Proteomic Profiling of COVID-19 Patients Sera: Differential Expression with Varying Disease Stage and Potential Biomarkers.

Authors: Dandachi, Iman¹ (AUTHOR) iman.j.d@hotmail.com, Alaiya, Ayodele² (AUTHOR) aalaiya@kfshrc.edu.sa, Shinwari, Zakia² (AUTHOR) szakia@kfshrc.edu.sa, Abbas, Basma³ (AUTHOR) bma_1403@hotmail.com, Karkashan, Alaa³ (AUTHOR) askarkashan@uj.edu.sa, Al-Amari, Ahod⁴ (AUTHOR) ahod.k.a@gmail.com, Aljabr, Waleed^1,5,6 (AUTHOR) wajabr@pha.gov.sa

Source: Diagnostics (2075-4418). Nov2024, Vol. 14 Issue 22, p2533. 19p.

Subject Terms: *COVID-19, *DRUG target, *COMPLEMENT activation, *DRUG development, *PROTEOMICS

Crosstalk between aryl hydrocarbon receptor (AhR) and BCL-2 pathways suggests the use of AhR antagonist to maintain normal differentiation state of mammary epithelial cells during BCL-2 inhibition therapy

Authors: Al-Dhfyan, Abdullah, Alaiya, Ayodele, Al-Mohanna, Falah, Attwa, Mohamed W, AlAsmari, Abdullah F, Bakheet, Saleh A, Korashy, Hesham M.

Source: Journal of advanced research. 50:177-192

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194785541.0x000001&indx=1&recIds=ETOCvdc_100194785541.0x000001

Inhibition of signaling downstream of beta‐2 adrenoceptor by propranolol in prostate cancer cells

Authors: Alaskar, Aljoharah, Abdulraqeb Ali, Amaal, Hassan, Sazzad, Shinwari, Zakia, Alaiya, Ayodele, Holzen, Urs, Miller, Lance, Kulik, George

Source: Prostate. 83(3):237-245

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170276629.0x000001&indx=1&recIds=ETOCvdc_100170276629.0x000001

Proteomics Analysis of Proteotoxic Stress Response in In-Vitro Human Neuronal Models.

Authors: Alaiya, Ayodele¹ (AUTHOR), Alharbi, Bothina Mohammed² (AUTHOR), Shinwari, Zakia¹ (AUTHOR), Rashid, Mamoon³ (AUTHOR), Albinhassan, Tahani H.^2,4 (AUTHOR), Bouchama, Abderrezak² (AUTHOR), Alwesmi, Mai B.⁵ (AUTHOR), Mohammad, Sameer² (AUTHOR), Malik, Shuja Shafi² (AUTHOR) maliksh@ngha.med.sa

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 12, p6787. 35p.

Subject Terms: *PROTEOMICS, *LOCUS coeruleus, *LIQUID chromatography-mass spectrometry, *AMINO acid metabolism, *HEAT shock proteins, *HEAT stroke, *PROTEIN folding

A homozygous truncating mutation of FGL2 is associated with immune dysregulation

Authors: Janssen, Erin, Alosaimi, Mohammad F., Alazami, Anas M., Alsuliman, Abdullah, Alaiya, Ayodele, Al-Saud, Bandar, Al-Mousa, Hamoud, Al-Zaid, Tariq Jassim, Smith, Emma, Platt, Craig D., Alruwaili, Hibah, Albanyan, Sarah, Al-Mayouf, Sulaiman M., Geha, Raif S.

Source: In The Journal of Allergy and Clinical Immunology February 2023 151(2):572-578

Dynamic cytosolic foci of DPPA4 in human pluripotent stem cells

Authors: Abu-Dawud, Raed, Mistry, Bhavesh V., Almahdali, Renad, Matin, Maryam M., Alaiya, Ayodele, Alghamdi, Fatimah, Alamari, Hala, Al-Yacoub, Nadya, Kashir, Junaid, Houssein, Marwa, Alawad, Abdullah, Andrews, Peter W., Assiri, Abdullah M.

Source: In Tissue and Cell October 2022 78

Distinct Phenotypic and Molecular Characteristics of CD34 − and CD34 + Hematopoietic Stem/Progenitor Cell Subsets in Cord Blood and Bone Marrow Samples: Implications for Clinical Applications.

