Validation and Characterization of FGFR2 Rearrangements in Cholangiocarcinoma with Comprehensive Genomic Profiling

Authors: Silverman, Ian M., Li, Meijuan, Murugesan, Karthikeyan, Krook, Melanie A., Javle, Milind M., Kelley, Robin K., Borad, Mitesh J., Roychowdhury, Sameek, Meng, Wei, Yilmazel, Bahar, Milbury, Coren, Shewale, Shantanu, Feliz, Luis, Burn, Timothy C., Albacker, Lee A.

Source: Journal of molecular diagnostics. 24(4):351-364

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166133868.0x000001&indx=1&recIds=ETOCvdc_100166133868.0x000001

Evaluation of a variant origin prediction (VOP) algorithm to distinguish clonal hematopoiesis (CH) variants from tumor-derived variants and to predict metastatic castrate resistant prostate cancer (mCRPC) clinical responses.

Authors: Sun, Daokun, He, Shai, Brown, Derek W, Tukachinsky, Hanna, Hughes, Jason D., Polisecki, Eliana, Madison, Russell, Pasquina, Lincoln W, Fine, Alexander D., Decker, Brennan J., Fabrizio, David, He, Jie, Shah, Kalpit, Assaf, Zoe June, Powles, Thomas, Sweeney, Christopher, Albacker, Lee A., White, Jared, Dennis, Lucas, Xu, Chang

Source: Journal of Clinical Oncology; 2/20/2025 Supplement 5, Vol. 43, p201-201, 288p

Genomic profiling of solid tumors harboring BRD4-NUT and response to immune checkpoint inhibitors

Authors: Riess, Jonathan W., Rahman, Shaila, Kian, Waleed, Edgerly, Claire, Heilmann, Andreas M., Madison, Russell, Ramkissoon, Shakti H., Klaitman, Shai Shlomi, Chung, Jon H., Trabucco, Sally E., Jin, Dexter X., Alexander, Brian M., Klempner, Samuel J., Albacker, Lee A., Frampton, Garrett M., Roisman, Laila C., Miller, Vincent A., Ross, Jeffrey S., Schrock, Alexa B., Gregg, Jeffrey P., Peled, Nir, Sokol, Ethan S., Ali, Siraj M.

Source: In Translational Oncology October 2021 14(10)

Prediction and characterization of diffuse large B-cell lymphoma cell-of-origin subtypes using targeted sequencing

Authors: Trabucco, Sally E, Sokol, Ethan S, Maund, Sophia L, Moore, Jay A, Frampton, Garrett M, Albacker, Lee A, Oestergaard, Mikkel Z, Venstrom, Jeffrey, Sehn, Laurie H, Bolen, Christopher R

Source: Future oncology. 17(31):4171-4183

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187771315.0x000001&indx=1&recIds=ETOCvdc_100187771315.0x000001

Blockade of RGMb inhibits allergen-induced airways disease

Authors: Yu, Sanhong, Leung, Krystle M., Kim, Hye-Young, Umetsu, Sarah E., Xiao, Yanping, Albacker, Lee A., Lee, Hyun-Jun, Umetsu, Dale T., Freeman, Gordon J., DeKruyff, Rosemarie H.

Source: In The Journal of Allergy and Clinical Immunology July 2019 144(1):94-108

CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Authors: Skoulidis, Ferdinandos, Araujo, Haniel A., Do, Minh Truong, Qian, Yu, Sun, Xin, Cobo, Ana Galan, Le, John T., Montesion, Meagan, Palmer, Rachael, Jahchan, Nadine, Juan, Joseph M., Min, Chengyin, Yu, Yi, Pan, Xuewen, Arbour, Kathryn C., Vokes, Natalie, Schmidt, Stephanie T., Molkentine, David, Owen, Dwight H., Memmott, Regan, Patil, Pradnya D., Marmarelis, Melina E., Awad, Mark M., Murray, Joseph C., Hellyer, Jessica A., Gainor, Justin F., Dimou, Anastasios, Bestvina, Christine M., Shu, Catherine A., Riess, Jonathan W., Blakely, Collin M., Pecot, Chad V., Mezquita, Laura, Tabbó, Fabrizio, Scheffler, Matthias, Digumarthy, Subba, Mooradian, Meghan J., Sacher, Adrian G., Lau, Sally C. M., Saltos, Andreas N., Rotow, Julia, Johnson, Rocio Perez, Liu, Corinne, Stewart, Tyler, Goldberg, Sarah B., Killam, Jonathan, Walther, Zenta, Schalper, Kurt, Davies, Kurtis D., Woodcock, Mark G., Anagnostou, Valsamo, Marrone, Kristen A., Forde, Patrick M., Ricciuti, Biagio, Venkatraman, Deepti, Van Allen, Eliezer M., Cummings, Amy L., Goldman, Jonathan W., Shaish, Hiram, Kier, Melanie, Katz, Sharyn, Aggarwal, Charu, Ni, Ying, Azok, Joseph T., Segal, Jeremy, Ritterhouse, Lauren, Neal, Joel W., Lacroix, Ludovic, Elamin, Yasir Y., Negrao, Marcelo V., Le, Xiuning, Lam, Vincent K., Lewis, Whitney E., Kemp, Haley N., Carter, Brett, Roth, Jack A., Swisher, Stephen, Lee, Richard, Zhou, Teng, Poteete, Alissa, Kong, Yifan, Takehara, Tomohiro, Paula, Alvaro Guimaraes, Parra Cuentas, Edwin R., Behrens, Carmen, Wistuba, Ignacio I., Zhang, Jianjun, Blumenschein, George R., Gay, Carl, Byers, Lauren A., Gibbons, Don L., Tsao, Anne, Lee, J. Jack, Bivona, Trever G., Camidge, D. Ross, Gray, Jhannelle E., Leighl, Natasha B., Levy, Benjamin, Brahmer, Julie R., Garassino, Marina C., Gandara, David R., Garon, Edward B., Rizvi, Naiyer A., Scagliotti, Giorgio Vittorio, Wolf, Jürgen, Planchard, David, Besse, Benjamin, Herbst, Roy S., Wakelee, Heather A., Pennell, Nathan A., Shaw, Alice T., Jänne, Pasi A., Carbone, David P., Hellmann, Matthew D., Rudin, Charles M., Albacker, Lee, Mann, Helen, Zhu, Zhou, Lai, Zhongwu, Stewart, Ross, Peters, Solange, Johnson, Melissa L., Wong, Kwok K., Huang, Alan, Winslow, Monte M., Rosen, Michael J., Winters, Ian P., Papadimitrakopoulou, Vassiliki A., Cascone, Tina, Jewsbury, Philip, Heymach, John V.

Source: Nature; November 2024, Vol. 635 Issue: 8038 p462-471, 10p

The Pan‐Cancer Landscape of Coamplification of the Tyrosine Kinases KIT, KDR, and PDGFRA

Authors: Disel, Umut, Madison, Russell, Abhishek, Kumar, Chung, Jon H., Trabucco, Sally E., Matos, Asli O., Frampton, Garrett M., Albacker, Lee A., Reddy, Venkataprasanth, Karadurmus, Nuri, Benson, Adam, Webster, Jennifer, Paydas, Semra, Cabanillas, Ruben, Nangia, Chaitali, Ozturk, M.A., Millis, Sherri Z., Pal, Sumanta K., Wilky, Breelyn, Sokol, Ethan S., Gay, Laurie M., Soman, Salil, Ganesan, Shridar, Janeway, Katherine, Stephens, Phil J., Zhu, Viola W., Ou, Sai‐Hong Ignatius, Lovly, Christine M., Gounder, Mrinal, Schrock, Alexa B., Ross, Jeffrey S., Miller, Vincent A., Klempner, Samuel J., Ali, Siraj M.

Source: Oncologist. 25(1):e39-e47

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099861960.0x000001&indx=1&recIds=ETOCvdc_100099861960.0x000001

Pan-tumor validation of a NGS fraction-based MSI analysis as a predictor of response to Pembrolizumab.

Authors: Lin, Douglas I., Quintanilha, Julia C. F., Danziger, Natalie, Lang, Lixin, Levitan, Diane, Hayne, Cynthia, Hiemenz, Matthew C., Smith, David L., Albacker, Lee A., Leibowitz, Jeffrey, Mata, Douglas A., Decker, Brennan, Lakis, Sotirios, Patel, Nimesh R., Graf, Ryon P., Elvin, Julia A., Ross, Jeffrey S., Pattani, Varun, Huang, Richard S. P., Wehn, Amy K.

