New hemisynthetic derivatives of sphaeropsidin phytotoxins triggering severe endoplasmic reticulum swelling in cancer cells

Authors: Aude Ingels, Robert Scott, Annie R. Hooper, Aletta E. van der Westhuyzen, Sachin B. Wagh, Joséphine de Meester, Lucia Maddau, Doris Marko, Georg Aichinger, Walter Berger, Marjorie Vermeersch, David Pérez-Morga, Vladimir A. Maslivetc, Antonio Evidente, Willem A. L. van Otterlo, Alexander Kornienko, Véronique Mathieu

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

Subject Terms: Sphaeropsidin, Diterpene, Iso-pimarane, Endoplasmic reticulum swelling, ER stress, Natural product, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/6c21a3354a474dd69508d75741c9d1ba

Epithelial-mesenchymal transition sensitizes breast cancer cells to cell death via the fungus-derived sesterterpenoid ophiobolin A

Authors: Keighley N. Reisenauer, Yongfeng Tao, Provas Das, Shuxuan Song, Haleigh Svatek, Saawan D. Patel, Sheridan Mikhail, Alec Ingros, Peter Sheesley, Marco Masi, Angela Boari, Antonio Evidente, Alexander Kornienko, Daniel Romo, Joseph Taube

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d75b28ec027d450f93ccf40375922980

Amaryllidaceae Alkaloids Decrease the Proliferation, Invasion, and Secretion of Clinically Relevant Cytokines by Cultured Human Colon Cancer Cells

Authors: Veronique Mathieu, Breana Laguera, Marco Masi, Sara Adriana Dulanto, Tanner W. Bingham, Lucas W. Hernandez, David Sarlah, Antonio Evidente, Denis L. J. Lafontaine, Alexander Kornienko, Michelle A. Lane

Source: Biomolecules, Vol 12, Iss 9, p 1267 (2022)

Subject Terms: colorectal cancer, Amaryllidaceae, narciclasine, pancratistatin, lycorine, haemanthamine, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/12/9/1267; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/b9b5ab1ef3e34de6aeefbfe47a867b39

In Vitro Effects of Fungal Phytotoxins on Cancer Cell Viability: First Insight into Structure Activity Relationship of a Potent Metabolite of Cochliobolus australiensis Radicinin

Authors: Veronique Mathieu, Stefano Superchi, Marco Masi, Patrizia Scafato, Alexander Kornienko, Antonio Evidente

Source: Toxins, Vol 14, Iss 8, p 517 (2022)

Subject Terms: fungi, phytotoxins, radicinin, natural and hemisynthetic derivatives, anticancer, SAR study, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/14/8/517; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/b6d9f7f763f547fd835cdf456a3a4dc3

Design and Synthesis of C-1 Methoxycarbonyl Derivative of Narciclasine and Its Biological Activity

Authors: Lihi Habaz, Korey Bedard, Mitchell Smith, Liqin Du, Alexander Kornienko, Tomas Hudlicky

Source: Molecules, Vol 27, Iss 12, p 3809 (2022)

Subject Terms: narciclasine, chemoenzymatic, synthesis, enantioselective synthesis, natural products, toluene dioxygenase, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/12/3809; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/94d46c11a84b4e0f86f9436b8ec3c162

Conversion of Natural Narciclasine to Its C-1 and C-6 Derivatives and Their Antitumor Activity Evaluation: Some Unusual Chemistry of Narciclasine

Authors: Juana Goulart Stollmaier, Jared Thomson, Mary Ann Endoma-Arias, Razvan Simionescu, Alexandra Vernaza, Nakya Mesa-Diaz, Mitchell Smith, Liqin Du, Alexander Kornienko, Tomas Hudlicky

Source: Molecules, Vol 27, Iss 13, p 4141 (2022)

Subject Terms: narciclasine, Amaryllidaceae alkaloids, Semi-synthesis, natural products, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/13/4141; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/9f9c0ee435974faa96ff85226fb24787

Data in support of a harmine-derived beta-carboline in vitro effects in cancer cells through protein synthesis

Authors: Annelise Carvalho, Jennifer Chu, Céline Meinguet, Robert Kiss, Guy Vandenbussche, Bernard Masereel, Johan Wouters, Alexander Kornienko, Jerry Pelletier, Véronique Mathieu

Source: Data in Brief, Vol 12, Iss C, Pp 546-551 (2017)

Subject Terms: beta-carboline, protein synthesis, cancer cells, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S235234091730197X; https://doaj.org/toc/2352-3409

Access URL: https://doaj.org/article/e46aa951c8874a4e96b41302feff1398

Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets

Authors: Renato B. Pereira, Nikolai M. Evdokimov, Florence Lefranc, Patrícia Valentão, Alexander Kornienko, David M. Pereira, Paula B. Andrade, Nelson G. M. Gomes

Source: Marine Drugs, Vol 17, Iss 6, p 329 (2019)

