Preclinical development of a replication-competent vesicular stomatitis virus-based Lassa virus vaccine candidate advanced into human clinical trials

Authors: Cooper, Christopher L. ^{a, i}, Morrow, Gavin ^{a, i}, Yuan, Maoli ^a, Postler, Thomas S. ^a, Neal, Maxwell L. ^f, Cross, Robert W. ^{c, d}, Woolsey, Courtney ^{c, d}, Agans, Krystle N. ^{c, d}, Borisevich, Viktoriya ^{c, d}, McNamara, Ryan P. ^e, Atyeo, Caroline ^e, Roy, Vicky ^e, Germosen, Daritza ^e, Hou, Fuxiang ^a, Li, Shui L. ^a, Reiserova, Lucia ^a, Choi, Yesle ^a, Wilson, Aaron ^a, Wagner, Denise ^a, Wallace-Selman, Olivia ^a, Carpov, Alexei ^a, Geng, Fuqiang ^a, Frederick, Deborah J. ^a, DeStefano, Joanne ^a, Ercolini, Anne M. ^a, Enriquez, Adrian S. ^h, Hastie, Kathryn M. ^h, Ramos da Silva, Suzane ^a, Sayeed, Eddy ^b, Coleman, John W. ^a, Kilianski, Andrew ^b, Alter, Galit ^e, Saphire, Erica Ollmann ^h, Aitchison, John D. ^{f, g}, Geisbert, Thomas W. ^{c, d}, Gupta, Swati B. ^b, Feinberg, Mark B. ^b, Parks, Christopher L. ^{a, ∗}

Source: In eBioMedicine April 2025 114

Humoral correlates of protection against Mycobacterium tuberculosis following intravenous BCG vaccination in rhesus macaques

Authors: Irvine, Edward B. ^{1, 2}, Darrah, Patricia A. ³, Wang, Shu ⁴, Wang, Chuangqi ^{4, 6}, McNamara, Ryan P. ¹, Roederer, Mario ³, Seder, Robert A. ³, Lauffenburger, Douglas A. ^{4, 7}, Flynn, JoAnne L. ^{5, 7}, Fortune, Sarah M. ^{1, 2, 7, ∗}, Alter, Galit ^{1, 7, 8, ∗∗}

Source: In iScience 20 December 2024 27(12)

Markov field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques

Authors: Wang, Shu, Myers, Amy J., Irvine, Edward B., Wang, Chuangqi, Maiello, Pauline, Rodgers, Mark A., Tomko, Jaime, Kracinovsky, Kara, Borish, H. Jacob, Chao, Michael C., Mugahid, Douaa, Darrah, Patricia A., Seder, Robert A., Roederer, Mario, Scanga, Charles A., Lin, Philana Ling, Alter, Galit, Fortune, Sarah M., Flynn, JoAnne L., Lauffenburger, Douglas A.

Source: In Cell Systems 18 December 2024 15(12):1278-1294

Determinants of immune responses predictive of protection against shigellosis in an endemic zone: a systems analysis of antibody profiles and function

Authors: Bernshtein, Biana, Kelly, Meagan, Cizmeci, Deniz, Zhiteneva, Julia A, Macvicar, Ryan, Kamruzzaman, Mohammad, Bhuiyan, Taufiqur R, Chowdhury, Fahima, Khan, Ashraful Islam, Qadri, Firdausi, Charles, Richelle C, Xu, Peng, Kováč, Pavol, Clarkson, Kristen A, Kaminski, Robert W, Alter, Galit, Ryan, Edward T

Source: In The Lancet Microbe October 2024 5(10)

SARS-CoV-2 infection prior to vaccination amplifies Fc-mediated humoral profiles in an age-dependent manner

Authors: Jung, Wonyeong, Abdelnour, Arturo, Kaplonek, Paulina, Herrero, Rolando, Shih-Lu Lee, Jessica, Barbati, Domenic R., Chicz, Taras M., Levine, Kate S., Fantin, Romain Clement, Loria, Viviana, Porras, Carolina, Lauffenburger, Douglas A., Gail, Mitchell H., Aparicio, Amada, Hildesheim, Allan, Alter, Galit, McNamara, Ryan P.

