Synthesis, biological evaluation, and in silico studies of phenyl naphthalene-2-sulfonate derived thiosemicarbazones as potential carbonic anhydrase inhibitors

Authors: Eshal, Javeria ^{a, 1}, Tariq, Hafiza Zara ^{b, 1}, Li, Jing ^b, Aftab, Hina ^a, Şenol, Halil ^c, Taslimi, Parham ^{d, ⁎}, Sadeghian, Nastaran ^d, Alharthy, Rima D. ^e, Akram, Muhammad Safwan ^{f, g}, Talib, Rimsha ^a, Shafiq, Zahid ^{a, ⁎}

Source: In Bioorganic Chemistry February 2025 155

Indole-based thiosemicarbazones for neurodegenerative diseases as prolyl oligopeptidase inhibitors

Authors: Pasha, Anam Rubbab, Khan, Ajmal, Ullah, Saeed, Halim, Sobia Ahsan, Alharthy, Rima D., Anwar, Muhammad Usman, Hussain, Javid, Naseer, Muhammad Moazzam, Kashtoh, Hamdy, Al-Harrasi, Ahmed, Shafiq, Zahid, Boshta, Nader M.

Source: In Journal of Molecular Structure 15 September 2024 1312 Part 2

Synthesis, biological evaluation, and molecular modelling of substituted thiazolyl thiourea derivatives: A new class of prolyl oligopeptidase inhibitors

Authors: Naseem, Saira, Oneto, Angelo, Ullah, Saeed, Fatima, Shamool, Mali, Suraj N., Jawarkar, Rahul D., Khan, Ajmal, Alharthy, Rima D., Kashtoh, Hamdy, Al-Harrasi, Ahmed, Shafiq, Zahid, Boshta, Nader M.

Source: In International Journal of Biological Macromolecules August 2024 275 Part 1

Coumarin-based thiosemicarbazones as colorimetric and fluorescent “Turn on” chemosensors for fluoride ions and their applications in logic circuits

Authors: Alharthy, Rima D., Tariq, Shoaib, Naseem, Saira, Islam, Muhammad, Ahmed, Nadeem, Pasha, Anam Rubbab, Shafiq, Zahid

Source: In Journal of Molecular Structure 15 December 2023 1294 Part 1

Synthesis of novel 3-hydroxy-2-naphthoic hydrazones as selective chemosensors for cyanide ionsElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3ra00788j

Authors: Alharthy, Rima D., Urooj, Ifra, Tasleem, Mussarat, Khalid, Muhammad, Asghar, Muhammad Adnan, Khan, Shaista Ijaz, Ajmal, Muhammad, Ahmed, Nadeem, Shafiq, Zahid

Source: RSC advances. 13(22):15208-15221

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183368525.0x000001&indx=1&recIds=ETOCvdc_100183368525.0x000001

Synthesis and biological evaluation of novel isatin-hydrazide conjugates as potential antidiabetic agents

Authors: Alharthy, Rima D., Zahra, Syeda Bakhtawar, Fatima, Noor, Tabassum, Arooma, Ullah, Saeed, Halim, Sobia Ahsan, Khan, Ajmal, Hussain, Javid, Al-Harrasi, Ahmed, Shafiq, Zahid

Source: In Journal of Molecular Structure 15 September 2023 1288

Deep learning-based prediction of inhibitors interaction with Butyrylcholinesterase for the treatment of Alzheimer's disease

Authors: Jabeen, Farah, Rehman, Zia Ur, Shah, Sajid, Alharthy, Rima D., Jalil, Saquib, Khan, Imtiaz Ali, Iqbal, Jamshed, El-Latif, Ahmed A. Abd

Source: In Computers and Electrical Engineering January 2023 105

Evaluation of trace and heavy metals in different varieties of sauces to characterize their impact on human health

Authors: Khaleeq, Anum, Ahmed, Mahmood, Huma, Rahila, Mujtaba, Aiman, Noor, Sara, Rehman, Rimsha, Sheikh, Tahir Ali, Qamar, Shaista, Iqbal, Dure Najaf, Alharthy, Rima D., Hameed, Abdul

Source: In Journal of Food Composition and Analysis December 2022 114

Fabrication, characterization, TD-DFT, optical and electrical properties of poly (aniline-co-para nitroaniline)/ZrO2 composite for solar cell applications

Authors: Attar, Alaa, Alharthy, Rima D., Zwawi, Mohammed, Algarni, Mohammed, Albatati, Faisal, Bassyouni, Mohamed, Abdel-Aziz, Mohamed Helmy, Zoromba, Mohamed Shafick, Al-Hossainy, A.F.

Source: In Journal of Industrial and Engineering Chemistry 25 May 2022 109:230-244

Nucleotide pyrophosphatase/phosphodiesterases (NPPs) including NPP1 and NPP2/ ATX as important drug targets: A patent review (2015-2020)

Authors: Bano, Sehrish, Al-Rashida, Mariya, Alharthy, Rima D, Khan, Imtiaz Ali, Iqbal, Jamshed

Source: Expert opinion on therapeutic patents. 32(7):743-751

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152926399.0x000001&indx=1&recIds=ETOCvdc_100152926399.0x000001

Binding selectivity analysis of AURKs inhibitors through molecular dynamics simulation studies.

