Enhancement of plasma kallikrein specificity of antitrypsin variants identified by phage display and partial reversion

Authors: Sangavi Sivananthan, Tyler Seto, Negin C. Tehrani, Varsha Bhakta, William P. Sheffield

Source: BMC Biotechnology, Vol 25, Iss 1, Pp 1-12 (2025)

Subject Terms: Phage display, Alpha-1 antitrypsin, Plasma kallikrein, Mutagenesis, Reactive centre loop, Hereditary angioedema, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://doaj.org/toc/1472-6750

Access URL: https://doaj.org/article/9a58c665048c4d129700ceee9c0673dd

Alpha-1 antitrypsin and vitamin D deficiency in COVID-19: correlation with risk of disease in Iraqi patients.

Authors: Alaa Hasan

Source: Microbes and Infectious Diseases, Vol 6, Iss 1, Pp 26-31 (2025)

Subject Terms: covid-19, alpha-1 antitrypsin, vitamin d, c-reactive protein, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://mid.journals.ekb.eg/article_368743_02a3fefce9014f76a6b8e9a2a1886634.pdf; https://doaj.org/toc/2682-4132; https://doaj.org/toc/2682-4140

Access URL: https://doaj.org/article/51a08547a3a74744a9e1ce9e7b3b8d03

Patient-centered assessment of treatment for alpha-1 antitrypsin deficiency: literature review to identify concepts and measures for people with alpha1-antitrypsin deficiency

Authors: Ekin Seçinti, Karolina Schantz, Laure Delbecque, John Krege, Rikki Mangrum, Sarah E. Curtis

Source: Orphanet Journal of Rare Diseases, Vol 20, Iss 1, Pp 1-16 (2025)

Subject Terms: Patient-reported outcome, Measurement, Literature review, Alpha-1 antitrypsin deficiency, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/34f4d5bc42d947c1bfc70a2056e11f7a

Alpha-1 antitrypsin reduces inflammation and vasculopathy in mice with oxygen-induced retinopathy

Authors: Varaporn Suphapimol, Yu-Han Liu, Sandro Prato, Alexander Karnowski, Charles Hardy, Adriana Baz Morelli, Abhirup Jayasimhan, Devy Deliyanti, Jennifer L. Wilkinson-Berka

Source: Journal of Inflammation, Vol 22, Iss 1, Pp 1-12 (2025)

Subject Terms: Alpha-1 antitrypsin, Oxygen-induced retinopathy, Inflammation, Microglia, Neovascularisation, Vascular leakage, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1476-9255

Access URL: https://doaj.org/article/c7ff20950a04470f845d3dd1c0b32123

Is It Time Alpha-1 Antitrypsin Deficiency Had a Specific Patient Reported Outcome Measure? A Review

Authors: De Soyza J, Chien HY, Onasanya AA, Turner AM

Source: Patient Related Outcome Measures, Vol Volume 16, Pp 23-35 (2025)

Subject Terms: alpha-1 antitrypsin deficiency, copd, chronic liver disease, rare diseases, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/is-it-time-alpha-1-antitrypsin-deficiency-had-a-specific-patient-repor-peer-reviewed-fulltext-article-PROM; https://doaj.org/toc/1179-271X

Access URL: https://doaj.org/article/ad755f6aaaab4bc589cf009145caf850

Risk of lung disease with the Pi*SS genotype of alpha-1 antitrypsin: the evidence in context

Authors: Helen O’Brien, Cormac McCarthy, Alessandro N. Franciosi

Source: Respiratory Research, Vol 26, Iss 1, Pp 1-3 (2025)

Subject Terms: Alpha-1 antitrypsin deficiency, AATD, Pi*S, Pi*SS, COPD, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/898e165fcfa5489f887356903dfb2c3c

High BMI and COPD Outcomes in Alpha-1 Antitrypsin Deficiency

Authors: Campos, Michael A. ^{a, ∗}, Riley, Leonard ^b, Lascano, Jorge ^c, Garnet, Brian ^a, Sandhaus, Robert ^{d, e}

Source: In CHEST Pulmonary March 2025 3(1)

Clinical implications of the SERPINA1 variant, MPalermo, and alpha-1 antitrypsin deficiency in Türkiye

