Genetic control of DNA methylation is largely shared across European and East Asian populations

Authors: Alesha A. Hatton, Fei-Fei Cheng, Tian Lin, Ren-Juan Shen, Jie Chen, Zhili Zheng, Jia Qu, Fan Lyu, Sarah E. Harris, Simon R. Cox, Zi-Bing Jin, Nicholas G. Martin, Dongsheng Fan, Grant W. Montgomery, Jian Yang, Naomi R. Wray, Riccardo E. Marioni, Peter M. Visscher, Allan F. McRae

Source: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/390e05448833466fa9d5072be811c288

Integration of datasets for individual prediction of DNA methylation-based biomarkers

Authors: Charlotte Merzbacher, Barry Ryan, Thibaut Goldsborough, Robert F. Hillary, Archie Campbell, Lee Murphy, Andrew M. McIntosh, David Liewald, Sarah E. Harris, Allan F. McRae, Simon R. Cox, Timothy I. Cannings, Catalina A. Vallejos, Daniel L. McCartney, Riccardo E. Marioni

Source: Genome Biology, Vol 24, Iss 1, Pp 1-12 (2023)

Subject Terms: DNA methylation, Prediction, Biomarker, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/27a94f213069468c9e6bc2caa52439dc

Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function

Authors: Sally Mortlock, Sahar Houshdaran, Idit Kosti, Nilufer Rahmioglu, Camran Nezhat, Allison F. Vitonis, Shan V. Andrews, Parker Grosjean, Manish Paranjpe, Andrew W. Horne, Alison Jacoby, Jeannette Lager, Jessica Opoku-Anane, Kim Chi Vo, Evelina Manvelyan, Sushmita Sen, Zhanna Ghukasyan, Frances Collins, Xavier Santamaria, Philippa Saunders, Kord Kober, Allan F. McRae, Kathryn L. Terry, Júlia Vallvé-Juanico, Christian Becker, Peter A. W. Rogers, Juan C. Irwin, Krina Zondervan, Grant W. Montgomery, Stacey Missmer, Marina Sirota, Linda Giudice

Source: Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/f61d2545020c46a2baff0d24cc8d121a

An overview of DNA methylation-derived trait score methods and applications

Authors: Marta F. Nabais, Danni A. Gadd, Eilis Hannon, Jonathan Mill, Allan F. McRae, Naomi R. Wray

Source: Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)

Subject Terms: Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/dcc7c30d3c2e45608ba5a52f4a21878e

Association between DNA methylation variability and self-reported exposure to heavy metals

Authors: Anna Freydenzon, Marta F. Nabais, Tian Lin, Kelly L. Williams, Leanne Wallace, Anjali K. Henders, Ian P. Blair, Naomi R. Wray, Roger Pamphlett, Allan F. McRae

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/2af8811ee1fb420aab5ac4855095106d

Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1

Authors: Restuadi Restuadi, Frederik J. Steyn, Edor Kabashi, Shyuan T. Ngo, Fei-Fei Cheng, Marta F. Nabais, Mike J. Thompson, Ting Qi, Yang Wu, Anjali K. Henders, Leanne Wallace, Chris R. Bye, Bradley J. Turner, Laura Ziser, Susan Mathers, Pamela A. McCombe, Merrilee Needham, David Schultz, Matthew C. Kiernan, Wouter van Rheenen, Leonard H. van den Berg, Jan H. Veldink, Roel Ophoff, Alexander Gusev, Noah Zaitlen, Allan F. McRae, Robert D. Henderson, Naomi R. Wray, Jean Giacomotto, Fleur C. Garton

Source: Genome Medicine, Vol 14, Iss 1, Pp 1-22 (2022)

Subject Terms: Motor neurone disease, MND, Genome-wide association study, Computational biology, Zebrafish, Neurodegenerative diseases, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/554d6d92682e49b2a277f81cb79542d2

Identical twins carry a persistent epigenetic signature of early genome programming

Authors: Jenny van Dongen, Scott D. Gordon, Allan F. McRae, Veronika V. Odintsova, Hamdi Mbarek, Charles E. Breeze, Karen Sugden, Sara Lundgren, Juan E. Castillo-Fernandez, Eilis Hannon, Terrie E. Moffitt, Fiona A. Hagenbeek, Catharina E. M. van Beijsterveldt, Jouke Jan Hottenga, Pei-Chien Tsai, BIOS Consortium, Genetics of DNA Methylation Consortium, Josine L. Min, Gibran Hemani, Erik A. Ehli, Franziska Paul, Claudio D. Stern, Bastiaan T. Heijmans, P. Eline Slagboom, Lucia Daxinger, Silvère M. van der Maarel, Eco J. C. de Geus, Gonneke Willemsen, Grant W. Montgomery, Bruno Reversade, Miina Ollikainen, Jaakko Kaprio, Tim D. Spector, Jordana T. Bell, Jonathan Mill, Avshalom Caspi, Nicholas G. Martin, Dorret I. Boomsma

