Admixture as a source for HLA variation in Neolithic European farming communities

Authors: Nicolas Antonio da Silva, Onur Özer, Magdalena Haller-Caskie, Yan-Rong Chen, Daniel Kolbe, Sabine Schade-Lindig, Joachim Wahl, Carola Berszin, Michael Francken, Irina Görner, Kerstin Schierhold, Joachim Pechtl, Gisela Grupe, Christoph Rinne, Johannes Müller, Tobias L. Lenz, Almut Nebel, Ben Krause-Kyora

Source: Genome Biology, Vol 26, Iss 1, Pp 1-23 (2025)

Subject Terms: Ancient DNA, European Neolithic, Population genetics, Admixture, Immune genes, HLA diversity, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/4bab6548a9f8462d931b008b230b5d7f

Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern EuropeansResearch in context

Authors: Ben Krause-Kyora, Nicolas Antonio da Silva, Elif Kaplan, Daniel Kolbe, Inken Wohlers, Hauke Busch, David Ellinghaus, Amke Caliebe, Efe Sezgin, Almut Nebel, Stefan Schreiber, Sabine Schade-Lindig, Joachim Wahl, Carola Berszin, Michael Francken, Irina Görner, Kerstin Schierhold, Joachim Pechtl, Gisela Grupe, Johannes Müller

Source: EBioMedicine, Vol 113, Iss , Pp 105591- (2025)

Subject Terms: IL23R, IL-23-signalling, Ancient genomics, Crohn's disease, Ulcerative colitis, Inflammatory bowel diseases, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396425000350; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/64c8ea62fad74534b601b000277019dd

Neolithic Yersinia pestis infections in humans and a dog

Authors: Julian Susat, Magdalena Haller-Caskie, Joanna H. Bonczarowska, Nicolas A. da Silva, Kerstin Schierhold, Michael M. Rind, Ulrich Schmölcke, Wiebke Kirleis, Holger Sondermann, Christoph Rinne, Johannes Müller, Almut Nebel, Ben Krause-Kyora

Source: Communications Biology, Vol 7, Iss 1, Pp 1-7 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/4a92b22954c240ba994cb268833f0a13

Genome-wide association study of population-standardised cognitive performance phenotypes in a rural South African community

Authors: Cassandra C. Soo, Jean-Tristan Brandenburg, Almut Nebel, Stephen Tollman, Lisa Berkman, Michèle Ramsay, Ananyo Choudhury

Source: Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/914fada798de47d5a5dd0987d12550e7

Pathogen genomics study of an early medieval community in Germany reveals extensive co-infections

Authors: Joanna H. Bonczarowska, Julian Susat, Barbara Mühlemann, Isabelle Jasch-Boley, Sebastian Brather, Benjamin Höke, Susanne Brather-Walter, Valerie Schoenenberg, Jonathan Scheschkewitz, Gabriele Graenert, Dirk Krausse, Michael Francken, Terry C. Jones, Joachim Wahl, Almut Nebel, Ben Krause-Kyora

Source: Genome Biology, Vol 23, Iss 1, Pp 1-16 (2022)

Subject Terms: Ancient DNA, Pathogen genomics, Ancient genomics, Variola virus, Smallpox, Leprosy, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/4b05cb5d83f740778e9bcd5eee5ed1ed

Genome-wide study of a Neolithic Wartberg grave community reveals distinct HLA variation and hunter-gatherer ancestry

Authors: Alexander Immel, Federica Pierini, Christoph Rinne, John Meadows, Rodrigo Barquera, András Szolek, Julian Susat, Lisa Böhme, Janina Dose, Joanna Bonczarowska, Clara Drummer, Katharina Fuchs, David Ellinghaus, Jan Christian Kässens, Martin Furholt, Oliver Kohlbacher, Sabine Schade-Lindig, Andre Franke, Stefan Schreiber, Johannes Krause, Johannes Müller, Tobias L. Lenz, Almut Nebel, Ben Krause-Kyora

Source: Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/717976e7bf6b47afb826711305978671

Corrigendum: Apolipoprotein E Genetic Variation and its Association With Cognitive Function in Rural-Dwelling Older South Africans