Authors: Dilek Karadoğan, Bettina Dreger, Lourdes Osaba, Enes Ahmetoğlu, Songül Özyurt, Bilge Yılmaz Kara, Nur Hürsoy, Tahsin Gökhan Telatar, Ünal Şahin

Source: BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-8 (2024)

Subject Terms: Alpha-1 antitrypsin deficiency, MPalermo, MMalton, COPD, Screening, Tobacco, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2466

Access URL: https://doaj.org/article/e4d5fe530aa24598b12f37612664eb53

Higher healthcare cost and utilization before and after diagnosis of AATD in the United States

Authors: Christopher M. Blanchette, Sarah Whitmire, Joshua Oh, Joshua Noone, Reuben Howden, Thomas Ardiles, Glenda A. Stone

Source: BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-9 (2024)

Subject Terms: Alpha-1 antitrypsin deficiency, COPD, PiZZ, Healthcare costs, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2466

Access URL: https://doaj.org/article/6c4a7feeaf764021953db4d1661824b6

The association between alpha-1 antitrypsin and B-type natriuretic peptide blood levels in healthy African Americans

Authors: Jeffrey Justin Margret, Sushil K. Jain

Source: BMC Research Notes, Vol 17, Iss 1, Pp 1-7 (2024)

Subject Terms: B-type natriuretic peptide, Blood pressure, Alpha-1 antitrypsin, Estradiol, Testosterone, Inflammation, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

File Description: electronic resource

Relation: https://doaj.org/toc/1756-0500

Access URL: https://doaj.org/article/fb323e6e5c38499bbba3371c1a28231c

Lung transplant outcomes for recipients with alpha-1 antitrypsin deficiency, by use of alpha-1 antitrypsin augmentation therapy

Authors: Atharv V. Oak, MEng, Jessica M. Ruck, MD, PhD, Alfred J. Casillan, MD, PhD, Armaan F. Akbar, BS, Ramon A. Riojas, MD, PhD, Pali D. Shah, MD, Jinny S. Ha, MD, MHS, Sara Strout, PharmD, Allan B. Massie, PhD, Dorry L. Segev, MD, PhD, Christian A. Merlo, MD, MPH, Errol L. Bush, MD

Source: JHLT Open, Vol 7, Iss , Pp 100201- (2025)

Subject Terms: alpha-1 antitrypsin, emphysema, lung transplant, augmentation therapy, survival outcomes, Surgery, RD1-811, Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950133424001514; https://doaj.org/toc/2950-1334

Access URL: https://doaj.org/article/e21b3b937d094698b595d0099d603dc6

Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes

Authors: Yunus E. Dogan, Niharika Bala, Erika S. Galban, Russell L. Lewis, Nancy D. Denslow, Sihong Song, Abdel A. Alli

Source: Frontiers in Molecular Biosciences, Vol 11 (2025)

Subject Terms: protein kinase C, diacylglycerols, alpha-1 antitrypsin, salt-sensitive hypertension, sodium-potassium-chloride co-transporter, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2024.1485506/full; https://doaj.org/toc/2296-889X

Access URL: https://doaj.org/article/08973d63b3384da3b184d3b803d12cf2

Increased Intestinal Inflammation and Permeability in Glaucoma

Authors: Wang Z, Guo S, He C, Chen L, Wang J, Xiu W, Zhang G, Chen Y, Li A, Zhu X, Xiao X, Yu L, Lu F

Source: Journal of Inflammation Research, Vol Volume 17, Pp 6895-6904 (2024)

Subject Terms: fecal lactoferrin, fecal alpha-1 antitrypsin, glaucoma, intestinal inflammation, intes-tinal permeability, intestinal barrier, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/increased-intestinal-inflammation-and-permeability-in-glaucoma-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031

Access URL: https://doaj.org/article/df757b32cd7243a0a3ebbc35d34c9d20

Prevalence of Alpha-1 Antitrypsin Deficiency Alleles in a Lithuanian Cohort of Wheezing Small Children

Authors: Edita Poluzioroviene, Joanna Chorostowska-Wynimko, Sigita Petraitiene, Arunas Strumila, Adriana Rozy, Aneta Zdral, Arunas Valiulis

