Adipocyte Angptl8 deletion improves glucose and energy metabolism and obesity associated inflammation in mice

Authors: Ghosh, Anindya ^{1, 4}, Chénier, Isabelle ^{1, 4}, Leung, Yat Hei ¹, Oppong, Abel K. ¹, Peyot, Marie-Line ¹, Madiraju, S. R. Murthy ¹, Al-Khairi, Irina ², Abubaker, Jehad ², Al-Mulla, Fahd ³, Prentki, Marc ^{1, 5, ∗}, Abu-Farha, Mohamed ^{2, 3, ∗∗}

Source: In iScience 20 December 2024 27(12)

Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling

Authors: Ghosh, Anindya, Leung, Yat Hei, Yu, Jeffrey, Sladek, Robert, Chénier, Isabelle, Oppong, Abel K., Peyot, Marie-Line, Madiraju, S.R. Murthy, Al-Khairi, Irina, Thanaraj, Thangavel Alphonse, Abubaker, Jehad, Al-Mulla, Fahd, Prentki, Marc, Abu-Farha, Mohamed

Source: In BBA - Molecular and Cell Biology of Lipids April 2024 1869(3)

Changes in the expression of meteorin‐like (METRNL), irisin (FNDC5), and uncoupling proteins (UCPs) after bariatric surgery

Authors: Jamal, Mohammad H., AlOtaibi, Fatemah, Dsouza, Carol, Al‐Sabah, Suleiman, Al‐Khaledi, Ghanim, Al‐Ali, Waleed, Ali, Hamad, Cherian, Preethi, Al‐Khairi, Irina, Devarajan, Sriraman, Abu‐Farha, Mohamed, Al‐Mulla, Fahd, Abubaker, Jehad

Source: Obesity. 30(8):1629-1638

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156245450.0x000001&indx=1&recIds=ETOCvdc_100156245450.0x000001

Effect of Dual Glucagon-Like Peptide 1/Glucose-Dependent Insulinotropic Polypeptide Receptor Agonist (Tirzepatide) versus Bariatric Surgery on Weight Loss and Nonalcoholic Fatty Liver Disease.

Authors: Al-Sabah, Salman^1,2 (AUTHOR), Al-Khairi, Irina³ (AUTHOR), Jamal, Mohammad^1,2 (AUTHOR), Qaddoumi, Mohammad⁴ (AUTHOR), Alajmi, Fahad³ (AUTHOR), Kumar, Jijin³ (AUTHOR), Abukhalaf, Nermeen⁵ (AUTHOR), Cherian, Preethi³ (AUTHOR), Madhu, Dhanya³ (AUTHOR), Arefanian, Hossein⁶ (AUTHOR), Dsouza, Carol³ (AUTHOR), Alam-Eldin, Nada³ (AUTHOR), AlSabagh, Abdullah³ (AUTHOR), Al Madhoun, Ashraf⁵ (AUTHOR), Al-Sabah, Suleiman⁷ (AUTHOR), Al-Mulla, Fahd⁸ (AUTHOR), Abu-Farha, Mohamed³ (AUTHOR), Abubaker, Jehad³ (AUTHOR)

Source: Medical Principles & Practice. 2024, Vol. 33 Issue 5, p478-490. 13p.

Subject Terms: *NON-alcoholic fatty liver disease, *TYPE 2 diabetes, *WEIGHT loss, *BARIATRIC surgery, *LIVER analysis, *GASTRIC bypass

Effect of sleeve gastrectomy on the expression of meteorin-like (METRNL) and Irisin (FNDC5) in muscle and brown adipose tissue and its impact on uncoupling proteins in diet-induced obesity rats

Authors: Jamal, Mohammad H., Abu-Farha, Mohamed, Al-Khaledi, Ghanim, Al-Sabah, Suleiman, Ali, Hamad, Cherian, Preethi, Al-Khairi, Irina, AlOtaibi, Fatemah, Al-Ali, Waleed, Bosso, Mira, Dsouza, Carol, Abubaker, Jehad, Al-Mulla, Fahd

Source: In Surgery for Obesity and Related Diseases December 2020 16(12):1910-1918

The multi-faces of Angptl8 in health and disease: Novel functions beyond lipoprotein lipase modulation

Authors: Abu-Farha, Mohamed, Ghosh, Anindya, Al-Khairi, Irina, Madiraju, S.R. Murthy, Abubaker, Jehad, Prentki, Marc

Source: In Progress in Lipid Research November 2020 80

Plasma insulin is required for the increase in plasma angiopoietin‐like protein 8 in response to nutrient ingestion

Authors: Abu‐Farha, Mohamed, Alatrach, Mariam, Abubaker, Jehad, Al‐Khairi, Irina, Cherian, Preethi, Agyin, Krisitn, Abdelgani, Siham, Norton, Luke, Adams, John, Al‐Saeed, Dalal, Al‐Ozairi, Ebaa, DeFronzo, Ralph A., Al‐Mulla, Fahd, Abdul‐Ghani, Muhammad

Source: Diabetes/metabolism research and reviews. 39(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191757721.0x000001&indx=1&recIds=ETOCvdc_100191757721.0x000001

Effect of pioglitazone on inflammatory response and clinical outcome in T2DM patients with COVID-19: a randomized multicenter double-blind clinical trial.