Source: NPJ Precision Oncology; 9/14/2024, Vol. 8 Issue 1, p1-9, 9p

Subject Terms: TREATMENT effectiveness, NUCLEOTIDE sequencing, TUMOR treatment, DATABASES, MICROSATELLITE repeats

Neoadjuvant talazoparib in patients with germline BRCA1/2 mutation-positive, early-stage triple-negative breast cancer: exploration of tumor BRCA mutational status.

Authors: Telli, Melinda L., Litton, Jennifer K., Beck, J. Thaddeus, Jones, Jason M., Andersen, Jay, Mina, Lida A., Brig, Raymond, Danso, Michael, Yuan, Yuan, Symmans, William F., Hopkins, Julia F., Albacker, Lee A., Abbattista, Antonello, Noonan, Kay, Mata, Marielena, Laird, A. Douglas, Blum, Joanne L.

Source: Breast Cancer (13406868); Sep2024, Vol. 31 Issue 5, p886-897, 12p

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

Authors: Foster, Scott A., Whalen, Daniel M., Özen, Ayşegül, Wongchenko, Matthew J., Yin, JianPing, Yen, Ivana, Schaefer, Gabriele, Mayfield, John D., Chmielecki, Juliann, Stephens, Philip J., Albacker, Lee A., Yan, Yibing, Song, Kyung, Hatzivassiliou, Georgia, Eigenbrot, Charles, Yu, Christine, Shaw, Andrey S., Manning, Gerard, Skelton, Nicholas J., Hymowitz, Sarah G., Malek, Shiva

Source: In Cancer Cell 11 April 2016 29(4):477-493

A Retrospective Genomic Landscape of 661 Young Adult Glioblastomas Diagnosed Using 2016 WHO Guidelines for Central Nervous System Tumors.

Authors: Haberberger, James F, Pegram, Worthy, Britt, Nicholas, Schiavone, Kelsie, Severson, Eric, Sharaf, Radwa, Albacker, Lee A, Williams, Erik, Lechpammer, Mirna, Hemmerich, Amanda, Lin, Douglas, Huang, Richard S P, Hiemenz, Matthew, Elvin, Julia, Graf, Ryon, Lesser, Glenn, Kram, David, Strowd, Roy, Bi, Wenya Linda, Ramkissoon, Lori A

Source: Oncologist; Jan2024, Vol. 29 Issue 1, pe47-e58, 12p

Subject Terms: GENETIC mutation, SEQUENCE analysis, CENTRAL nervous system tumors, GLIOMAS, RETROSPECTIVE studies, MACHINE learning, CANCER relapse, GENOMICS, GENE expression profiling, GENOTYPES, LONGITUDINAL method, ADULTS

Company/Entity: WORLD Health Organization

Genomic analysis of 63, 220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies

Authors: Hartmaier, Ryan, Charo, Jehad, Fabrizio, David, Goldberg, Michael, Albacker, Lee, Pao, William, Chmielecki, Juliann

Source: Genome medicine. 9(1):1-9

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111623614.0x000001&indx=1&recIds=ETOCvdc_100111623614.0x000001

Emergence of novel and dominant acquired EGFR solvent-front mutations at Gly796 (G796S/R) together with C797S/G and L792F/H mutations in one EGFR (L858R/T790M) NSCLC patient who progressed on osimertinib

Authors: Ou, Sai-Hong Ignatius, Cui, Jean, Schrock, Alexa B., Goldberg, Michael E., Zhu, Viola W., Albacker, Lee, Stephens, Philip J., Miller, Vincent A., Ali, Siraj M.