Authors: Gaafar, Ameera, Hamza, Fatheia Nabeil, Yousif, Rama, Shinwari, Zakia, Alotaibi, Aminah Ghazi, Iqniebi, Alia, Al-Hussein, Khalid, Al-Mazrou, Amer, Manogaran, Pulicat Subramanian, Elhassan, Tusneem, Marquez-Méndez, Marcela, Aljurf, Mahmood, Al-Humaidan, Hind, Alaiya, Ayodele

Source: Diagnostics (2075-4418); Feb2025, Vol. 15 Issue 4, p447, 19p

Subject Terms: CORD blood, BIOMARKERS, ALDEHYDE dehydrogenase, BONE marrow, PROTEIN expression

Quantitative proteomics analysis reveals unique but overlapping protein signatures in HIV infections

Authors: Al-Mozaini, Maha, Alzahrani, Alhusain, Alsharif, Ibtihaj, Shinwari, Zakia, Halim, Magid, Alhokail, Abdullah, Alrajhi, Abdulrahman, Alaiya, Ayodele

Source: In Journal of Infection and Public Health June 2021 14(6):795-802

Kinome inhibition reveals a role for polo‐like kinase 1 in targeting post‐transcriptional control in cancer

Authors: Al‐Qahtani, Qamraa H., Moghrabi, Walid N., Al‐Yahya, Suhad, Al‐Haj, Latifa, Al‐Saif, Maher, Mahmoud, Linah, Al‐Mohanna, Falah, Al‐Souhibani, Norah, Alaiya, Ayodele, Hitti, Edward, Khabar, Khalid S. A.

Source: Molecular oncology. 15(8):2120-2139

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100124980412.0x000001&indx=1&recIds=ETOCvdc_100124980412.0x000001

Physio-Morphology and Proteomic Attitude of Ziziphus Spina-Christi in Copper-Contaminated Sites in Saudi Arabia: Is It a Candidate Bioremediator?

Authors: Alotaibi, Modhi Obaidan, Mohammed, Afrah Eltayeb, Almutairi, Taghreed, Shinwari, Zakia, Alaiya, Ayodele, Elobeid, Mudawi Mukhtar

Source: Current proteomics. 18(3):279-292

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128922038.0x000001&indx=1&recIds=ETOCvdc_100128922038.0x000001

Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1

Authors: Islam, Syed S., Uddin, Mohammed, Noman, Abu Shadat M., Akter, Hosneara, Dity, Nusrat J., Basiruzzman, Mohammad, Uddin, Furkan, Ahsan, Jahanara, Annoor, Sunera, Alaiya, Ayodele A., Al-Alwan, Monther, Yeger, Herman, Farhat, Walid A.

Source: In EBioMedicine May 2019 43:211-224

Endogenous osteoprotegerin (OPG) represses ERα and promotes stemness and chemoresistance in breast cancer cells.

Authors: Alraouji, Noura N., Colak, Dilek, Al-mohanna, Falah H., Alaiya, Ayodele A., Aboussekhra, Abdelilah

Source: Cell Death Discovery; 8/24/2024, Vol. 10 Issue 1, p1-12, 12p

A novel pH-sensitive liposome to trigger delivery of afatinib to cancer cells: Impact on lung cancer therapy

Authors: Almurshedi, Alanood S., Radwan, Mahasen, Omar, Samia, Alaiya, Ayodele A., Badran, Mohamed M., Elsaghire, Hanaa, Saleem, Imran Y., Hutcheon, Gillian A.

Source: In Journal of Molecular Liquids 1 June 2018 259:154-166

Association of TATA box-binding protein-associated factor RNA polymerase I subunit C (TAF1C) with T2DM

Authors: Abdulwahab, Rabab Asghar, Allaith, Abdul Ameer A., Shinwari, Zakia, Alaiya, Ayodele, Giha, Hayder A.

Source: Gene. 706:43-51

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100081997085.0x000001&indx=1&recIds=ETOCvdc_100081997085.0x000001

Impact of Resolvin-E1 and Maresin-1 on Bone Marrow Stem Cell Osteogenesis under Inflammatory Stress.

Authors: AlZahrani, Shahd, Shinwari, Zakia, Alaiya, Ayodele, Al-Kahtani, Ahmed

Source: Cells (2073-4409); Jun2024, Vol. 13 Issue 11, p932, 16p

Subject Terms: BONE marrow cells, BONE regeneration, BONE growth, MESENCHYMAL stem cells, BONE metabolism, PROTEIN expression

PD-L1 intrinsically promotes the proliferation of breast cancer cells through the SKP2-p27/p21 axis.