Source: In Cell Reports 24 September 2024 43(9)

Transforming vaccinology

Authors: Rappuoli, Rino, Alter, Galit, Pulendran, Bali

Source: In Cell 19 September 2024 187(19):5171-5194

Longitudinal humoral analysis in RSV-infected infants identifies pre-existing RSV strain-specific G and evolving cross-reactive F antibodies

Authors: Nziza, Nadège, Jung, Wonyeong, Mendu, Maanasa, Chen, Tina, Julg, Boris, Graham, Barney, Ramilo, Octavio, Mejias, Asuncion, Alter, Galit

Source: In Immunity 9 July 2024 57(7):1681-1695

Borrelia-specific antibody profiles and complement deposition in joint fluid distinguish antibiotic-refractory from -responsive Lyme arthritis

Authors: Bowman, Kathryn A. ^{1, 2, 9}, Wiggins, Christine D. ^{3, 9}, DeRiso, Elizabeth ¹, Paul, Steffan ⁴, Strle, Klemen ⁵, Branda, John A. ⁶, Steere, Allen C. ^{7, ∗}, Lauffenburger, Douglas A. ^{3, 10, ∗∗}, Alter, Galit ^{1, 8, ∗∗∗}

Source: In iScience 16 February 2024 27(2)

Beta-spike-containing boosters induce robust and functional antibody responses to SARS-CoV-2 in macaques primed with distinct vaccines

Authors: Deng, Yixiang, Atyeo, Caroline, Yuan, Dansu, Chicz, Taras M., Tibbitts, Timothy, Gorman, Matthew, Taylor, Sabian, Lecouturier, Valerie, Lauffenburger, Douglas A., Chicz, Roman M., Alter, Galit, McNamara, Ryan P.

Source: In Cell Reports 28 November 2023 42(11)

Multimodal, broadly neutralizing antibodies against SARS-CoV-2 identified by high-throughput native pairing of BCRs from bulk B cells

Authors: Keitany, Gladys J., Rubin, Benjamin E.R., Garrett, Meghan E., Musa, Andrea, Tracy, Jeff, Liang, Yu, Ebert, Peter, Moore, Amanda J., Guan, Jonathan, Eggers, Erica, Lescano, Ninnia, Brown, Ryan, Carbo, Adria, Al-Asadi, Hussein, Ching, Travers, Day, Austin, Harris, Rebecca, Linkem, Charles, Popov, Dimitry, Wilkins, Courtney, Li, Lianqu, Wang, Jiao, Liu, Chuanxin, Chen, Li, Dines, Jennifer N., Atyeo, Caroline, Alter, Galit, Baldo, Lance, Sherwood, Anna, Howie, Bryan, Klinger, Mark, Yusko, Erik, Robins, Harlan S., Benzeno, Sharon, Gilbert, Amy E.

Source: In Cell Chemical Biology 16 November 2023 30(11):1377-1389

IFN-γ independent markers of Mycobacterium tuberculosis exposure among male South African gold miners

Authors: Davies, Leela R.L., Smith, Malisa T., Cizmeci, Deniz, Fischinger, Stephanie, Shih-Lu Lee, Jessica, Lu, Lenette L., Layton, Erik D., Grant, Alison D., Fielding, Katherine, Stein, Catherine M., Boom, W. Henry, Hawn, Thomas R., Fortune, Sarah M., Wallis, Robert S., Churchyard, Gavin J., Alter, Galit, Seshadri, Chetan

Source: In eBioMedicine July 2023 93

Airway T cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques

Authors: Darrah, Patricia A., Zeppa, Joseph J., Wang, Chuangqi, Irvine, Edward B., Bucsan, Allison N., Rodgers, Mark A., Pokkali, Supriya, Hackney, Joshua A., Kamath, Megha, White, Alexander G., Borish, H. Jacob, Frye, L. James, Tomko, Jaime, Kracinovsky, Kara, Lin, Philana Ling, Klein, Edwin, Scanga, Charles A., Alter, Galit, Fortune, Sarah M., Lauffenburger, Douglas A., Flynn, JoAnne L., Seder, Robert A., Maiello, Pauline, Roederer, Mario

