Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages.

Authors: Simonis, Alexander, Theobald, Sebastian J, Koch, Anna E, Mummadavarapu, Ram, Mudler, Julie M, Pouikli, Andromachi, Göbel, Ulrike, Acton, Richard, Winter, Sandra, Albus, Alexandra, Holzmann, Dmitriy, Albert, Marie-Christine, Hallek, Michael, Walczak, Henning, Ulas, Thomas, Koch, Manuel, Tessarz, Peter, Hänsel-Hertsch, Robert, Rybniker, Jan

Source: Molecular Systems Biology; Apr2025, Vol. 21 Issue 4, p341-360, 20p

Subject Terms: IMMUNOLOGIC memory, MEDICAL sciences, BOOSTER vaccines, NUCLEIC acids, PROMOTERS (Genetics)

Primary cilia suppress Ripk3-mediated necroptosis.

Authors: Kieckhöfer, Emilia, Slaats, Gisela G., Ebert, Lena K., Albert, Marie-Christine, Dafinger, Claudia, Kashkar, Hamid, Benzing, Thomas, Schermer, Bernhard

Source: Cell Death Discovery; 12/2/2022, Vol. 8 Issue 1, p1-12, 12p

Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination.

Authors: Theobald, Sebastian J, Simonis, Alexander, Mudler, Julie M, Göbel, Ulrike, Acton, Richard, Kohlhas, Viktoria, Albert, Marie‐Christine, Hellmann, Anna‐Maria, Malin, Jakob J, Winter, Sandra, Hallek, Michael, Walczak, Henning, Nguyen, Phuong‐Hien, Koch, Manuel, Rybniker, Jan

Source: EMBO Molecular Medicine; 8/8/2022, Vol. 14 Issue 8, p1-15, 15p

BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis.

Authors: Flores‐Romero, Hector, Hohorst, Lisa, John, Malina, Albert, Marie‐Christine, King, Louise E, Beckmann, Laura, Szabo, Tamas, Hertlein, Vanessa, Luo, Xu, Villunger, Andreas, Frenzel, Lukas P, Kashkar, Hamid, Garcia‐Saez, Ana J

Source: EMBO Journal; Jan2022, Vol. 41 Issue 2, p1-17, 17p

Subject Terms: BCL-2 proteins, SHIGELLOSIS, CYTOCHROME c, IMMUNE response, APOPTOSIS, PROTEINS

Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19.

Authors: Theobald, Sebastian J, Simonis, Alexander, Georgomanolis, Theodoros, Kreer, Christoph, Zehner, Matthias, Eisfeld, Hannah S, Albert, Marie‐Christine, Chhen, Jason, Motameny, Susanne, Erger, Florian, Fischer, Julia, Malin, Jakob J, Gräb, Jessica, Winter, Sandra, Pouikli, Andromachi, David, Friederike, Böll, Boris, Koehler, Philipp, Vanshylla, Kanika, Gruell, Henning

Source: EMBO Molecular Medicine; 8/9/2021, Vol. 13 Issue 8, p1-20, 20p

CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage.

Authors: Albert, Marie-Christine, Brinkmann, Kerstin, Pokrzywa, Wojciech, Günther, Saskia Diana, Krönke, Martin, Hoppe, Thorsten, Kashkar, Hamid

Source: Cell Death & Disease; Sep2020, Vol. 11 Issue 9, p1-15, 15p

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.

Authors: Fritsch, Melanie, Günther, Saskia D., Schwarzer, Robin, Albert, Marie-Christine, Schorn, Fabian, Werthenbach, J. Paul, Schiffmann, Lars M., Stair, Neil, Stocks, Hannah, Seeger, Jens M., Lamkanfi, Mohamed, Krönke, Martin, Pasparakis, Manolis, Kashkar, Hamid

Source: Nature; 11/28/2019, Vol. 575 Issue 7784, p683-687, 5p, 2 Color Photographs, 9 Graphs

Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair.

Authors: Lagunas, Kristel Martinez¹, Savcigil, Deniz Pinar¹, Zrilic, Matea¹, Fraile, Carlos Carvajal¹, Craxton, Andrew², Self, Emily², Uranga-Murillo, Iratxe³, de Miguel, Diego³, Arias, Maykel^3,4,5, Willenborg, Sebastian⁶, Piekarek, Michael⁶, Albert, Marie Christine^7,8, Nugraha, Kalvin¹, Lisewski, Ina¹, Janakova, Erika¹, Igual, Natalia¹, Tonnus, Wulf^9,10, Hildebrandt, Ximena^1,7,11, Ibrahim, Mohammed^1,7,11, Ballegeer, Marlies^12,13

Source: Science Advances. 7/28/2023, Vol. 9 Issue 30, p1-17. 17p.

Subject Terms: *CELL death, *VIRUS diseases, *SKIN regeneration, *DEATH receptors, *SOFT tissue injuries, *INTERFERON gamma, *BONE marrow cells