dykstra, Ryan, Gutierrez, Osvaldo, Fleming, Fraser F.

Source: Nature Communications; 10/28/2022, Vol. 13 Issue 1, p1-8, 8p

Subject Terms: ISOCYANIDES, CARBON-carbon bonds, ORGANIC synthesis, CYCLOHEXADIENE

Manufacturing Process Development for Belzutifan, Part 5: A Streamlined Fluorination–Dynamic Kinetic Resolution Process.

Authors: Tao Wang, Phillips, Eric M., Dalby, Stephen M., Sirota, Eric, Axnanda, Stephanus, Shultz, C. Scott, Patel, Pratiq, Waldman, Jacob H., Alwedi, Embarek, Xiao Wang, Zawatzky, Kerstin, Chow, Matthew, Padivitage, Nilusha, Weisel, Mark, Whittington, Michael, Jianjun Duan, Taotao Lu

Source: Organic Process Research & Development; 3/18/2022, Vol. 26 Issue 3, p543-550, 8p

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process.

Authors: Maloney, Kevin M., Zhang, Si-Wei, Mohan, Anne E., Lee, Alfred Y., Larpent, Patrick, Ren, Hong, Humphrey, Guy R., Desmond, Richard, DiBenedetto, Michael, Liu, Wenjun, Lee, Ivan H., Sirota, Eric, Di Maso, Michael J., Alwedi, Embarek, Song, Siqing, Chang, Hsieh Yao D.

Source: Organic Process Research & Development; 11/20/2020, Vol. 24 Issue 11, p2498-2504, 7p

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Oxazole Synthesis by Sequential Asmic-Ester Condensations and Sulfanyl–Lithium Exchange–Trapping

Authors: Mueller, Louis G., Chao, Allen, Alwedi, Embarek, Natrajan, Maanasa, Fleming, Fraser F.

Source: Organic Letters; February 2021, Vol. 23 Issue: 4 p1500-1503, 4p

Asmic Isocyanide‐Nitrile Isomerization‐Alkylations.

Authors: Alwedi, Embarek¹ (AUTHOR), Lujan‐Montelongo, J. Armando² (AUTHOR), Cortés‐Mejía, Rodrigo³ (AUTHOR), del Campo, Jorge M.³ (AUTHOR) jmdelc@unam.mx, Altundas, Bilal⁴ (AUTHOR), Fleming, Fraser F.⁴ (AUTHOR) fleming@drexel.edu

Source: European Journal of Organic Chemistry. 8/7/2019, Vol. 2019 Issue 29, p4644-4648. 5p.

Subject Terms: *CHELATION, *CHELATING agents

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Chain Extension of Boronic Esters with Lithiooxiranes Generated by Sulfoxide-Metal Exchange - Stereocontrolled Access to 2°/2°, 2°/3°, and 3°/3° Vicinal Diols and Related Compounds.

Authors: Alwedi, Embarek¹, Zakharov, Lev N.¹, Blakemore, Paul R.¹, paul.blakemore@science.oregonstate.edu

Source: European Journal of Organic Chemistry; Oct2014, Vol. 2014 Issue 30, p6643-6648, 6p