Source: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4deb6641205f44abb1762c5892e3dccd

1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

Authors: Ida E. Sønderby, Dennis van der Meer, Clara Moreau, Tobias Kaufmann, G. Bragi Walters, Maria Ellegaard, Abdel Abdellaoui, David Ames, Katrin Amunts, Micael Andersson, Nicola J. Armstrong, Manon Bernard, Nicholas B. Blackburn, John Blangero, Dorret I. Boomsma, Henry Brodaty, Rachel M. Brouwer, Robin Bülow, Rune Bøen, Wiepke Cahn, Vince D. Calhoun, Svenja Caspers, Christopher R. K. Ching, Sven Cichon, Simone Ciufolini, Benedicto Crespo-Facorro, Joanne E. Curran, Anders M. Dale, Shareefa Dalvie, Paola Dazzan, Eco J. C. de Geus, Greig I. de Zubicaray, Sonja M. C. de Zwarte, Sylvane Desrivieres, Joanne L. Doherty, Gary Donohoe, Bogdan Draganski, Stefan Ehrlich, Else Eising, Thomas Espeseth, Kim Fejgin, Simon E. Fisher, Tormod Fladby, Oleksandr Frei, Vincent Frouin, Masaki Fukunaga, Thomas Gareau, Tian Ge, David C. Glahn, Hans J. Grabe, Nynke A. Groenewold, Ómar Gústafsson, Jan Haavik, Asta K. Haberg, Jeremy Hall, Ryota Hashimoto, Jayne Y. Hehir-Kwa, Derrek P. Hibar, Manon H. J. Hillegers, Per Hoffmann, Laurena Holleran, Avram J. Holmes, Georg Homuth, Jouke-Jan Hottenga, Hilleke E. Hulshoff Pol, Masashi Ikeda, Neda Jahanshad, Christiane Jockwitz, Stefan Johansson, Erik G. Jönsson, Niklas R. Jørgensen, Masataka Kikuchi, Emma E. M. Knowles, Kuldeep Kumar, Stephanie Le Hellard, Costin Leu, David E. J. Linden, Jingyu Liu, Arvid Lundervold, Astri Johansen Lundervold, Anne M. Maillard, Nicholas G. Martin, Sandra Martin-Brevet, Karen A. Mather, Samuel R. Mathias, Katie L. McMahon, Allan F. McRae, Sarah E. Medland, Andreas Meyer-Lindenberg, Torgeir Moberget, Claudia Modenato, Jennifer Monereo Sánchez, Derek W. Morris, Thomas W. Mühleisen, Robin M. Murray, Jacob Nielsen, Jan E. Nordvik, Lars Nyberg, Loes M. Olde Loohuis, Roel A. Ophoff, Michael J. Owen, Tomas Paus, Zdenka Pausova, Juan M. Peralta, G. Bruce Pike, Carlos Prieto, Erin B. Quinlan, Céline S. Reinbold, Tiago Reis Marques, James J. H. Rucker, Perminder S. Sachdev, Sigrid B. Sando, Peter R. Schofield, Andrew J. Schork, Gunter Schumann, Jean Shin, Elena Shumskaya, Ana I. Silva, Sanjay M. Sisodiya, Vidar M. Steen, Dan J. Stein, Lachlan T. Strike, Ikuo K. Suzuki, Christian K. Tamnes, Alexander Teumer, Anbupalam Thalamuthu, Diana Tordesillas-Gutiérrez, Anne Uhlmann, Magnus O. Ulfarsson, Dennis van ‘t Ent, Marianne B. M. van den Bree, Pierre Vanderhaeghen, Evangelos Vassos, Wei Wen, Katharina Wittfeld, Margaret J. Wright, Ingrid Agartz, Srdjan Djurovic, Lars T. Westlye, Hreinn Stefansson, Kari Stefansson, Sébastien Jacquemont, Paul M. Thompson, Ole A. Andreassen, for the ENIGMA-CNV working group

Source: Translational Psychiatry, Vol 11, Iss 1, Pp 1-16 (2021)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2158-3188

