Predicting Pharmacokinetics in Rats Using Machine Learning: A Comparative Study Between Empirical, Compartmental, and PBPK‐Based Approaches.

Authors: Walter, Moritz¹ (AUTHOR), Aljayyoussi, Ghaith² (AUTHOR), Gerner, Bettina² (AUTHOR), Rapp, Hermann² (AUTHOR), Tautermann, Christofer S.¹ (AUTHOR), Balazki, Pavel³ (AUTHOR), Skalic, Miha¹ (AUTHOR), Borghardt, Jens M.² (AUTHOR) jens_markus.borghardt@boehringer‐ingelheim.com, Humbeck, Lina¹ (AUTHOR) lina.humbeck@boehringer‐ingelheim.com

Source: CTS: Clinical & Translational Science. Mar2025, Vol. 18 Issue 3, p1-11. 11p.

Subject Terms: *PHARMACOKINETICS, *MACHINE learning, *DRUG discovery, *RATS, *DRUG metabolism

Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone.

Authors: Haines, Lee R., Trett, Anna, Rose, Clair, García, Natalia, Sterkel, Marcos, McGuinness, Dagmara, Regnault, Clément, Barrett, Michael P., Leroy, Didier, Burrows, Jeremy N., Biagini, Giancarlo, Ranganath, Lakshminarayan R., Aljayyoussi, Ghaith, Acosta-Serrano, Álvaro

Source: Science Translational Medicine; 3/26/2025, Vol. 17 Issue 791, p1-16, 16p

Dose prediction for repurposing nitazoxanide in SARS‐CoV‐2 treatment or chemoprophylaxis

Authors: Rajoli, Rajith K. R., Pertinez, Henry, Arshad, Usman, Box, Helen, Tatham, Lee, Curley, Paul, Neary, Megan, Sharp, Joanne, Liptrott, Neill J., Valentijn, Anthony, David, Christopher, Rannard, Steven P., Aljayyoussi, Ghaith, Pennington, Shaun H., Hill, Andrew, Boffito, Marta, Ward, Steve A., Khoo, Saye H., Bray, Patrick G., O'Neill, Paul M., Hong, W. David, Biagini, Giancarlo A., Owen, Andrew

Source: British journal of clinical pharmacology. 87(4):2078-2088

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129007542.0x000001&indx=1&recIds=ETOCvdc_100129007542.0x000001

Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose—Response Relationship Using Intracellular Pharmacodynamic Modeling (PD~i)

Authors: Donnellan, Samantha, Martínez-Rodríguez, Carmen, Aljayyoussi, Ghaith, Biagini, Giancarlo A.

Source: Methods in molecular biology. 2296:393-410

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626643310&indx=1&recIds=ETOCRN626643310

Human Direct Skin Feeding Versus Membrane Feeding to Assess the Mosquitocidal Efficacy of High-Dose Ivermectin (IVERMAL Trial)

Authors: Smit, Menno R., Ochomo, Eric O., Aljayyoussi, Ghaith, Kwambai, Titus K., Abong’o, Bernard O., Bousema, Teun, Waterhouse, David, Bayoh, Nabie M., Gimnig, John E., Samuels, Aaron M., Desai, Meghna R., Phillips-Howard, Penelope A., Kariuki, Simon K., Wang, Duolao, Ward, Stephen A., ter Kuile, Feiko O.

Source: Clinical Infectious Diseases, 2019 Oct 01. 69(7), 1112-1119.

Access URL: https://www.jstor.org/stable/26784650

Ivermectin as a novel complementary malaria control tool to reduce incidence and prevalence: a modelling study

Authors: Slater, Hannah C ^*, Foy, Brian D, Kobylinski, Kevin, Chaccour, Carlos, Watson, Oliver J, Hellewell, Joel, Aljayyoussi, Ghaith, Bousema, Teun, Burrows, Jeremy, D'Alessandro, Umberto, Alout, Haoues, Ter Kuile, Feiko O, Walker, Patrick G T, Ghani, Azra C, Smit, Menno R

Source: In The Lancet Infectious Diseases April 2020 20(4):498-508

Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics

Authors: Arshad, Usman, Pertinez, Henry, Box, Helen, Tatham, Lee, Rajoli, Rajith K. R., Curley, Paul, Neary, Megan, Sharp, Joanne, Liptrott, Neill J., Valentijn, Anthony, David, Christopher, Rannard, Steve P., O'Neill, Paul M., Aljayyoussi, Ghaith, Pennington, Shaun H., Ward, Stephen A., Hill, Andrew, Back, David J., Khoo, Saye H., Bray, Patrick G., Biagini, Giancarlo A., Owen, Andrew

