ENDOLUNG trial, part II. A phase II study of the Akt/mTOR inhibitor and autophagy inducer ibrilatazar (ABTL0812) in combination with paclitaxel/carboplatin in patients with squamous non-small cell lung cancer

Authors: Bosch-Barrera, Joaquim ^{a, 1}, Estévez-García, Purificación ^b, Martín-Martorell, Paloma ^c, Sabatier, Renaud ^d, Nadal, Ernest ^e, Sais, Elia ^a, Gascón, Pere ^f, Oaknin, Ana ^g, Rodon, Jordi ^h, Lizcano, Jose M. ^{i, j}, Muñoz-Guardiola, Pau ^{i, k}, Fierro-Durán, Gemma ^k, Pedrós-Gámez, Oriol ^k, Pérez-Montoyo, Héctor ^k, Yeste-Velasco, Marc ^k, Cortal, Marc ^k, Pérez-Campos, Antonio ^k, Alfón, José ^{k, 1}, Domènech, Carles ^{k, 1, ⁎}, Morán, Teresa ^{l, 1}

Source: In Lung Cancer March 2025 201

Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models.

Authors: Mancini, Andrea, Colapietro, Alessandro, Cristiano, Loredana, Rossetti, Alessandra, Mattei, Vincenzo, Gravina, Giovanni Luca, Perez-Montoyo, Héctor, Yeste-Velasco, Marc, Alfon, Jose, Domenech, Carles, Festuccia, Claudio

Source: Frontiers in Oncology; 2025, p1-17, 17p

Subject Terms: UNFOLDED protein response, BRAIN tumors, TUMOR growth, GLIOBLASTOMA multiforme, OVERALL survival

A first-in-human phase I/Ib dose-escalation clinical trial of the autophagy inducer ABTL0812 in patients with advanced solid tumours

Authors: Vidal, Laura, Victoria, Ivan, Gaba, Lydia, Martín, Marta Gil, Brunet, Mercè, Colom, Helena, Cortal, Marc, Gómez-Ferrería, Mariana, Yeste-Velasco, Marc, Perez, Antonio, Rodon, Jordi, Sohal, Davendra P.S., Lizcano, José Miguel, Domènech, Carles, Alfón, José, Gascón, Pere

Source: In European Journal of Cancer March 2021 146:87-94

Corrigendum: Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models.

Authors: Mancini, Andrea, Colapietro, Alessandro, Cristiano, Loredana, Rossetti, Alessandra, Mattei, Vincenzo, Gravina, Giovanni Luca, Perez-Montoyo, Héctor, Yeste-Velasco, Marc, Alfon, Jose, Domenech, Carles, Festuccia, Claudio

Source: Frontiers in Oncology; 2025, p1-3, 3p

Subject Terms: ORAL drug administration, CELL nuclei, TUMOR growth, GLIOBLASTOMA multiforme, TUBULINS, EVEROLIMUS

Therapeutic potential of the new TRIB3-mediated cell autophagy anticancer drug ABTL0812 in endometrial cancer

Authors: Felip, Isidre, Moiola, Cristian Pablo, Megino-Luque, Cristina, Lopez-Gil, Carlos, Cabrera, Silvia, Solé-Sánchez, Sonia, Muñoz-Guardiola, Pau, Megias-Roda, Elisabet, Pérez-Montoyo, Héctor, Alfon, José, Yeste-Velasco, Marc, Santacana, María, Dolcet, Xavier, Reques, Armando, Oaknin, Ana, Rodríguez-Freixinos, Victor, Lizcano, José Miguel, Domènech, Carles, Gil-Moreno, Antonio, Matias-Guiu, Xavier, Colas, Eva, Eritja, Nuria

Source: In Gynecologic Oncology May 2019 153(2):425-435

Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models.

Authors: Mancini, Andrea, Colapietro, Alessandro, Cristiano, Loredana, Rossetti, Alessandra, Mattei, Vincenzo, Gravina, Giovanni Luca, Perez-Montoyo, Héctor, Yeste-Velasco, Marc, Alfon, Jose, Domenech, Carles, Festuccia, Claudio

Source: Frontiers in Oncology; 11/2/2022, Vol. 12, p1-17, 17p, 8 Graphs

HMG-CoA reductase inhibitors reduce vascular monocyte chemotactic protein-1 expression in early lesions from hypercholesterolemic swine independently of their effect on plasma cholesterol levels

Authors: Martı́nez-González, José, Alfón, José, Berrozpe, Marı́a, Badimon, Lina ^*

Source: In Atherosclerosis 2001 159(1):27-33

Nitric oxide synthase II (NOS II) gene expression correlates with atherosclerotic intimal thickening. Preventive effects of HMG-CoA reductase inhibitors

Authors: Alfon, José, Guasch, Joan F, Berrozpe, Marı́a, Badimon, Lina ^*

Source: In Atherosclerosis August 1999 145(2):325-331

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Anti-theft device for automobile vehicles

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Phase 2 clinical trial of the proautophagic drug ABTL0812 combined with paclitaxel and carboplatin in first-line patients with advanced squamous non-small cell lung carcinoma.

Authors: Bosch-Barrera, Joaquim, Moran, Teresa, Estévez-García, Purificación, Martín-Martorell, Paloma, Sabatier, Renaud, Nadal, Ernest, Lizcano, Jose M., Pedrós-Gámez, Oriol, Pérez-Montoyo, Héctor, Yeste-Velasco, Marc, Domenech, Carles, Alfon, Jose Alberto

Source: Journal of Clinical Oncology; 2023 Supplement 16, Vol. 41, p9059-9059, 1p

Alternative Binding Assay of GP IIb/IIIa Antagonists With a Nonradioactive Labeling Method of Platelets

Authors: Alfón, José ^*, Fernández de Arriba, Alberto, Gómez-Casajús, Lluı́s A, Merlos, Manuel

Source: In Thrombosis Research 2001 102(3):247-253

The Effect of Immunosuppression by Total-Body Irradiation on the Pharmacodynamics of Centrally Active Drugs in Rats.

Authors: Hoffman, Amnon, Alfon, Jose, Habib, Gustav, Pinto, Evelyne, Gorodetsky, Raphael

Source: Pharmaceutical Research; May1994, Vol. 11 Issue 5, p704-708, 5p

Pharmacodynamics of Phenobarbital Anesthesia and Pentylenetetrazol-Induced Maximal Seizures in a Rat Model of Neoplastic Spinal Cord Compression.

Authors: Hoffman, Amnon, Alfon, Jose, Siegal, Tzony, Siegal, Tali

Source: Pharmaceutical Research; Apr1994, Vol. 11 Issue 4, p536-540, 5p

High-Dose Methotrexate Does Not Affect the Pharmacodynamics of Phenobarbital Hypnotic Action but Decreases the Central Nervous System (CNS) Sensitivity to Pentylenetetrazol-Induced Maximal Seizures in Rats.

Authors: Hoffman, Amnon, Alfon, Jose

Source: Pharmaceutical Research; Oct1992, Vol. 9 Issue 10, p1295-1298, 4p

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