The reverse transsulfuration pathway affects the colonic microbiota and contributes to colitis in mice

Authors: Alain P. Gobert, Yvonne L. Latour, Kara M. McNamara, Caroline V. Hawkins, Kamery J. Williams, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Alberto G. Delgado, Ginger L. Milne, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, Keith T. Wilson

Source: Amino Acids, Vol 56, Iss 1, Pp 1-12 (2024)

Subject Terms: Cystathionine g-lyase, Inflammatory bowel disease, Colitis, Colitis-associated carcinogenesis, Cysteine, Gut microbiota, Biochemistry, QD415-436, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1438-2199

Access URL: https://doaj.org/article/699bc7b9acaf4d59bea2765f7ec37397

Hypusination in intestinal epithelial cells protects mice from infectious colitis

Authors: Alain P. Gobert, Caroline V. Hawkins, Kamery J. Williams, Lydia A. Snyder, Daniel P. Barry, Mohammad Asim, Margaret M. Allaman, Kara M. McNamara, Alberto G. Delgado, Yu Wang, Shilin Zhao, Kristie L. Rose, M. Blanca Piazuelo, Keith T. Wilson

Source: Gut Microbes, Vol 16, Iss 1 (2024)

Subject Terms: Polyamines, hypusine, translation, attaching and effacing pathogen, Enteropathogenic Escherichia coli, Citrobacter rodentium, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/2fb1850dd0fb406b991131a6758490a3

Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation

Authors: Yvonne L. Latour, Kara M. McNamara, Margaret M. Allaman, Daniel P. Barry, Thaddeus M. Smith, Mohammad Asim, Kamery J. Williams, Caroline V. Hawkins, Justin Jacobse, Jeremy A. Goettel, Alberto G. Delgado, M. Blanca Piazuelo, M. Kay Washington, Alain P. Gobert, Keith T. Wilson

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/fb0bf8276c3646598c802c501115e29e

Epithelial talin-1 protects mice from Citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing T cell immunity

Authors: Yvonne L. Latour, Margaret M. Allaman, Daniel P. Barry, Thaddeus M. Smith, Kamery J. Williams, Kara M. McNamara, Justin Jacobse, Jeremy A. Goettel, Alberto G. Delgado, M. Blanca Piazuelo, Shilin Zhao, Alain P. Gobert, Keith T. Wilson

Source: Gut Microbes, Vol 15, Iss 1 (2023)

Subject Terms: Talin, C. rodentium, colonic epithelial cells, neutrophils, T cells, colon organoids, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/f9ea48e1d73a40c2ba5b50cc0608468a

Targeting hypoxia-inducible factor-1 alpha suppresses Helicobacter pylori-induced gastric injury via attenuation of both cag-mediated microbial virulence and proinflammatory host responses

Authors: Jennifer M. Noto, M. Blanca Piazuelo, Judith Romero-Gallo, Alberto G. Delgado, Giovanni Suarez, Konstantina Akritidou, Miguel Girod Hoffman, Juan Carlos Roa, Cormac T. Taylor, Richard M. Peek

Source: Gut Microbes, Vol 15, Iss 2 (2023)

Subject Terms: Helicobacter pylori, gastric inflammation, gastric cancer, hypoxia-inducible factor-1 alpha (HIF-1α), dimethyloxalylglycine (DMOG), prolyl hydroxylase (PHD), Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/5ca1554c76e54c8382886b3806ff21b3

Up-regulation of Aquaporin 5 Defines Spasmolytic Polypeptide-Expressing Metaplasia and Progression to Incomplete Intestinal MetaplasiaSummary

Authors: Su-Hyung Lee, Bogun Jang, Jimin Min, Ela W. Contreras-Panta, Kimberly S. Presentation, Alberto G. Delgado, M. Blanca Piazuelo, Eunyoung Choi, James R. Goldenring

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 199-217 (2022)

Subject Terms: AQP5, Gastric Cancer, IM, TROP2, SPEM, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X21001843; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/a0b008990421406eb518941db7b2bc23

Helicobacter pylori actively suppresses innate immune nucleic acid receptors

Authors: Samuel D.R. Dooyema, Jennifer M. Noto, Lydia E. Wroblewski, M. Blanca Piazuelo, Uma Krishna, Giovanni Suarez, Judith Romero-Gallo, Alberto G. Delgado, Richard M. Peek

Source: Gut Microbes, Vol 14, Iss 1 (2022)

Subject Terms: Helicobacter pylori, gastric cancer, TLR9, STING, RIG-I, TRIM30, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/f93259ca2dbb4a9897baa17e0061a47a

Cystathionine γ-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation

Authors: Yvonne L. Latour, Johanna C. Sierra, Jordan L. Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Thaddeus M. Smith, Kara M. McNamara, Paula B. Luis, Claus Schneider, Justin Jacobse, Jeremy A. Goettel, M. Wade Calcutt, Kristie L. Rose, Kevin L. Schey, Ginger L. Milne, Alberto G. Delgado, M. Blanca Piazuelo, Bindu D. Paul, Solomon H. Snyder, Alain P. Gobert, Keith T. Wilson

