The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00355h

Authors: Aldred, Gregory G., Rooney, Timothy P. C., Willems, Henriette M. G., Boffey, Helen K., Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.

Source: RSC medicinal chemistry. 14(10):2035-2047

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196339198.0x000001&indx=1&recIds=ETOCvdc_100196339198.0x000001

The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules.

Authors: Rooney, Timothy P. C., Aldred, Gregory G., Boffey, Helen K., Willems, Henriëtte M. G., Edwards, Simon, Chawner, Stephen J., Scott, Duncan E., Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.

Source: Journal of Medicinal Chemistry; 1/12/2023, Vol. 66 Issue 1, p804-821, 18p

An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase

Authors: Al-Khawaldeh, Islam, Al Yasiri, Mohammed J., Aldred, Gregory G., Basmadjian, Christine, Bordoni, Cinzia, Harnor, Suzannah J., Heptinstall, Amy B., Hobson, Stephen J., Jennings, Claire E., Khalifa, Shaimaa, Lebraud, Honorine, Martin, Mathew P., Miller, Duncan C., Shrives, Harry J., de Souza, João V., Stewart, Hannah L., Temple, Max, Thomas, Huw D., Totobenazara, Jane, Tucker, Julie A., Tudhope, Susan J., Wang, Lan Z., Bronowska, Agnieszka K., Cano, Céline, Endicott, Jane A., Golding, Bernard T., Hardcastle, Ian R., Hickson, Ian, Wedge, Stephen R., Willmore, Elaine, Noble, Martin E. M., Waring, Michael J.

Source: Journal of Medicinal Chemistry; July 2021, Vol. 64 Issue: 14 p10001-10018, 18p

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