Source: Advances in Respiratory Medicine, Vol 92, Iss 4, Pp 291-299 (2024)

Subject Terms: alpha-1 antitrypsin deficiency, children, wheeze, SERPINA1, COPD, Diseases of the respiratory system, RC705-779, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/2543-6031/92/4/28; https://doaj.org/toc/2543-6031

Access URL: https://doaj.org/article/8859bf38c0a74bd6b83656c53b036ad7

Retrospective Database Analysis of Liver-Related Clinical Events in Adult and Pediatric Patients with Alpha-1 Antitrypsin Deficiency in the United States

Authors: Hagiwara M, Divino V, Munnangi S, Delegge M, Park S, Marins EG, Ren K, Strange C

Source: Hepatic Medicine: Evidence and Research, Vol Volume 16, Pp 55-64 (2024)

Subject Terms: alpha-1 antitrypsin deficiency, genetic disease, liver disease, lung disease, pediatric, adult, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://www.dovepress.com/retrospective-database-analysis-of-liver-related-clinical-events-in-ad-peer-reviewed-fulltext-article-HMER; https://doaj.org/toc/1179-1535

Access URL: https://doaj.org/article/f5ee4d1fff124388a65daa365beeff5f

Role of biomarkers in community-acquired pneumonia management

Authors: Bahaeddin Onur, Hakan Barış Demirbas, Arif Gulmez

Source: Journal of Acute Disease, Vol 13, Iss 3, Pp 87-92 (2024)

Subject Terms: curb-65, community-acquired pneumonia, procalcitonin, alpha-1 antitrypsin, serum amyloid a, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/jad.jad_65_24; https://doaj.org/toc/2221-6189; https://doaj.org/toc/2589-5516

Access URL: https://doaj.org/article/0e47330c645540a5aed3f0c6bfc62262

Occurrence of Emphysema in Individuals With Williams-Beuren Syndrome: A Narrative Review

Authors: Majumdar, Uddalak ^{a, ∗}, Kline, Theresa M. ^b, Stoller, James K. ^{a, c}

Source: In CHEST Pulmonary March 2025 3(1)

Does hypersialylation compensate the functional Alpha1-AntiTrypsin (A1AT) deficiency in all critically ill patients?

Authors: Deplanque, Dominique, Faure, Karine, Lefevre, Guillaume, Alidjinou, Kazali, Bordet, Régis, Engelmann, Ilka, Garrigue, Delphine, Goffard, Anne, Kipnis, Eric, Labalette, Myriam, Lambert, Marc, Launay, David, Mathieu, Daniel, Maurage, Claude Alain, Poissy, Julien, Remy, Martine, Sendid, Boualem, Susen, Sophie, Caillier, Maxime, Laurent, Laurent Schwarb, Hisbergues, Michael, Balduyck, Malika ^{a, b}, Afif, Sarah ^a, Onraed, Brigitte ^c, Jourdain, Mercédes ^{d, e}, Nseir, Saad ^{d, f}, Pigny, Pascal ^{a, g, ⁎}, Zerimech, Farid ^{a, h}

Source: In Biochimie March 2025 230:114-120

What is the role of alpha-1 antitrypsin in the management of acute graft versus host disease?

Authors: Yigenoglu, Tugce Nur ^{a, ⁎}, Erkurt, Mehmet Ali ^b, Dagdas, Simten ^c, Ulu, Bahar Uncu ^a, Kuku, Irfan ^b, Durdu, Ali ^a, Pepeler, Mehmet Sezgin ^c, Kul, Sinem ^a, Dal, Mehmet Sinan ^a, Kaya, Emin ^b, Korkmaz, Serdal ^d, Ulaş, Turgay ^a, Altuntas, Fevzi ^{a, e}

Source: In Transfusion and Apheresis Science February 2025 64(1)

Novel Lobe-based Transformer model (LobTe) to predict emphysema progression in Alpha-1 Antitrypsin Deficiency

Authors: Curiale, Ariel Hernán ^⁎, San José Estépar, Raúl ^⁎

Source: In Computers in Biology and Medicine February 2025 185