Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10

Authors: Owen, Nicola E., Nyimanu, Duuamene, Kuc, Rhoda E., Upton, Paul D., Morrell, Nicholas W., Alexander, Graeme J., Maguire, Janet J., Davenport, Anthony P. ^*

Source: In Peptides February 2021 136

Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis

Authors: Owen, Nicola E., Alexander, Graeme J., Sen, Sambit, Bunclark, Katherine, Polwarth, Gary, Pepke-Zaba, Joanna, Davenport, Anthony P., Morrell, Nicholas, W., Upton, Paul. D.

Source: In EBioMedicine June 2020 56

Unacceptable failures: the final report of the Lancet Commission into liver disease in the UK

Authors: Williams, Roger ^*, Aithal, Guruprasad, Alexander, Graeme J, Allison, Michael, Armstrong, Iain, Aspinall, Richard, Baker, Alastair, Batterham, Rachel, Brown, Katrina, Burton, Robyn, Cramp, Matthew E, Day, Natalie, Dhawan, Anil, Drummond, Colin, Ferguson, James, Foster, Graham, Gilmore, Ian, Greenberg, Jonny, Henn, Clive, Jarvis, Helen, Kelly, Deirdre, Mathews, Mead, McCloud, Annie, MacGilchrist, Alastair, McKee, Martin, Moriarty, Kieran, Morling, Joanne, Newsome, Philip, Rice, Peter, Roberts, Stephen, Rutter, Harry, Samyn, Marianne, Severi, Katherine, Sheron, Nick, Thorburn, Douglas, Verne, Julia, Vohra, Jyotsna, Williams, John, Yeoman, Andrew

Source: In The Lancet 18-24 January 2020 395(10219):226-239

Pruritus Is Common and Undertreated in Patients With Primary Biliary Cholangitis in the United Kingdom

Authors: Hegade, Vinod S., Mells, George F., Fisher, Holly, Kendrick, Stuart, DiBello, Julia, Gilchrist, Kim, Alexander, Graeme J., Hirschfield, Gideon M., Sandford, Richard N., Jones, David E.J.

