P16 INK4A drives nonalcoholic fatty liver disease phenotypes in high fat diet fed mice through biliary E2F1/FOXO1/IGF-1 signaling

Authors: Kundu, Debjyoti, Kennedy, Lindsey, Zhou, Tianhao, Ekser, Burcin, Meadows, Vik, Sybenga, Amelia, Kyritsi, Konstantina, Chen, Lixian, Ceci, Ludovica, Wu, Nan, Wu, Chaodong, Glaser, Shannon, Carpino, Guido, Onori, Paolo, Gaudio, Eugenio, Alpini, Gianfranco, Francis, Heather

Source: Hepatology. 78(1):243-257

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191469827.0x000001&indx=1&recIds=ETOCvdc_100191469827.0x000001

Prolonged administration of a secretin receptor antagonist inhibits biliary senescence and liver fibrosis in Mdr2−/− mice

Authors: Wu, Nan, Zhou, Tianhao, Carpino, Guido, Baiocchi, Leonardo, Kyritsi, Konstantina, Kennedy, Lindsey, Ceci, Ludovica, Chen, Lixian, Wu, Chaodong, Kundu, Debjyoti, Barupala, Nipuni, Franchitto, Antonio, Onori, Paolo, Ekser, Burcin, Gaudio, Eugenio, Francis, Heather, Glaser, Shannon, Alpini, Gianfranco

Source: Hepatology. 77(6):1849-1865

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191135345.0x000001&indx=1&recIds=ETOCvdc_100191135345.0x000001

Secretin alleviates biliary and liver injury during late-stage primary biliary cholangitis via restoration of secretory processes

Authors: Kennedy, Lindsey, Carpino, Guido, Owen, Travis, Ceci, Ludovica, Kundu, Debjyoti, Meadows, Vik, Kyritsi, Konstantina, Franchitto, Antonio, Onori, Paolo, Isidan, Abdulkadir, Zhang, Wenjun, Ekser, Burcin, Alvaro, Domenico, Gaudio, Eugenio, Gershwin, M. Eric, Francis, Heather, Glaser, Shannon, Alpini, Gianfranco

Source: Journal of hepatology. 78(1):99-113

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185229376.0x000001&indx=1&recIds=ETOCvdc_100185229376.0x000001

Hepatocyte Adenosine Kinase Promotes Excessive Fat Deposition and Liver Inflammation

Authors: Li, Honggui, Zheng, Juan, Xu, Qian, Yang, Yongjian, Zhou, Jing, Guo, Xinlei, Cai, Yongfeng, Cai, James J., Xie, Linglin, Awika, Joseph, Han, Xianlin, Li, Qingsheng, Kennedy, Lindsey, Francis, Heather, Glaser, Shannon, Huo, Yuqing, Alpini, Gianfranco, Wu, Chaodong

Source: Gastroenterology. 164(1):134-146

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177941537.0x000001&indx=1&recIds=ETOCvdc_100177941537.0x000001

Development of Scaffold-Free Three-Dimensional Cholangiocyte Organoids to Study the Progression of Primary Sclerosing Cholangitis

Authors: Zhang, Wenjun, Kyritsi, Konstantina, Isidan, Abdulkadir, Park, Yujin, Li, Ping, Cross-Najafi, Arthur A., Lopez, Kevin, Kennedy, Lindsey, Sato, Keisaku, Glaser, Shannon, Francis, Heather, Alpini, Gianfranco, Ekser, Burcin

Source: In The American Journal of Pathology September 2023 193(9):1156-1169

Endothelin Receptor-A Inhibition Decreases Ductular Reaction, Liver Fibrosis, and Angiogenesis in a Model of Cholangitis

Authors: Owen, Travis, Carpino, Guido, Chen, Lixian, Kundu, Debjyoti, Wills, Payton, Ekser, Burcin, Onori, Paolo, Gaudio, Eugenio, Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey

Source: In Cellular and Molecular Gastroenterology and Hepatology 2023 16(4):513-540

Mast cells in liver disease progression: An update on current studies and implications

Authors: Pham, Linh, Kennedy, Lindsey, Baiocchi, Leonardo, Meadows, Vik, Ekser, Burcin, Kundu, Debjyoti, Zhou, Tianhao, Sato, Keisaku, Glaser, Shannon, Ceci, Ludovica, Alpini, Gianfranco, Francis, Heather

Source: Hepatology. 75(1):213-218

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100143331168.0x000001&indx=1&recIds=ETOCvdc_100143331168.0x000001

Lipid nanoparticles for oral delivery of nucleic acids for treating inflammatory bowel disease

Authors: Yang, Chunhua, Alpini, Gianfranco, Glaser, Shannon, Merlin, Didier

Source: Nanomedicine. 17(21):1501-1504

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191692413.0x000001&indx=1&recIds=ETOCvdc_100191692413.0x000001

Melatonin receptor 1A, but not 1B, knockout decreases biliary damage and liver fibrosis during cholestatic liver injury

Authors: Wu, Nan, Carpino, Guido, Ceci, Ludovica, Baiocchi, Leonardo, Francis, Heather, Kennedy, Lindsey, Zhou, Tianhao, Chen, Lixian, Sato, Keisaku, Kyritsi, Konstantina, Meadows, Vik, Ekser, Burcin, Franchitto, Antonio, Mancinelli, Romina, Onori, Paolo, Gaudio, Eugenio, Glaser, Shannon, Alpini, Gianfranco

Source: Hepatology. 75(4):797-813

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191466084.0x000001&indx=1&recIds=ETOCvdc_100191466084.0x000001

Mast cells selectively target large cholangiocytes during biliary injury via H2HR‐mediated cAMP/pERK1/2 signaling