Authors: Cassandra C. Soo, Meagan T. Farrell, Stephen Tollman, Lisa Berkman, Almut Nebel, Michèle Ramsay

Source: Frontiers in Genetics, Vol 13 (2022)

Subject Terms: apolipoprotein E ε4, cognitive function, african population, educational attainment, memory, executive function, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2022.795349/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/286cc16d662f4269bab6f65783b86292

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Authors: Joris Deelen, Daniel S. Evans, Dan E. Arking, Niccolò Tesi, Marianne Nygaard, Xiaomin Liu, Mary K. Wojczynski, Mary L. Biggs, Ashley van der Spek, Gil Atzmon, Erin B. Ware, Chloé Sarnowski, Albert V. Smith, Ilkka Seppälä, Heather J. Cordell, Janina Dose, Najaf Amin, Alice M. Arnold, Kristin L. Ayers, Nir Barzilai, Elizabeth J. Becker, Marian Beekman, Hélène Blanché, Kaare Christensen, Lene Christiansen, Joanna C. Collerton, Sarah Cubaynes, Steven R. Cummings, Karen Davies, Birgit Debrabant, Jean-François Deleuze, Rachel Duncan, Jessica D. Faul, Claudio Franceschi, Pilar Galan, Vilmundur Gudnason, Tamara B. Harris, Martijn Huisman, Mikko A. Hurme, Carol Jagger, Iris Jansen, Marja Jylhä, Mika Kähönen, David Karasik, Sharon L. R. Kardia, Andrew Kingston, Thomas B. L. Kirkwood, Lenore J. Launer, Terho Lehtimäki, Wolfgang Lieb, Leo-Pekka Lyytikäinen, Carmen Martin-Ruiz, Junxia Min, Almut Nebel, Anne B. Newman, Chao Nie, Ellen A. Nohr, Eric S. Orwoll, Thomas T. Perls, Michael A. Province, Bruce M. Psaty, Olli T. Raitakari, Marcel J. T. Reinders, Jean-Marie Robine, Jerome I. Rotter, Paola Sebastiani, Jennifer Smith, Thorkild I. A. Sørensen, Kent D. Taylor, André G. Uitterlinden, Wiesje van der Flier, Sven J. van der Lee, Cornelia M. van Duijn, Diana van Heemst, James W. Vaupel, David Weir, Kenny Ye, Yi Zeng, Wanlin Zheng, Henne Holstege, Douglas P. Kiel, Kathryn L. Lunetta, P. Eline Slagboom, Joanne M. Murabito

Source: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/43040ac329044c8a980e87b5849d94cd

Apolipoprotein E Genetic Variation and Its Association With Cognitive Function in Rural-Dwelling Older South Africans

Authors: Cassandra C. Soo, Meagan T. Farrell, Stephen Tollman, Lisa Berkman, Almut Nebel, Michèle Ramsay

Source: Frontiers in Genetics, Vol 12 (2021)

Subject Terms: apolipoprotein E 𝝴4, cognitive function, African population, educational attainment, memory, executive function, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2021.689756/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/3427339be5764db1b081582b572e0bcb

Ancient DNA Study in Medieval Europeans Shows an Association Between HLA-DRB1*03 and Paratyphoid Fever

Authors: Magdalena Haller, Joanna H. Bonczarowska, Dirk Rieger, Tobias L. Lenz, Almut Nebel, Ben Krause-Kyora

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: Salmonella enterica Paratyphi C, enteric fever, human leukocyte antigen, trade-off, antigen binding prediction, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.691475/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/84f59abbf63c49339a07ab25a3c1b683

A 5,000-year-old hunter-gatherer already plagued by Yersinia pestis

Authors: Julian Susat, Harald Lübke, Alexander Immel, Ute Brinker, Aija Macāne, John Meadows, Britta Steer, Andreas Tholey, Ilga Zagorska, Guntis Gerhards, Ulrich Schmölcke, Mārcis Kalniņš, Andre Franke, Elīna Pētersone-Gordina, Barbara Teßman, Mari Tõrv, Stefan Schreiber, Christian Andree, Valdis Bērziņš, Almut Nebel, Ben Krause-Kyora

Source: Cell Reports, Vol 35, Iss 13, Pp 109278- (2021)