Authors: Elfoly, Marwa, Mirza, Jumanah Y., Alaiya, Ayodele, Al-Hazzani, Amal A., Tulbah, Asma, Al-Alwan, Monther, Ghebeh, Hazem

Source: Cancer Cell International; 5/9/2024, Vol. 24 Issue 1, p1-16, 16p

Subject Terms: CANCER cell proliferation, PROGRAMMED death-ligand 1, CANCER cell growth, PHASE transitions, NUCLEAR proteins, GENE expression

Wild-type S100A3 and S100A13 restore calcium homeostasis and mitigate mitochondrial dysregulation in pulmonary fibrosis patient-derived cells.

Authors: Al-Mutairy, Eid A., Al Qattan, Somaya, Khalid, Mohammed, Al-Enazi, Azizah A., Al-Saif, Maher M., Imtiaz, Faiqa, Ramzan, Khushnooda, Raveendran, Vineesh, Alaiya, Ayodele, Meyer, Brian F., Atamas, Sergei P., Collison, Kate S., Khabar, Khalid S., Hasday, Jeffrey D., Al-Mohanna, Futwan

Source: Frontiers in Cell & Developmental Biology; 2023, p1-12, 12p

Subject Terms: CALCIUM, HOMEOSTASIS, MITOCHONDRIA, RECOMBINANT proteins, INFLAMMATORY mediators

Cytotoxicity of poly-guanidine in medulloblastoma cell lines.

Authors: Gallo-Oller, Gabriel, de Ståhl, Teresita Díaz, Alaiya, Ayodele, Nilsson, Sten, Holmberg, Anders R., Márquez-Méndez, Marcela

Source: Investigational New Drugs; Oct2023, Vol. 41 Issue 5, p688-698, 11p

Subject Terms: MUSCLE proteins, DNA, FLUOROIMMUNOASSAY, MICROSCOPY, GLIOMAS, ORGANIC compounds, APOPTOSIS, CELL motility, RESEARCH funding, CARBOXYLIC acids, CELL lines, CYTOPLASM

HMOX1 is partly responsible for phenotypic and functional abnormalities in mesenchymal stem cells/stromal cells from placenta of preeclampsia (PE) patients

Authors: Basmaeil, Yasser S., Algudiri, Dana, Alenzi, Reem, Al Subayyil, Abdullah, Alaiya, Ayodele, Khatlani, Tanvir

Source: Stem cell research & therapy. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130479379.0x000001&indx=1&recIds=ETOCvdc_100130479379.0x000001

Clinical Characterization, Cancer Incidence and Long-Term Outcomes of Fanconi Anemia Patients : A Single Center Analysis of 97 Patients

Authors: Al-Sabbagh, Afnan ^*, Alzahrani, Hazza ^*, Dasouki, Majed J. ^*, Hussain, Taimoor ^*, Alaiya, Ayodele ^*, Alahmari, Ali ^*, Ghabashi, Emad ^*, Al Ammari, Raghad ^*, Demirkaya, Abdullah Faruk ^*, Alawwami, Moheeb ^*, Chaudhri, Naeem A., Alsharif, Fahad, Rasheed, Walid, Hanbali, Amr ^*, Shaheen, Marwan ^*, Alfraih, Feras Abdulaziz ^*, Elfakih, Riad ^*, Hashmi, Shahrukh K., Alhayli, Saud ^*, Alotaibi, Ahmad S. ^*, Alshaibani, Alfadel ^*, Albabtain, Abdulwahab ^*, Alotaibi, Shaykhah ^*, Saleh, Mostafa ^*, Abdrabou, Ahmed ^*, Bin salman, Ahmed ^*, Alfadhil, Haroon ^*, Al Sagheir, Ahmed ^*, Youniss, Riad ^*, Abraham, Manju ^*, Alotaibi, Bandar ^*, Ramadan, Sahar ^*, Alhuraiji, Ahmad ^*, Fahad, Almohareb ^*, Aljurf, Mahmoud, Ahmed, Syed O. ^*

Source: In Blood 15 November 2022 140 Supplement 1:11471-11473