Source: JCI Insight, Vol 7, Iss 12 (2022)

Subject Terms: Gastroenterology, Immunology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/19c8a2f445654133870ff2cc83d6103c

Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori–induced inflammation–driven gastric carcinogenesis

Authors: Jennifer M. Noto, M. Blanca Piazuelo, Shailja C. Shah, Judith Romero-Gallo, Jessica L. Hart, Chao Di, James D. Carmichael, Alberto G. Delgado, Alese E. Halvorson, Robert A. Greevy, Lydia E. Wroblewski, Ayushi Sharma, Annabelle B. Newton, Margaret M. Allaman, Keith T. Wilson, M. Kay Washington, M. Wade Calcutt, Kevin L. Schey, Bethany P. Cummings, Charles R. Flynn, Joseph P. Zackular, Richard M. Peek Jr.

Source: The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)

Subject Terms: Gastroenterology, Infectious disease, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/7d198f5f9fa7400583ab84388b9c0680

Temporal Control of the Helicobacter pylori Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis

Authors: Aung Soe Lin, Mark S. McClain, Amber C. Beckett, Rhonda R. Caston, M. Lorena Harvey, Beverly R. E. A. Dixon, Anne M. Campbell, Jennifer H. B. Shuman, Neha Sawhney, Alberto G. Delgado, John T. Loh, M. Blanca Piazuelo, Holly M. Scott Algood, Timothy L. Cover

Source: mBio, Vol 11, Iss 3 (2020)

Subject Terms: Helicobacter pylori, type IV secretion system, gastric cancer, carcinogenesis, animal model, hit-and-run hypothesis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/3791960f61674d22a55ee21aa1db0972

Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

Authors: Alain P. Gobert, Yvonne L. Latour, Mohammad Asim, Jordan L. Finley, Thomas G. Verriere, Daniel P. Barry, Ginger L. Milne, Paula B. Luis, Claus Schneider, Emilio S. Rivera, Kristie Lindsey-Rose, Kevin L. Schey, Alberto G. Delgado, Johanna C. Sierra, M. Blanca Piazuelo, Keith T. Wilson

Source: mBio, Vol 10, Iss 5 (2019)

Subject Terms: Helicobacter pylori, immune evasion, immunometabolism, innate immunity, macrophages, pathogenic bacteria, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/db50a92f548d4b85beae15ff68935760

The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria.

Authors: Kshipra Singh, Nicole T Al-Greene, Thomas G Verriere, Lori A Coburn, Mohammad Asim, Daniel P Barry, Margaret M Allaman, Dana M Hardbower, Alberto G Delgado, M Blanca Piazuelo, Bruce A Vallance, Alain P Gobert, Keith T Wilson

Source: PLoS Pathogens, Vol 12, Iss 10, p e1005984 (2016)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5081186?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/dde25832be474145b30f534c31096627

Effect of smoking on failure of H. pylori therapy and gastric histology in a high gastric cancer risk area of Colombia

Authors: M Constanza Camargo, M Blanca Piazuelo, Robertino M Mera, Elizabeth TH Fontham, Alberto G Delgado, M Clara Yepez, Cristina Ceron, Luis E Bravo, Juan C Bravo, Pelayo Correa

Source: Acta Gastroenterológica Latinoamericana, Vol 37, Iss 4, Pp 238-245 (2007)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869, Medicine

File Description: electronic resource

Relation: http://www.redalyc.org/articulo.oa?id=199317426007; https://doaj.org/toc/0300-9033

Access URL: https://doaj.org/article/e834ad7d5f10458c9ad7435af645f1a1

The host protein calprotectin modulates the Helicobacter pylori cag type IV secretion system via zinc sequestration.

Authors: Jennifer A Gaddy, Jana N Radin, John T Loh, M Blanca Piazuelo, Thomas E Kehl-Fie, Alberto G Delgado, Florin T Ilca, Richard M Peek, Timothy L Cover, Walter J Chazin, Eric P Skaar, Holly M Scott Algood

Source: PLoS Pathogens, Vol 10, Iss 10, p e1004450 (2014)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4199781?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/ac24f7971a53476f94e4cccfb96bf4d1

Helicobacter pylori promotes the expression of Krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo.

Authors: Jennifer M Noto, Tinatin Khizanishvili, Rupesh Chaturvedi, M Blanca Piazuelo, Judith Romero-Gallo, Alberto G Delgado, Shradha S Khurana, Johanna C Sierra, Uma S Krishna, Giovanni Suarez, Anne E Powell, James R Goldenring, Robert J Coffey, Vincent W Yang, Pelayo Correa, Jason C Mills, Keith T Wilson, Richard M Peek

Source: PLoS ONE, Vol 8, Iss 1, p e54344 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3553174?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/1cc0b00deeb940f8b0d725b0b82385e7