Subject Terms: Yersinia pestis, aDNA, hunter-gatherer, zoonosis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124721006458; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/01cc12552ad7439981304caadd9962d3

Mass burial genomics reveals outbreak of enteric paratyphoid fever in the Late Medieval trade city Lübeck

Authors: Magdalena Haller, Kimberly Callan, Julian Susat, Anna Lena Flux, Alexander Immel, Andre Franke, Alexander Herbig, Johannes Krause, Anne Kupczok, Gerhard Fouquet, Susanne Hummel, Dirk Rieger, Almut Nebel, Ben Krause-Kyora

Source: iScience, Vol 24, Iss 5, Pp 102419- (2021)

Subject Terms: Paleontology, Microbiology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004221003874; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/d5ac82ad086a47568ad8c162eb019048

Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans

Authors: Ben Krause-Kyora, Marcel Nutsua, Lisa Boehme, Federica Pierini, Dorthe Dangvard Pedersen, Sabin-Christin Kornell, Dmitriy Drichel, Marion Bonazzi, Lena Möbus, Peter Tarp, Julian Susat, Esther Bosse, Beatrix Willburger, Alexander H. Schmidt, Jürgen Sauter, Andre Franke, Michael Wittig, Amke Caliebe, Michael Nothnagel, Stefan Schreiber, Jesper L. Boldsen, Tobias L. Lenz, Almut Nebel

Source: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8fa5ee6a3c694f099a3d3800433d8665

Identification and characterization of two functional variants in the human longevity gene FOXO3

Authors: Friederike Flachsbart, Janina Dose, Liljana Gentschew, Claudia Geismann, Amke Caliebe, Carolin Knecht, Marianne Nygaard, Nandini Badarinarayan, Abdou ElSharawy, Sandra May, Anne Luzius, Guillermo G. Torres, Marlene Jentzsch, Michael Forster, Robert Häsler, Kathrin Pallauf, Wolfgang Lieb, Céline Derbois, Pilar Galan, Dmitriy Drichel, Alexander Arlt, Andreas Till, Ben Krause-Kyora, Gerald Rimbach, Hélène Blanché, Jean-François Deleuze, Lene Christiansen, Kaare Christensen, Michael Nothnagel, Philip Rosenstiel, Stefan Schreiber, Andre Franke, Susanne Sebens, Almut Nebel

Source: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f1d90b23cde74314abd23e1b467785a0

High mitochondrial diversity of domesticated goats persisted among Bronze and Iron Age pastoralists in the Inner Asian Mountain Corridor.

Authors: Taylor R Hermes, Michael D Frachetti, Dmitriy Voyakin, Antonina S Yerlomaeva, Arman Z Beisenov, Paula N Doumani Dupuy, Dmitry V Papin, Giedre Motuzaite Matuzeviciute, Jamsranjav Bayarsaikhan, Jean-Luc Houle, Alexey A Tishkin, Almut Nebel, Ben Krause-Kyora, Cheryl A Makarewicz

Source: PLoS ONE, Vol 15, Iss 5, p e0233333 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/d7ece1437b5b424a9cf2c7a72d0a2966

Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes

Authors: Joris Deelen, Daniel S. Evans, Dan E. Arking, Niccolò Tesi, Marianne Nygaard, Xiaomin Liu, Mary K. Wojczynski, Mary L. Biggs, Ashley van der Spek, Gil Atzmon, Erin B. Ware, Chloé Sarnowski, Albert V. Smith, Ilkka Seppälä, Heather J. Cordell, Janina Dose, Najaf Amin, Alice M. Arnold, Kristin L. Ayers, Nir Barzilai, Elizabeth J. Becker, Marian Beekman, Hélène Blanché, Kaare Christensen, Lene Christiansen, Joanna C. Collerton, Sarah Cubaynes, Steven R. Cummings, Karen Davies, Birgit Debrabant, Jean-François Deleuze, Rachel Duncan, Jessica D. Faul, Claudio Franceschi, Pilar Galan, Vilmundur Gudnason, Tamara B. Harris, Martijn Huisman, Mikko A. Hurme, Carol Jagger, Iris Jansen, Marja Jylhä, Mika Kähönen, David Karasik, Sharon L. R. Kardia, Andrew Kingston, Thomas B. L. Kirkwood, Lenore J. Launer, Terho Lehtimäki, Wolfgang Lieb, Leo-Pekka Lyytikäinen, Carmen Martin-Ruiz, Junxia Min, Almut Nebel, Anne B. Newman, Chao Nie, Ellen A. Nohr, Eric S. Orwoll, Thomas T. Perls, Michael A. Province, Bruce M. Psaty, Olli T. Raitakari, Marcel J. T. Reinders, Jean-Marie Robine, Jerome I. Rotter, Paola Sebastiani, Jennifer Smith, Thorkild I. A. Sørensen, Kent D. Taylor, André G. Uitterlinden, Wiesje van der Flier, Sven J. van der Lee, Cornelia M. van Duijn, Diana van Heemst, James W. Vaupel, David Weir, Kenny Ye, Yi Zeng, Wanlin Zheng, Henne Holstege, Douglas P. Kiel, Kathryn L. Lunetta, P. Eline Slagboom, Joanne M. Murabito

