Generation of corrected hiPSC clones from a Cornelia de Lange Syndrome (CdLS) patient through CRISPR-Cas-based technology

Authors: Alessandro Umbach, Giulia Maule, Eyemen Kheir, Alessandro Cutarelli, Marika Foglia, Luca Guarrera, Luca L. Fava, Luciano Conti, Enrico Garattini, Mineko Terao, Anna Cereseto

Source: Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2022)

Subject Terms: Cornelia de Lange Syndrome (CdLS), CRISPR-Cas9, Homology Directed Repair (HDR), Base editor, Prime editor, Patient-derived hiPSCs, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/a3317733e436485fa7844778aed951b2

Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics

Authors: Valentina Zamboni, Maria Armentano, Gaia Berto, Elisa Ciraolo, Alessandra Ghigo, Donatella Garzotto, Alessandro Umbach, Ferdinando DiCunto, Elena Parmigiani, Marina Boido, Alessandro Vercelli, Nadia El-Assawy, Alessandro Mauro, Lorenzo Priano, Luisa Ponzoni, Luca Murru, Maria Passafaro, Emilio Hirsch, Giorgio R. Merlo

Source: Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/638ec94828f043b0b3fe8bf5f8131542

Choice of Alternative Polyadenylation Sites, Mediated by the RNA-Binding Protein Elavl3, Plays a Role in Differentiation of Inhibitory Neuronal Progenitors

Authors: Elena Grassi, Roberto Santoro, Alessandro Umbach, Anna Grosso, Salvatore Oliviero, Francesco Neri, Luciano Conti, Ugo Ala, Paolo Provero, Ferdinando DiCunto, Giorgio R. Merlo

Source: Frontiers in Cellular Neuroscience, Vol 12 (2019)

Subject Terms: neuron differentiation, GABAergic, polyadenylation, RNA binding protein, Elavl3, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fncel.2018.00518/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/86178271a5044edfa486c8c90c385375