NS3 helicase inhibitory potential of the marine sponge Spongia irregularisElectronic supplementary information (ESI) available. See DOI: 10.1039/d1ra08321j

Authors: Abdelaleem, Enas Reda, Samy, Mamdouh Nabil, Ali, Taha F. S., Mustafa, Muhamad, Ibrahim, Mahmoud A. A., Bringmann, Gerhard, Ahmed, Safwat A., Abdelmohsen, Usama Ramadan, Desoukey, Samar Yehia

Source: RSC advances. 12(5):2992-3002

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139903863.0x000001&indx=1&recIds=ETOCvdc_100139903863.0x000001

Secondary metabolites of Livistona decipiens as potential inhibitors of SARS-CoV-2Electronic supplementary information (ESI) available. See https://doi.org/10.1039/d2ra01306a

Authors: El-hawary, Seham S., Ali, Taha F. S., Abo El-Ela, Sara O., Elwekeel, Ahlam, Abdelmohsen, Usama Ramadan, Owis, Asmaa I.

Source: RSC advances. 12(30):19505-19511

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155212405.0x000001&indx=1&recIds=ETOCvdc_100155212405.0x000001

Antiproliferative potential of moluccella laevis L. aerial parts family lamiaceae (labiatae), supported by phytochemical investigation and molecular docking study

Authors: Hamed, Ashraf N. E., Abdelaty, Nousiba A., Attia, Eman Z., Amin, Mohamed N., Ali, Taha F. S., Afifi, Ahmed H., Abdelmohsen, Usama R., Desoukey, Samar Y.

Source: Natural product research. 36(5):1391-1395

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144621017.0x000001&indx=1&recIds=ETOCvdc_100144621017.0x000001

Antidepressant potential of Mesembryanthemum cordifolium roots assisted by metabolomic analysis and virtual screening

Authors: Said, Asmaa Abo Elgoud, Ali, Taha F. S., Attia, Eman Zekry, Ahmed, Al-Shaimaa F., Shehata, Alaa H., Abdelmohsen, Usama Ramadan, Fouad, Mostafa Ahmed

Source: Natural product research. 35(23):5493-5497

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135248751.0x000001&indx=1&recIds=ETOCvdc_100135248751.0x000001

NS3/4A helicase inhibitory alkaloids from Aptenia cordifolia as HCV targetElectronic supplementary information (ESI) available. See DOI: 10.1039/d1ra06139a

Authors: Elgoud Said, Asmaa Abo, Afifi, Ahmed H., Ali, Taha F. S., Samy, Mamdouh Nabil, Abdelmohsen, Usama Ramadan, Fouad, Mostafa A., Attia, Eman Zekry

Source: RSC advances. 11(52):32740-32749

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135152080.0x000001&indx=1&recIds=ETOCvdc_100135152080.0x000001

An antifibrotic compound that ameliorates hyperglycaemia and fat accumulation in cell and HFD mouse models.

Authors: Toma, Tsugumasa, Miyakawa, Nobukazu, Arakaki, Yuiichi, Watanabe, Takuro, Nakahara, Ryosei, Ali, Taha F. S., Biswas, Tanima, Todaka, Mikio, Kondo, Tatsuya, Fujita, Mikako, Otsuka, Masami, Araki, Eiichi, Tateishi, Hiroshi

Source: Diabetologia; Nov2024, Vol. 67 Issue 11, p2568-2584, 17p

Indole-based FLT3 inhibitors and related scaffolds as potential therapeutic agents for acute myeloid leukemia.

Authors: Ezelarab, Hend A. A.¹ (AUTHOR), Ali, Taha F. S.¹ (AUTHOR), Abbas, Samar H.¹ (AUTHOR) samar_hafez@mu.edu.eg, Hassan, Heba A.¹ (AUTHOR), Beshr, Eman A. M.¹ (AUTHOR) eman_beshr@mu.edu.eg

Source: BMC Chemistry. 7/12/2023, Vol. 17 Issue 1, p1-31. 31p.

Subject Terms: *ACUTE myeloid leukemia, *PROTEIN-tyrosine kinases, *INDOLE compounds, *OVERALL survival

Company/Entity: UNITED States. Food & Drug Administration

Discovery of oxindole‐based FLT3 inhibitors as a promising therapeutic lead for acute myeloid leukemia carrying the oncogenic ITD mutation

Authors: Bender, Onur, Shoman, Mai E., Ali, Taha F. S., Dogan, Rumeysa, Celik, Ismail, Mollica, Adriano, Hamed, Mohammed I. A., Aly, Omar M., Alamri, Abdulwahab, Alanazi, Jowaher, Ahemad, Nafees, Gan, Siew Hua, Malik, Jonaid Ahmad, Anwar, Sirajudheen, Atalay, Arzu, Beshr, Eman A. M.

Source: Archiv der Pharmazie. 356(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173048937.0x000001&indx=1&recIds=ETOCvdc_100173048937.0x000001

Design and Synthesis of New Dihydropyrimidine Derivatives with a Cytotoxic Effect as Dual EGFR/VEGFR‑2 Inhibitors.

Authors: Al-Wahaibi, Lamya H., Elshamsy, Ali M., Ali, Taha F. S., Youssif, Bahaa G. M., Bräse, Stefan, Abdel-Aziz, Mohamed, El-Koussi, Nawal A.

Source: ACS Omega; 8/13/2024, Vol. 9 Issue 32, p34358-34369, 12p

Design and synthesis of new dihydropyrimidine/sulphonamide hybrids as promising anti-inflammatory agents via dual mPGES-1/5-LOX inhibition.