Source: Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/22274fdaa9da45edb97a7c76d79337dd

Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe.

Authors: Verena J Schuenemann, Charlotte Avanzi, Ben Krause-Kyora, Alexander Seitz, Alexander Herbig, Sarah Inskip, Marion Bonazzi, Ella Reiter, Christian Urban, Dorthe Dangvard Pedersen, G Michael Taylor, Pushpendra Singh, Graham R Stewart, Petr Velemínský, Jakub Likovsky, Antónia Marcsik, Erika Molnár, György Pálfi, Valentina Mariotti, Alessandro Riga, M Giovanna Belcastro, Jesper L Boldsen, Almut Nebel, Simon Mays, Helen D Donoghue, Sonia Zakrzewski, Andrej Benjak, Kay Nieselt, Stewart T Cole, Johannes Krause

Source: PLoS Pathogens, Vol 14, Iss 5, p e1006997 (2018)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/1d2b1eeff903483cbb6c16855a091083

Neolithic and medieval virus genomes reveal complex evolution of hepatitis B

Authors: Ben Krause-Kyora, Julian Susat, Felix M Key, Denise Kühnert, Esther Bosse, Alexander Immel, Christoph Rinne, Sabin-Christin Kornell, Diego Yepes, Sören Franzenburg, Henrike O Heyne, Thomas Meier, Sandra Lösch, Harald Meller, Susanne Friederich, Nicole Nicklisch, Kurt W Alt, Stefan Schreiber, Andreas Tholey, Alexander Herbig, Almut Nebel, Johannes Krause

Source: eLife, Vol 7 (2018)

Subject Terms: hepatitis B, virus evolution, ancient DNA, human evolution, ancient pathogens, next generation sequencing, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/36666; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/5d8afae15af841bfbc522b33d6cc248b

Publisher Correction: Identification and characterization of two functional variants in the human longevity gene FOXO3

Authors: Friederike Flachsbart, Janina Dose, Liljana Gentschew, Claudia Geismann, Amke Caliebe, Carolin Knecht, Marianne Nygaard, Nandini Badarinarayan, Abdou ElSharawy, Sandra May, Anne Luzius, Guillermo G. Torres, Marlene Jentzsch, Michael Forster, Robert Häsler, Kathrin Pallauf, Wolfgang Lieb, Céline Derbois, Pilar Galan, Dmitriy Drichel, Alexander Arlt, Andreas Till, Ben Krause-Kyora, Gerald Rimbach, Hélène Blanché, Jean-François Deleuze, Lene Christiansen, Kaare Christensen, Michael Nothnagel, Philip Rosenstiel, Stefan Schreiber, Andre Franke, Susanne Sebens, Almut Nebel

Source: Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3a301166958a4d53891142c0787acc2f

Family-Based Benchmarking of Copy Number Variation Detection Software.

Authors: Marcel Elie Nutsua, Annegret Fischer, Almut Nebel, Sylvia Hofmann, Stefan Schreiber, Michael Krawczak, Michael Nothnagel

Source: PLoS ONE, Vol 10, Iss 7, p e0133465 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4510559?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f8816f9cc90a4aa0a44c8f852e88edd4