Source: In Clinical Gastroenterology and Hepatology June 2019 17(7):1379-1387

Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score

Authors: Thomas, Caradog, Rahman, Meshbah, Yapp, Tom, Lye Ch'ng, Chin, Harrison, Melanie, Sturgess, Richard, Galaska, Roman, Healey, Chris, Whiteman, Jessica, Czaijkowski, Marek, Gray, Catherine, Gunasekera, Anton, Gyawli, Pranab, Premchand, Purushothaman, Mann, Steven, Elliott, Keith, Kapur, Kapil, Watson, Alan, Foster, Graham, Trembling, Paul, Subhani, Javaid, Harvey, Rory, McCorry, Roger, Adgey, Carolyn, Hobson, Lucie, Mulvaney-Jones, Caroline, Evans, Richard, Mathialahan, Thiriloganathan, Ramanaden, David, Gasem, Jaber, Van Duyvenvoorde, Greta, Shorrock, Christopher, Seward, Katie, Southern, Paul, Tibble, Jeremy, Penn, Ruth, Gorard, David, Maiden, Jane, Damant, Rose, Palegwala, Altaf, Jones, Susan, Alexander, Graeme, Mells, George, Sandford, Richard, Dolwani, Sunil, Prince, Martin, Silvestre, Valeria, Foxton, Matthew, Dungca, Eleanor, Mitchison, Harriet, Wheatley, Natalie, Gooding, Ian, Doyle, Helen, Karmo, Mazn, Kent, Melanie, Saksena, Sushma, Braim, Delyth, Patel, Minesh, Lord, Susan, Ede, Roland, Paton, Alison, Austin, Andrew, Lancaster, Nicola, Sayer, Joanna, Gibbins, Andrew, Hogben, Karen, Hovell, Chris, Fisher, Neil, Carter, Martyn, Koss, Konrad, Musselwhite, Janine, Muscariu, Florin, Piotreowicz, Andrzej, McKay, Alexandra, Grimley, Charles, Neal, David, Ting Tan, Lai, Lim, Guan, Brighton, Jacqueline, Foale, Carole, Ala, Aftab, Saeed, Athar, Flahive, Kerry, Wood, Gordon, Townshend, Paula, Ford, Chris, Brown, Jonathan, Kordula, Jean, Bowles, Jane, Wilkinson, Mark, Palmer, Caroline, Ramage, John, Gordon, Harriet, Featherstone, James, Ridpath, Jo, Ngatchu, Theodore, Levi, Sass, Shaukat, Syed, Sadeghian, Joy, Shidrawi, Ray, Williams, Bronwen, Abouda, George, Jones, Sarah, Duggan, Claire, Hynes, Abigail, Narain, Mark, Rees, Ian, Salam, Imroz, Crossey, Mary, Taylor-Robinson, Simon, Brown, Ashley, MacNicol, Carolyn, Williams, Simon, Wilhelmsen, Elva, Banim, Paul, Raymode, Parizade, Chilton, Andrew, Das, Debasish, Lee, Hye-Jeong, Curtis, Howard, Heneghan, Michael, Gess, Markus, Durant, Emma, Drake, IM, Bishop, Rebecca, Davies, Mervyn, Jones, Rebecca, Aldersley, Mark, Ncube, Noma, McNair, Alistair, Srirajaskanthan, Raj, Sen, Sambit, Casey, Rebecca, Bird, George, Mendall, Mike, Cowley, Caroline, Barnardo, Adrian, Kitchen, Paul, Yoong, Kevin, Amore, Kelly, Sirdefield, Dawn, Orpe, Jacky, Mathew, Ray, MacFaul, George, Wrigth, Aruna, Shah, Amir, Evans, Chris, Keggans, Janie, Bird, Bridget, Baxter, Gwen, Saha, Subrata, Pollock, Katharine, Hughes, Maggie, Bramley, Peter, Grieve, Emma, Young, Karin, Fraser, Andrew, Mukhopadhya, Ashis, Ocker, Kate, Mills, Peter, Hines, Francis, Shallcross, Chris, Wilkins, Joy, Grellier, Leonie, Campbell, Stewart, Martin, Kirsty, Bathgate, Andrew, Innes, Caron, Shepherd, Alan, Rushbrook, Simon, Valliani, Talal, Przemioslo, Robert, Fairlamb, Helen, Macdonald, Chris, Eastick, Anne, Metcalf, Jane, Tanqueray, Elizabeth, Shmueli, Udi, Holbrook, Becky, Davis, Andrew, Browning, Julie, Naqvi, Asifabbas, Walker, Kirsten, Lee, Tom, Verheyden, Juliette, Slininger, Susan, Ryder, Stephen D, Chapman, Roger, Collier, Jane, O'Donnell, Denise, Stafford, Lizzie, Williamson, Kate, Kent, Linda, Klass, Howard, Ninkovic, Mary, March, Linda, Cramp, Matthew, Simpson, Diane, Dickson, Christine, Sharer, Nicholas, Hayes, Maria, Goggin, Patrick, Quinne, Mary, Pearson, Sallyanne, Hoeroldt, Barbara, Jones, Linda, Wright, Alice, Booth, Jonathan, Loftus, Alison, Lipscomb, George, Dewhurst, Hannah, Gunter, Emma, Williams, Earl, Fouracres, Anna, Farrington, Liz, Graves, Lyn, Hussaini, Hyder, Stableforth, Bill, Marriott, Suzie, Ayres, Reuben, Leoni, Marina, Burroughs, Andrew, Marshall, Eileen, Thorburn, Douglas, Tyrer, David, Martin, Kate, Lombard, Martin, Patanwala, Imran, Dali-Kemmery, Lola, Lambourne, Victoria, Maltby, Julia, Vyas, Samir, Colley, Julie, Shinder, Bal, Singhal, Saket, Jones, Jayne, Mills, Marisa, Gleeson, Dermot, Carnahan, Mandy, Butterworth, Jeff, Boulton, Kerenza, Taylor, Natalie, George, Keith, Harding, Tim, Tregonning, Julie, Douglass, Andrew, Brown, Carly, Clifford, Gayle, Panter, Simon, Gocher, Denise, Shearman, Jeremy, Bray, Gary, Hamilton, Maria, Butcher, Graham, Forton, Daniel, Mclindon, John, Curtis, Janette, Das, Debashis, Shewan, Tracey, Cowan, Matthew, Whatley, Gregory, Nasseri, Mariam, Grover, Bob, Sivaramakrishnan, Nurani, Ducker, Samantha, Houghton, Kathryn, Jones, David, Griffiths, Laura, Tripoli, Sherill, Pitcher, Maxton, Shpuza, Ervin, White, Nikki, Ghosh, Deb, Douds, Andrew, Green, Marie, Brookes, Matthew, Cumlat, Lourdes, Wong, Voi Shim, Warner, Karen, Netherton, Kimberley, Mandal, Adtya, Jain, Snjiv, Gupta, Hemant, Sanghi, Pradeep, Pereira, Steve, Neuberger, James, Gunson, Bridget, Hirschfield, Gideon, Lim, Reina Teegan, Gallagher, Susan, Clement, Darren, Brind, Alison, Watts, Gill, Mupudzi, Mcdonald, Wright, Mark, Gitahi, Jane, Gordon, Fiona, Gocher, Denis, Unitt, Esther, Pateman, Hilary, Batham, Sally, Delahooke, Toby, Grant, Allister, Conder, Jill, Higham, Andrew, Cox, Mark, O'Donohoe, Lynn, Currie, Lynn, King, Alistair, Oblak, Metod, Collins, Carole, Whalley, Simon, Quinn, Marie, Baird, Yolanda, Amey, Isobel, Fraser, Jocelyn, Li, Andy, Cotterill, Donna, Bell, Andrew, Singhal, Amit, Gee, Ian, Greer, Sandra, Ang, Yeng, Ransford, Rupert, Allison, Joanna, Gotto, James, Dyer, Simon, Sweeting, Helen, Millson, Charles, Invernizzi, Pietro, Carbone, Marco, Cristoferi, Laura, Bonato, Giulia, Malinverno, Federica, Bernuzzi, Francesca, Alvaro, Domenico, Labbadia, Giancarlo, Bragazzi, Maria Consiglia, Andreone, Pietro, Muratori, Luigi, Azzaroli, Francesco, Floreani, Annarosa, Galli, Andrea, Tarocchi, Mirko, Giannini, Edoardo, Miele, Luca, Gasbarrini, Antonio, Grieco, Antonio, Marrone, Giuseppe, Donato, Maria Francesca, Valenti, Luca, Marra, Fabio, Marzioni, Marco, Maroni, Luca, Rigamonti, Cristina, Zuin, Massimo, Battezzati, Pier Maria, Picciotto, Antonino, Nardi, Alessandra, Flack, Steve, Carpino, Guido, Varvaropoulou, Nikoletta, Gavrila, Caius, Spicer, Ann, Badrock, Jonathan, Cardinale, Vincenzo, Ainsworth, Holly F, Heneghan, Michael A, Neuberger, James M, Donato, Maria F, Kirby, John, Mitchell-Thain, Robert, Sampaziotis, Fotios, Gaudio, Eugenio, Ronca, Vincenzo, Gerussi, Alessio, Stocken, Deborah D, Cordell, Heather J, Hirschfield, Gideon M, Alexander, Graeme J, Sandford, Richard N, Jones, David E, Mells, George F