Source: Lung cancer. 108:228-231

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100084288465.0x000001&indx=1&recIds=ETOCvdc_100084288465.0x000001

Checkpoint inhibitor is active against large cell neuroendocrine carcinoma with high tumor mutation burden

Authors: Wang, Victoria, Urisman, Anatoly, Albacker, Lee, Ali, Siraj, Miller, Vincent, Aggarwal, Rahul, Jablons, David

Source: Journal for immunotherapy of cancer. 5(1):1-4

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141941382.0x000001&indx=1&recIds=ETOCvdc_100141941382.0x000001

Comprehensive Genomic Profiling Facilitates Implementation of the National Comprehensive Cancer Network Guidelines for Lung Cancer Biomarker Testing and Identifies Patients Who May Benefit From Enrollment in Mechanism-Driven Clinical Trials

Authors: Suh, James H., Johnson, Adrienne, Albacker, Lee, Wang, Kai, Chmielecki, Juliann, Frampton, Garrett, Gay, Laurie, Elvin, Julia A., Vergilio, Jo-Anne, Ali, Siraj

Source: Oncologist. 21(6):684-691

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN606990921&indx=1&recIds=ETOCRN606990921

A pan-sarcoma landscape of telomeric content shows that alterations in RAD51B and GID4 are associated with higher telomeric content.

Authors: Sharaf, Radwa, Jin, Dexter X., Grady, John, Napier, Christine, Ebot, Ericka, Frampton, Garrett M., Albacker, Lee A., Thomas, David M., Montesion, Meagan

Source: NPJ Genomic Medicine; 11/20/2023, Vol. 8 Issue 1, p1-10, 10p

Genomic analysis of advanced breast cancer tumors from talazoparib-treated gBRCA1/2mut carriers in the ABRAZO study.

Authors: Turner, Nicholas C., Laird, A. Douglas, Telli, Melinda L., Rugo, Hope S., Mailliez, Audrey, Ettl, Johannes, Grischke, Eva-Maria, Mina, Lida A., Balmaña, Judith, Fasching, Peter A., Hurvitz, Sara A., Hopkins, Julia F., Albacker, Lee A., Chelliserry, Jijumon, Chen, Ying, Conte, Umberto, Wardley, Andrew M., Robson, Mark E.

Source: NPJ Breast Cancer; 10/6/2023, Vol. 9 Issue 1, p1-9, 9p

Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity

Authors: Kim, Hye Young, Chang, Ya-Jen, Subramanian, Srividya, Lee, Hyun-Hee, Albacker, Lee A., Matangkasombut, Ponpan, Savage, Paul B., McKenzie, Andrew N.J., Smith, Dirk E., Rottman, James B., DeKruyff, Rosemarie H., Umetsu, Dale T.

Source: In The Journal of Allergy and Clinical Immunology 2012 129(1):216-227

Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity

Authors: Robichaux, Jacqulyne P., Elamin, Yasir Y., Vijayan, R.S.K., Nilsson, Monique B., Hu, Lemei, He, Junqin, Zhang, Fahao, Pisegna, Marlese, Poteete, Alissa, Sun, Huiying, Li, Shuai, Chen, Ting, Han, Han, Negrao, Marcelo Vailati, Ahnert, Jordi Rodon, Diao, Lixia, Wang, Jing, Le, Xiuning, Meric-Bernstam, Funda, Routbort, Mark, Roeck, Brent, Yang, Zane, Raymond, Victoria M., Lanman, Richard B., Frampton, Garrett M., Miller, Vincent A., Schrock, Alexa B., Albacker, Lee A., Wong, Kwok-kin, Cross, Jason B., Heymach, John V.

Source: Cancer cell. 36(4):444-457.e7

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099914246.0x000001&indx=1&recIds=ETOCvdc_100099914246.0x000001

TALAPRO-1: Talazoparib monotherapy in metastatic castration-resistant prostate cancer (mCRPC) with tumor DNA damage response alterations (DDRm)—Exploration of germline DDR alteration landscape and potential associations with antitumor activity.

Authors: Dorff, Tanya B., Fizazi, Karim, Laird, Douglas, Barthélémy, Philippe, Delva, Remy, Maruzzo, Marco, Stirling, Adam, Machiels, Jean-Pascal H., Dumez, Herlinde, Renard, Vincent, Hopkins, Julia, Albacker, Lee A., Chen, Hsiang-Chun, Healy, Cynthia G., Chelliserry, Jijumon, van Oort, Inge M., Scagliotti, Giorgio V., De Bono, Johann S., Mehra, Niven

Source: Journal of clinical oncology. 40(6 suppl):157-157

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152981674.0x000001&indx=1&recIds=ETOCvdc_100152981674.0x000001