Source: In Cell Host & Microbe 14 June 2023 31(6):962-977

Selective SARS-CoV2 BA.2 escape of antibody Fc/Fc-receptor interactions

Authors: Bartsch, Yannic C. ¹, Cizmeci, Deniz ¹, Kang, Jaewon ¹, Gao, Hailong ², Shi, Wei ², Chandrashekar, Abishek ³, Collier, Ai-ris Y. ³, Chen, Bing ², Barouch, Dan H. ^{1, 3}, Alter, Galit ^{1, 4, ∗}

Source: In iScience 19 May 2023 26(5)

Antibodies against the Ebola virus soluble glycoprotein are associated with long-term vaccine-mediated protection of non-human primates

Authors: Gunn, Bronwyn M., McNamara, Ryan P., Wood, Lianna, Taylor, Sabian, Devadhasan, Anush, Guo, Wenyu, Das, Jishnu, Nilsson, Avlant, Shurtleff, Amy, Dubey, Sheri, Eichberg, Michael, Suscovich, Todd J., Saphire, Erica Ollmann, Lauffenburger, Douglas, Coller, Beth-Ann, Simon, Jakub K., Alter, Galit

Source: In Cell Reports 25 April 2023 42(4)

Fc-mediated pan-sarbecovirus protection after alphavirus vector vaccination

Authors: Adams, Lily E., Leist, Sarah R., Dinnon, Kenneth H., III, West, Ande, Gully, Kendra L., Anderson, Elizabeth J., Loome, Jennifer F., Madden, Emily A., Powers, John M., Schäfer, Alexandra, Sarkar, Sanjay, Castillo, Izabella N., Maron, Jenny S., McNamara, Ryan P., Bertera, Harry L., Zweigart, Mark R., Higgins, Jaclyn S., Hampton, Brea K., Premkumar, Lakshmanane, Alter, Galit, Montgomery, Stephanie A., Baxter, Victoria K., Heise, Mark T., Baric, Ralph S.

Source: In Cell Reports 25 April 2023 42(4)

Discrepancy between Mtb-specific IFN-γ and IgG responses in HIV-positive people with low CD4 counts

Authors: Mthembu, Maphe, Bowman, Kathryn A., Davies, Leela R.L., Khuzwayo, Sharon, Mazibuko, Lusanda, Bassett, Thierry, Ramjit, Dirhona, Mhlane, Zoey, Karim, Farina, Alter, Galit, Ndung'u, Thumbi, Wong, Emily B.

Source: In eBioMedicine April 2023 90

Diagnostic TR-FRET assays for detection of antibodies in patient samples

Authors: Yue, Hong, Nowak, Radosław P., Overwijn, Daan, Payne, N. Connor, Fischinger, Stephanie, Atyeo, Caroline, Lam, Evan C., St. Denis, Kerri, Brais, Lauren K., Konishi, Yoshinobu, Sklavenitis-Pistofidis, Romanos, Baden, Lindsey R., Nilles, Eric J., Karlson, Elizabeth W., Yu, Xu G., Li, Jonathan Z., Woolley, Ann E., Ghobrial, Irene M., Meyerhardt, Jeffrey A., Balazs, Alejandro B., Alter, Galit, Mazitschek, Ralph, Fischer, Eric S.

Source: In Cell Reports Methods 27 March 2023 3(3)

Antibody effector functions are associated with protection from respiratory syncytial virus

Authors: Bartsch, Yannic C., Cizmeci, Deniz, Kang, Jaewon, Zohar, Tomer, Periasamy, Sivakumar, Mehta, Nickita, Tolboom, Jeroen, Van der Fits, Leslie, Sadoff, Jerry, Comeaux, Christy, Callendret, Benoit, Bukreyev, Alexander, Lauffenburger, Douglas A., Bastian, Arangassery Rosemary, Alter, Galit

Source: In Cell 22 December 2022 185(26):4873-4886

A multifaceted high-throughput assay for probing antigen-specific antibody-mediated primary monocyte phagocytosis and downstream functions

Authors: Zohar, Tomer, Atyeo, Caroline, Wolf, Caitlin R., Logue, Jennifer K., Shuey, Kiel, Franko, Nicholas, Choi, Robert Y., Wald, Anna, Koelle, David M., Chu, Helen Y., Lauffenburger, Douglas A., Alter, Galit

Source: In Journal of Immunological Methods November 2022 510

The next frontier in vaccine design: blending immune correlates of protection into rational vaccine design

Authors: Britto, Carl, Alter, Galit

Source: In Current Opinion in Immunology October 2022 78