Dendritic Cell‐Mediated Cross‐Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS‐CoV‐2

Authors: Rodrigo Lázaro‐Gorines, Patricia Pérez, Ignacio Heras‐Murillo, Irene Adán‐Barrientos, Guillermo Albericio, David Astorgano, Sara Flores, Joanna Luczkowiak, Nuria Labiod, Seandean L. Harwood, Alejandro Segura‐Tudela, Laura Rubio‐Pérez, Yudhi Nugraha, Xiaoran Shang, Yuxing Li, Carlos Alfonso, Kaylin A. Adipietro, Dinendra L. Abeyawardhane, Rocío Navarro, Marta Compte, Wenbo Yu, Alexander D. MacKerell Jr, Laura Sanz, David J. Weber, Francisco J. Blanco, Mariano Esteban, Edwin Pozharski, Raquel Godoy‐Ruiz, Inés G. Muñoz, Rafael Delgado, David Sancho, Juan García‐Arriaza, Luis Álvarez‐Vallina

Source: Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)

Subject Terms: bispecific trimerbody, cross‐priming, CTL responses, dendritic cells, neutralizing antibody, SARS‐CoV‐2, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/83ee823ecfc342e88a1c1efafa321622

A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response

Authors: Laura Rubio-Pérez, Rodrigo Lázaro-Gorines, Seandean L. Harwood, Marta Compte, Rocío Navarro, Antonio Tapia-Galisteo, Jaume Bonet, Belén Blanco, Simon Lykkemark, Ángel Ramírez-Fernández, Mariola Ferreras-Gutiérrez, Carmen Domínguez-Alonso, Laura Díez-Alonso, Alejandro Segura-Tudela, Oana Hangiu, Ainhoa Erce-Llamazares, Francisco J. Blanco, Cruz Santos, José L. Rodríguez-Peralto, Laura Sanz, Luis Álvarez-Vallina

Source: OncoImmunology, Vol 12, Iss 1 (2023)

Subject Terms: Cancer immunotherapy, bispecific antibody, dual action, epithelial growth factor receptor, immune checkpoint blockade, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/87732fe8a8464638935a3dfe1b8c3ab0

Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategies

Authors: Ángel Ramírez-Fernández, Óscar Aguilar-Sopeña, Laura Díez-Alonso, Alejandro Segura-Tudela, Carmen Domínguez-Alonso, Pedro Roda-Navarro, Luis Álvarez-Vallina, Belén Blanco

Source: OncoImmunology, Vol 11, Iss 1 (2022)

Subject Terms: CD19+ B cell malignancies, T cell-redirecting strategies, STAb, BiTE, CAR, leukemia relapse, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/a738330a8b26462fa166a9c5d196ff70

Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations

Authors: Beatriz Martín-Antonio, Belén Blanco, África González-Murillo, Laura Hidalgo, Jordi Minguillón, Gema Pérez-Chacón, Next Generation CART MAD Consortium, Lucía Fernández, Halin Bareke, Andrés París-Muñoz, Adriana Mañas, Cristina Aguirre-Portolés, Alfonso Navarro-Zapata, Carmen Mestre-Durán, Marta Ibáñez-Navarro, Laura Clares-Villa, Sara Naharro, Antonio Perez-Martinez, Marcos Aldea, María Gaibar, Javier Ruiz-Navarro, Manuel Izquierdo, Juan M. Zapata, África González Murillo, Elena García Sánchez, Jorge García Martínez, Alba Rubio San Simón, Blanca Herrero, Gonzalo García Aguilera, Beatriz Horcajo Morera, Manuel Ramírez Orellana, Belén Blanco-Durango, Anais Jiménez-Reinoso, Rodrigo Lázaro-Gorines, Ivana Zagorac, Antonio Tapia Galisteo, Ángel Ramirez-Fernández, Laura Díez-Alonso, Carmen Dominguez-Alonso, Ainhoa Erce-Llamazares, Oana Hangiu, Laura Rubio Pérez, Marina Gómez Rosel, Alejandro Segura Tudela, Javier Arroyo-Ródena, Luis Álvarez-Vallina, Miguel Ángel Rodríguez Milla, Patricia García Rodríguez, Beatriz Somovilla Crespo, Javier García-Castro, Esperanza Esquinas Tarifa, Juana Serrano-López, Pilar Llamas-Sillero, Beatriz Martin-Antonio

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: CAR-T cells, NK cells, TILs, TCR therapy, immunological synapse, cancer, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1386856/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/49d95b3c222f4b7389eb0625d73c49df