Access URL: https://doaj.org/article/d73de80b364645c5b361b86e0292b8a5

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

Authors: Marta F. Nabais, Simon M. Laws, Tian Lin, Costanza L. Vallerga, Nicola J. Armstrong, Ian P. Blair, John B. Kwok, Karen A. Mather, George D. Mellick, Perminder S. Sachdev, Leanne Wallace, Anjali K. Henders, Ramona A. J. Zwamborn, Paul J. Hop, Katie Lunnon, Ehsan Pishva, Janou A. Y. Roubroeks, Hilkka Soininen, Magda Tsolaki, Patrizia Mecocci, Simon Lovestone, Iwona Kłoszewska, Bruno Vellas, the Australian Imaging Biomarkers and Lifestyle study, the Alzheimer’s Disease Neuroimaging Initiative, Sarah Furlong, Fleur C. Garton, Robert D. Henderson, Susan Mathers, Pamela A. McCombe, Merrilee Needham, Shyuan T. Ngo, Garth Nicholson, Roger Pamphlett, Dominic B. Rowe, Frederik J. Steyn, Kelly L. Williams, Tim J. Anderson, Steven R. Bentley, John Dalrymple-Alford, Javed Fowder, Jacob Gratten, Glenda Halliday, Ian B. Hickie, Martin Kennedy, Simon J. G. Lewis, Grant W. Montgomery, John Pearson, Toni L. Pitcher, Peter Silburn, Futao Zhang, Peter M. Visscher, Jian Yang, Anna J. Stevenson, Robert F. Hillary, Riccardo E. Marioni, Sarah E. Harris, Ian J. Deary, Ashley R. Jones, Aleksey Shatunov, Alfredo Iacoangeli, Wouter van Rheenen, Leonard H. van den Berg, Pamela J. Shaw, Cristopher E. Shaw, Karen E. Morrison, Ammar Al-Chalabi, Jan H. Veldink, Eilis Hannon, Jonathan Mill, Naomi R. Wray, Allan F. McRae

Source: Genome Biology, Vol 22, Iss 1, Pp 1-30 (2021)

Subject Terms: Neurodegenerative disorders, DNA methylation, Mixed-linear models, Methylation profile score, Out-of-sample classification, Inflammatory markers, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/201eefeb04d04cf0871060b72f55eedd

Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture

Authors: Qian Zhang, Julia Sidorenko, Baptiste Couvy-Duchesne, Riccardo E. Marioni, Margaret J. Wright, Alison M. Goate, Edoardo Marcora, Kuan-lin Huang, Tenielle Porter, Simon M. Laws, Australian Imaging Biomarkers and Lifestyle (AIBL) Study, Perminder S. Sachdev, Karen A. Mather, Nicola J. Armstrong, Anbupalam Thalamuthu, Henry Brodaty, Loic Yengo, Jian Yang, Naomi R. Wray, Allan F. McRae, Peter M. Visscher

Source: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/2864aaa787e447968771d91143faf890

Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults

Authors: Robert F. Hillary, Daniel Trejo-Banos, Athanasios Kousathanas, Daniel L. McCartney, Sarah E. Harris, Anna J. Stevenson, Marion Patxot, Sven Erik Ojavee, Qian Zhang, David C. Liewald, Craig W. Ritchie, Kathryn L. Evans, Elliot M. Tucker-Drob, Naomi R. Wray, Allan F. McRae, Peter M. Visscher, Ian J. Deary, Matthew R. Robinson, Riccardo E. Marioni

Source: Genome Medicine, Vol 12, Iss 1, Pp 1-15 (2020)

Subject Terms: Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13073-020-00754-1; https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/19534d9a8ec84e659ab1448d4b67f986

Bayesian reassessment of the epigenetic architecture of complex traits

Authors: Daniel Trejo Banos, Daniel L. McCartney, Marion Patxot, Lucas Anchieri, Thomas Battram, Colette Christiansen, Ricardo Costeira, Rosie M. Walker, Stewart W. Morris, Archie Campbell, Qian Zhang, David J. Porteous, Allan F. McRae, Naomi R. Wray, Peter M. Visscher, Chris S. Haley, Kathryn L. Evans, Ian J. Deary, Andrew M. McIntosh, Gibran Hemani, Jordana T. Bell, Riccardo E. Marioni, Matthew R. Robinson

Source: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/74bbcbe2232d46d983d1a26fad579404

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

Authors: Yang Wu, Ting Qi, Huanwei Wang, Futao Zhang, Zhili Zheng, Jennifer E. Phillips-Cremins, Ian J. Deary, Allan F. McRae, Naomi R. Wray, Jian Zeng, Jian Yang

Source: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/08b3f8555e2b481cb0c089930895e8c3

Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease

Authors: Costanza L. Vallerga, Futao Zhang, Javed Fowdar, Allan F. McRae, Ting Qi, Marta F. Nabais, Qian Zhang, Irfahan Kassam, Anjali K. Henders, Leanne Wallace, Grant Montgomery, Yu-Hsuan Chuang, Steve Horvath, Beate Ritz, Glenda Halliday, Ian Hickie, John B. Kwok, John Pearson, Toni Pitcher, Martin Kennedy, Steven R. Bentley, Peter A. Silburn, Jian Yang, Naomi R. Wray, Simon J. G. Lewis, Tim Anderson, John Dalrymple-Alford, George D. Mellick, Peter M. Visscher, Jacob Gratten

Source: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8ab912eda75443699d2e15309d47801d

An epigenome-wide association study of sex-specific chronological ageing

Authors: Daniel L. McCartney, Futao Zhang, Robert F. Hillary, Qian Zhang, Anna J. Stevenson, Rosie M. Walker, Mairead L. Bermingham, Thibaud Boutin, Stewart W. Morris, Archie Campbell, Alison D. Murray, Heather C. Whalley, David J. Porteous, Caroline Hayward, Kathryn L. Evans, Tamir Chandra, Ian J. Deary, Andrew M. McIntosh, Jian Yang, Peter M. Visscher, Allan F. McRae, Riccardo E. Marioni

Source: Genome Medicine, Vol 12, Iss 1, Pp 1-11 (2019)

Subject Terms: DNA methylation, Ageing, Sexual dimorphism, X chromosome, Generation Scotland, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/8184cb0748bd44328eeb2be72f9dbcf1

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Authors: Qian Zhang, Costanza L. Vallerga, Rosie M. Walker, Tian Lin, Anjali K. Henders, Grant W. Montgomery, Ji He, Dongsheng Fan, Javed Fowdar, Martin Kennedy, Toni Pitcher, John Pearson, Glenda Halliday, John B. Kwok, Ian Hickie, Simon Lewis, Tim Anderson, Peter A. Silburn, George D. Mellick, Sarah E. Harris, Paul Redmond, Alison D. Murray, David J. Porteous, Christopher S. Haley, Kathryn L. Evans, Andrew M. McIntosh, Jian Yang, Jacob Gratten, Riccardo E. Marioni, Naomi R. Wray, Ian J. Deary, Allan F. McRae, Peter M. Visscher

Source: Genome Medicine, Vol 11, Iss 1, Pp 1-11 (2019)

Subject Terms: DNA methylation, Age prediction, Epigenetic clock, Ageing, Mortality, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13073-019-0667-1; https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/46389891d1954dbea4f0f5efb1f60145

The effect of X-linked dosage compensation on complex trait variation

Authors: Julia Sidorenko, Irfahan Kassam, Kathryn E. Kemper, Jian Zeng, Luke R. Lloyd-Jones, Grant W. Montgomery, Greg Gibson, Andres Metspalu, Tonu Esko, Jian Yang, Allan F. McRae, Peter M. Visscher

Source: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/013d3c416c61462f8755c27f7c64fc0a

Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936

Authors: Robert F. Hillary, Daniel L. McCartney, Sarah E. Harris, Anna J. Stevenson, Anne Seeboth, Qian Zhang, David C. Liewald, Kathryn L. Evans, Craig W. Ritchie, Elliot M. Tucker-Drob, Naomi R. Wray, Allan F. McRae, Peter M. Visscher, Ian J. Deary, Riccardo E. Marioni

Source: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/eb036a77eede4ca581fe18fef0869311

OSCA: a tool for omic-data-based complex trait analysis

Authors: Futao Zhang, Wenhan Chen, Zhihong Zhu, Qian Zhang, Marta F. Nabais, Ting Qi, Ian J. Deary, Naomi R. Wray, Peter M. Visscher, Allan F. McRae, Jian Yang

Source: Genome Biology, Vol 20, Iss 1, Pp 1-13 (2019)

Subject Terms: Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13059-019-1718-z; https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/25fb6e8af3e64a74a4734fc85ba69133

Using Monozygotic Twins to Dissect Common Genes in Posttraumatic Stress Disorder and Migraine

Authors: Charlotte K. Bainomugisa, Heidi G. Sutherland, Richard Parker, Allan F. Mcrae, Larisa M. Haupt, Lyn R. Griffiths, Andrew Heath, Elliot C. Nelson, Margaret J. Wright, Ian B. Hickie, Nicholas G. Martin, Dale R. Nyholt, Divya Mehta

Source: Frontiers in Neuroscience, Vol 15 (2021)

Subject Terms: DNA methylation, twins, posttraumatic stress disorder, migraine, genes, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2021.678350/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/8878ae1cca454298a603996fc7b1e204