Subject Terms: cytarabine, trabectedin, eribulin, brentuximab vedotin, plitidepsin, lurbinectedin, plinabulin, marizomib, plocabulin, antibody–drug conjugates, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1660-3397/17/6/329; https://doaj.org/toc/1660-3397

Access URL: https://doaj.org/article/fa138da9e8b44d40ba337e27a4767bf3

Novel Topologically Complex Scaffold Derived from Alkaloid Haemanthamine

Authors: Karthik Govindaraju, Marco Masi, Margaux Colin, Veronique Mathieu, Antonio Evidente, Todd W. Hudnall, Alexander Kornienko

Source: Molecules, Vol 23, Iss 2, p 255 (2018)

Subject Terms: natural product-like, diversity-oriented synthesis, haemanthamine, haemanthidine, iodoalkoxylation, biological activity, Organic chemistry, QD241-441

File Description: electronic resource

Relation: http://www.mdpi.com/1420-3049/23/2/255; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/69a47887b9b144639ebfca6fa859370f

(2S,3R,4S,4aR)-2,3,4,7-Tetrahydroxy-3,4,4a,5-tetrahydro[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one hemihydrate

Authors: Mikhail Antipin, Antonio Evidente, Marco Masi, Alexander Kornienko, Evgheni Jucov

Source: Acta Crystallographica Section E, Vol 69, Iss 1, Pp o9-o10 (2013)

Subject Terms: Crystallography, QD901-999

File Description: electronic resource

Relation: http://scripts.iucr.org/cgi-bin/paper?S1600536812048763; https://doaj.org/toc/1600-5368

Access URL: https://doaj.org/article/c2117b4ec11a44299ca93dc4d5aed912

Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the 'Supply Problem'

Authors: Nelson G. M. Gomes, Ramesh Dasari, Sunena Chandra, Robert Kiss, Alexander Kornienko

Source: Marine Drugs, Vol 14, Iss 5, p 98 (2016)

Subject Terms: eribulin, trabectedin, mycalamide A, spongistatin 1, stelletin A, monanchocidin A, phenylmethylene hydantoin, frondoside A, discodermolide, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.mdpi.com/1660-3397/14/5/98; https://doaj.org/toc/1660-3397

Access URL: https://doaj.org/article/c45a6732989f4cd3bcef9fbd23e5cac6

One-Pot Multicomponent Synthesis of Diversely Substituted 2-Aminopyrroles. A Short General Synthesis of Rigidins A, B, C, and D.

Authors: Liliya V. Frolova, Nikolai M. Evdokimov, Kathryn Hayden, Indranil Malik, Snezna Rogelj, Alexander Kornienko, Igor V. Magedov

Source: Organic Letters; Mar2011, Vol. 13 Issue 5, p1118-1121, 4p

Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Antitumor Activity in Cancer Cells That Display Resistance to Proapoptotic Stimuli: An Investigation of Structure−Activity Relationship and Mechanistic Insight.

Authors: Delphine Lamoral-Theys, Anna Andolfi, Gwendoline Van Goietsenoven, Alessio Cimmino, Benjamin Le Calvé, Nathalie Wauthoz, Véronique Mégalizzi, Thierry Gras, Céline Bruyère, Jacques Dubois, Véronique Mathieu, Alexander Kornienko, Robert Kiss, Antonio Evidente

Source: Journal of Medicinal Chemistry; Oct2009, Vol. 52 Issue 20, p6244-6256, 13p

Anticancer evaluation of structurally diverse Amaryllidaceae alkaloids and their synthetic derivatives.

Authors: Antonio Evidente, Alexander Kornienko

Source: Phytochemistry Reviews; Jun2009, Vol. 8 Issue 2, p449-459, 11p

Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 2. Antiproliferative and Antitubulin Activities of Pyrano[3,2-c]pyridones and Pyrano[3,2-c]quinolones.

Authors: Igor V. Magedov, Alexander Kornienko, Madhuri Manpadi, Marcia A. Ogasawara, Adriana S. Dhawan, Snezna Rogelj, Severine Van slambrouck, Wim F. A. Steelant, Nikolai M. Evdokimov, Pavel Y. Uglinskii, Eerik M. Elias, Erica J. Knee, Paul Tongwa, Mikhail Yu. Antipin

Source: Journal of Medicinal Chemistry. Mar2008, Vol. 51 Issue 8, p2561-2570. 10p.

Subject Terms: *NATURAL products, *HETEROCYCLIC chemistry, *CELL cycle, *CELL lines

Discovery and Investigation of Antiproliferative and Apoptosis-Inducing Properties of New Heterocyclic Podophyllotoxin Analogues Accessible by a One-Step Multicomponent Synthesis.

Authors: Igor V. Magedov, Madhuri Manpadi, Severine Van slambrouck, Wim F. A. Steelant, Elena Rozhkova, Nikolai M. Przheval'skii, Snezna Rogelj, Alexander Kornienko

Source: Journal of Medicinal Chemistry; Oct2007, Vol. 50 Issue 21, p5183-5192, 10p