Source: Clinical pharmacology & therapeutics. 108(4):775-790

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100106692121.0x000001&indx=1&recIds=ETOCvdc_100106692121.0x000001

AWZ1066S, a highly specific anti- Wolbachia drug candidate for a short-course treatment of filariasis

Authors: Hong, W. David, Benayoud, Farid, Nixon, Gemma L., Ford, Louise, Johnston, Kelly L., Clare, Rachel H., Cassidy, Andrew, Cook, Darren A. N., Siu, Amy, Shiotani, Motohiro, Webborn, Peter J. H., Kavanagh, Stefan, Aljayyoussi, Ghaith, Murphy, Emma, Steven, Andrew, Archer, John, Struever, Dominique, Frohberger, Stefan J., Ehrens, Alexandra, Hübner, Marc P., Hoerauf, Achim, Roberts, Adam P., Hubbard, Alasdair T. M., Tate, Edward W., Serwa, Remigiusz A., Leung, Suet C., Qie, Li, Berry, Neil G., Gusovsky, Fabian, Hemingway, Janet, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., O’Neill, Paul M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Jan . 116(4), 1414-1419.

Access URL: https://www.jstor.org/stable/26580255

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria

Authors: O' Neill, Paul M., Stocks, Paul A., Sabbani, Sunil, Roberts, Natalie L., Amewu, Richard K., Shore, Emma R., Aljayyoussi, Ghaith, Angulo-Barturén, Iñigo, Belén, María, Jiménez-Díaz, Bazaga, Santiago Ferrer, Martínez, María Santos, Campo, Brice, Sharma, Raman, Charman, Susan A., Ryan, Eileen, Chen, Gong, Shackleford, David M., Davies, Jill, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.

Source: In Bioorganic & Medicinal Chemistry 15 July 2018 26(11):2996-3005

Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial

Authors: Smit, Menno R, Ochomo, Eric O, Aljayyoussi, Ghaith, Kwambai, Titus K, Abong'o, Bernard O, Chen, Tao, Bousema, Teun, Slater, Hannah C, Waterhouse, David, Bayoh, Nabie M, Gimnig, John E, Samuels, Aaron M, Desai, Meghna R, Phillips-Howard, Penelope A, Kariuki, Simon K, Wang, Duolao, Ward, Steve A, ter Kuile, Feiko O

Source: In The Lancet Infectious Diseases June 2018 18(6):615-626

Pharmacokinetics‐Pharmacodynamics of High‐Dose Ivermectin with Dihydroartemisinin‐Piperaquine on Mosquitocidal Activity and QT‐Prolongation (IVERMAL)

Authors: Smit, Menno R., Ochomo, Eric O., Waterhouse, David, Kwambai, Titus K., Abong'o, Bernard O., Bousema, Teun, Bayoh, Nabie M., Gimnig, John E., Samuels, Aaron M., Desai, Meghna R., Phillips‐Howard, Penelope A., Kariuki, Simon K., Wang, Duolao, ter Kuile, Feiko O., Ward, Stephen A., Aljayyoussi, Ghaith

Source: Clinical pharmacology & therapeutics. 105(2):388-401

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100084329986.0x000001&indx=1&recIds=ETOCvdc_100084329986.0x000001

Remdesivir–ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2

Authors: Jeffreys, Laura N., Pennington, Shaun H., Duggan, Jack, Caygill, Claire H., Lopeman, Rose C., Breen, Alastair F., Jinks, Jessica B., Ardrey, Alison, Donnellan, Samantha, Patterson, Edward I., Hughes, Grant L., Hong, David W., O'Neill, Paul M., Aljayyoussi, Ghaith, Owen, Andrew, Ward, Stephen A., Biagini, Giancarlo A.

Source: International journal of antimicrobial agents. 59(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166542245.0x000001&indx=1&recIds=ETOCvdc_100166542245.0x000001

Synthesis and profiling of benzylmorpholine 1, 2, 4, 5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria

Authors: O' Neill, Paul M., Stocks, Paul A., Sabbani, Sunil, Roberts, Natalie L., Amewu, Richard K., Shore, Emma R., Aljayyoussi, Ghaith, Angulo-Barturén, Iñigo, Belén, María, Bazaga, Santiago Ferrer, Martínez, María Santos, Campo, Brice, Sharma, Raman, Charman, Susan A., Ryan, Eileen, Chen, Gong, Shackleford, David M., Davies, Jill, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.

Source: Bioorganic & medicinal chemistry. 26(11):2996-3005

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100096738424.0x000001&indx=1&recIds=ETOCvdc_100096738424.0x000001

Riboswitch-controlled IL-12 gene therapy reduces hepatocellular cancer in mice.