Authors: Zhou, Tianhao, Meadows, Vik, Kundu, Debjyoti, Kyritsi, Konstantina, Owen, Travis, Ceci, Ludovica, Carpino, Guido, Onori, Paolo, Gaudio, Eugenio, Wu, Nan, Glaser, Shannon, Ekser, Burcin, Alpini, Gianfranco, Kennedy, Lindsey, Francis, Heather

Source: Hepatology communications. 6(10):2715-2731

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190646869.0x000001&indx=1&recIds=ETOCvdc_100190646869.0x000001

Development and Characterization of Human Primary Cholangiocarcinoma Cell Lines

Authors: Isidan, Abdulkadir, Yenigun, Ali, Soma, Daiki, Aksu, Eric, Lopez, Kevin, Park, Yujin, Cross-Najafi, Arthur, Li, Ping, Kundu, Debjyoti, House, Michael G., Chakraborty, Sanjukta, Glaser, Shannon, Kennedy, Lindsey, Francis, Heather, Zhang, Wenjun, Alpini, Gianfranco, Ekser, Burcin

Source: American journal of pathology. 192(9):1200-1217

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169229380.0x000001&indx=1&recIds=ETOCvdc_100169229380.0x000001

The Functional Roles of Immune Cells in Primary Liver Cancer

Authors: Pham, Linh, Kyritsi, Konstantina, Zhou, Tianhao, Ceci, Ludovica, Baiocchi, Leonardo, Kennedy, Lindsey, Chakraborty, Sanjukta, Glaser, Shannon, Francis, Heather, Alpini, Gianfranco, Sato, Keisaku

Source: American journal of pathology. 192(6):826-836

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164927627.0x000001&indx=1&recIds=ETOCvdc_100164927627.0x000001

FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2−/− Mouse Model of Primary Sclerosing Cholangitis

Authors: O'Brien, April, Zhou, Tianhao, White, Tori, Medford, Abigail, Chen, Lixian, Kyritsi, Konstantina, Wu, Nan, Childs, Jonathan, Stiles, Danaleigh, Ceci, Ludovica, Chakraborty, Sanjukta, Ekser, Burcin, Baiocchi, Leonardo, Carpino, Guido, Gaudio, Eugenio, Wu, Chaodong, Kennedy, Lindsey, Francis, Heather, Alpini, Gianfranco, Glaser, Shannon

Source: Hepatology communications. 6(7):1574-1588

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154052035.0x000001&indx=1&recIds=ETOCvdc_100154052035.0x000001

Indole supplementation ameliorates MCD-induced NASH in mice

Authors: Zhu, Bilian, Li, Honggui, Lu, Bangchao, Guo, Xinlei, Wu, Chiashan, Wang, Fen, Li, Qingsheng, Xie, Linglin, Glaser, Shannon, Francis, Heather, Alpini, Gianfranco, Wu, Chaodong

Source: In The Journal of Nutritional Biochemistry September 2022 107

Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model

Authors: Ceci, Ludovica, Chen, Lixian, Baiocchi, Leonardo, Wu, Nan, Kennedy, Lindsey, Carpino, Guido, Kyritsi, Konstantina, Zhou, Tianhao, Owen, Travis, Kundu, Debjyoti, Sybenga, Amelia, Isidan, Abdulkadir, Ekser, Burcin, Franchitto, Antonio, Onori, Paolo, Gaudio, Eugenio, Mancinelli, Romina, Francis, Heather, Alpini, Gianfranco, Glaser, Shannon

Source: In Cellular and Molecular Gastroenterology and Hepatology 2022 14(4):877-904

Targeting Lymphangiogenesis and Lymph Node Metastasis in Liver Cancer

Authors: Roy, Sukanya, Banerjee, Priyanka, Ekser, Burcin, Bayless, Kayla, Zawieja, David, Alpini, Gianfranco, Glaser, Shannon S., Chakraborty, Sanjukta

Source: In The American Journal of Pathology December 2021 191(12):2052-2063

Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Is Associated with Increased Intestinal Inflammation

Authors: Matthews, Destiny R., Li, Honggui, Zhou, Jing, Li, Qingsheng, Glaser, Shannon, Francis, Heather, Alpini, Gianfranco, Wu, Chaodong

Source: In The American Journal of Pathology October 2021 191(10):1743-1753

Adipocyte inducible 6-phosphofructo-2-kinase suppresses adipose tissue inflammation and promotes macrophage anti-inflammatory activation

Authors: Xu, Hang, Zhu, Bilian, Li, Honggui, Jiang, Boxiong, Wang, Yina, Yin, Qiongli, Cai, James, Glaser, Shannon, Francis, Heather, Alpini, Gianfranco, Wu, Chaodong

Source: In The Journal of Nutritional Biochemistry September 2021 95

Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells

Authors: Zhu, Bilian, Guo, Xin, Xu, Hang, Jiang, Boxiong, Li, Honggui, Wang, Yina, Yin, Qiongli, Zhou, Tianhao, Cai, James J., Glaser, Shannon, Meng, Fanyin, Francis, Heather, Alpini, Gianfranco, Wu, Chaodong

Source: In Laboratory Investigation March 2021 101(3):328-340

Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis Through Farnesoid X Receptor Signaling

Authors: Meadows, Vik, Kennedy, Lindsey, Ekser, Burcin, Kyritsi, Konstantina, Kundu, Debjyoti, Zhou, Tianhao, Chen, Lixian, Pham, Linh, Wu, Nan, Demieville, Jennifer, Hargrove, Laura, Glaser, Shannon, Alpini, Gianfranco, Francis, Heather

Source: Hepatology. 74(5):2684-2698

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135392398.0x000001&indx=1&recIds=ETOCvdc_100135392398.0x000001