Authors: Baagar, Khaled, Alessa, Thamer, Abu-Farha, Mohamed, Abubaker, Jehad, Alhumaidi, Heba, Franco Ceruto, Jose Antonio, Hamad, Mohammad Khair, Omrani, Ali, Abdelrahman, Salma, Haq, Muhammad Zaka-Ul, Safi, Abdul Wajid, Alhariri, Bassem, Barman, Manish, Abdelmajid, Alaaeldin, Cancio, Humberto Vidal Denis, Elmekaty, Eman, Al-Khairi, Irina, Cherian, Preethi, Jayyousi, Lina, Ahmed, Mohammed

Source: Frontiers in Immunology; 2024, p1-9, 9p

Subject Terms: COVID-19, TYPE 2 diabetes, TREATMENT effectiveness, PEOPLE with diabetes, COMMUNICABLE diseases

Dysregulated Urinary Extracellular Vesicle Small RNAs in Diabetic Nephropathy: Implications for Diagnosis and Therapy.

Authors: Ali, Hamad, Malik, Md Zubbair, Abu-Farha, Mohamed, Abubaker, Jehad, Cherian, Preethi, Al-Khairi, Irina, Nizam, Rasheeba, Jacob, Sindhu, Bahbahani, Yousif, Attar, Abdulnabi Al, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

Source: Journal of the Endocrine Society; Aug2024, Vol. 8 Issue 8, p1-11, 11p

Subject Terms: NON-coding RNA, MICRORNA, TYPE 2 diabetes, CHRONIC kidney failure, EXTRACELLULAR vesicles, DIABETIC nephropathies

Reduced miR-181d level in obesity and its role in lipid metabolism via regulation of ANGPTL3

Authors: Abu-Farha, Mohamed, Cherian, Preethi, Al-Khairi, Irina, Nizam, Rasheeba, Alkandari, Abdullah, Arefanian, Hossein, Tuomilehto, Jaakko, Al-Mulla, Fahd, Abubaker, Jehad

Source: Scientific reports. 9(1):1-10

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189430603.0x000001&indx=1&recIds=ETOCvdc_100189430603.0x000001

Remyelination modulators in multiple sclerosis patients

Authors: Al-Temaimi, Rabeah, AbuBaker, Jehad, Al-khairi, Irina, Alroughani, Raed

Source: In Experimental and Molecular Pathology December 2017 103(3):237-241

Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in Kuwait.

Authors: Alramah, Tahani, Cherian, Preethi, Al-Khairi, Irina, Abu-Farha, Mohamed, Thanaraj, Thangavel Alphonse, Albatineh, Ahmed N., Safadi, Fayez, Ali, Hamad, Abdul-Ghani, Muhammad, Tuomilehto, Jaakko, Koistinen, Heikki A., Al-Mulla, Fahd, Abubaker, Jehad

Source: Frontiers in Endocrinology; 5/6/2024, p1-10, 10p

Subject Terms: TYPE 2 diabetes, BLOOD pressure, SOUTH Asians, SCLEROSTIN, DIASTOLIC blood pressure, BONE health

Geographic Terms: KUWAIT

Angiopoietin-2 and Angiopoietin-like Proteins with a Prospective Role in Predicting Diabetic Nephropathy.

Authors: Alshawaf, Eman, Abu-Farha, Mohamed, Mohammad, Anwar, Devarajan, Sriraman, Al-Khairi, Irina, Cherian, Preethi, Ali, Hamad, Al-Matrouk, Hawra, Al-Mulla, Fahd, Al Attar, Abdulnabi, Abubaker, Jehad

Source: Biomedicines; May2024, Vol. 12 Issue 5, p949, 13p

Subject Terms: ANGIOPOIETIN-like proteins, DIABETIC nephropathies, ANGIOPOIETIN-2, MULTIPLE regression analysis, RECEIVER operating characteristic curves

Ethnic Variations in the Levels of Bone Biomarkers (Osteoprostegerin, Receptor Activator of Nuclear Factor Kappa-Β Ligand and Glycoprotein Non-Metastatic Melanoma Protein B) in People with Type 2 Diabetes.