Authors: Düchs, Matthias J., Kratzer, Ramona F., Vieyra-Garcia, Pablo, Strobel, Benjamin, Schönberger, Tanja, Groß, Peter, Aljayyoussi, Ghaith, Gupta, Aradhana, Lang, Isabel, Klein, Holger, Morilla, Sandra Martinez, Hopf, Stefan, Park, John, Kreuz, Sebastian, Klugmann, Matthias, Igney, Frederik H.

Source: Frontiers in Immunology; 2024, p1-19, 19p

Subject Terms: HEPATOCELLULAR carcinoma, LIVER cancer, GENE therapy, GENE expression, MICE

Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis.

Authors: Hegde, Shrilakshmi, Marriott, Amy E., Pionnier, Nicolas, Steven, Andrew, Bulman, Christina, Gunderson, Emma, Voge, Ian, Kosche, Marianne, Ehrens, Alexandra, Lustigman, Sara, Voronin, Denis, Tricoche, Nancy, Hoerauf, Achim, Hübner, Marc P., Sankanari, Judy, Aljayyoussi, Ghaith, Gusovsky, Fabian, Dagley, Jessica, Hong, David W., O'Neil, Paul

Source: Frontiers in Microbiology; 2024, p1-17, 17p

Subject Terms: FILARIASIS, MONGOLIAN gerbil, PARASITIC diseases, ANTHELMINTICS, ANIMAL diseases

Auto-fluorescent PAMAM-based dendritic molecules and their potential application in pharmaceutical sciences

Authors: El-Betany, Alaa M.M., Kamoun, Elbadawy A., James, Craig, Jangher, Abdulhakim, Aljayyoussi, Ghaith, Griffiths, Peter, McKeown, Neil B., Gumbleton, Mark

Source: International journal of pharmaceutics. 579

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115232335.0x000001&indx=1&recIds=ETOCvdc_100115232335.0x000001

Identification of 2‑Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis.

Authors: Jeffreys, Laura N., Ardrey, Alison, Hafiz, Taghreed A., Dyer, Lauri-Anne, Warman, Ashley J., Mosallam, Nada, Nixon, Gemma L., Fisher, Nicholas E., Hong, W. David, Leung, Suet C., Aljayyoussi, Ghaith, Bibby, Jaclyn, Almeida, Deepak V., Converse, Paul J., Fotouhi, Nader, Berry, Neil G., Nuermberger, Eric L., Upton, Anna M., O'Neill, Paul M., Ward, Stephen A.

Source: ACS Infectious Diseases; 2/10/2023, Vol. 9 Issue 2, p221-238, 18p

The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro.

Authors: Walz, Annabelle, Duffey, Maëlle, Aljayyoussi, Ghaith, Sax, Sibylle, Leroy, Didier, Besson, Dominique, Burrows, Jeremy N., Cherkaoui-Rbati, Mohammed H., Gobeau, Nathalie, Westwood, Marie-Anne, Siethoff, Christoph, Gamo, Francisco-Javier, Mäser, Pascal, Wittlin, Sergio

Source: Pharmaceuticals (14248247); Feb2023, Vol. 16 Issue 2, p163, 16p

Subject Terms: PLASMODIUM falciparum, PARASITES, PLASMODIUM, QUALITY control

Geographic Terms: AFRICA

Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis

Authors: Aljayyoussi, Ghaith, Tyrer, Hayley E., Ford, Louise, Sjoberg, Hanna, Pionnier, Nicolas, Waterhouse, David, Davies, Jill, Gamble, Joanne, Metuge, Haelly, Cook, Darren A. N., Steven, Andrew, Sharma, Raman, Guimaraes, Ana F., Clare, Rachel H., Cassidy, Andrew, Johnston, Kelly L., Myhill, Laura, Hayward, Laura, Wanji, Samuel, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A.

Source: Scientific reports. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131378519.0x000001&indx=1&recIds=ETOCvdc_100131378519.0x000001

Erratum: Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

Authors: Sharma, Raman, Aljayyoussi, Ghaith, Tyrer, Hayley E., Gamble, Joanne, Hayward, Laura, Guimaraes, Ana F., Davies, Jill, Waterhouse, David, Cook, Darren A. N., Myhill, Laura J., Clare, Rachel H., Cassidy, Andrew, Steven, Andrew, Johnston, Kelly L., Ford, Louise, Turner, Joseph D., Ward, Stephen A., Taylor, Mark J.

Source: Scientific reports. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130641813.0x000001&indx=1&recIds=ETOCvdc_100130641813.0x000001