Authors: Al-Wahaibi, Lamya H., Elshamsy, Ali M., Ali, Taha F. S., Youssif, Bahaa G. M., Brase, S., Abdel-Aziz, Mohamed, El-Koussi, Nawal A., Lauro, Gianluigi

Source: Frontiers in Chemistry; 2024, p1-16, 16p

Subject Terms: SULFONAMIDES, ANTI-inflammatory agents, PYRIMIDINES, LIPOXYGENASES, PROSTAGLANDINS

Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor.

Authors: Soudi, Aya, Bender, Onur, Celik, Ismail, El-Hafeez, Amer Ali Abd, Dogan, Rumeysa, Atalay, Arzu, Elkaeed, Eslam B., Alsfouk, Aisha A., Abdelhafez, Elshimaa M. N., Aly, Omar M., Sippl, Wolfgang, Ali, Taha F. S.

Source: Pharmaceuticals (14248247); May2024, Vol. 17 Issue 5, p659, 28p

Subject Terms: MEDICAL screening, PROTEIN kinases, KINASE inhibitors, COLON cancer, CYCLIN-dependent kinases, KINASES, PROTEIN-tyrosine kinases

Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity.

Authors: Ali, Taha F. S.^1,2 (AUTHOR) hiciftci@kumamoto-u.ac.jp, Ciftci, Halil I.^2,3 (AUTHOR) mohamedradwan@kumamoto-u.ac.jp, Radwan, Mohamed O.^2,4 (AUTHOR) htateishi@kumamoto-u.ac.jp, Roshdy, Eslam^1,5 (AUTHOR), Shawky, Ahmed M.^6,7 (AUTHOR) amesmail@uqu.edu.sa, Abourehab, Mohammed A. S.⁸ (AUTHOR) maabourehab@uqu.edu.sa, Tateishi, Hiroshi² (AUTHOR) motsuka@gpo.kumamoto-u.ac.jp, Otsuka, Masami^2,3 (AUTHOR), Fujita, Mikako² (AUTHOR) taha.ali@mu.edu.eg

Source: Pharmaceuticals (14248247). Apr2022, Vol. 15 Issue 4, pN.PAG-N.PAG. 19p.

Subject Terms: *GLYCOGEN synthase kinase, *TAU proteins, *ALZHEIMER'S disease, *NEUROPROTECTIVE agents, *GLYCOGEN synthase kinase-3, *DRUG therapy, *NEURODEGENERATION

New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization.

Authors: Ezelarab, Hend A. A., Ali, Taha F. S., Abbas, Samar H., Sayed, Ahmed M., Beshr, Eman A. M., Hassan, Heba A.

Source: Molecular Diversity; Apr2024, Vol. 28 Issue 2, p563-580, 18p

Combination of an Oxindole Derivative with (−)-β-Elemene Alters Cell Death Pathways in FLT3/ITD + Acute Myeloid Leukemia Cells.

Authors: Alanazi, Jowaher, Bender, Onur, Dogan, Rumeysa, Malik, Jonaid Ahmad, Atalay, Arzu, Ali, Taha F. S., Beshr, Eman A. M., Shawky, Ahmed M., Aly, Omar M., Alqahtani, Yasir Nasser H., Anwar, Sirajudheen

Source: Molecules; Jul2023, Vol. 28 Issue 13, p5253, 15p

Subject Terms: ACUTE myeloid leukemia, MYELOID cells, CELL death, BCL genes, CELL morphology, CELL analysis

Vanillin-Based Indolin-2-one Derivative Bearing a Pyridyl Moiety as a Promising Anti-Breast Cancer Agent via Anti-Estrogenic Activity.

Authors: Bender, Onur, Celik, Ismail, Dogan, Rumeysa, Atalay, Arzu, Shoman, Mai E., Ali, Taha F. S., Beshr, Eman A. M., Mohamed, Mahmoud, Alaaeldin, Eman, Shawky, Ahmed M., Awad, Eman M., Ahmed, Al-Shaimaa F., Younes, Kareem M., Ansari, Mukhtar, Anwar, Sirajudheen

Source: ACS Omega; 2/21/2023, Vol. 8 Issue 7, p6968-6981, 14p

In silico drug discovery of SIRT2 inhibitors from natural source as anticancer agents.

Authors: Ibrahim, Mahmoud A. A., Abdeljawaad, Khlood A. A., Roshdy, Eslam, Mohamed, Dina E. M., Ali, Taha F. S., Gabr, Gamal A., Jaragh-Alhadad, Laila A., Mekhemer, Gamal A. H., Shawky, Ahmed M., Sidhom, Peter A., Abdelrahman, Alaa H. M.

Source: Scientific Reports; 2/8/2023, Vol. 13 Issue 1, p1-16, 16p

Subject Terms: DRUG discovery, ANTINEOPLASTIC agents, MOLECULAR dynamics, BINDING energy, SIRTUINS, NATURAL products

Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration.

Authors: Toma, Tsugumasa, Tateishi, Hiroshi, Kawakami, Kensaku, Ali, Taha F. S., Kamo, Masahiro, Monde, Kazuaki, Nakashima, Yuta, Fujita, Mikako, Otsuka, Masami

Source: International Journal of Molecular Sciences; May2022, Vol. 23 Issue 9, p5047-5047, 16p

Subject Terms: TRANSFORMING growth factors, EPITHELIAL-mesenchymal transition, NON-small-cell lung carcinoma, CELL migration, DRUG development, AMP-activated protein kinases

Applying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug.

Authors: Aly, Usama Farghaly, Sarhan, Hatem Abdelmonsef, Ali, Taha F. S., Sharkawy, Hosny Abd El-Bakey

Source: Drug Design, Development & Therapy; May2020, Vol. 14, p1851-1865, 15p, 6 Diagrams, 3 Charts, 5 Graphs

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