Authors: Cherian, Preethi, Al-Khairi, Irina, Abu-Farha, Mohamed, Alramah, Tahani, Albatineh, Ahmed N., Alhomaidah, Doha, Safadi, Fayez, Ali, Hamad, Abdul-Ghani, Muhammad, Tuomilehto, Jaakko, Koistinen, Heikki A., Al-Mulla, Fahd, Abubaker, Jehad

Source: Biomedicines; May2024, Vol. 12 Issue 5, p1019, 12p

Subject Terms: TYPE 2 diabetes, BONE health, ASIANS, ARABS, BIOMARKERS

Geographic Terms: KUWAIT

Investigating the Role of FABP4 in Diabetes and Obesity and the Influence of Age and Ethnicity: A Comprehensive Analysis of a Cohort from the KEDP-Study.

Authors: Abdalla, Mohammed A., Abubaker, Jehad, Abu-Farha, Mohamed, Al-Khairi, Irina, Cherian, Preethi, Qaddoumi, Mohammad G., Al-Rashed, Fatema, Thanaraj, Thangavel Alphonse, Albatineh, Ahmed N., Al-Mulla, Fahd

Source: International Journal of Molecular Sciences; May2024, Vol. 25 Issue 9, p4578, 12p

Subject Terms: ETHNICITY, OBESITY, COHORT analysis, AGE groups, DIABETES

Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone

Authors: Khadir, Abdelkrim, Kavalakatt, Sina, Abubaker, Jehad, Cherian, Preethi, Madhu, Dhanya, Al-Khairi, Irina, Abu-Farha, Mohamed, Warsame, Samia, Elkum, Naser, Dehbi, Mohammed, Tiss, Ali

Source: In Metabolism September 2016 65(9):1409-1420

Adolescent obesity and ANGPTL8: correlations with high sensitivity C-reactive protein, leptin, and chemerin.

Authors: Hammad, Maha M., Channanath, Arshad M., Abu-Farha, Mohamed, Rahman, Abdur, Al Khairi, Irina, Cherian, Preethi, Alramah, Tahani, Alam-Eldin, Nada, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse, Abubaker, Jehad

Source: Frontiers in Endocrinology; 2024, p1-12, 12p

Subject Terms: ADOLESCENT obesity, CHEMERIN, ANGIOPOIETIN-like proteins, OVERWEIGHT children, C-reactive protein, LEPTIN

Geographic Terms: KUWAIT

Increased expression level of ANGPTL8 in white adipose tissue under acute and chronic cold treatment.

Authors: Arefanian, Hossein¹ (AUTHOR), Al-Khairi, Irina² (AUTHOR), Khalaf, Nermeen Abu³ (AUTHOR), Cherian, Preethi² (AUTHOR), Kavalakatt, Sina² (AUTHOR), Madhu, Dhanya² (AUTHOR), Mathur, Aditi⁴ (AUTHOR), Qaddoumi, Mohamed G.⁵ (AUTHOR), Al-Mulla, Fahd⁶ (AUTHOR), Abubaker, Jehad^2,7 (AUTHOR) jehad.abubakr@dasmaninstitute.org, Abu-Farha, Mohamed^2,7 (AUTHOR) mohamed.abufarha@dasmaninstitute.org

Source: Lipids in Health & Disease. 9/26/2021, Vol. 20 Issue 1, p1-11. 11p.

Subject Terms: *WHITE adipose tissue, *ADIPOSE tissues, *ANGIOPOIETIN-like proteins, *BROWN adipose tissue, *LIVER proteins, *LIPOPROTEIN lipase

Early autoantibody screening for type 1 diabetes: a Kuwaiti perspective on the advantages of multiplexing chemiluminescent assays.

Authors: Al-Mulla, Fahd, Alhomaidah, Doha, Abu-Farha, Mohamed, Hasan, Amal, Al-Khairi, Irina, Nizam, Rasheeba, Alqabandi, Rawan, Alkandari, Hessa, Abubaker, Jehad

Source: Frontiers in Immunology; 2023, p1-7, 7p

Subject Terms: TYPE 1 diabetes, CHEMILUMINESCENCE assay, AUTOIMMUNE diseases, MEDICAL screening, AUTOANTIBODIES, CHILD patients

Geographic Terms: KUWAIT

Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes

Authors: Qaddoumi, Mohammad G., Alanbaei, Muath, Hammad, Maha M., Al Khairi, Irina, Cherian, Preethi, Channanath, Arshad, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd, Abu-Farha, Mohamed, Abubaker, Jehad

Source: Scientific reports. 10(1)

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