Source: In The Lancet Gastroenterology & Hepatology September 2018 3(9):626-634

Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System

Authors: Goode, Elizabeth C., Clark, Allan B., Mells, George F., Srivastava, Brijesh, Spiess, Kelly, Gelson, William T.H., Trivedi, Palak J., Lynch, Kate D., Castren, Edit, Vesterhus, Mette N., Karlsen, Tom H., Ji, Sun‐Gou, Anderson, Carl A., Thorburn, Douglas, Hudson, Mark, Heneghan, Michael A., Aldersley, Mark A., Bathgate, Andrew, Sandford, Richard N., Alexander, Graeme J., Chapman, Roger W., Walmsley, Martine, Hirschfield, Gideon M., Rushbrook, Simon M.

Source: Hepatology. 69(5):2120-2135

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100090617615.0x000001&indx=1&recIds=ETOCvdc_100090617615.0x000001

Characterising the association of latency with α1-antitrypsin polymerisation using a novel monoclonal antibody

Authors: Tan, Lu, Perez, Juan, Mela, Marianna, Miranda, Elena, Burling, Keith A, Rouhani, Farshid N, DeMeo, Dawn L, Haq, Imran, Irving, James A, Ordóñez, Adriana, Dickens, Jennifer A, Brantly, Mark, Marciniak, Stefan J, Alexander, Graeme J M, Gooptu, Bibek, Lomas, David A

Source: In International Journal of Biochemistry and Cell Biology January 2015 58:81-91

HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection

Authors: Khakoo, Salim I., Thio, Chloe L., Martin, Maureen P., Brooks, Collin R., Gao, Xiaojiang, Astemborski, Jacquie, Cheng, Jie, Goedert, James J., Vlahov, David, Hilgartner, Margaret, Cox, Steven, Little, Ann-Margeret, Alexander, Graeme J., Cramp, Matthew E., O'Brien, Stephen J., Thomas, David L., Carrington, Mary

Source: Science, 2004 Aug 01. 305(5685), 872-874.