Authors: Alharthy, Rima D.¹ (AUTHOR), Fatima, Ghulam² (AUTHOR), Yousaf, Numan² (AUTHOR), Iqbal, Muhammad Shaheen² (AUTHOR), Sattar, Sadia² (AUTHOR), Alanzi, Abdullah R.³ (AUTHOR), Ali, Ijaz⁴ (AUTHOR), Muddassar, Muhammad² (AUTHOR) mmuddassar@gmail.com

Source: PLoS ONE. 12/19/2023, Vol. 18 Issue 12, p1-20. 20p.

Subject Terms: *MOLECULAR dynamics, *AURORA kinases, *BINDING energy, *DRUG target, *PROTEIN structure

Synthesis, characterization and biological evaluation of indomethacin derived thioureas as purinergic (P2Y1, P2Y2, P2Y4, and P2Y6) receptor antagonists

Authors: Bano, Sehrish, Shabir, Ghulam, Saeed, Aamer, Ul-Hamid, Anwar, Alharthy, Rima D., Iqbal, Jamshed

Source: In Bioorganic Chemistry November 2021 116

Development of coumarin-thiosemicarbazone hybrids as aldose reductase inhibitors: Biological assays, molecular docking, simulation studies and ADME evaluation

Authors: Imran, Aqeel, Tariq Shehzad, Muhammad, al Adhami, Taha, Miraz Rahman, Khondaker, Hussain, Dilawar, Alharthy, Rima D., Shafiq, Zahid, Iqbal, Jamshed

Source: In Bioorganic Chemistry October 2021 115

Application of asymmetric dicationic ionic liquids for oil spill remediation in sea water

Authors: El shafiee, C.E., El-Nagar, R.A., Nessim, M.I., Khalil, M.M.H., Shaban, M.E., Alharthy, Rima D., Ismail, D.A, Abdallah, R.I., Moustafa, Y.M.

Source: In Arabian Journal of Chemistry May 2021 14(5)

Synthesis of chromone-based thiosemicarbazone as selective chemosensor for cyanide ion and its DFT calculation studies.

Authors: Alharthy, Rima D.¹ (AUTHOR), Khalid, Sana² (AUTHOR), Ahmed, Nadeem³ (AUTHOR), Zahra, Syeda Bakhtawar² (AUTHOR), Mali, Suraj N.⁴ (AUTHOR), Kuznetsov, Aleksey⁵ (AUTHOR), Shafiq, Zahid⁶ (AUTHOR) zahidshafiq@bzu.edu.pk

Source: Supramolecular Chemistry. May/Jun2023, Vol. 34 Issue 5/6, p223-238. 16p.

Subject Terms: *CYANIDES, *THIOSEMICARBAZONES, *DENSITY functional theory, *SUPRAMOLECULAR chemistry, *BINDING constant, *IONS, *ULTRAVIOLET-visible spectroscopy

Functionalized Diazabenzo[a]anthracenediones: Regioselective Multicomponent Synthesis and Biological and Computational Studies as Potential Cholinesterase Inhibitors

Authors: Tariq Riaz, Muhammad, Taslimi, Parham, Yaqub, Muhammad, al‐Rashida, Mariya, Alharthy, Rima D., El‐Gokha, Ahmed, Shafiq, Zahid

Source: ChemistrySelect. 8(22)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186113743.0x000001&indx=1&recIds=ETOCvdc_100186113743.0x000001

Pyrazole derivatives of pyridine and naphthyridine as proapoptotic agents in cervical and breast cancer cells.

Authors: Alharthy, Rima D.¹ (AUTHOR), Rashid, Faisal² (AUTHOR), Ashraf, Abida³ (AUTHOR), Shafiq, Zahid^4,5 (AUTHOR), Ford, Steven⁶ (AUTHOR), al-Rashida, Mariya⁷ (AUTHOR), Yaqub, Muhammad⁴ (AUTHOR), Iqbal, Jamshed² (AUTHOR) jamshediqb@googlemail.com

Source: Scientific Reports. 4/1/2023, Vol. 13 Issue 1, p1-14. 14p.

Subject Terms: *CANCER cells, *BREAST cancer, *CERVICAL cancer, *PYRAZOLE derivatives, *CELL cycle

Design and Synthesis of Novel Pyrazolo[3, 4-d]Pyrimidines: In Vitro Cytotoxic Evaluation and Free Radical Scavenging Activity Studies

Authors: Alharthy, Rima D.

Source: Pharmaceutical chemistry journal. 54(3):273-278

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171652689.0x000001&indx=1&recIds=ETOCvdc_100171652689.0x000001

Synthesis of the chromone‐thiosemicarbazone scaffold as promising α‐glucosidase inhibitors: An in vitro and in silico approach toward antidiabetic drug design.

Authors: Alharthy, Rima D., Khalid, Sana, Fatima, Shamool, Ullah, Saeed, Khan, Ajmal, Mali, Suraj N., Jawarkar, Rahul D., Dhabarde, Sanjay S., Kashtoh, Hamdy, Taslimi, Parham, Al‐Harrasi, Ahmed, Shafiq, Zahid, Boshta, Nader M.

Source: Archiv der Pharmazie; Aug2024, Vol. 357 Issue 8, p1-18, 18p

Acridine-based (thio)semicarbazones and hydrazones: Synthesis, in vitro urease inhibition, molecular docking and in-silico ADME evaluation

Authors: Isaac, Ibanga Okon, al-Rashida, Mariya, Rahman, Shafiq Ur, Alharthy, Rima D., Asari, Asnuzilawati, Hameed, Abdul, Khan, Khalid Mohammed, Iqbal, Jamshed

Source: In Bioorganic Chemistry February 2019 82:6-16