Access URL: https://www.jstor.org/stable/3837721

Age-related Macular Degeneration and Modification of Systemic Complement Factor H Production Through Liver Transplantation

Authors: Khandhadia, Samir, Hakobyan, Svetlana, Heng, Ling Z., Gibson, Jane, Adams, David H., Alexander, Graeme J., Gibson, Jonathan M., Martin, Keith R., Menon, Geeta, Nash, Kathryn, Sivaprasad, Sobha, Ennis, Sarah, Cree, Angela J., Morgan, B. Paul, Lotery, Andrew J.

Source: In Ophthalmology August 2013 120(8):1612-1618

The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC cohort

Authors: Pells, Greta, Mells, George F., Carbone, Marco, Newton, Julia L., Bathgate, Andrew J., Burroughs, Andrew K., Heneghan, Michael A., Neuberger, James M., Day, Darren B., Ducker, Samantha J., Sandford, Richard N., Alexander, Graeme J., Jones, David E.J.

Source: In Journal of Hepatology July 2013 59(1):67-73

Sex and Age Are Determinants of the Clinical Phenotype of Primary Biliary Cirrhosis and Response to Ursodeoxycholic Acid

Authors: Carbone, Marco, Mells, George F., Pells, Greta, Dawwas, Muhammad F., Newton, Julia L., Heneghan, Michael A., Neuberger, James M., Day, Darren B., Ducker, Samantha J., Sandford, Richard N., Alexander, Graeme J., Jones, David E.J.

Source: In Gastroenterology March 2013 144(3):560-569

Renal impairment in cirrhosis unrelated to hepatorenal syndrome

Authors: Low, Gavin, Alexander, Graeme J. M., Lomas, David J.

Source: Canadian journal of gastroenterology & hepatology. 29(5):253-258

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN601617613&indx=1&recIds=ETOCRN601617613

A comprehensive HBV array for the detection of HBV mutants and genotype

Authors: Chan, Kaimin, Yam, Irene, Yuen, John, Yuen, Man-Fung, Lai, Ching-Lung, Alexander, Graeme J., Chan, Tai-Kwong, Chan, Vivian

Source: In Clinical Biochemistry 2011 44(14):1253-1260

Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis

Authors: Srivastava, Brijesh, Mells, George F, Cordell, Heather J, Muriithi, Agnes, Brown, Matthew, Ellinghaus, Eva, Franke, Andre, Consortium, UK-PSC, Karlsen, Tom H, Sandford, Richard N, Alexander, Graeme J, Chapman, Roger W, Rushbrook, Simon M, Melum, Espen

Source: Scandinavian journal of gastroenterology. 47(7):820-826

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100104104409.0x000001&indx=1&recIds=ETOCvdc_100104104409.0x000001

Trends in Deaths from Malignant Neoplasia of Liver Are Poor Indicator of Hepatitis C Infection

Authors: Harris, Helen E., Ramsay, Mary E., Balogun, Koye, Alexander, Graeme J. M.

Source: BMJ: British Medical Journal, 1999 Mar . 318(7186), 808-809.

Access URL: https://www.jstor.org/stable/25184079

Prospective Study Of Hepatitis B Vaccination In Patients With Chronic Hepatitis C

Authors: Wong, Voishim, Wreghitt, Tim G., Alexander, Graeme J. M.

Source: BMJ: British Medical Journal, 1996 May . 312(7042), 1336-1337.

Access URL: https://www.jstor.org/stable/29731739

Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression.

Authors: Wijayasiri, Pramudi, Astbury, Stuart, Kaye, Philip, Oakley, Fiona, Alexander, Graeme J., Kendall, Timothy J., Aravinthan, Aloysious D.

Source: Cells (2073-4409); Jul2022, Vol. 11 Issue 14, pN.PAG-N.PAG, 13p

Subject Terms: KUPFFER cells, LIVER cells, HEPATIC fibrosis, LIVER histology, NON-alcoholic fatty liver disease, P16 gene

Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis.

Authors: Darlay, Rebecca¹, Ayers, Kristin L.¹, Cordell, Heather J.¹, Hall, Lynsey S.^1,2, Mells, George F.³, Sandford, Richard N.³, Liu, Jimmy Z.⁴, Anderson, Carl A.⁴, Almarri, Mohamed A.^4,5, Alexander, Graeme J.⁶, Jones, David E.⁷

Source: PLoS Genetics; 12/3/2018, Vol. 14 Issue 12, p1-29, 29p

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